• 환경생물
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• 제42권2호
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• pp.207-218
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• 2024

Food webs have received global attention as next-generation biomonitoring tools; however, it remains challenging because revealing trophic links between species is costly and laborious. Although a link-extrapolation method utilizing published trophic link data can address this difficulty, it has limitations when applied to construct food webs in domestic streams due to the lack of information on endemic species in global literature. Therefore, this study aimed to develop a link extrapolation-based food web model adapted to Korean stream ecosystems. We considered taxonomic similarity of predation and dominance of generalists in aquatic ecosystems, designing taxonomically higher-level matching methods: family matching for all fish (Family), endemic fish (Family-E), endemic fish playing the role of consumers (Family-EC), and resources (Family-ER). By adding the commonly used genus matching method (Genus) to these four matching methods, a total of five matching methods were used to construct 103 domestic food webs. Predictive power of both individual links and food web indices were evaluated by comparing constructed food webs with corresponding empirical food webs. Results showed that, in both evaluations, proposed methods tended to perform better than Genus in a data-poor environment. In particular, Family-E and Family-EC were the most effective matching methods. Our model addressed domestic data scarcity problems when using a link-extrapolation method. It offers opportunities to understand stream ecosystem food webs and may provide novel insights into biomonitoring.

• Asian Pacific Journal of Cancer Prevention
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• 제13권2호
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• pp.479-482
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• 2012

Aim: Soy foods are the major source of isoflavones, which are believed to play important roles in genesis of breast cancer and its progression. We here conducted a prospective study to evaluate the association of soy isoflavone food consumption with breast cancer prognosis. Methods: A prospective study was performed from January 2004 and January 2006 in China. Trained interviewers conducted face-to-face interviews using a structured questionnaire to collect information on dietary habits and potential confounding factors. The relative risk [hazard ratio (HR)] and 95% CI were calculated from the Cox regression model for all significant predictors from cancer diagnosis to the endpoint of the study (event). Results: After a median follow up of 52.1 months (range, 9-60 months), a total of 79 breast cancer related deaths were recorded in our study, risk being inversely associated with a high intake of soy isoflavone. With an average intake of soy isoflavone above 17.3 mg/day, the mortality of breast cancer can be reduced by about 38-36%. We also found the decreased breast cancer death with high soy protein intake, with a HR (95% CI) of 0.71 (0.52-0.98). Stratified analysis with reference to the ER status, further demonstrated a better prognosis of ER positive breast cancer with a high intake of soy isoflavone (HR 0.59, 0.40-0.93). Conclusion: Our study shows the soy food intake is associated with longer survival and low recurrence among breast cancer patients. A cohort study with a larger sample size and long term follow-up is now needed.

• 성인간호학회지
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• 제14권1호
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• pp.83-92
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• 2002

Purpose: This study was performed to identify the process of change, decisional balance and self-efficacy corresponding to the stage of exercise behavior using Transtheoretical Model in patients with type 2 diabetes mellitus. Method: The study method was a survey in 100 type 2 DM patients at out-patients clinic of Y medical center from March 19, 2000 to October 30, 2000. Result: The results were as follows: The subjects were divided into five stages of exercise behavior ; 15.0% in pre-contemplation stage, 33.0% in contemplation stage, 17.0% in preparation stage, 16.0% in action stage and 19.0% in maintenance stage. The subjects in pre-contemplation stage used all processes of change in the least. "Dramatic relief(DR)", "Environmental reevaluation(ER)" and "Self reevaluation(SR)" were identified as main processes of change in contemplation stage. "Consciousness raising(CR)", "DR" were used higher than average in preparation stage. Helping relationships(HR)", "CR", "ER", "SR", "Social liberation(SL)", "Counter conditioning (CC)", "Reinforcement management(RM)", "Self iberation(SEL)" and "Stimulus control(SC)" were used higher than average in action stage. The subjects in maintenance stage used all process of change the highest except "DR"and "HR". "Cons" score of decisional balance was the highest in pre-contemplation stage, "Pros" score was the highest in action stage and "Self-efficacy" score was the highest in maintenance stage. Conclusion: This study can provide the basis of staged matching exercise program using TTM for more effective and useful intervention.

