• The Korea Journal of Herbology
• /
• v.32 no.1
• /
• pp.69-74
• /
• 2017

Objectives : This study aimed to investigate the effects of Angelicae sinensis Radix on longitudinal bone growth rate in rats. We have screened traditional medicinal herbs to develop the longitudinal bone growth stimulator by well-established rat model. A. sinensis was identified as one of the effective herbs in the screening process. Methods : Adolescent female rats were administered A. sinensis at doses of 30 mg/kg and 300 mg/kg for 10 consecutive days. To observe the rate of longitudinal bone growth, tetracycline was injected intraperitoneally on day 8 to stain a fluorescent band on the anew formed bone. To elucidate the mode of action, we observed insulin-like growth factor-1 (IGF-1) and bone morphogenetic protein-2 (BMP-2) expression after A. sinensis administration in growth plate. Results : In the 300 mg/kg A. sinensis group, the length between the proximal endpoint of the tetracycline label and the division line between growth plate and bone was significantly increased compared with vehicle-treated control group. Height of the proximal tibial growth plate was higher in the A. sinensis group compared with control group. A. sinensis also upregulated the expressions of IGF-1 and BMP-2 in the proliferative zone and hypertrophic zone of the proximal tibial growth plate. Conclusions : A. sinensis increases longitudinal bone growth rate in rats. According to immunohistochemistry, A. sinensis increases local IGF-1 and BMP-2 expressions in the growth plate which can be considered as direct stimulation of GH on the local growth plate.

• Journal of Periodontal and Implant Science
• /
• v.36 no.2
• /
• pp.473-488
• /
• 2006

Adequate bone quality and stress distribution to the bone are of decisive importance for implant success. Even though the success rates of dental implants have been high, implant failures do occur. Overloading has been identified as a primary factor behind dental implant failure. The purpose of this study was to theoretically investigate the effect of two types of implants on the stress distribution in poor bone quality. Employing the finite element method, the study modeled a 4.1 mm diameter, 12.0 mm length implant placed in cortical or spongeous bone. A static loading of lOON was applied at the occlusal surface at 0, 30 degrees angle to the vertical axis of the implant. von Mises stresses concentrations in the supporting bone were analyzed with finite element analysis program. The results were as follows; 1. The stresses at the marginal bone were higher under buccal oblique load(30 degrees off of the long axis) than under vertical load. 2. Under buccal oblique load, the stresses were higher at the lingual marginal bone than at the buccal marginal bone, and the differences were almost the same. 3, Under vertical and oblique load, the stress was the highest at the marginal bone and lowest at the bone around apical portions of implant in cortical bone. 4, Under vertical load, Model 1 showed more effective stress distribution than Model 2 irrespective of bone types. On the other hand, Model 2 showed lower stress concentration than Model 1 under buccal oblique load.

• Journal of the Korea Society of Computer and Information
• /
• v.24 no.10
• /
• pp.167-174
• /
• 2019

In this paper, We propose the purpose the examine the physical factors that influence the success rate during the endotracheal intubation and to provide the basic data for effective intubation success. The subject of this study was 42 students in emergency rescue department who had completed the BLS Health Care-provider and a specialized airway maintenance course dealing with endotracheal intubation and it is a similar experimental study after the non-equivalence single group. For data analysis, SPSS 23.0 Version was used. The study methods were measuring the grip fotce of subjects, the angle of arm during intubation tube, distance from manikin, palm length, etc. The results showed that there was a correlation between the time of successful endotracheal intubation and the physical characteristics. In particular, when performing endotracheal intubation, it was related to the angle of the arm and the execution time of the performer, and the narrower the angle of the arm, the shorter the execution time. The results of this study suggest that successful endotracheal intubation could be implemented if the operator tried to reduce the angle of the arm when performing endotracheal intubation, and through further research on various job groups, identify the possibility of clinical use will be necessary.

