• Asian Pacific Journal of Cancer Prevention
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• v.15 no.11
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• pp.4617-4622
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• 2014

Background: Several studies have previously focused on associations between the (GT)n repeat polymorphism of the heme oxygenase-1 (HO-1) gene promoter region and risk of cancers, but results are complex. We conducted the present meta-analysis to integrate relevant findings and evaluate the association between HO-1(GT)n repeat polymorphism and cancer susceptibility. Materials and Methods: Published literature was retrieved from the PubMed/MEDLINE, EMBASE and ISI Web of Science databases before November 2013. For all alleles and genogypes, odds ratios were pooled to assess the strength of the associations using either fixed-effects or random-effects models according to heterogeneity. Subgroup analysis was conducted according to ethnicity and histopathology. Results: A total of 10 studies involving 2,367 cases and 2,870 controls were identified. The results showed there was no association between HO-1 (GT)n repeat polymorphism and the cancer risk both at the allelic and genotypic level. However, in the stratified analysis, we observed an increased risk of squamous cell carcinoma in persons carrying the LL genotype and the LL+LS genotype as compared with those carrying the SS genotype. When the LS and SS genotypes were combined, the odds ratio for squamous cell carcinoma in LL-genotype carriers, were also significantly increased. No publication bias was observed. Conclusions: The LL genotype and L-allele carrying genotypes (LL+LS) of HO-1 (GT)n repeat polymorphism are potential genetic factors for developing squamous cell carcinoma. More large and well-designed studies are required for further validations.

• Journal of the Korean earth science society
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• v.41 no.2
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• pp.137-146
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• 2020

A great number of geological research data have been produced by individually conducted researchers and then personally stored in domestic universities and research institutes. However, it is difficult to share data with other researchers owing to low and limited accessibility. The purpose of this study is to systematically establish metadata for inaccessible data, to manage them collectively and to provide opportunities for utilizing the data to those who require efficient research methods. Approximately 1,000 geological specimens (900 rocks and fossils, 100 thin sections) were gathered, along with their metadata such as high-resolution photographs, classification, name, owner, address, and geographical coordinates of the sample site, to establish their features. Additionally, 3D modeling data for 100 rocks and fossils were generated. On the basis of this study, it is possible for researchers to access and share crucial geological data that have a high potential to be lost and have been neglected in restricted spaces; by avoiding the wasted time, energy, and costs caused by repetitive collection of data, researchers may perform effective research and achieve qualified and competitive research results. Moreover, vulnerable and important geological data in the field can be protected from damage caused by indiscriminate, repetitive collection of specimens that have previously been secured. Through the establishment of additional metadata concerning the diversity of rocks, fossils, and thin sections kept at other universities and research institutes, much more data can be recognized, leading to advanced research results. Furthermore, specialized comparison and analysis of basic mineralogy and petrology knowledge are anticipated, based on the use of the metadata.

• Journal of The Korean Association of Information Education
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• v.21 no.4
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• pp.451-462
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• 2017

This study selected 3D printing that is highly likely to be adopted in schools. This research was conducted in two stages: 1) proposing the learning activity framework for utilizing 3D printing in education, and 2) exploring the potential of integrating 3D printing in the school field. The '3D printing learning activity framework' proposed in this study includes four phases that are categorized according to the complexity of problem-solving processes and collaborative interaction: Step 1 as production through replication, Phase 2 as means of imaginary expression, Phase 3 as near problem-solving, and Phase 4 as expanded problem-solving. Next, we conducted the field study with 23 students in the 6th grade math class where they learned the various solid shapes and volumes through 3D printing-integrated activities. The lesson was considered as Phase 1, which is the production through replication. Overall, the results showed that the participants had positive perceptions about the efficacy of 3D printing activities, the quality of learning experience, and satisfaction. On the other hand, it was found that the usability of 3D printers and CAD program needs further improvement The contribution of this study can be found in the learning activity framework that can guide 3D printing activity design in school, and in the exploration of enhancing the connection between 3D printing activities and curricular relevance beyond simple interest toward a novel technology.

