• Journal of Digital Convergence
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• v.15 no.10
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• pp.367-376
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• 2017

The purpose of this study was to identify the impact of empowerment on achievement in the team based learning by college nursing students and the mediation effects of co-regulation. A convenience sample of 243 subjects were recruited from one university in G city. And data were collected from May 23 to May 30, 2017. Data were analyzed using descriptive statistics, t-test, ANOVA, Pearson's Correlation, Multiple regression analyses with SPSS 21.0 Program. The psychological empowerment showed a significantly positive correlation of co-regulation and achievement, co-regulation showed a significantly positive correlation of achievement. The factors affecting the achievement were co-regulation, psychological empowerment, improvement on cooperation and modification, grade, and explanatory power was 57.2%. Co-regulation had a partial mediating effect in the relationship between shared psychological empowerment and Achievement. This study provided basic data for developing the nursing education program to improve achievement. and it is necessary to repeat the study including various variables related to achievement of the task in the future.

• The Journal of the Korea Contents Association
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• v.21 no.10
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• pp.712-722
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• 2021

The primary purpose of this study was to examine the mediating effect of cognitive emotion regulation strategies in the relationship between adult attachment and interpersonal relationship competence. To achieve the purpose of the study, college students from nationwide completed the questionnaire and analyzed 326 valid ones. Descriptive statistics, Pearson correlation analysis, and structural equation model were performed using SPSS 22.0 and AMOS 23.0. The results are as follows. First, adult attachment(attachment anxiety and attachment avoidance) were negatively correlated with interpersonal relationship competence. Also, attachment avoidance was significantly influenced on interpersonal relationship competence than attachment anxiety. Second, in the relationship between adult attachment and interpersonal relationship competence, attachment anxiety was fully mediated and attachment avoidance was partially mediated with cognitive emotion regulation strategies. Attachment anxiety and attachment avoidance mediated with adaptive cognitive emotion regulation strategies. Based on these results, we verified the importance and the possibility of changing the cognitive emotion regulation for increasing the level of interpersonal relationship competence. Finally, this study may provide an insight in terms of developing education and programs of adaptive cognitive emotion regulation strategies in counseling session.

• Asian-Australasian Journal of Animal Sciences
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• v.17 no.8
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• pp.1062-1068
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• 2004

Leptin has a major role in the regulation of food intake and energy homeostasis. In addition, leptin participates in many physiological functions including regulation of lipid metabolism. Bovine recombinant leptin protein was produced in E. coli cells in order to understand function of leptin in the regulation of lipid metabolism. The leptin expression vector was constructed in pGEX-4T-3 vector and transformed into E. coli BL21 cells. Expression of the GST-leptin fusion protein was induced with IPTG. The fusion protein was purified using glutathione sepharose 4B batch method, and the recombinant leptin was eluted after thrombin protease digestion. The effect of leptin on glucose transport was examined in the differentiated adipocytes of 3T3-L1 cells. Leptin had no effect on basal and insulin-stimulated glucose transport in 3T3-L1 cells (p>0.05). Effect of recombinant leptin on glucose and acetate transport was examined in adipose tissues of Korean cattle (Hanwoo). Insulin stimulated glucose transport in both intramuscular and subcutaneous adipose tissues (p<0.05), but leptin did not affect glucose transport in both adipose tissues (p>0.05). Insulin stimulated acetate transport in bovine adipose tissues (p<0.05), but leptin did not affect acetate transport (p>0.05). Northern and RT-PCR analyses showed that mRNA levels of uncoupling protein-2 were increased by leptin treatment in 3T3-L1 cells without statistical difference (p>0.05). In conclusion, bovine recombinant leptin did not affect glucose and acetate transport in both 3T3-L1 adipocytes and bovine adipose tissues, while it stimulates UCP-2 mRNA expression in 3T3-L1 cells.

• The Journal of Korean Physical Therapy
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• v.27 no.4
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• pp.201-206
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• 2015

Purpose: This study was conducted in order to understand the influence of professionalism on job satisfaction and job performance of the physical therapist. Methods: Subjects were 148 physical therapists. We conducted a questionnaire survey on professionalism, job satisfaction, and job performance. Professionalism questions were 'Compliance of professional organization', 'Beliefs about public service', 'Autonomy', 'Beliefs about self-regulation', and 'Vocation awareness of the profession'. A regression analysis was then performed. Results: The subjects' average score for professionalism was $3.18{\pm}0.31$ points. The lowest score for satisfaction was observed for 'Compliance of professional organization'. Professionalism had an effect on job satisfaction. 'Vocation awareness of the profession (${\beta}=0.44$, p<0.001)', 'Beliefs about public service (${\beta}=0.25$, p<0.01)', and 'Autonomy (${\beta}=0.17$, p<0.05)' had an effect on job satisfaction. R square=0.46 (adjusted R square=0.45). Professionalism had an effect on job performance. 'Autonomy (${\beta}=0.29$), p<0.001)', 'Vocation awareness of the profession (${\beta}=0.22$, p<0.05)', and 'Beliefs about self-regulation (${\beta}=0.18$, p<0.05)' had an effect on job performance. R square=0.25 (adjusted R square=0.22). Conclusion: The results of this study indicate that in order to improve job satisfaction and job performance, it is necessary to improve professionalism. Therefore physical therapists should improve their professionalism ('Compliance of professional organization', 'Beliefs about public service', 'Autonomy', 'Beliefs about self-regulation', and 'Vocation awareness of the profession') in order to improve their job satisfaction and job performance. In addition, research to improve professionalism of the physical therapist should be continued.

