• 동아시아식생활학회지
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• 제15권5
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• pp.606-612
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• 2005

This study was performed to provide basic data that predict the application of Saengmaegsan(SMS) as medicinal food. SMS has been used in oriental medicine for many years as a therapeutic agent for cerebral disease. We examined the effects of SMS on physiological function in isolated abdominal aorta and femoral artery from rabbit and measured the changes of regional cerebral hood flow(rCBF), which was continually monitored by laser-doppler flowmeter and pressure transducer in anesthetized adult Spargue-Dawley rats through the data acquisition system composed of MacLab and Macintosh computer. The contraction forces by injection of norephinephrine in isolated abdominal aorta and femoral artery were significantly decreased in each concentration of SMS treatment compared with control. rCBF was increased by SMS in a dose-dependent manner. These results suggest that SMS causes a diverse response of rCBF and arterial diameter. These mechanism in rCBF increase may be mediated by prostaglandis, cyclic GMP and adrenergic $\beta-receptor$. Also mechanism in artery contraction decrease is also mediated by prostaglandis and cyclic GMP. These results indicate that SMS can be nsed as a safe and clinically applicable as a supplementation of diet therapy for cerebral cardiovascular disease patients.

• 동아시아식생활학회지
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• 제19권3호
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• pp.356-362
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• 2009

The objective of this study was to investigate the biological activities of fermented mugworts and their effects on the lipid metabolism in hyperlipidemia-induced rats. The proximate compositions of two kinds of mugwort, Artemisia capillaris Thumberg and Artemisiae asiaticae Nakai, were compared before and after fermentation. In both types of mugwort crude protein and amino nitrogen contents markedly increased with fermentation. Thrombolytic activity determined from the size of the clear zone on a fibrin plate was higher for the Artemisiae asiaticae Nakai, especially in the fermented sample. Antioxidative activity according to DPPH(1,1-diphenyl-2-picrylhydrazyl) radical scavenging effects was higher for Artemisia capillaris Thumberg but no significant differences were found between the samples after fermentation. The body weights of hyperlipidemia-induced rats that were fed the mugworts for 4 weeks were lower than those of the control group. In all the mugwort-fed rats serum total cholesterol and LDL-cholesterol levels remarkably decreased. Furthermore the fermented mugworts were found to be more effective at decreasing triglyceride (TG) levels. It is also noteworthy that the highest HDL-cholesterol levels were observed in the rats treated with the fermented Artemisiae asiaticae Nakai. And fatty liver weights were higher in the rats fed Artemisia capillaris Thumberg. In conclusion the feeding of fermented Artemisiae asiaticae Nakai was effective for increasing thrombolytic activity and HDL-cholesterol levels as well as reducing TG levels in rats.

• 동아시아식생활학회지
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• 제14권5호
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• pp.407-417
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• 2004

This study was conducted to investigate the application possibility of leaf and stem extract(LSE) extracted from the mixture of leaf and stem of ginseng radix(Panax ginseng CA. Meyer). This study measured the intake levels and efficiency ratio, growth rate, absorption ratio of carbohydrate, lipid and protein of rat by feeding with LSE during 6 weeks. We analyse the hematological and serum metabolic variables, serum lipid concentrations. Total diet and protein intake levels were low, but efficiency ratios were significantly high in LSE administered groups than the control group. Weight gain, liver and kidney weight of LSE groups were significantly higher than the control group. Blood RBC, Hct, Hb, total protein and albumin concentrations were reasonable levels in LSE administered groups compared to the basal diet group. Also serum total cholesterol, LDL-cholesterol, triglyceride contents of LSE groups were low, but HDL-cholesterol level was higher than the basal diet group. These results imply that leaf and stem of ginseng radix could be used as possible food resources, functional food material and feed stuff.

• 한국한의학연구원논문집
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• 제17권2호
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• pp.29-37
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• 2011

