• Proceedings of the KSRS Conference
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• 2002.10a
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• pp.633-633
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• 2002

We investigated the distributions of sea ice using various microwave remote sensing techniques in the part of Drake passage, Antarctica, between the area 45-75$^{\circ}$W and 55-66$^{\circ}$S. We used Topex/Poseidon(T/P) radar altimeter, ERS-1 altimeter, ERS-2 scatterometer, Nimbus-7 Scanning Multichannel Microwave Radiometer (SMMR), and DMSP Special Sensor Microwave/Imager(SSM/I) data. The sea ice distributions were estimated between May and Jun., 1995 and Oct. and Nov., 1998. The two altimeter measurements (T/P and ERS-1) showed good coherence with the results from the radiometer data in the given period when the ice concentration of 20% and greater was selected. The scatterometer data also showed good correlation with altimetry-implied sea ice surface. The maximum and minimum values of sea ice distribution were appeared in Aug. and Feb., respectively. In general, the sea ice distributions estimated from radar altimeter, radioneter, and scatterometer are well correlated.

• Proceedings of the KIPE Conference
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• 1997.07a
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• pp.251-255
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• 1997

The conventional high frequency phase-shifted full bridge dc/dc converter has a disadvantage that a circulating current flows through transformer and switching devices during the freewheeling interval. Due to this circulating current, RMS current stress, conduction losses of transformer and switching devices are increased. To alleviate this problem, this paper provides a circulating current free type high frequency soft switching phase-shifted full bridge (FB) dc/dc converter with energy recovery snubber (ERS) attached at the secondary side of transformer. The energy recovery snubber (ERS) adopted in this study is consisted of three fast recovery diode(Ds1, DS2, Ds3), two resonant capacitor (Cs1, Cs2)

• Proceedings of the KSRS Conference
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• 2003.11a
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• pp.337-339
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• 2003

This paper describes the SAR geocoding module, which is the sub-module of a IRHIS ('Integrated RS s/w for High resolution satellite ImageS'): package of 'Development of High Resolution Satellite Image Processing Technique' project in Electronics and Telecommunications Research Institute (ETRI). The function of this module is following. 1) Orbit Type : ERS1/ERS2, RADARSAT 2) Data Format : SAR CEOS Format(Single Look Complex) 3) Function: - Geocode : Generate a map projected SAR image based on only orbit information - Orthorectify: Generate a rigorous geocoded SAR image with a DEM information In this paper, we briefly describe the algorithm that is adopted to the functions, and component architecture.

• Journal of Wetlands Research
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• v.8 no.3
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• pp.29-38
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• 2006

Digital Elevation Model (DEM) of intertidal flat can be widely used not only for scientific fields, coastal management, fisheries, ocean safety, military, but also for understanding natural and artificial topographic changes of the tidal flat. In this study, we generated DEM of the Ganghwado southern intertidal flat, the largest tidal flat in the west coast of the Korean Peninsula, using waterline method and interferometric synthetic aperture radar (InSAR). Constructed DEM which applied waterline method to the Landsat-5 TM and Landsat-7 ETM+ images closely expresses overall topographic relief of tidal flat. We found that the accuracy was determined by the number of waterlines which reflect various tidal conditions. The application of InSAR to the ERS-1/2 and ENVISAT images showed that only ERS-1/2 tandem pairs successfully generated DEM in the part of northern Yeongjongdo, but construction of DEM in the other areas was difficult due to the low coherence caused by a lot of surface remnant waters. In the near future, Kompsat-2 will provide satellite images having multi-spectral and high spatial resolution within a relatively short period at different sea levels. Application of waterline method to these images will help us construct a high precision tidal flat DEM. Also, we should develop DEM generation method using single-pass microwave satellite images.

