• 한국멀티미디어학회논문지
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• 제16권8호
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• pp.972-981
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• 2013

비선형 편집(Non-linear Editing)이란 전통적인 선형 편집(Linear Editing) 방법과 달리 편집자가 원하는 대로 프레임 사이에 새로운 프레임을 삽입할 수 있는 편집 방법이다. 비선형 편집 시스템이란 이러한 편집방법을 지원하는 시스템으로 하나의 컴퓨터와 편집 소프트웨어 그리고 영상의 입 출력을 담당하는 캡처보드(Capture Board)로 구성된다. 현재 TV방송과 영화제작 과정에서는 이러한 비선형 편집 시스템을 사용하고 있다. 촬영된 영상이나 다양한 그래픽 소스는 비선형 편집 시스템을 통하여 하나의 영상콘텐츠로 제작된다. 본 논문에서는 많은 편집자들이 사용하고 있는 어도비 프리미어(Adobe Premiere)를 중심으로 비선형 편집 소프트웨어의 기능과 영상 편집 과정에서의 장 단점을 살펴보고 앞으로의 비선형 편집 소프트웨어의 개선 방향에 대하여 논의한다.

• BMB Reports
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• 제55권6호
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• pp.251-258
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• 2022

Innovative genome editing techniques developed in recent decades have revolutionized the biomedical research field. Liver is the most favored target organ for genome editing owing to its ability to regenerate. The regenerative capacity of the liver enables ex vivo gene editing in which the mutated gene in hepatocytes isolated from the animal model of genetic disease is repaired. The edited hepatocytes are injected back into the animal to mitigate the disease. Furthermore, the liver is considered as the easiest target organ for gene editing as it absorbs almost all foreign molecules. The mRNA vaccines, which have been developed to manage the COVID-19 pandemic, have provided a novel gene editing strategy using Cas mRNA. A single injection of gene editing components with Cas mRNA is reported to be efficient in the treatment of patients with genetic liver diseases. In this review, we first discuss previously reported gene editing tools and cases managed using them, as well as liver diseases caused by genetic mutations. Next, we summarize the recent successes of ex vivo and in vivo gene editing approaches in ameliorating liver diseases in animals and humans.

• Journal of Genetic Medicine
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• 제10권1호
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• pp.27-32
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• 2013

Post-transcriptional nucleotide sequence modification of transcripts by RNA editing is an important molecular mechanism in the regulation of protein function and is associated with a variety of human disease phenotypes. Identification of RNA editing sites is the basic step for studying RNA editing. Databases and bioinformatics resources are used to annotate and evaluate as well as identify RNA editing sites. No method is free of limitations. Correctly establishing an analytic pipeline and strategic application of both experimental and bioinformatics methods constitute the first step in investigating RNA editing. This review summarizes modern bioinformatics approaches and related resources for RNA editing research.

• Journal of Microbiology and Biotechnology
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• 제34권7호
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• pp.1522-1529
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• 2024

CRISPR-Cas system is being used as a powerful genome editing tool with developments focused on enhancing its efficiency and accuracy. Recently, the miniature CRISPR-Cas12f1 system, which is small enough to be easily loaded onto various vectors for cellular delivery, has gained attention. In this study, we explored the influence of temperature conditions on multiplex genome editing using CRISPR-Cas12f1 in an Escherichia coli model. It was revealed that when two distinct targets in the genome are edited simultaneously, the editing efficiency can be enhanced by allowing cells to recover at a reduced temperature during the editing process. Additionally, employing 3'-end truncated sgRNAs facilitated the simultaneous single-nucleotide level editing of three targets. Our results underscore the potential of optimizing recovery temperature and sgRNA design protocols in developing more effective and precise strategies for multiplex genome editing across various organisms.

