• The Transactions of The Korean Institute of Electrical Engineers
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• v.66 no.7
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• pp.1007-1016
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• 2017

This paper aims to analyze the safety evaluation of the existing transformer for the 0.85 millions of public rental apartments as EVs(Electric Vehicles) increase in order to overcome the environment pollution issue and maintain sustainable development. It is analyzed that the 56.4% capacity of power transformer could secure as EV charging infrastructure, based on the analysis of respective utilization patterns of the housing and power transformer. The acceptable number of EVs is 0.04~0.06 per household from the spare capacity of the power transformer. It is analyzed that EV stock is prospected less than 0.03 per household in 2030, considering the condition of the public rental apartments residents and the growth rate of EVs according to practical scenario. The power demand for EVs is within the allowable capacity range of the power transformer, so the research shows that there is no problem in the stability of the existing transformer until 2030.

• BMB Reports
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• v.55 no.1
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• pp.20-29
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• 2022

Stem cell-based therapy is a promising approach for treating a variety of disorders, including acute brain insults and neurodegenerative diseases. Stem cells such as mesenchymal stem cells (MSCs) secrete extracellular vesicles (EVs), circular membrane fragments (30 nm-1 ㎛) that are shed from the cell surface, carrying several therapeutic molecules such as proteins and microRNAs. Because EV-based therapy is superior to cell therapy in terms of scalable production, biodistribution, and safety profiles, it can be used to treat brain diseases as an alternative to stem cell therapy. This review presents evidences evaluating the role of stem cell-derived EVs in stroke, traumatic brain injury, and degenerative brain diseases, such as Alzheimer's disease and Parkinson' disease. In addition, stem cell-derived EVs have better profiles in biocompatibility, immunogenicity, and safety than those of small chemical and macromolecules. The advantages and disadvantages of EVs compared with other strategies are discussed. Even though EVs obtained from native stem cells have potential in the treatment of brain diseases, the successful clinical application is limited by the short half-life, limited targeting, rapid clearance after application, and insufficient payload. We discuss the strategies to enhance the efficacy of EV therapeutics. Finally, EV therapies have yet to be approved by the regulatory authorities. Major issues are discussed together with relevant advances in the clinical application of EV therapeutics.

• Proceedings of the KIPE Conference
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• 2017.11a
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• pp.159-160
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• 2017

본 논문에서는 리튬배터리의 전기화학적 분석법으로 전기 화학적 전압 분광법(electrochemical voltage spectroscopy;EVS)을 사용하였다. 전기화학적 활성상태의 밀도를 직접 측정하는 기법으로 정전압(potentiostatic) 제어를 기반으로 한다. EVS 테스트에서 양전극의 전압은 각 단계가 전기화학적 평행상태에 도달할 때 까지 유지되며 이 방법은 배터리의 전기화학적 산화 환원 전위의 미세한 차이에 기초하여 활성 물질의 상태에 대한 정확한 정보를 얻을 수 있다.

• Proceedings of the KIEE Conference
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• 2015.07a
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• pp.521-522
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• 2015

Many countries concern about environmental problems. Therefore, they have made regulation for mandatory reduction of greenhouse gases. Electric Vehicles(EVs) are one of the most effective counterproposals for it. EVs are usually charging for it by using actual distribution system of the Korea Electric Power Corporation(KEPCO). However, it could cause adverse effects such as increase of the power demand and voltage variation on the distribution system. To reduce adverse effects for demand power side, in this paper, charging for EVs by using PV(Photovolatic Power Generation) connected with ESS(Energy Storage System) are modeled by using Electro Magnetic Transient Program(EMTP). And then, the simulation results are compared with EVs that are connected to the distribution system of KEPCO for using charge.

• Journal of the korean Society of Automotive Engineers
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• v.23 no.2
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• pp.79-81
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• 2001

• Journal of Animal Science and Technology
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• v.65 no.3
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• pp.652-663
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• 2023

The rumen fluids contain a wide range of bacteria, protozoa, fungi, and viruses. The various ruminal microorganisms in the rumen provide nutrients by fermenting the forage they eat. During metabolic processes, microorganisms present in the rumen release diverse vesicles during the fermentation process. Therefore, in this study, we confirmed the function of rumen extracellular vesicles (EVs) and their interaction with the host. We confirmed the structure of the rumen EVs by transmission electron microscope (TEM) and the size of the particles using nanoparticle tracking analysis (NTA). Rumen EVs range in size from 100 nm to 400 nm and are composed of microvesicles, microparticles, and ectosomes. Using the Caenorhabditis elegans smart animal model, we verified the interaction between the host and rumen EVs. Exposure of C. elegans to rumen EVs did not significantly enhance longevity, whereas exposure to the pathogenic bacteria Escherichia coli O157:H7 and Staphylococcus aureus significantly increased lifespan. Furthermore, transcriptome analysis showed gene expression alterations in C. elegans exposed to rumen EVs, with significant changes in the metabolic pathway, fatty acid degradation, and biosynthesis of cofactors. Our study describes the effect of rumen EV interactions with the host and provides novel insights for discovering biotherapeutic agents in the animal industry.