• Journal of the Korea Institute of Building Construction
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• v.18 no.4
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• pp.321-327
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• 2018

Blast furnace slag has been actively used as a substitute for cement in the construction field with high value-added through resource recycling research. However, most of the slag cannot find a clear recycling purpose. This is because some slags contain unstable materials and are used for road-use asphalt and embankment, which are low value-added materials. Electric arc furnace reduction slag(ERS) has been reported to contain a large amount of unstable free CaO due to deoxidation and component adjustment. In this study, free CaO of ERS which is generated in Korean steelmakers is quantitatively evaluated by using ethylene glycol method. As a result of free CaO quantitative evaluation of ERS, it was confirmed that there is a big difference according to the location of each field. In addition, ERS generally existed in powder form as undifferentiated characteristics, but it was confirmed that free CaO content was different due to hydration product in aggregate form due to water treatment. In addition, free CaO is an amorphous material and its crystallization characteristics are different due to the influence of temperature when it is cooled. ERS requires a long-term aging period as it contains a lot of free CaO.

• Proceeding of EDISON Challenge
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• 2015.03a
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• pp.14-23
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• 2015

Alzheimer's disease is one of the most common types of degenerative dementia. As a considerable cause of Alzheimer's disease, neurotoxic plaques composed of 39 to 42 residue-long amyloid beta($A{\beta}$) fibrils have been found in the patient's brain in large quantity. A previous study found that erythrosine B (ER), a red color food dye approved by FDA, inhibits the formation of amyloid beta fibril structures. Here, in an attempt to elucidate the inhibition mechanism, we performed molecular dynamics simulations to demonstrate the conformational change of $A{\beta}40$ induced by 2 ERs in atomistic detail. During the simulation, the ERs bound to the surfaces of both N-terminus and C-terminus regions of $A{\beta}40$ rapidly. The observed stacking of the ERs and the aromatic side chains near the N-terminus region suggests a possible inhibition mechanism in which disturbing the inter-chain stacking of PHEs destabilizes beta-sheet enriched in amyloid beta fibrils. The bound ERs block water molecules and thereby help stabilizing alpha helical structure at the main chain of C-terminus and interrupt the formation of the salt-bridge ASP23-LYS28 at the same time. Our findings can help better understanding of the current and upcoming treatment studies for Alzheimer's disease by suggesting inhibition mechanism of ER on the conformational transition of $A{\beta}40$ at the molecular level.

• Molecules and Cells
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• v.40 no.1
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• pp.66-72
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• 2017

Pathological hypertrophy of the heart is closely associated with endoplasmic reticulum stress (ERS), leading to maladaptations such as myocardial fibrosis, induction of apoptosis, and cardiac dysfunctions. Salubrinal is a known selective inhibitor of protein phosphatase 1 (PP1) complex involving dephosphorylation of phospho-eukaryotic translation initiation factor 2 subunit $(p-eIF2)-{\alpha}$, the key signaling process in the ERS pathway. In this study, the effects of salubrinal were examined on cardiac hypertrophy using the mouse model of transverse aortic constriction (TAC) and cell model of neonatal rat ventricular myocytes (NRVMs). Treatment of TAC-induced mice with salubrinal ($0.5mg{\cdot}kg^{-1}{\cdot}day^{-1}$) alleviated cardiac hypertrophy and tissue fibrosis. Salubrinal also alleviated hypertrophic growth in endothelin 1 (ET1)-treated NRVMs. Therefore, the present results suggest that salubrinal may be a potentially efficacious drug for treating pathological cardiac remodeling.

• Korean Journal of Veterinary Service
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• v.42 no.4
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• pp.289-296
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• 2019