• Korean Journal of Clinical Pharmacy
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• v.21 no.3
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• pp.280-291
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• 2011

Vaccines are products for immunization which can provoke antibodies by eliciting immune reponses without causing disease and have played an important role in preventing fatal and contagious diseases as well as H1N1 influenza. They are classified by two following categories; lived attenuated vaccine and killed vaccine and currently commonly using vaccines are BCG, diphtheria, tetanus, mumps, measles, rubella, polio, Haemophilus influenza type b, hepatitis B, influenza etc. All vaccines must be used correctly to reach optimal therapeutic goals and also informed well to patients to decrease potential problems. In order to do, pharmacists must have good knowledge of vaccines. The purpose of this study is to evaluate the necessity of vaccine education for pharmacists and develop a vaccine leaflet for patient counseling. We have performed a survey with questionnaire for a total of 176 pharmacists and nurses(hospital pharmacists, n=65; community pharmacists, n=50; hospital nurses, n=61) from January 27th to March 12th, 2010. The questionnaire includes items about vaccine education and counseling and 12 quizzes to evaluate responders' knowledge of vaccines. We used the SPSS(Version 12. for windows) program to analyze the data. In results, 94.9% of all responders said they had not been educated on vaccines. And only 1.1% of all responders said they know about vaccines enough to counsel patients. Pharmacists who have an experience recommending vaccines to other people are 21.7%. On the other hand, nurses who have an experience recommending vaccines to other people are 55.7%(p=0.000). The mean number of correct answers at the 12 quizzes are followings; hospital pharmacist, 8.1; community pharmacist, 6.1, hospital nurses, 6.2(p=0.000). A vaccine leaflet for patient counseling is developed with several references. In conclusion, due to no opportunity of vaccine education, pharmacists have no confidence to counsel patients and lack of knowledge of vaccine. But importance of vaccine's role is increasing, pharmacists should counsel patients in vaccination. So they need vaccine education and a vaccine leaflet will be helpful for their counseling.

• Journal of the Korean Institute of Landscape Architecture
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• v.46 no.5
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• pp.93-107
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• 2018

The concepts of geotourism and geoparks have emerged due to the paradigm shift in tourism and the increased recognition of geosites and geoheritage as legacies that must be protected and preserved. The number of geoparks designated by UNESCO and national governments is increasing globally. The purpose of this paper is to propose directions for enhancing Jeju Geopark to perform as a geological educational venue. This study reviewed the present conditions of the education and communication, the media, and the facilities of the geopark with respect to the required conditions to be effective for geological education. Data surveys, field surveys, visitor questionnaires, and interviews were conducted to examine the educational and guidance system of the geopark, the physical space configuration, and the operation and management methods. The research process is as follows. First, the study analyzed the status of the education and communication in Jeju Geopark, according to the criteria of the UNESCO GGN, using data acquired from the survey. Second, the study analyzed and evaluated the educational and communication facilities, and media, focusing on four aspects of the geopark: the geo-trail, spatial composition and layout, communicational and educational facilities, and the system and design of signboards. Third, the study assessed the perception and satisfaction of visitors to the geopark. Fourth, the study summarized the potential and limitations of the Jeju Geopark through in-depth interviews. The four analyses showed that enhancements in the exploration environment, communication, media, and operation and management system are all necessary for effective geological education. Based on these results, this study suggests directions for enhancing the geopark in the four following aspects. Management and maintenance must be improved to meet UNESCO criteria, while the improvements in the visiting environment quality, the supplementing of communication and facilities, and enhancements in the organization and system of operation and management also must be taken on.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.3
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• pp.2037-2042
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• 2013

Background: Different methods of diagnosis have been found to be inefficient in terms of screening and early diagnosis of lung cancer. Cancer cells produce proteins whose serum levels may be elevated during the early stages of cancer development. Therefore, those proteins may be recognized as potential cancer markers. The aim of this study was to differentiate healthy individuals and lung cancer cases by analyzing their serum protein profiles and evaluate the efficacy of this method in the early diagnosis of lung cancer. Materials and Methods: 170 patients with lung cancer, 53 under high risk of lung cancer, and 47 healthy people were included in our study. Proteomic analysis of the samples was performed with the SELDI-TOF-MS approach. Results: The most discriminatory peak of the high risk group was 8141. When tree classification analysis was performed between lung cancer and the healthy control group, 11547 was determined as the most discriminatory peak, with a sensitivity of 85.5%, a specificity of 89.4%, a positive predictive value (PPV) of 96.7% and a negative predictive value (NPV) of 62.7%. Conclusions: We determined three different protein peaks 11480, 11547 and 11679 were only present in the lung cancer group. The 8141 peak was found in the high-risk group, but not in the lung cancer and control groups. These peaks may prove to be markers of lung cancer which suggests that they may be used in the early diagnosis of lung cancer.

