• Genomics & Informatics
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• v.21 no.3
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• pp.30.1-30.13
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• 2023

Ephs belong to the largest family of receptor tyrosine kinase and are highly conserved both sequentially and structurally. The structural organization of Eph is similar to other receptor tyrosine kinases; constituting the extracellular ligand binding domain, a fibronectin domain followed by intracellular juxtamembrane kinase, and SAM domain. Eph binds to respective ephrin ligand, through the ligand binding domain and forms a tetrameric complex to activate the kinase domain. Eph-ephrin regulates many downstream pathways that lead to physiological events such as cell migration, proliferation, and growth. Therefore, considering the importance of Eph-ephrin class of protein in tumorigenesis, 7,620 clinically reported missense mutations belonging to the class of variables of unknown significance were retrieved from cBioPortal and evaluated for pathogenicity. Thirty-two mutations predicted to be pathogenic using SIFT, Polyphen-2, PROVEAN, SNPs&GO, PMut, iSTABLE, and PremPS in-silico tools were found located either in critical functional regions or encompassing interactions at the binding interface of Eph-ephrin. However, seven were reported in nonsmall cell lung cancer (NSCLC). Considering the relevance of receptor tyrosine kinases and Eph in NSCLC, these seven mutations were assessed for change in the folding pattern using molecular dynamic simulation. Structural alterations, stability, flexibility, compactness, and solvent-exposed area was observed in EphA3 Trp790Cys, EphA7 Leu749Phe, EphB1 Gly685Cys, EphB4 Val748Ala, and Ephrin A2 Trp112Cys. Hence, it can be concluded that the evaluated mutations have potential to alter the folding pattern and thus can be further validated by in-vitro, structural and in-vivo studies for clinical management.

• Journal of The Korean Association For Science Education
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• v.28 no.6
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• pp.603-617
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• 2008

Inspired by the socio-cultural perspective on teaching and learning science, we have explored how the teacher and students interact with one another and develop meanings in science classrooms. Data came from four 10th grade science classrooms, and video recordings and verbatim transcripts of the lessons were analyzed. Focus of the analysis was on the participation structures as well as the possibility of developing the space for hybrid meaning making. The participation structures identified were mainly teacher-led, and students rarely took an active stance to initiate an opportunity for generating new meanings. However, some participation structures had the potential to develop a new discursive space in which hybrid meaning can be constructed through negotiation between participants. Implications for future research and more desirable educational practices were discussed based on the result.

• 대한공업교육학회지
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• v.33 no.2
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• pp.120-136
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• 2008

Using the tangible programming tools, which combines physical objects (e.g. robot) and educational programming language, may help to encourage learners' creative thinking as well as to enhance problem solving ability. That is, learners can have opportunities to simulate problem solving processes through the physical objects, such as robots. Therefore, they can minimize an fixation about problem solving process. These experience is effective to induce creative thinking that is useful to find new solutions and change environment actively. Therefore, we developed a robot based programming teaching and learning curriculum and implemented it in college level introductory programming courses. The result shows that the robot based programming learning has a positive effect in all three factors of learners' creative problem solving potential, especially in a cognitive factor. The cognitive factor includes general problem solving abilities as well as factors that explain creativity, such as divergent thinking, problem recognition, problem representation. These result means that the developed robot based programming teaching and learning curriculum give positive effect to creative problem solving abilities.

• Journal of Gifted/Talented Education
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• v.14 no.3
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• pp.41-52
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• 2004