• Journal of Multimedia Information System
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• 제5권3호
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• pp.201-208
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• 2018

High Efficiency Video Coding range extensions (HEVC RExt) is a kind of extension model of HEVC. HEVC RExt was specially designed for dealing the high quality images. HEVC RExt is very essential for studio editing which handle the very high quality and various type of images. There are some problems to dealing these massive data in studio editing. One of the most important procedure is re-encoding and decoding procedure during the editing. Various codecs are widely used for studio data editing. But most of the codecs have common problems to dealing the massive data in studio editing. First, the re-encoding and decoding processes are frequently occurred during the studio data editing and it brings enormous time-consuming and video quality loss. This paper, we suggest new video coding structure for the efficient studio video editing. The coding structure which is called "ultra-low delay (ULD)". It has the very simple and low-delayed referencing structure. To simplify the referencing structure, we can minimize the number of the frames which need decoding and re-encoding process. It also prevents the quality degradation caused by the frequent re-encoding. Various fast coding algorithms are also proposed for efficient editing such as tool-level optimization, multi-serve based distributed coding and SIMD (Single instruction, multiple data) based parallel processing. It can reduce the enormous computational complexity during the editing procedure. The proposed method shows 9500 times faster coding speed with negligible loss of quality. The proposed method also shows better coding gain compare to "intra only" structure. We can confirm that the proposed method can solve the existing problems of the studio video editing efficiently.

• 한국멀티미디어학회논문지
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• 제6권7호
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• pp.1302-1311
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• 2003

본 논문에서는 삼각 메쉬에 관한 보다 안정되고 직관적인 새로운 다중해상도 메쉬 편집 기술을 제안한다. 본 논문의 기본 아이디어는 3차원 메쉬 상에서 편집 영역을 선택하여 2차원 영역으로 임베딩을 하는 과정과 사용자에 의해서 정의되는 편집 정보를 보간하는 곡면을 생성하는 과정으로 이루어지며, 이를 통해 편집 영역 안에 있는 다른 꼭지점의 변위 정보를 곡면 함수값으로부터 생성한다. 본 논문에서 사용되는 임베딩 방법은 확장 볼록 조합 매개변수화 방법으로서 임베딩된 2차원 메쉬의 삼각형들은 자기 교차를 하지 않으며 또한 볼록 조합 계수를 정의할 때 모양 유지 방법을 사용하기 때문에 3차원 삼각형의 모양을 제대로 유지할 수 있다. 또한 편집 결과의 영역을 조절할 수 있도록 하기 위하여 다단계 B-스플라인 곡면을 이용하여, 상호작용적이며 직관적이어서 보다 안정되고 효율적인 메쉬 편집 결과를 얻을 수 있다.

• 한국수학사학회지
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• 제33권4호
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• pp.237-257
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• 2020

In this paper, we classify the mathematical terms in Korean Standard Unabridged Dictionary into four groups; ① group 1 consists of the terms which coincide with the mathematical terms in the 2015 Editing Material, ② group 2 consists of the terms which are synonyms or old terms or inflection forms of the mathematical terms in the Editing Material, ③ group 3 consists of the terms which do not belong to group 1 or group 2, but relate to the elementary or secondary school mathematics, ④ group 4 consists of the terms which do not relate to the elementary or secondary school mathematics. And then we make a comparative study with the mathematical terms in the Editing Material. In this study, we find out the mathematical terms in the Editing Material, but not in Korean Standard Unabridged Dictionary. And by using synonyms and old terms of the mathematical terms in the Editing Material we guess the rough tendency which terms belong to the Editing Material. By investigating the terms in group 3 and 4, we find out the mathematical terms which may belong to the Editing Material. We also find out the wrong or inconsistent explanations in Korean Standard Unabridged Dictionary.

