• The Journal of the Acoustical Society of Korea
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• v.41 no.5
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• pp.501-506
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• 2022

Echogenic liposome contains both liquid and gas inside the shell. In ultrasound mediated drug delivery, sonoporation, these new microbubbles can be an attractive drug carrier since they can be loaded water soluble drugs and drug molecules can be unloaded at the specific location with ultrasound sonication. In this paper, the structure of the echogenic liposome was confirmed with EF-TEM and the positive effect of sonoporation with echogenic liposome was comparatively evaluated on MDA-MB-231 cells which is a type of breast cancer cell with Doxorubicin. Control group (Group 1), Doxorubicin only (Group 2), sonoporation with Doxorubicin and hollow microbubbles (Group 3), sonoporation with Doxorubicin loaded echogenic liposome (Group 4) were classified and experiments were conducted. According to the results, Group 4 is at least 1.4 times better in inducing necrosis of cancer cells. Therefore, we conclude echogenic liposome could be one of the most useful form of microbubbles in sonoporation.