• Korean Journal of Pharmacognosy
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• v.48 no.2
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• pp.97-107
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• 2017

There is no doubt that the effect of ginseng on blood pressure could be different depending upon the type of ginseng employed for the experiment and methodology, thereby can exert bilateral modulatory activity on blood pressure. It has been reported that ginseng induced no significant change in blood pressure in those subjects with normal blood pressure, but had a normalizing effect on the subjects with abnormal blood pressure. Especially, experimental evidence indicates that ginsenoside Rg3, a major component of red ginseng, has been found to lower blood pressure, which is mediated by release of endothelium-derived NO, enhancing the accumulation of cGMP in the rat aorta. This clinical results further support the beneficial effect of Korean ginseng on blood pressure elucidated by animal experiment. As expected, a multicentric non-controlled clinical study shows that the effect of ginseng consumption has been found to normalize blood pressure in hypertensive or hypotensive individuals as compared to virtually no effect in normotensives. In addition, ginseng has been known to exhibit blood pressure decreased with no significant side effect and deteriorated QOL during the combination therapy of ginseng and anti-hypertensive drugs. This review provides a comprehensive overview on the effects of Korean ginseng on blood pressure.

• Archives of Pharmacal Research
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• v.27 no.9
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• pp.978-983
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• 2004

The effects of glycyrrhizic acid (GLZ) on protein binding of diltiazem, verapamil, and nifedipine were investigated. Protein binding studies (human serum, human serum albumin (HSA) and (X1-acid glycoprotein (AAG)) were conducted using the equilibrium dialysis method with and without addition of GLZ. The binding parameters, such as the number of moles of bound drug per mole of protein, the number of binding sites per protein molecule, and the association con-stant, were estimated using the Scatchard plot. The serum binding of nifedipine, verapamil, and diltiazem was displaced with addition of GLZ, and the decreases of Ks for serum were observed. GLZ decreased the association constants of three drugs for HSA and AAG, while the binding capacity remained similar with addition of GLZ. Although the characteristics of interaction were not clear, GLZ seemed to mainly affect HSA binding of nifedipine rather than AAG binding, while GLZ seemed to affect both AAG- and HSA-bindings of verapamil and dilt-iazem resulting in a serum binding displacement.

• Korean Journal of Biological Psychiatry
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• v.1 no.1
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• pp.17-30
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• 1994

Several different classes of antidepressants(ADs) with newer drugs becoming available have been used for the phamacological management of a broad spectrum of mental disorders, among which depressive disorder is most commonly indicated. Successful clinical use of ADs requires a complete understanding of the psychopharmacological properties of ADs and on accurate knowledge of patients, characteristics based on clinical experience and theoretical framework. This paper aims at providing some practical information on the clinical use of ADs to assist clinicians in treating patients with major depression. The author describes (1) different classes of ADs and their presumed mechanisms of action, (2) clinical characteristics of ADs focusing on side-effect profiles, (3) some issues arising during the treatment course such as : a) pretreatment tasks, b) choice of ADs, c) therapeutic drug dose and monitoring of drug concentration, d) three stages of treatment and e) strategies in refractory depression and (4) ADs in special patient groups.

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.242.3-243
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• 2003

The compound of 2"-O-benzoylcinnamaldehyde(CB-ph) is a derivative of 2"-hydroxycinnamaldehyde whcih is a methanol extract of cinnamomum cassia blume. It"s a new anti-cancer agent which has been showed to inhibit the growth of various tumor cells in vitro and in vivo. In order to investigate the effective drug concentration and bio-distribution of CB-ph, the plasma protein binding was studied. In this study, the degree of the binding of Cb-ph to various serum proteins, the binding parameters, the binding site of CB-ph in human serum albumin, and the effect of some extensive protein-binding drugs on the protein binding of CB-ph in human serum ablumin were investigated respectively by ultrafilteration and fluorescence spectrometry. (omitted)

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.274.1-274.1
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• 2002

There have been some reports showing that cardiovascular response is affected by exposure to extremely low frequency magnetic field (ELF-MF). In this experiment. we intended to observe if ELF-MF affects the basal level of cardiovascular response and effect of drugs acting on sympathetic nervous system. Rats exposed to MF (60 Hz. 20 G) for 1 or 5 days and sham were anesthetized with pentobarbital-Na. Carotid artery and jugular vein were intubated to measure blood pressure (BP) and inject drug respectively. (omitted)