• Steel and Composite Structures
• /
• v.18 no.2
• /
• pp.425-442
• /
• 2015

This paper addresses theoretically the bending and buckling behaviors of size-dependent nanobeams made of functionally graded materials (FGMs) including the thickness stretching effect. The size-dependent FGM nanobeam is investigated on the basis of the nonlocal continuum model. The nonlocal elastic behavior is described by the differential constitutive model of Eringen, which enables the present model to become effective in the analysis and design of nanostructures. The present model incorporates the length scale parameter (nonlocal parameter) which can capture the small scale effect, and furthermore accounts for both shear deformation and thickness stretching effects by virtue of a sinusoidal variation of all displacements through the thickness without using shear correction factor. The material properties of FGM nanobeams are assumed to vary through the thickness according to a power law. The governing equations and the related boundary conditions are derived using the principal of minimum total potential energy. A Navier-type solution is developed for simply-supported boundary conditions, and exact expressions are proposed for the deflections and the buckling load. The effects of nonlocal parameter, aspect ratio and various material compositions on the static and stability responses of the FGM nanobeam are discussed in detail. The study is relevant to nanotechnology deployment in for example aircraft structures.

• Korean Journal of Optics and Photonics
• /
• v.19 no.4
• /
• pp.276-286
• /
• 2008

The representative alignments for taking a stereo image by using a stereoscopic camera are the toed-in and the parallel alignment. In this paper, we tried to find important factors in the process that captures the stereo image by modifying parallel type 3D camera alignment to take the same object information as, for instance, when toed-in type was used. The modified parallel type 3D camera has merits in both types. As a result, three important factors are found by simulation to be inter-camera distance, field of view and convergence angle for both types. And the change of the convergence angle is known to be the most important factor at the stereo fusible area in processing. The effective ranges of these factors to simulate perfectly toed-in type by modified parallel type are strongly dependent on a user's circumstances such as mobile, official, theater and so on. Additionally, the error of the simulation is reduced when the focal length of the stereo camera is short and the convergence angle becomes smaller.

• Health Policy and Management
• /
• v.31 no.4
• /
• pp.472-478
• /
• 2021

Background: Early identification of patients who are highly likely to develop severe illness among confirmed cases of coronavirus disease 19 (COVID-19) can be expected to lead to effective treatment. This study therefore aimed to determine whether the presence of nonalcoholic fatty liver disease (NAFLD) has an impact on the exacerbation of COVID-19 symptoms. Methods: The study used the Korean National Health Insurance claim data for treatment of COVID-19 patients in 2020. NAFLD includes nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH). The outcome variables used were hospitalization and the use of medical devices. Hospitalization was defined by a length of stay exceeding one day and the use of medical devices was defined as one or more uses of a ventilator or extracorporeal membrane oxygenation. Multivariable logistic regression analysis was performed to determine if there was a difference in the hospitalization and use of medical devices of COVID-19 patients depending on the presence of NAFLD. Results: The odds ratio of hospitalization was 1.059, indicating slightly higher odds of hospitalization for patients with NAFL or NASH compared to those without the conditions, but it was not statistically significant (0.969-1.156). On the other hand, the odds ratio of use of medical devices was high at 1.667 and was statistically significant (1.111-2.501). Conclusion: The study results found NAFLD to be a risk factor that can exacerbate symptoms in COVID-19 patients. Accordingly, it is necessary to identify NAFLD patients through preemptive screening and provide them with appropriate treatments.

• Journal of the Korea Society of Computer and Information
• /
• v.24 no.5
• /
• pp.93-102
• /
• 2019

The nation's fraternity and elite players who have built up a global bicycle infrastructure often find it to be a problem with the bicycle's speed and speed reduction, pain in knees and hip joints, or even with the bike itself, or with the bike's own physical defects or a riding posture. However, we found that most cases of cleat adjustment errors were likely to be true. Accurate adjustment of the cleats is the most important of the entire fitting process and can be the basis for improving the ability of the bicycle rider and preventing injury. Therefore, the study was intended to give a prior study of bicycle fitting, which can improve bicycle efficiency and prevent injury when riding bicycle, and specific ways of adjusting bicycle shoe cleats, and the following results were obtained. First, the cleat characteristics of Shimano, LOOK and Speedplay, which are currently used in public, and the characteristics during the cleat adjustment process, were derived. In addition, the structure and characteristics of dedicated shoes using cleats and the method of using pedalling by the structure of shoes after adjusting the cleats were derived. Second, the position of the shoe and its relationship with torque in pedalling was discussed, and the method of adjusting front and back of cleats was derived. Third, leg length, ASIS, Q-Angle and Q-factor etc. were analyzed and the method of setting and adjusting cleat left and right values were derived. Fourth, the relationship between walking angle and cleat rotation was analyzed, the method was derived, and the torque size and angle behind the cleat adjustment were compared and analyzed using the spinner to indicate the torque and the effective mean torque angle after the cleat adjustment.

