• The Korean Journal of Physiology and Pharmacology
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• v.24 no.1
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• pp.101-110
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• 2020

Transient receptor potential canonical 4 (TRPC4) channel is a nonselective calcium-permeable cation channels. In intestinal smooth muscle cells, TRPC4 currents contribute more than 80% to muscarinic cationic current (mIcat). With its inward-rectifying current-voltage relationship and high calcium permeability, TRPC4 channels permit calcium influx once the channel is opened by muscarinic receptor stimulation. Polyamines are known to inhibit nonselective cation channels that mediate the generation of mIcat. Moreover, it is reported that TRPC4 channels are blocked by the intracellular spermine through electrostatic interaction with glutamate residues (E728, E729). Here, we investigated the correlation between the magnitude of channel inactivation by spermine and the magnitude of channel conductance. We also found additional spermine binding sites in TRPC4. We evaluated channel activity with electrophysiological recordings and revalidated structural significance based on Cryo-EM structure, which was resolved recently. We found that there is no correlation between magnitude of inhibitory action of spermine and magnitude of maximum current of the channel. In intracellular region, TRPC4 attracts spermine at channel periphery by reducing access resistance, and acidic residues contribute to blocking action of intracellular spermine; channel periphery, E649; cytosolic space, D629, D649, and E687.

• Journal of Korea Society of Industrial Information Systems
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• v.20 no.3
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• pp.37-49
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• 2015

To develop the contents making profit, we propose the program operation methods that can apply the needs of students and the demand of the times, and consider the capacity of the operating agency overall. First, we suggest the distance training motivation, the effective content type, appropriate interaction ratio, the effective teaching and learning methods and the assessment methods. Second, we suggest the development strategy of educational contents, assess quantitative the demand of students and the will of teacher overall, measure the potential success. Third by applying the strategies in the educational field, we product the 12 major development field. These fields are divided into categories A and B, category A is the very high success field and category B is the high potential success field. By applying the proposed strategy, You will select the most suitable contents here and now.

• Journal of the Korean Geographical Society
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• v.46 no.3
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• pp.366-381
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• 2011

A competitive location problem in discrete space is computationally difficult to solve in general because of its combinatorial feature. In this paper, we address an alternative method for solving competitive location problems in discrete space, particularly employing deterministic allocation. The key point of the suggested method is to reducing the number of predefined potential facility sites associated with the size of problem by utilizing geometric concepts. The suggested method was applied to the existing broadband marketplace with increasing competition as an application. Specifically, we compared computational results and spatial configurations of two different sized problems: the problem with the original potential sites over the study area and the problem with the reduced potential sites extracted by a GIS-based geometric algorithm. The results show that the competitive location model with the reduced potential sites can be solved more efficiently, while both problems presented the same optimal locations maximizing customer capture.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.15 no.1
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• pp.107-117
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• 2012

We estimated the potential area roof greening in Gyeonggi-do that will mitigate the heat island effect. The estimation was based on building age, roof shape, and building use which were recorded in the building register from "Sewoomteo, the Building Administration System in the Ministry of Land, Transport and Maritime Affairs. The estimated potential roof greening area in Gyeonggi-do was approximately $102.5km^2$ assuming that the buildings for residence, public, education(school), office, shopping mall are appropriate for roof greening. The area occupied by apartment buildings over six-story was 76.3% of the potential roof greening area 10.2% for individual houses, 5.9% for under five-story apartment buildings, and 3.7% for school buildings. The result indicated that it is residential buildings that we need to pay attention for roof greening, especially high-rise buildings over six-story. Greening of the whole estimated area, $102.5km^2$, in Gyeonggi-do will result in the increase of green space per capita by $8.74m^2$. This is 1.65 times greater than the area of current urban parks, and 1.97 times greater than the total area of neighborhood parks, children's parks, and pocket parks. Greening of the estimated roof area will increase green coverage of urban area by twice, adding to current green coverage of the urban areas, 11.3%, in 10 major cities. In particular, the effect of roof greening would be remarkable in inceasing the green space of Anyang City, Gwangmyeong City, and Guri City where neighborhood park area falls short.

• Journal of Gifted/Talented Education
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• v.25 no.2
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• pp.217-236
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• 2015

The purpose of this study was to investigate factors that affected achievement of socially succeeded people, and to draw ways to improve gifted education. To do this, we interviewed 60 achievers. The interview was administrated as semi-structured deep interview about 6 areas - education, major, family and parent, personal relationship, leisure time activity, achievement and motivation of success. The results showed that achievers were active students during their school days. They thought differentiated education and student-centered lessons are important. Many achievers answered they do not have any personal mentee, and decision of majors and education should be matched with the perception of one's potential and interest. Exercises, music, and reading books were strongly suggested as leisure time activities, and the key inner factors for success were curiosity and self-confidence. Beneficiaries of gifted education perceived their experience of gifted education had a positive influence on their achievement. Based on the these results, ways to improve gifted education were discussed.