A novel rapid procedure with liquid chromatography tandem mass spectrometry (LC-MS/MS) detection has been developed by changing various conditions including sample preparation such as QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) methodology. This work has been involved the optimization and validation of detection method for fluoroquinolones which are widespread used in livestock especially in the chicken. Five grams of homogenized chicken muscle were extracted with QuEChERS EN and acetonitrile containing 5% formic acid and cleaned with anhydrous magnesium sulfate and C₁₈ sorbent. The separation was performed on Acquity UPLC HSS T3 (2.1 mm×100 mm, 1.8 ㎛) column. The mobile phase A and B were composed of water containing 0.1% formic acid and acetonitrile containing 0.1% formic acid, respectively. Flow rate was 0.25 mL/min and column temperate was 40℃. LC-MS/MS with multiple reaction monitoring has been optimized for ten fluoroquinolones (ciprofloxacin, danofloxacin, difloxacin, enrofloxacin, marbofloxacin, norfloxacin, ofloxacin, orbifloxacin, pefloxacin and sarafloxacin). The method developed in this study has been presented good linearity with correlation coefficient (R²) of 0.9971~0.9998. LOD and LOQ values ranged from 0.09 to 0.76 ppb and from 0.26 to 2.29 ppb, respectively. The average recoveries were from 77.46 to 111.83% at spiked levels of 10.0 and 20.0 ㎍/kg. Relative standard deviation (%) ranged 1.28~11.90% on intra-day and 3.10~8.38 % on inter-day, respectively. This analysis method was applicable to the livestock residue laboratories and was expected to be satisfactory for the residue surveillance system.

• Physical Therapy Korea
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• v.12 no.3
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• pp.67-73
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• 2005

Prospective memory (PM) is related to remember to carry out a previously intented behaviour. The purpose of this study was to develop a paradigm for measuring PM function to diagnosis in mild cognitive impairment 1 or brain injury in patients 2. among brain injured patients Thirty-eight normal healthy subjects participated in current study. The paradigm was composed of four conditions: a baseline and three intention conditions (expectation, execution 1 and 2). In the expectation condition, subjects were asked to make a new response to intented stimuli during ongoing task, but the intented stimuli never occurred. In the execution 1 (one type of expected stimulus) and 2 (two types of expected stimuli), the intended stimuli did occur in 20% of trials. The reaction time and error rate were calculated in each condition. Repeated measures using ANOVA of subject's mean reaction times (RTs) and mean error rates (ERs) showed main effects of conditions during ongoing task. The comparison of PM tasks in executive condition 1 and 2 also showed significance in RTs and ERs. This paradigm reflects sufficiently the performance of prospective memory function during ongoing task in normal individuals. Thus, we suggest that the paradigm will be helpful to study neural network of PM function using brain imaging techniques and diagnosis of PM dysfunction.

• Proceedings of the KSRS Conference
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• 2007.03a
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• pp.177-182
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• 2007

한반도 주변해역에서의 해수면 고도는 1993년부터 2005년까지의 기간 동안 연평균 3.89 mm $yr^{-1}$ 상승하였으며， 이는 전세계 해수면 상승률의 1.3배에 해당한다. 본 연구에서는 AVISO (Archiving, Validation and Interpretation of Satellite Oceanographic data)에서 제공하는 복합위성자료 (Topex/Poseidon, Jason-1, ERS, Envisat)인 DT-MSLA (Delayed Time - Maps of Sea Level Anomalies)를 이용하여 동해와 황해, 남해, 한국해협에서의 해수면 고도 변화를 연구하였다. 해수면 고도의 평균적인 변화는 증가하는 경향을 보임과 동시에, 여름에는 $4{\sim}5$년，겨울에는 3년의 주기성을 가지고 진동하였다. 조화분석을 통하여 해수면 고도와 해수면 온도의 연주기 모드와 반년주기 모드의 진폭과 위상을 나타내었다. 해수면 고도의 연주기 진폭은 한반도 주변해역에서 남동쪽이 높게，북서쪽이 낮게 나타나는 반면, 해수면 온도는 이와는 반대의 분포를 보였다. 월별 해수면 고도와 해수면 온도의 상관을 구한 결과，$6{\sim}8$월에 동해와 남해에서 1 / 2달 시간지연 일 때，상관계수가 0.7정도로 높게 나타났다. 이러한 결과를 통해 여름철 동해와 남해가 쿠로시오 해류의 영향을 크게 받고 있음을 짐작할 수 있다.