Molecules and Cells

Korean Society for Molecular and Cellular Biology (한국분자세포생물학회)
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Salubrinal Alleviates Pressure Overload-Induced Cardiac Hypertrophy by Inhibiting Endoplasmic Reticulum Stress Pathway

  • Rani, Shilpa (School of Life Sciences, Gwangju Institute of Science and Technology (GIST)) ;
  • Sreenivasaiah, Pradeep Kumar (School of Life Sciences, Gwangju Institute of Science and Technology (GIST)) ;
  • Cho, Chunghee (School of Life Sciences, Gwangju Institute of Science and Technology (GIST)) ;
  • Kim, Do Han (School of Life Sciences, Gwangju Institute of Science and Technology (GIST))
  • Received : 2016.10.26
  • Accepted : 2016.12.30
  • Published : 2017.01.31
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Abstract

Pathological hypertrophy of the heart is closely associated with endoplasmic reticulum stress (ERS), leading to maladaptations such as myocardial fibrosis, induction of apoptosis, and cardiac dysfunctions. Salubrinal is a known selective inhibitor of protein phosphatase 1 (PP1) complex involving dephosphorylation of phospho-eukaryotic translation initiation factor 2 subunit $(p-eIF2)-{\alpha}$, the key signaling process in the ERS pathway. In this study, the effects of salubrinal were examined on cardiac hypertrophy using the mouse model of transverse aortic constriction (TAC) and cell model of neonatal rat ventricular myocytes (NRVMs). Treatment of TAC-induced mice with salubrinal ($0.5mg{\cdot}kg^{-1}{\cdot}day^{-1}$) alleviated cardiac hypertrophy and tissue fibrosis. Salubrinal also alleviated hypertrophic growth in endothelin 1 (ET1)-treated NRVMs. Therefore, the present results suggest that salubrinal may be a potentially efficacious drug for treating pathological cardiac remodeling.

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References

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