• The Korean Journal of Physiology and Pharmacology
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• 제23권3호
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• pp.181-189
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• 2019

Curcumin, an active ingredient of Curcuma longa L., can reduce the concentration of low-density lipoproteins in plasma, in different ways. We had first reported that curcumin exhibits hypocholesterolemic properties by improving the apolipoprotein B (apoB) mRNA editing in primary rat hepatocytes. However, the role of curcumin in the regulation of apoB mRNA editing is not clear. Thus, we investigated the effect of curcumin on the expression of multiple editing components of apoB mRNA cytidine deamination to uridine (C-to-U) editosome. Our results demonstrated that treatment with $50{\mu}M$ curcumin markedly increased the amount of edited apoB mRNA in primary mouse hepatocytes from 5.13%-8.05% to 27.63%-35.61%, and significantly elevated the levels of the core components apoB editing catalytic polypeptide-1 (APOBEC-1), apobec-1 complementation factor (ACF), and RNA-binding-motif-protein-47 (RBM47), as well as suppressed the level of the inhibitory component glycine-arginine-tyrosine-rich RNA binding protein. Moreover, the increased apoB RNA editing by $50{\mu}M$ curcumin was significantly reduced by siRNA-mediated APOBEC-1, ACF, and RBM47 knockdown. These findings suggest that curcumin modulates apoB mRNA editing by coordinating the multiple editing components of the edito-some in primary hepatocytes. Our data provided evidence for curcumin to be used therapeutically to prevent atherosclerosis.

• International journal of advanced smart convergence
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• 제10권2호
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• pp.86-96
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• 2021

This cross-sectional survey research carried out with the inquisitive agenda on satisfaction of the translation outcomes as performed by human translation and (machine translation) post-editing. The survey group consisted of 166 Korean translators primarily working with the English, Chinese, and Japanese languages. They were asked to rate the satisfactory level with accuracy, fluency, idiomatic expression, and terminology in the Richter's scale of four. The result reveals that human translation is more satisfactory than post-editing with respect to accuracy, but it is uneasy to assert that accuracy is unsatisfactory in post-editing. On the other hand, the Korean translators are less satisfied with fluency, idiomatic expression, and terminology than accuracy. It can be assumed that although human translation is more satisfactory than post-editing, the accuracy of post-editing seems to be more acknowledged than fluency, idiomatic expression, and terminology, which lead the translators to take the accuracy of raw machine-translation products and to go on to improve the fluency, idiomatic expression, and terminology. Nevertheless, Korean translators believe Korean idiomatic expressions cannot be satisfactorily produced in post-editing, while fluency and terminology can be improved in post-editing.

• 방송공학회논문지
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• 제20권4호
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• pp.619-631
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• 2015

본 논문에서는 방송 콘텐츠와 개인 콘텐츠를 편집하기 위한 새로운 온라인 콘텐츠 편집 시스템을 제안한다. 제안하는 편집 시스템은 콘텐츠를 저장하고 관리하기 위한 콘텐츠 관리 서버와 사용자 인터페이스를 통해 콘텐츠 편집을 수행하는 콘텐츠 편집기로 구성된다. 편집 대상 콘텐츠를 다운로드 받아 편집을 수행하는 기존의 콘텐츠 편집 방법과는 달리, 제안하는 편집 시스템에서는 콘텐츠 관리 서버에 저장되어 있는 콘텐츠를 콘텐츠 편집기에서 스트리밍 기술을 이용하여 재생하며 편집을 수행한다. 그러나 콘텐츠 편집기가 스트리밍 기술을 이용하여 콘텐츠의 전체 구간을 재생하며 편집을 수행하는 것은 비효율적이다. 이러한 문제점을 해결하기 위해, 제안하는 편집 시스템에서는 편집 대상 콘텐츠의 씬 검출을 수행한 후, 검출된 씬 정보를 콘텐츠 재생 및 편집에 사용한다. 콘텐츠 편집기를 통해 콘텐츠 편집이 완료되면, 편집 정보는 메타데이터 형태로 콘텐츠 관리서버에 업로드된다. 제안하는 편집 시스템에서는 콘텐츠의 씬 정보와 편집 정보가 메타데이터 형태로만 존재하며, 씬 단위 혹은 편집 분절 단위의 물리적인 콘텐츠 분할은 수행되지 않는다. 구현 결과는 제안한 편집 시스템이 편집 대상 콘텐츠를 다운로드한 후 편집하는 기존의 콘텐츠 편집 방법을 사용하지 않고서도 기존의 방법과 유사한 성능을 제공함을 보여준다.