• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2005.11a
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• pp.107-108
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• 2005

In this paper, we first applied the chemical mechanical polishing (CMP) process to the planarization of ferroelectric film in order to obtain a good planarity of electrode/ferroelectric film interface. $Pb_{1.1}(Zr_{0.52}Ti_{0.48})O_3$ (shortly PZT) ferroelectric film was fabricated by the sol-gel method. And then, we compared the structural characteristics before and after CMP process of PZT films. Their dependence on slurry composition was also investigated. We expect that our results will be useful promise of global planarization for ferroelectric random access memories (FRAM) application in the near future.

• Journal of Chest Surgery
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• v.27 no.1
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• pp.43-47
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• 1994

Prompt recognition and proper treatment of esophageal perforation or rupture may ax~ert death or minimize complications. We have experienced sixteen patients of esophageal perforation at the department of thoracic and cardiovascular surgery, Hallym Medical college during the period fromJan. 1986 to Sep. 1993. The ratio between male and female patient was 13:3 and their age ranged from 23 years to 67 years old. The major cause of esophageal perforations was spontaneous rupture in 7 cases[45%], surgical trauma in 2 cases[12%], instrumental trauma in 2 cases[12%], and others in 5 cases[31%]. The common site of esophageal perforation was in the lower third portion of the esophagus[10 cases, 62%]. The most consistent symptom of esophageal perforation was chest pain in 11 cases, temperature elevation within a few hours was 9 cases.Contrast roentgenographic studies demonstrated the perforation in all but 2 of the 16 patients. The frequent complications of esophageal perforation were empyema in 7 cases[45 %] and mediastinitis in 2 cases[12%]. fourteen patients had suture closure and drainage with 2 deaths, and 2 patient received only drainage procedures. The mortality rate was 12%[2 cases] and cause of death was sepsis and aortic rupture.

• Journal of the Korean Ceramic Society
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• v.35 no.8
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• pp.850-856
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• 1998

The dynaamic fatigue behavior of alumina ceramics was observed at room temperature using four-point bending method. Dynamic fatigue fracture strength was observed as function of down speed and notch length. The crack growth exponent of the specimens was calculated from the fracture strength and lifetime in dynamic fatigue test. After loading the stresses in the range of 0% to 105% compared with the average in-ert strength the value of residual fracture strength was measured for unnotched and 0.5mm notched speci-mens at the 0.001 and 0.0005 mm/min down speed respectively. After the 95% stress of the average inert strength was applied repeatedly the value of rsidual fracture strength was measured for 0.5mm notched specimens at the 0.001 and 0.0005 mm/min down speed respectively. The material constant A was found to be almost the same and not to depend on the loading mode or the down speed for unnotched and notched specimen. The value of fracture strength with time calculated from the constants n and A was in good agreement with the measured value.

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.140.2-140.2
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• 2003

Isoflavone found in Leguminosae is one of natural phytoestrogens and its effect on bone remodeling is one of key investigational interests in terms of estrogen replacement therapy (ERT). As commonly known, osteoporosis is one of hormonal deficiency diseases, especially in menopausal women. When estrogen is blocked, local factors such as 1L-1$\beta$ and IL-6 that are related in bone resorption are increased and enhance osteoclastogenesis, which is responsible for bone resorption. In the present study, we investigated the effect of isoflavones (Isocal) extracted from Sophorae Fructus on bone resorption in vitro. (omitted)

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.140.3-141
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• 2003

Isoflavones have been a central subject in natural phytoestrogens found in Leguminosae. Their effects on bone formation and remodeling are an important turning point in that they can act like estrogen by binding on estrogen receptors on target cell surface. We, therefore, believed that isoflavones may be applied in estrogen deficiency disease such as osteoporosis in terms of estrogen replacement therapy (ERT). As commonly known, osteoporosis is one of hormonal deficiency diseases, especially in menopausal women. (omitted)

• Journal of mucopolysaccharidosis and rare diseases
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• v.5 no.1
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• pp.12-16
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• 2021

Mucopolysaccharidosis type II (MPS II, Hunter syndrome) is an X-linked lysosomal storage disorder caused by deficiency of the enzyme iduronate-2-sulfatase, leading to the accumulation of glycosaminoglycans (GAGs), which affects multiple organs and systems. Current treatments for MPS II include enzyme replacement therapy (ERT) and hematopoietic cell transplantation (HCT) to reduce the accumulation of GAGs. HCT has the potential advantage that donor-derived enzyme-competent cells can provide a continuous secreting source of the enzyme. However, HCT as a treatment for MPS II remains controversial because its effectiveness is unclear, particularly in terms of neurological symptoms. To date, several clinical experiences with HCT in MPS II have been reported. In this paper, we review post-HCT outcomes in the previously published literature and discuss the effects of HCT on each of the clinical signs and symptoms of MPS II.