• The Korean Journal of Food And Nutrition
• /
• v.35 no.6
• /
• pp.513-520
• /
• 2022

The purpose of this study was to investigate the effect of Cheonggukjang pills with aronia and blueberries on dextran sulfate sodium (DSS)-induced colitis in mice. There have been several reports that Cheonggukjang is effective for intestinal health, but the efficacy of Cheonggukjang containing fruits has not yet been reported. In this study, we showed the effect of cheonggukjang pills with blueberries and aronia (CPBA) on DSS-induced colitis in BALB/c mice. CPBA was obtained from Soonchang Moonokae foods and orally administered once a day for 2 weeks before DSS treatment. Colitis was induced in mice by feeding 5% (w/v) DSS drinking water for 7 days. The results showed that CPBA treatment significantly alleviated DSS-induced disease activity index associated with a decrease in colon length. CPBA improved DSS-induced histological changes and intestinal epithelial barrier integrity in mice colon. In addition, CPBA administration significantly reduced the levels of DSS-mediated interferon-γ and interleukin-6 in serum and tumor necrosis factor-α in colon tissue. Moreover, the gene expression of COX-2 and iNOS, which are factors involved in inflammatory signaling, was significantly reduced by CPBA treatment. These results suggest that CPBA have a protective effect against DSS-induced mice colitis and may be a candidate for colitis treatment.

• Geomechanics and Engineering
• /
• v.31 no.5
• /
• pp.505-518
• /
• 2022

This study introduces soil resistance multipliers at locations encompassed by the zone of influence of the helix plate to consider the added lateral resistance provided to the helical pile. The zone of influence of a helix plate is a function of its diameter and serves as a boundary condition for the modified soil resistance springs. The concept is based on implementing p-multipliers as a reduction factor for piles in group action. The application of modified p-y springs in the analysis of helical piles allows for better characterization and understanding of the lateral behavior of helical piles, which will help further the development of design methods. To execute the proposed method, a finite difference program, HPCap (Helical Pile Capacity), was developed by the authors using Matlab. The program computes the deflection, shear force, bending moment, and soil resistance of the helical pile and allows the user to freely input the value of the zone of influence and Ω (a coefficient that affects the value of the p-multiplier). Results from ten full-scale lateral load tests on helical piles embedded at depths of 3.0 m with varying shaft diameters, shaft thicknesses, and helix configurations were analyzed to determine the zone of influence and the magnitude of the p-multipliers. The analysis determined that the value of the p-multipliers is influenced by the ratio between the pile embedment length and the shaft diameter (D_p), the effective helix diameter (D_h-D_p), and the zone of influence. Furthermore, the zone of influence is recommended to be 1.75 times the helix diameter (D_h). Using the numerical analysis method presented in this study, the predicted deflections of the various helical pile cases showed good agreement with the observed field test results.

• Steel and Composite Structures
• /
• v.44 no.4
• /
• pp.451-471
• /
• 2022

In the present paper, the static bending and buckling responses of functionally graded carbon nanotubes-reinforced composite (FG-CNTRC) beam under various boundary conditions are investigated within the framework of higher shear deformation theory. The significant feature of the proposed theory is that it provides an accurate parabolic distribution of transverse shear stress through the thickness satisfying the traction-free boundary conditions needless of any shear correction factor. Uniform (UD) and four graded distributions of CNTs which are FG-O, FG-X, FG- and FG-V are selected here for the analysis. The effective material properties of FG-CNTRC beams are estimated according to the rule of mixture. To model the FG-CNTRC beam realistically, an efficient Hermite-Lagrangian finite element formulation is successfully developed. The accuracy and efficiency of the present model are demonstrated by comparison with published benchmark results. Moreover, comprehensive numerical results are presented and discussed in detail to investigate the effects of CNTs volume fraction, distribution patterns of CNTs, boundary conditions, and length-to-thickness ratio on the bending and buckling responses of FG-CNTRC beam. Several new referential results are also reported for the first time which will serve as a benchmark for future studies in a similar direction. It is concluded that the FG-X-CNTRC beam is the strongest beam that carries the lowest central deflection and is followed by the UD, V, Λ, and FG-O-CNTRC beam. Besides, the critical buckling load belonging to the FG-X-CNTRC beam is the highest, followed by UD and FG-O.