The purpose of this study is to introduce the historical material documents 'Kumgo'("檢考"), 'Haeyeongkumandenglok'("海營檢案謄錄"), 'Wanyeong-kumjedenglok'("完營檢題謄錄冊") which were possessed by C.V. Starr East Asian Library, University Of California Berkeley. These documents are a kinds of the coroner's inquest reports that were made out by the provincial magistrate of the Chos$\u{o}$n dynasty in the nineteenth century. The important contents of these documents consist of the murder cases include the trial records of the persons who connected with the case and the reports of the corpse, etc. Especially, 'Kumgo'("檢考") is the investigator's guide book, the outline of this book is how to investigate the murder's case and how to make out the reports. The 'Haeyeong-kumandenglok'("海營檢案謄錄") is an old book of the transcribe from the many kinds of the murder case's reports which were occurred in Whanghae province("黃海道"), 1882-1884. The book of the 'Wanyeong-kumjedenglok ("完營檢題謄錄冊") is transcribe from the text of the murder's case decisions by the provincial magistrate, in Jeonra province("全羅道"), 1837-1839. The result of this study is as follows ; These documents have the valuable material factors especially in the fields of korean old law, social, woman history. and it seems that these documents will be used in the variety fields of the human scientific researches.

• 동의생리병리학회지
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• 제26권6호
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• pp.855-863
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• 2012

The organic and holistic recognition method about nature in east asian philosophy is also applied to the study of the human body in Korean medicine. In Korean medicine, the human body is being understood from a holistic point of view rather than a mechanical or reductive one. The main east asian philosophies are the heavens thought and the Yin-yang/Five Phase Theory. This study will explore the influence the general flow of heavens thought has on explaining the human body in Korean medicine and the formation of how the human body is perceived in "Huangdineijing"(黃帝內經). First, the primitive meaning of heaven was developed to include the natural heaven of Xia (夏), the lord heaven of Shang(商) and the moral heaven of Zhou(周) dynasties. Among these, the natural heaven notion of the Xia(夏) dynasty which recognized heaven as the one with the power to create everything. This was followed by Taoism which established the contrasting system of heaven and earth. Based on this, "Huangdineijing"(黃帝 內經) developed the perception of the human body, taking into account, heaven as the original substance to generate the human body through the mutual sympathy between heavenly energy and earthly form. The perspective of the correspondence between nature and human in "Huainantzu"(淮南子) and "L$\breve{u}$shichunqiu"(呂氏春秋) was succeeded by Tung Chung-Shu(董仲舒). Based on this development, the perception of the human body in "Huangdineijing"(黃帝內經) is related to the seasonal cycle and the notion of night and day to balance the physiology of the human body. It recognizes that its structure, shape, emotional state and physiological actions are correlated with heaven.

• 대한한의학회지
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• 제32권1호
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• pp.121-129
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• 2011

Objective: The propose of this study is to build a conceptual framework for representing clinical findings in Traditional East Asian Medicine(TEAM). As the existing standard models have been developed without considering features of Traditional Medicine, in this study we introduced unique characteristics for the TEAM. Method: This study was composed of three steps. First, we analyzed whether the existing clinical information models are suitable for representing clinical findings. Second, we analyzed ISO/TS 22789 model which is a ISO medical informatics standard, to find out the problem by applying clinical findings of TEAM into the model. Finally, we defined semantic links and a concept hierarchy in our model based on the analyzed results. The model includes the concepts for clinical findings and terms, and the semantic links can be regarded as relations between concepts, so that the representating clinical findings are completed by connecting concepts with other concepts. Results: Our framework was developed by removing unnecessary semantic links, and adding some necessary ones based on ISO/TS 22789 model. The ISO/TS 22789 model has a simple concept hierarchy, but in this study we subdivided the hierarchy and also considered interoperability with other terminological systems and standard models. Conclusions: This research needs more discussions, but is meaningful as proposing a way how to develop Traditional Medicine terminological systems. This study shows the limitations of existing models in describing clinical findings for TEAM, and what should be considered to represent Traditional Medicine knowledge, and propose a solution to improve the problem.

• 한국의사학회지
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• 제27권1호
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• pp.33-40
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• 2014

Traditional medicine in Asian countries show similarity according to geography, building up their own medical tradition upon indigenous cultural background. Mongolian medicine, in particular, displays district fusion of several medical systems accepted from neighboring countries adding to their traditional system. Those are Mongol Dhom medicine, acupuncture and moxibustion medicine, medicine of "Four Medical Tantras (四部醫典)", and combined system of Mongolian and biomedicine. Compared to East asian medicine, this is a different kind of diversity or hybridity resulting from idiosyncrasy of nomadic culture. Each current of Mongolian medical tradition has its own origin of historical backdrop. Mongol Dhom originated from ancient nomadic life, and medicine of "Four Medical Tantras (四部醫典)" was formed along with transmission of Tibetan Buddhism. Acupuncture and moxibustion is directly related to Chinese medical tradition, however, moxibustion is also referred to be regional origination. Lastly, biomedicine was transplanted during the modernization era, encouraging scientific approach toward Mongolian traditional medicine and producing combined medical practice. It is effective to derive each particular aspects of Mongolian medicine and analyze its specificity, in order to properly understand current Mongolian medical system. This paper aims at discovering socio-cultural meanings of each current and their nomadic feature beneath the diversity.