• Journal of Korean Home Economics Education Association
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• v.17 no.2
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• pp.95-112
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• 2005

This thesis attempts to describe motherhood discourses in colonial period based on analysing $\lceil$Shinyeosung$\rfloor$ (1923-1934). The motherhood discourses written in $\lceil$Shinyeosung$\rfloor$ were generally divided as follows : (1) women's motherhood (2) recognition of the children (3) eugenic (4) care and education of the children (5) disease of the children and their nursing (6) pregnancy and delivery. Main writers were also experts like medical doctors and professors. It was science that contributed to highlighting the greatness of mother. Science put emphasis on how 'pregnancy, delivery, care' are challenging and dangerous job. Accordingly, every woman, regarded as a potential mother, was requested to equip herself with all kind of skills in care. As new women's role were restricted within private area, they were cut off from various public issue. This type of motherhood became an essential part of 'modern family'.

• Education of Primary School Mathematics
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• v.11 no.1
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• pp.39-57
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• 2008

The purpose of this study is to affirm what influences the lessons applied by reorganizing the ratio-graph unit of level 6-A on the basis on Realistic Mathematics Education(RME) give on mathematical scholastic achievements and mathematical preferences.In order to achieve the purpose of this study, the experimental study was exerted by making two classes of 6 grades in J elementary school located in Gumi city, Gyeongbuk province as subjects. In this study, test of degree of the mathematics learning ability of student, multiple-choice test and descriptive test of the learning dispositions of student were exerted and the results were t-test officially. The results and the conclusions of this study were as follows: First, the results acquired by officially t-test the levels of the mathematics learning ability of student of the group taught by lessons according to the teaching materials reorganized on the basis of RME and the group taught by lessons according to the 7th curriculum show a meaningful difference(p=.007). This means that the lessons according to the teaching materials reorganized on the basis of RME showed meaningful influences on the improvement of degree of the mathematics learning ability of student. Second, the results acquired by officially t-test the learning dispositions of student multiple-choice test of the group taught by lessons according to the teaching materials reorganized on the basis of RME and the group taught by lessons according to the 7th curriculum show a meaningful difference. Especially in the factors of 'mathematical will'(p=.017) and 'mathematical value'(p=.029) were meaningful differences. Also in the descriptive test of the learning dispositions of student, the experimental class showed that it had the potential possibility to have more positive attitudes meaningfully in comparison with the compared class. This means that the lessons according to the teaching materials reorganized on the basis of RME showed meaningful influences on the learning dispositions of student.

• Communications of Mathematical Education
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• v.28 no.3
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• pp.353-366
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• 2014

Recently, the widespread usage of 3D-Printing has grown rapidly in popularity and development of a high level technology for 3D-Printing has become more necessary. Given these circumstances, effectively using mathematical knowledge is required. So, we have developed free web tools for 3D-Printing with Sage, for mathematical 3D modeling and have utilized them in college education, and everybody may access and utilize online anywhere at any time. In this paper, we introduce the development of our innovative 3D-Printing environment based on Calculus, Linear Algebra, which form the basis for mathematical modeling, and various 3D objects representing mathematical concept. By this process, our tools show the potential of solving real world problems using what students learn in university mathematics courses.

• Journal of Ginseng Research
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• v.40 no.2
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• pp.97-104
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• 2016

Background: Rhizobacteria play an important role in plant defense and could be promising sources of biocontrol agents. This study aimed to screen antagonistic bacteria and develop a biocontrol system for root rot complex of Panax notoginseng. Methods: Pure-culture methods were used to isolate bacteria from the rhizosphere soil of notoginseng plants. The identification of isolates was based on the analysis of 16S ribosomal RNA (rRNA) sequences. Results: A total of 279 bacteria were obtained from rhizosphere soils of healthy and root-rot notoginseng plants, and uncultivated soil. Among all the isolates, 88 showed antagonistic activity to at least one of three phytopathogenic fungi, Fusarium oxysporum, Fusarium solani, and Phoma herbarum mainly causing root rot disease of P. notoginseng. Based on the 16S rRNA sequencing, the antagonistic bacteria were characterized into four clusters, Firmicutes, Proteobacteria, Actinobacteria, and Bacteroidetesi. The genus Bacillus was the most frequently isolated, and Bacillus siamensis (Hs02), Bacillus atrophaeus (Hs09) showed strong antagonistic activity to the three pathogens. The distribution pattern differed in soil types, genera Achromobacter, Acidovorax, Brevibacterium, Brevundimonas, Flavimonas, and Streptomyces were only found in rhizosphere of healthy plants, while Delftia, Leclercia, Brevibacillus, Microbacterium, Pantoea, Rhizobium, and Stenotrophomonas only exist in soil of diseased plant, and Acinetobacter only exist in uncultivated soil. Conclusion: The results suggest that diverse bacteria exist in the P. notoginseng rhizosphere soil, with differences in community in the same field, and antagonistic isolates may be good potential biological control agent for the notoginseng root-rot diseases caused by F. oxysporum, Fusarium solani, and Panax herbarum.