• Biomolecules & Therapeutics
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• v.32 no.4
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• pp.432-441
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• 2024

Systemic sclerosis is an autoimmune disease characterized by inflammatory reactions and fibrosis. Myofibroblasts are considered therapeutic targets for preventing and reversing the pathogenesis of fibrosis in systemic sclerosis. Although the mechanisms that differentiate into myofibroblasts are diverse, transforming growth factor β (TGF-β) is known to be a key mediator of fibrosis in systemic sclerosis. This study investigated the effects of extracellular vesicles derived from human adipose stem cells (ASC-EVs) in an in vivo systemic sclerosis model and in vitro TGF-β1-induced dermal fibroblasts. The therapeutic effects of ASC-EVs on the in vivo systemic sclerosis model were evaluated based on dermal thickness and the number of α-smooth muscle actin (α-SMA)-expressing cells using hematoxylin and eosin staining and immunohistochemistry. Administration of ASC-EVs decreased both the dermal thickness and α-SMA expressing cell number as well as the mRNA levels of fibrotic genes, such as Acta2, Ccn2, Col1a1 and Comp. Additionally, we discovered that ASC-EVs can decrease the expression of α-SMA and CTGF and suppress the TGF-β pathway by inhibiting the activation of SMAD2 in dermal fibroblasts induced by TGF-β1. Finally, TGF-β1-induced dermal fibroblasts underwent selective death through ASC-EVs treatment. These results indicate that ASC-EVs could provide a therapeutic approach for preventing and reversing systemic sclerosis.

• BMB Reports
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• v.49 no.11
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• pp.585-586
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• 2016

Extracellular vesicles (EVs) are natural carriers of biomolecules that play central roles in cell-to-cell communications. Based on this, there have been various attempts to use EVs as therapeutic drug carriers. From chemical reagents to nucleic acids, various macromolecules were successfully loaded into EVs; however, loading of proteins with high molecular weight has been huddled with several problems. Purification of recombinant proteins is expensive and time consuming, and easily results in modification of proteins due to physical or chemical forces. Also, the loading efficiency of conventional methods is too low for most proteins. We have recently proposed a new method, the so-called exosomes for protein loading via optically reversible protein-protein interaction (EXPLORs), to overcome the limitations. Since EXPLORs are produced by actively loading of intracellular proteins into EVs using blue light without protein purification steps, we demonstrated that the EXPLOR technique significantly improves the loading and delivery efficiency of therapeutic proteins. In further in vitro and in vivo experiments, we demonstrate the potential of EXPLOR technology as a novel platform for biopharmaceuticals, by successful delivery of several functional proteins such as Cre recombinase, into the target cells.

• Journal of Electrical Engineering and Technology
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• v.10 no.4
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• pp.1492-1501
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• 2015

This paper analyzes the effect of voltage sag on distribution systems due to the connection of Electric Vehicles (EVs). In order to study the impact of the voltage sag on the power system, two scenarios have been selected in this paper. The distribution system and EVs are modeled using the Electro Magnetic Transients Program (EMTP). The numbers of EVs are predicted based on the number of vehicles in distribution system of Seoul. In addition, the number of EVs is set up using real-time traffic in Seoul to simulate Scenario I and II. The simulation results show that voltage sag can occur if the distribution system has more than 30% of the total number of vehicles.

• Journal of Electrical Engineering and Technology
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• v.12 no.5
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• pp.1934-1944
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• 2017

As a key component of high-voltage power conversion system for electric vehicles (EVs), bidirectional DC/DC (Bi-DC/DC) is required to have high efficiency and light weight. Conventional design methods optimize the Bi-DC/DC at the maximum power dissipation point (MPDP). For EVs application, the work condition of the Bi-DC/DC is not strict as the MPDP, where the design method using MPDP may not be optimal during travel of EVs. This paper optimizes the Bi-DC/DC converter targeting efficiency and weight based on the driving cycle. By analyzing the two-phase interleaved Bi-DC/DC for hybrid energy storage systems (HESS) of EVs, its power dissipation is calculated, and an efficiency model is derived. On this basis, weight models of capacitor, inductor and heat sink are built, as well as a dynamic temperature model of heat sink. Based on these models, a method using New European Driving Cycle (NEDC) for optimal design of Bi-DC/DC which simultaneously considered efficiency and weight is proposed. The simulation result shows that compare with conventional optimization methods revealed that the optimization approach based on driving cycle allowed significant weight reduction while meeting the efficiency requirements.