• Bulletin of the Korean Chemical Society
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• 제34권12호
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• pp.3553-3558
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• 2013

The three dimensional-quantitative structure activity relationship (3D-QSAR) studies on chemical features of pyridine-2-amines in the external region of c-Met active site (ER chemical features of pyridine-2-amines) were conducted by docking, comparative molecular field analysis (CoMFA), and topomer CoMFA methods. The CoMFA model obtained the partial least-squares (PLS) statistical results, cross-validated correlation coefficient ($q^2$) of 0.703, non cross-validated correlation coefficient ($r^2$) of 0.947 with standard error of estimate (SEE) of 0.23 and the topomer CoMFA obtained $q^2$ of 0.803, $r^2$ of 0.940, and SEE of 0.24. Further, the test set was applied to validate predictive abilities of models, where the predictive $r^2$ ($r{^2}_{pred}$) for CoMFA and topomer CoMFA models were 0.746 and 0.608, respectively. Each contribution of ER chemical features of pyridine-2-amines to the inhibitory potency showed correlation coefficients, $r^2$ of 0.670 and 0.913 for two core parts, 3-(benzo[d]oxazol-2-yl)pyridine-2-amine and 3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy) pyridine-2-amine, respectively, with corresponding experimental $pIC_{50}$.

• 한국전자거래학회지
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• 제10권1호
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• pp.41-60
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• 2005

본 논문에서는 국방CALS의 구현을 위한 표준방법론인 ID EF1/1X를 무기체계 연구개발 절차에 적용하여 연구개발 수행과정에서의 연구목표, 정보의 입력, 산출, 제약조건에 대한 정보모델링을 제시하였다. ID EF1/1X를 실행하는 프로그램인 SmartER를 이용하여 연구개발 수행기관 내부에 존재하는 모든 정보자원의 관리에 대한 요구분석을 실시하여 관리해야 할 정보를 식별한 후 TO-BE모델에 대한 정보모델링을 제시한 것이다. ID EF 적용대상인 무기체계 연구개발의 절차는 개념연구, 탐색개발, 체계개발, 그리고 시제품 제작을 거쳐 연구개발 결과 보고서 작성 단계로 구성되어 있다. 본 연구의 정보모델링 결과로 무기체계 통합데이터베이스(IWSDB)를 이용하여 정보를 공유하고 연구개발업무를 수행하는 것을 제시하였다. 무기체계 연구개발사업과 같은 대형 체계개발 사업에 대한 프로세스의 효율성을 기하기 위해서 적절한 방법론으로 알려진 IDEF에 대한 본격적인 연구가 진행되어 국방CALS를 구현하는 계기가 되었으면 한다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권13호
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• pp.5537-5540
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• 2015

Purpose: To research the association between pre-treatment elevated platelet count and clinicopathologic characteristics in breast cancer (BC), as well as explore the relationship between pre-treatment elevated platelet count and HER2 status and prognosis of BC patients. Materials and Methods: A retrospective cohort of BC patients who were newly diagnosed or treated by surgery only and had pathological detection results and platelet values in the Department of Oncology, the First Affiliated Hospital of Liaoning Medical College were enrolled from 1/1/2008 until 31/12/2009, and followed up until 31/12/2014. Age, thrombocyte parameters before chemotherapy and/or radiotherapy, immunohistochemical (IHM) indexes, and regional lymph node (LN) involvement and progression-free survival (PFS) were recorded. Results: A total of 447 eligible subjects were included in this research. As we analyzed, for HER2, positive and negative, the incidence rates of elevated platelet count were 25.8% and 14.7% (P<0.05). In the Cox proportional hazards model both variables were independent risk factors for BC (for HER2, OR, 0.592, 95% confidence interval, CI, 0.355 to 0.985, P=0.044;f or PLT, OR, 0.998, 95% CI, 0.996 to 1.000, P=0.042). For ER, PR, Ki67 and LN involvement, the differences were not statistically significant (P>0.05). Conclusions: In this research, pre-treatment elevated level of platelet count demostrated a significantrelationship with HER2 amplification/overexpression, and both variables significantly influenced the prognosis of BC. However, elevated platelet count did not exhibit any association with ER, PR, Ki67 and LN involvement.