• Neonatal Medicine
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• v.16 no.1
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• pp.18-24
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• 2009

Seizures are the most common clinical symptom of a neurologic insult and have long been recognized as an obvious marker of brain dysfunction in newborns. Presence of seizures in newborn infants may signify substantial risk for subsequent neurodevelopmental impairment including postneonatal epilepsy and death. The outcomes of seizures in neonates are determined mainly by the etiology of the seizures. Despite the decreasing trend of mortality of neonatal seizures, the prevalence of long-term neurodevelopmental sequelae in survivors has remained unchanged over time. Clinical studies have contributed to identifying significant prognostic factors for neurodevelopmental outcome. The underlying etiology of the seizures and electroencepaphalography background pattern are considered as most reliable early predictors of later neurologic sequelae. However, clinicians managing neonatal seizures are still challenged by difficult therapeutic and prognostic questions because of many unresolved issues in seizure recognition, terminology, relationships to the underlying brain lesion, effect of current management, particularly antiepileptic drugs on long-term outcomes. This review presents the prognosis of neonatal seizures, especially about mortality and neurodevelopmental deficit, and predictors of outcomes.

• Journal of Pharmaceutical Investigation
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• v.2 no.1
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• pp.52-57
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• 1972

There are many reports on the stability of drugs in powders and various dosage forms. The author studied on the stability of ascorbic acid mixed with talcs. From the result of this experiment, it was considered that talcs markedly accelerated oxidative degredation of ascorbic acid in powders and the acceleration rate depends on the varieties of crude talcs. Iron salts seem to be the principal factor influencing the degradation of ascorbic acid Degradation rate of ascorbic acid mixed with purified talc is significantly slower than that with the crnde talcs. The more the concetration of ascorbic acid is diluted, the faster the degradation rate and degredation rate of Ascorbic acid is the function of tme.

• Bulletin of the Korean Chemical Society
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• v.11 no.1
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• pp.54-58
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• 1990

Acid-base equilibria and spectroscopic properties of diazepam and chlorodiazepoxide were investigated in sodium dodecyl sulfate (SDS) micellar solutions as functions of pH. The results were compared with the behaviors in homogeneous aqueous media. The presence of SDS increased the $pK_a$ of chlorodiazepoxide to 6.3 from 4.7, while it has little effect on the $pK_a$ of diazepam. The acidic protonated form of diazepam was moderately fluorescent when the solution was excited at 350 nm, and emissnion intensity of the species was enhanced about 5 fold by the presence of SDS. On the other hand, the acidic solution of chlorodiazepoxide was non-fluorescent, but the neutral solution of the compound was fluorescent upon excitation at 350 nm. The emission peak of the neutral chlorodiazepoxide shifted to shorter wavelength region without significant change in the emission intensity upon the addition of SDS. Procedures for assay of the individual drugs from their mixture by the use of SDS micelle were discussed.

• Proceedings of the PSK Conference
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• 2003.04a
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• pp.196.1-196.1
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• 2003

Cinnamic acid derivatives(CAD) originating from vegetable kingdom have some biological activity. Effect of CAD on reversed cutaneous anaphylaxis (RCA) and hemolysin (HY) titer were studied in rats. Experiments were carried out to determine RCA as the skin edema induced at 2 hours after injection of 0.05 $m\ell$/site of anti-rat serum rabbit serum. Drugs were orally administered at one hour before antigen challenge. (omitted)

• Journal of Digestive Cancer Research
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• v.8 no.2
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• pp.77-80
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• 2020

Gastric cancer is one of the leading causes of cancer-related deaths worldwide. The increased expression of cyclooxygenase (COX)-2 has been implicated in the development and progression of gastric cancers. A number of recent studies have been published evaluating the chemopreventive effect of aspirin and non steroidal anti inflammatory drungs (NSAIDs) against gastric cancer. Aspirin and NSAIDs use may reduce the risk of gastric cancer incidence and death, whereas other studies have reported contradictory results. Therefore, further study should be needed to clarify the role of aspirin and NSAIDs in the chemoprevention of gastric cancer.