• The Bulletin of The Korean Astronomical Society
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• v.45 no.1
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• pp.50.2-50.2
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• 2020

The dark matter (DM) only simulations have been exploited to study e.g. the large scale structures and properties of a halo. In a baryon side, the high-resolution hydrodynamic simulation such as IllustrisTNG has helped extend the physics of gas along with stars and DM. However, the expansive computational cost of hydrodynamic simulations limits the size of a simulated universe whereas DM-only simulations can generate the universe of the cosmological horizon size approximately. I will introduce a pipeline to estimate baryonic properties of a galaxy inside a dark matter (DM) halo in DM-only simulations using a machine trained on high-resolution hydrodynamic simulations. An extremely randomized tree (ERT) algorithm is used together with multiple novel improvements such as a refined error function in machine training and two-stage learning. By applying our machine to the DM-only simulation of a large volume, I then validate the pipeline that rapidly generates a galaxy catalog from a DM halo catalog using the correlations the machine found in hydrodynamic simulations. I will discuss the benefits that machine-based approaches like this entail, as well as suggestions to raise the scientific potential of such approaches.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.18 no.3
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• pp.78-86
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• 2018

Purpose: We aimed to delineate clinical spectrum and short-term effects after enzyme replacement therapy (ERT) for 5 mucopolysaccharidosis type II (MPS II). Methods: Five patients were diagnosed with MPS II by clinical findings, enzyme activity, and genetic testing. Idursulfase was administered by intravenous infusion at a dose of 0.5 mg/kg every week. Observational chart analysis of patients, who underwent systematic investigations more than 12 months after initiation of ERT was done retrospectively. Results: Three patients were classified as having the attenuated type, and 2 patients were classified as having the severe type. The median age at the diagnosis was 9.6 years (range 3.4-26 years). Four different mutations in 5 Korean patients (4 families) with MPS II were identified, among which two were novel mutations (1 small insertion mutation: p.Thr409Hisfs*22, and 1 missense mutation: p.Gly134Glu). Two severe type sibling patients with the same mutation had different clinical manifestation. Urinary glycosaminoglycan excretion decreased within the twelve months of ERT (P=0.043). Liver and spleen volumes showed reductions that were maintained in all patients (P=0.043 and P=0.043, respectively). Improvements were also noted in left ventricular mass index (P=0.042), shoulder flexion (P=0.043), shoulder abduction (P=0.039), knee flexion (P=0.043), elbow flexion (P=0.042), and respiratory distress index (P=0.041). Conclusion: This study demonstrates that Korean patients with MPS II are clinically heterogeneous and indicates that idursulfase is relatively effective in several clinical parameters including heart size and respiratory distress index without infusion-related reactions in patients with MPS II.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.17 no.2
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• pp.55-62
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• 2017

Gaucher disease (GD) is an autosomal recessive lysosomal storage disorder caused by beta-glucosidase deficiency. An 18 month-old male with hepatosplenomegaly, anemia, thrombocytopenia, and growth retardation referred to our hospital. The patient showed neurological symptoms, such as supranuclear gaze palsy and developmental delay. Bone marrow biopsy performed to rule out malignancy and the results revealed no malignant cell; however, abnormal histiocytes suggesting storage disease was noted. Based on hepatosplenomegaly, bicytopenia and unexplained neurologic manifestations, enzyme activity and genetic analysis were conducted emergently with a strong suspicion of GD. Beta-glucosidase activity in leukocyte was decreased. GBA sequencing to confirm the diagnosis revealed compound heterozygous pathogenic variants (i.e., c.754T>A, c.887G>A), both previously reported as the cause of neuronopathic GD. Under the diagnosis of type 3 GD, the patient immediately received enzyme replacement therapy (ERT). After 17 months of ERT, the size of spleen decreased, and hemoglobin and platelet count returned to normal. In addition, the activity of chitotriosidase and angiotensin converting enzyme decreased. However, myoclonic movement and generalized seizure occurred at the age of 19 months and antiepileptic drug was started. Other neurological deterioration including supranuclear gaze palsy and developmental delay also persisted. A new therapy to overcome neurologic problems should be developed for patients with type 3 GD.

• Journal of KIISE:Computing Practices and Letters
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• v.14 no.8
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• pp.783-787
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• 2008

IEEE 802.16/WiBro, one of the representative Broadband Wireless Access (BWA) systems, defines QoS negotiation between BS and SS and five service classes to guarantee QoS for flows. The five service classes are UGS, ertPS, rtPS, nrtPS, and BE, but the standard does not define how to provide services to flows according to the service classes. Existing research works have been studied about the scheduler architecture to effectively utilize the IEEE 802.16/WiBro systems. These works use the original packet scheduling algorithm for service classes. However, it is necessary to consider bandwidth allocation mechanisms in scheduling algorithms since bandwidth allocation mechanisms are different according to service classes. Especially, bandwidth allocation mechanisms should be considered for the scheduling of rtPS class since rtPS class uses the polling mechanism that takes time to allocate bandwidth and has the minimum latency constraint. Therefore, we propose two stage dropping scheme for rtPS class that is sensitive to latency, and thus it reduces the wasted resources and provides efficient service to rtPS class.