• Asian Pacific Journal of Cancer Prevention
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• 제15권20호
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• pp.9027-9031
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• 2014

Background: Helicobacter pylori (H. pylori) infection is an established cause of peptic ulcers and gastric cancer. The aim of this study was to identify H. pylori genotypes and to examine their associations with geographical regions and gastritis, peptic ulcers and gastric cancer in Laos. Materials and Methods: A total of 329 Lao dyspeptic patients who underwent gastroscopy at Mahosot Hospital, Vientiane, Laos during December 2010 - March 2012 were enrolled. Two biopsy specimens (one each from the antrum and corpus) were obtained for CLO testing and only CLO test-positive gastric tissue were used to extract DNA. PCR and sequencing were identified for variants of the cagA and vacA genotypes. Results: Some 119 Laos patients (36.2%) were found to be infected with H. pylori including 83 with gastritis, 13 with gastric ulcers (GU), 20 with duodenal ulcers (DU) and 3 with gastric cancer. cagA was detected in 99.2%. East-Asian-type cagA (62%) and vacA s1c (64.7%) were predominant genotypes in Laos. vacA s1c-m1b was significantly higher in GU than gastritis (53.8% vs. 24.1%; P-value=0.04) whereas vacA s1a-m2 was significantly higher in DU than gastritis (40.0% vs. 16.9%; P-value=0.03). East-Asian-type cagA and vacA s1c were significantly higher in highland than lowland Lao (100% vs. 55.8%; P-value=0.001 and 88.2% vs. 61.5%, P-value=0.03 respectively). Conclusions: H. pylori is a common infection in Laos, as in other countries in Southeast Asia. The cagA gene was demonstrated in nearly all Laos patients, cagA and vacA genotypes being possible important factors in explaining H. pylori infection and disease outcomes in Laos.

• Asian Pacific Journal of Cancer Prevention
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• 제17권4호
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• pp.1899-1902
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• 2016

Background: Despite the fact that testicular cancer is a major health issue with its increasing incidence, very few studies have described its characteristics in the Middle East, particularly in Lebanon. Materials and Methods: We report in this paper a retrospective pilot study of the characteristics of testicular cancer in Lebanon. The demographic, epidemiologic and survival characteristics of 178 patients diagnosed between 1990 and 2015 at an oncology clinic affiliated to Hotel Dieu de France Hospital were analyzed. Results: The mean age at diagnosis was $32{\pm}10years$. The most prevalent testicular tumor was the germ cell type (GCT) (95.2%) of which non-seminomatous tumors (NST) were the commonest (64.7%). Most of our patients were diagnosed at an early stage. Lymph node spread affected most commonly the retroperitoneal region and distant visceral metastases occurred in 14.6%. All patients underwent orchiectomy with 67% receiving adjuvant treatment, mainly chemotherapy. After a median follow up of 2,248 days (75.9 months) 16 patients were reported dead. Two, five and ten-year overall survival rates were 96%, 94% and 89% respectively. The median overall survival rate was not reached. Conclusions: Despite being part of the developing world, demographic, epidemiologic and survival analyses of testicular cancer reported in our study are in line with those reported from developed countries and would allow us to extrapolate management plans from these populations.

• Parasites, Hosts and Diseases
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• 제49권3호
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• pp.323-326
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• 2011

While the presence of pinworm eggs in archaeological samples has been reported by many researchers in the New World, those have been detected very scarcely in the Old World, especially in East Asian countries. In fact, many parasite species were recovered from the archeological remains in Korea, eggs of Enterobius vermicularis had not been found. Recently, a female mummy buried in the 17th century was discovered in the Joseon tomb from Dangjin-gun, Chungcheongnam-do, Korea. After rehydration process for 12 days, investigations were carried on the luminal surface of the colon. From them, 3 eggs of E. vermicularis were recovered. They were elliptical, transparent with a thin egg shell, $50.3{\pm}5.2\;{\mu}m$ (length) and $28.2{\pm}3.9\;{\mu}m$ (width) in size. This is the first discovery of E. vermicularis eggs in East Asia.