No educational provision for the gifted and talented works in a cultural vacuum, and this is as true for out-of-school activities as for what happens in school itself. There is evidence that excellence in children's achievements can come from widely differing special provision or from no special provision at all. Cultural influences affect attitudes as to who might be gifted and talented and what might be done for them. Whatever the size and influence of special centres anywhere, there is always overlap between in-school and out-of-school activities. For all styles of provision, cooperation between the two is a vital aspect of success. The major cultural dichotomy in this field is between the perception, usually found in the Far East that 'most children have gifted potential' and the largely Western view that 'few children have gifted potential'. It is safe to say that children who are selected for aptitude and ability, and who are keen to learn, will get more from special enrichment than those who of equal potential who have not had that experience. But this does not necessarily show the provision as the best possible method for enhancing gifts and talents. In fact, I do not know of a single scientific investigation, either cross-culturally or within one country, which compares any aspect of an out-of-school programme with another. As a result it is hard to say what type of provision would be most appropriate and effective in any given situation. Outcomes are also dependent on the enthusiasm, organisation and money put into any scheme - as well as the way youngsters are chosen for it. Some of the largest and most influential out-of-school American institutions were founded on the psychological understanding of human abilities that was current in the 1920s. These early influences of seeking an IQ cut-off point (or equivalent) to identify the gifted still affect their practice. in addition, the big American Talent Searches so often select youngsters for summer-schools not only by their high-level achievements, but also by their parent's ability to pay the sometimes high fees. Opinions about the identification of the brightest children and consequential educational practice underlie all provision for their education, whether in or outside school hours. Because of cross-cultural differences, it would not seem wise to copy any action directly from one culture to another without recognising these influences and possibly modifying the model. The growing trend around the world is to offer high-level opportunities to as many youngsters as possible, so that no keen learner is turned away without even a change of sampling them.

• Journal of vocational education research
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• v.35 no.6
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• pp.39-63
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• 2016

The purpose of this study was to identify the factors affecting the actual employment rate and job retention rate after completion of the training program the unemployed. Survival analysis was conducted by utilizing employment insurance status and subscription data over two years of 840 patients who finally completed a training course from 889 patients in response to survey about the training service quality in 2012. The finding of the study were as follows. First, the highest employment rate (36.8%) after the completion time was within three months, a period more than 50% of the trainees were employed within six months. While employment continued to occur even with the lapse of one year and two years after the completion point, the employment rate over time was found to decrease gradually. Second, the factors affecting employment rate after completing training, appeared teaching competency(-) among training service quality and potential employability(+), which low awareness of teaching capacity and high awareness potential employability increased the possibility of their employment. Third, the highest periods (each 22.0%, 22.3%) of employment loss rate were within three months and within three to six months, and more than 50% of the trainees have lost their unemployment insurance were less than 8.8 months. Fourth, the factors affecting job retention rates after employment, appeared relationship between teachers and students(+), a fellow student relationships(+) among training service quality and training satisfaction(+), which high awareness of teacher-student relationships, fellow student relationships and training satisfaction increased the possibility of their maintaining employment.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.6
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• pp.550-557
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• 2021

This study examined the latent groups regarding the changes and difficulties after becoming a single parent and analyzed the differences in the backgrounds and depressive levels according to each group. The data of 2,500 single parents from the 2018 Single Parent Family Survey were analyzed by Latent Profile Analysis (LPA). LPA indicated four-profile groups: 1) parenting stability group, 2) normal group, 3) economic stability group, and 4) potential-risk group. Its determinants included gender and economic status, including government funding type and employment status rather than academic status. Specifically, female single parents with an unemployed or low-income support household were more likely to be linked to the potential-risk group. In addition, the potential-risk group showed a higher depressive level than the parenting stability group, normal group, and economic stability group. The significance of this study is that distinguished intervention based on the characteristics of each group can promote the effectiveness of single-parent family support policy.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.sup1
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• pp.31-36
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• 2016

Scientific evidence on all aspects of smoking amongst youth is very important for designing appropriate interventions to reduce smoking among this vulnerable population. This paper describes current access to anti-smoking information among school children aged 13 to 15 years in Vietnam in 2014 and examines its potential impact on preventing smoking initiation. The data used in this paper were obtained from the 2014 Global Youth Tobacco Survey (GYTS) in Vietnam. Students were asked questions about their level of awareness of anti-smoking information from various sources in the past 30 days and about lessons in school regarding the dangers of tobacco use during the last 12 months. Those who have never smoked were asked "whether or not they thought about avoiding cigarettes because of health warnings on cigarette packages" and answers were analyzed in combination with data on access to anti-smoking information from other sources. The prevalence of exposure to antismoking campaigns was high among school children in Viet Nam: 55.3% of current smokers reported thoughts of smoking cessation because of health warnings on cigarette packages; 60.5% of never smokers avoided initiating smoking because of the same health warnings. The potential impact of graphic health warnings to prevent school-aged children from smoking initiation would be stronger if there was concurrent access to anti-smoking programs on the dangers of tobacco use in schools. However, school education for tobacco prevention and control has not been as strong as expected. A more comprehensive school curriculum on tobacco prevention and control is recommended to reinforce antismoking messages among school children.