• The Transactions of the Korean Institute of Electrical Engineers A
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• v.48 no.6
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• pp.692-698
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• 1999

This paper analyzes the effect of DGS(Dispersed Generation System) on the voltage regulation of the traditional distribution system of which the voltage is controlled by the bank LDC(Line Drop Compensator). Through the simulation results for 22.9kV class distribution system with DGSs, some general relationships among the operating power factor and introduction limit of DGS, and the sending-end reference voltage determined by internal setting coefficients of the LDC are derived. Those relationships are that the introduction limit of DGS increases as the power factor of DGS goes from lagging to leading and also as the allowance of the sending-end reference voltage increases. From the relationships, a operation method of the power distribution system integrated with DGSs is proposed from the view point of the operating power factor of DGS and new voltage regulation method.

• Proceedings of the Korean Society of Veterinary Pathology Conference
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• 2003.10a
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• pp.42-42
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• 2003

The contamination of the environment with pollutants is one of the main problems of modern life, and the levels pollution in industrialized regions are giving raise to increased public concern. The mitogen-activated protein kinase (MAP kinase) are playa pivotal role in the regulation of important cellular functions by activation of specific signal transduction pathways from cell the surface to the nuclei. Three major subgroups of MAP kinases have been identified, and these comprise the extracellular signal-regulated kinase (ERK), the c-Jun amino-terminal kinase (JNK), and the p38 MAP kinases [1-3]. Herein, we investigated the effect of regulation of phospho-JNK (p-JNK), phospho-p38 (p-p38) and phospho-ERK (p-ERK) by TCDD. (omitted)

• Molecules and Cells
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• v.42 no.7
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• pp.512-522
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• 2019

Chromosomes located in the nucleus form discrete units of genetic material composed of DNA and protein complexes. The genetic information is encoded in linear DNA sequences, but its interpretation requires an understanding of three-dimensional (3D) structure of the chromosome, in which distant DNA sequences can be juxtaposed by highly condensed chromatin packing in the space of nucleus to precisely control gene expression. Recent technological innovations in exploring higher-order chromatin structure have uncovered organizational principles of the 3D genome and its various biological implications. Very recently, it has been reported that large-scale genomic variations may disrupt higher-order chromatin organization and as a consequence, greatly contribute to disease-specific gene regulation for a range of human diseases. Here, we review recent developments in studying the effect of structural variation in gene regulation, and the detection and the interpretation of structural variations in the context of 3D chromatin structure.

• BMB Reports
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• v.52 no.2
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• pp.113-118
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• 2019

The small ubiquitin-related modification molecule (SUMO), one of the post-translational modification molecules, is involved in a variety of cellular functions where it regulates protein activity and stability, transcription, and cell cycling. Modulation of protein SUMOylation or deSUMOylation modification has been associated with regulation of carcinogenesis in breast cancer. In the dynamic processes of SUMOylation and deSUMOylation in a variety of cancers, SUMO proteases (SENPs), reverse SUMOylation by isopeptidase activity and SENPs are mostly elevated, and are related to poor patient prognosis. Although underlying mechanisms have been suggested for how SENPs participate in breast cancer tumorigenesis, such as through regulation of target protein transactivation, cancer cell survival, cell cycle, or other post-translational modification-related machinery recruitment, the effect of SENP isoform-specific inhibitors on the progression of breast cancer have not been well evaluated. This review will introduce the functions of SENP1 and SENP2 and the underlying signaling pathways in breast cancer for use in discovery of new biomarkers for diagnosis or therapeutic targets for treatment.

• YAKHAK HOEJI
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• v.56 no.3
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• pp.180-185
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• 2012

The aim of present study was to investigate the possible influence and related mechanism of alcohol on the arterial contraction. Vascular contraction involves the activation of thick or thin filament pathway. However, there are no reports addressing the question whether this pathway is involved in alcohol-induced regulation. We hypothesized that alcohol plays a role in vascular contraction evoked by a vasoconstrictor in rat aortae regardless of endothelial function. Denuded arterial rings from male rats were used and isometric contractions were recorded using a computerized data acquisition system. Interestingly, alcohol at a low concentration (3% v/v) inhibited thromboxane $A_2$ or phorbol ester-induced contraction with endothelial function but at a high concentration (10%) didn't inhibit and rather increased the contraction in the denuded muscle. Therefore, alcohol at a low concentration decreases the contraction and alcohol at a high concentration increases the contraction suggesting that additional pathways different from endothelial nitric oxide synthesis might be involved in the regulation of contractility. In conclusion, alcohol has some effect on the regulation of contractility regardless of endothelial function.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.64 no.2
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• pp.289-296
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• 2015

In this paper, we propose the nonlinear control based on singular perturbation theory for position tracking and yaw regulation of planar motor. Singular perturbation theory is characterized by the existence of slow and fast transients in the system dynamics. The proposed method consists of auxiliary control to decouple error dynamics. We develop model reduction with control input. Also, we derIve decoupled error dynamics with auxiliary input. The controller is designed in order to guarantee the desired position and yaw regulation without current feedback or estimation. Simulation results validate the effect of proposed method.