• The Journal of Art Theory & Practice
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• no.1
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• pp.71-92
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• 2003

This study examined the condition of an educational discourse, relating the concept of creativity, culture, culture-centered, and critical thinking, to explore Culture-based Art Education(CBAE). In particular, art education practice was examined using interpretations of creativity and critical theory positions from the field of education. Discourse analysis was used as the research method to contextually situate and analyze the ways in which art education theory and practice of creativity and of critical studies encoded meanings. The study helped build an understanding that creativity was formed as a modernist discourse in the humanistic stance. In education, creativity became the fundamental concern for progressive educators who pursued innate ability of individuals. The way to enhance creative potential of students was to induce their motive, as was the same case in art education, while in artist training, free expression was its main method. In this way, as creativity was intimately connected with the concept of expression, in art education art making is the only course for enhancing creativity. However, because creative process cannot intelligently be regarded as logically distinct from the creative product, and creativity can only be said by product, it seems valid to think that creativity is the quality not to be achieved by teaching. Furthermore, its emphasis on art making resulted in unbalance of art making and art appreciation in art education. It was the late sixties when several alternatives for creative education were made their appearance. Critical studies in art adopted critical theory as its theoretical background has developed as an alternative of creative art education, when research and theory for creativity could not be adequate to deal with the problem of practice. Critical theory is a broad and diverse field of theory and practice drawing on aspects of the modernist perspective of the later Frankfurt School, feminism, Freirean pedagogy, postcolonial discourse as well as postmodernism to construct a practical approach to education. It is very this eclectic nature to provide the mosaic that need to experience cultures from different perspectives in a pluralistic society. Because one's personality is formed by multiple aspects of culture which is very complex and is made up of what we do and value, creativity cannot make part of educational discourse with the philosophy of culture centered. On the other hand, critical studies, as a school art program of critical theory, can perform the role of CBAE, because it would have to deal with the investigation of social and cultural issues form multiple personal, local, national, and global perspectives.

• Journal of Nutrition and Health
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• v.43 no.1
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• pp.57-68
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• 2010

Worksite health promotion programs have been associated with reductions in health risks but are labor-intensive and costly to implement. Therefore, innovative strategies to provide a cost-effective approach to health education program are needed. The purpose of this study was to investigate the effects of a worksite on-line health education program by email on metabolic syndrome risk factors and dietary intakes in male workers with metabolic syndrome. Anthropometric and biochemical parameters were measured and the nutrient intakes were assessed through FFQ. The diagnosis of metabolic syndrome was adapted from NCEP-ATP III with blood pressure, fasting blood glucose, triglyceride, HDL cholesterol, and Asia-Pacific definition with waist circumference. The education group consisted of 212 male workers and the non-education group of 236 age-matched male workers. The on-line health education program provided 10 sessions by e-mail. After a worksite on-line health education program, systolic blood pressure (p < 0.001), diastolic blood pressure (p < 0.001) and fasting blood glucose (p < 0.001) were significantly decreased and HDL cholesterol (p < 0.001) was significantly increased in the education group. Intakes of total energy (p < 0.05), carbohydrate (p < 0.05), sodium (p < 0.05) were significantly decreased in the education group, but there were no significant differences in dietary intakes in the non-education group after a worksite on-line health education program. The results indicate that online health education program by e-mail is effective for improving metabolic syndrome risk factors and dietary intakes in male workers and show potential for use in the working setting.

• The Journal of the Convergence on Culture Technology
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• v.10 no.4
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• pp.729-736
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• 2024

In connection with the OECD's core competency proposal, we would like to consider an attempt to realize this in liberal arts education at Korean universities and examine what kind of education plan it is desirable to present to learners. Universities are expanding competency-based education into human and social fields by reconsidering new talent awards and the direction of education. In this way, each university selects and organizes core competencies and incorporates the core competencies that the university pursues into educational goals. Under the supervision of the Ministry of Education, education centered on core competencies is exploring its potential in liberal arts courses at universities above all else. We want to explore a methodology that can achieve learner-centered teaching and learning effects in the process of incorporating and accepting this. Language acquisition along with cross-cultural understanding is above all else a part that can promote learners' competencies in terms of diversity and mutual understanding. Therefore, we reflect this in French liberal arts education and explore teaching and learning processes by incorporating respect for diversity and mutual cultural understanding competency education related to learners' motivation into lectures. We aim to supplement this through collaboration and mutual cultural understanding processes as presentation tasks in order to overcome the existing competency-based evaluation while deriving acceptance results from learners. Therefore, they recognize that the direction of core competency education naturally shifts to value-centered education.

• Proceedings of the Safety Management and Science Conference
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• 2010.11a
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• pp.283-297
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• 2010

This study carried out the investigation about the actual conditions of the management, disaster analysis and safety awareness on excavator in one of construction equipment and tried to make it's preventive measures. To achieve this, first of all, the accident of the internal Construction Industry process Investigation and Analysis, and then analyze an cause of accident based on it. Next, For the conditions of safety management conduct a survey to Investigation and Analysis and Propose preventive measures. The results of this study can be summarized as follows. 1st, Status of safety awareness and management of construction equipment tend to seek quickly and easily for the interests of sight. 2nd, Half the precincts of the equipment is causing major disaster. 3rd, The risk of excavator operation's indicators and drivers is so much potential. 4th, The preventive measures are needed for strengthening safety education, professional legal education, changes in safety awareness, the development of prevention system.

• Horticultural Science & Technology
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• v.33 no.3
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• pp.390-395
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• 2015

The synthesis of chimeras is a breeding approach for horticultural crops. In our breeding program, a new diploid citrus chimera, named 'Hongrou Taoye' (Citrus sinensis [L.] Osbeck + Citrus unshiu Marc.), was found arising at the junction where a 'Taoye' sweet orange (C. sinensis) scion was grafted onto Satsuma mandarin (C. unshiu). As an artificial chimera, its fruit traits derived from the L1 cell layer, with juice color and carotenoid complement, in which ${\beta}$-cryptoxanthin accumulated predominantly, similar to those of Satsuma mandarin. By contrast, traits originating from the L2/L3 cell layer, including pollen, seed, and rind aroma characteristics, were the same as those of 'Taoye' sweet orange (the scion). SSR and cpSSR analyses showed that both nuclear and chloroplast genomes of the chimera were a combination of both donor parents. 'Hongrou Taoye' thus combined the valuable traits of both donor plants, and therefore has good potential in citrus fresh market.