• Interdisciplinary Bio Central
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• v.2 no.4
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• pp.11.1-11.8
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• 2010

Indonesia is a mega-biodiversity country having at least one trillion US Dollars value of biological resources per year over the next 20 years. Indonesia is home to 11 percent of the world's flowering plant species and 12 percent of all mammals. Many of Indonesia's species and more than half of the archipelago's endemic plant species are found nowhere else on the Earth. This information is just a small portion of all higher plants and animals being found in Indonesia. Former studies described that total number of species in Indonesia is estimated more than 1,000,000 and most of them remain unknown scientifically. Most of lower plants and animals have not been studied yet, so that greatest portion of Indonesia's biological resources has never been assessed with respect to its economic value or conservation status. Many developed countries are building cooperation with Indonesia on resources, mainly in the fields of grant aid, socio-economic services, R & D, researcher exchange, technology transfer, infrastructure, education/training, finance, etc. Indonesia will obtain greater benefits and management of its biological richness via increasing its international capacity to add value and information to its biological diversity. These goals can be achieved by close international collaboration on search of important biological resources and other bioactive products that have potential economic values. Development of biological resource-based technology stands as the industry of the $21^{st}$ century and, therefore, Indonesia has a unique opportunity to lead the process in the world.

• Journal of radiological science and technology
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• v.40 no.3
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• pp.501-508
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• 2017

The purpose of present research is to offer a specialized educational opportunity for potential users, university students in radiology, by developing specific curriculum on site at KAERI, using HANARO research reactor and National radiation research facilities. The specific items of this research accomplished are: First, Development and operation of various curricula for specific research using HANARO and National radiation research facilities to provide university students with opportunities to use the facilities. Second, Operation of the experiment training programs for university students in radiology to foster next generation specialists. Third, through the on-site experiment training for students in radiology, support future potential experts of the radiation research fields, and broaden the base. A textbook and a teaching aid, a questionnaire have been developed to support the program. 714 university students have completed the courses for radiology experiment from 2006 to 2017. It is hoped that these experiments broaden public awareness and acceptance by the present and potential future utilization of the research reactor and national radiation research facilities, thereby bring positive impacts to policy making.

• Journal of Family Resource Management and Policy Review
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• v.20 no.3
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• pp.95-113
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• 2016

This study investigates the potential for multi-cultural youths, given their innate bilingual and dual culture, to be trained as the competent ODA professionals. For the purpose of collecting information, we organized two different kinds of FGI in 2015. The first FGI was conducted with a group of 10 expert participants from August 17 to September 25. The second FGI was conducted four times, from October 5 to October 23, with 13 adolescents from multi-cultural families from Russia, Mongolia, Vietnam, India, Indonesia, Japan, and China. The semi-structured interview items were passed through a formal review process of the Institutional Ethics Committee. Furthermore, with the participants' pre-consent to recording, all recorded data were categorized through the transcription process. The results are as follows. While the potential for nourishing bilingual and dual cultural capabilities are high for the adolescent children of multi-cultural families, the expert group also emphasized the negative aspects of these capabilities being suppressed due to the relatively oppressed family environment. The expert group therefore suggests the following: building parent awareness of ODA human resources, developing an educational career transition roadmap, and providing institutional incentives for ODA. In addition, to some extent, the researchers were able to detect some positive self-esteem among the adolescent children of multi-cultural families as a result of the bilingual and dual cultural competencies required to be ODA personnel. In sum, the research provides insight into the need for national social support for the adolescent children of multi-cultural families, so that their strengths are not extinguished, in order that they might grow up as competent ODA personnel.