• 한국콘텐츠학회논문지
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• 제15권6호
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• pp.487-498
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• 2015

본 연구는 호텔 직원의 감정노동이 육체적 정신적 스트레스 및 역할 외 행동과 어떠한 인과구조를 형성하는지 실증 분석함으로써, 인사관리 측면의 실무적 정보를 제공하고 육체적 스트레스에 관한 연구의 부재를 해소하는 것에 주목적을 두고 있다. 이를 위해 서울 시내 특1급 호텔 직원으로부터 264개의 표본을 추출하였으며, 주요 분석결과는 다음과 같다. 첫째, 감정노동의 표면적 행위는 육체적 정신적 스트레스에 정(+)의 영향을 미쳤으며, 내면적 행위는 정신적 스트레스에만 부(-)의 효과를 보일 뿐, 육체적 스트레스에는 유의하지 않았다. 둘째, 내면적 행위는 역할 외 행동에 정(+)의 영향력을 보인 반면, 표면적 행위의 효과는 유의미하지 않았다. 셋째, 정신적 스트레스는 역할 외 행동에 부(-)의 영향을 미치는 것으로 확인되었으며, 육체적 스트레스 또한 역할 외 행동에 유의한 효과를 나타냈다. 하지만 육체적 스트레스는 예상된 부(-)의 이론적 부호와는 달리 정(+)의 영향을 도출하였는데, 결론에서는 이러한 결과를 자기 보상 심리에 기초하여 논의하였다.

• 한국축산식품학회지
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• 제36권5호
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• pp.635-640
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• 2016

Lactobacillus acidophilus n.v. Er2 317/402 strain Narine is known as a health beneficial functional probiotic culture and supplementary source of nutrition for newborns. In this study, in vitro antimicrobial activities of Narine-lyophilized (Narine-L), Narine-heat treated (Narine-HT), and Narine crude cell-free extract (Narine-CCFE) were evaluated against pathogen Cronobacter sakazakii (C. sakazakii) in agar as well as in a reconstituted powdered infant formula (RPIF) model. Inhibition zones of 30 mg Narine-L and Narine-HT were both 150 U, whereas inhibition zone of 30 mg Narine-CCFE was 200 U. Narine-L (1 g) and Narine-HT (1 g) were added to 10 mL of artificially contaminated RPIF, respectively, containing 100 μL of C. sakazakii (1.62×10⁸ colony forming unit (CFU)/mL). After treatment with Narine-L and Narine-HT for 3 h and 6 h at 37℃, less than ≤107 CFU/mL of C. sakazakii was detected in RPIF. Without Narine-L and Narine-HT treatment, the population of C. sakazakii increased up to 5.36×10⁹ CFU/mL after 6 h. Examination by transmission electron microscopy confirmed C. sakazakii cells were damaged by Narine-CCFE. Thus, employing Narine culture as a natural and safe bio-preservative may protect infants from C. sakazakii.

• 한국조사연구학회지:조사연구
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• 제12권2호
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• pp.51-76
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• 2011

본 연구는 조사항목에 체계적으로 응답하는 경향인 응답스타일과 성격특성과의 관련을 탐색한다. 보다 구체적으로, 내용에 관계없이 설문문항에 긍정적으로 응답하는 경향인 묵인응답스타일(ARS)와 가장 극단의 응답범주를 지지하는 경향인 극단응답스타일(ERS)이 외향성, 친화성, 성실성, 정서적 안정성, 경험에 대한 개방성 등 성격 5요인 모형에 의해 어느 정도 설명되는지를 검증한다. 2009년 일반종합사회조사의 자료를 이용하여, 응답자의 특성과 면접상황의 효과를 통제한 상태에서, 성격특성변수가 ERS와 ARS 성향에 미치는 효과를 분석하였다. 분석의 결과, ERS의 발생은 응답자의 외향성, 개방성, 친화성, 성실성과 정적인 관련을 맺고 있었으며, ARS는 성격특성과의 관련이 발견되지 않았다. 분석결과의 함의와 함께 응답스타일에 따른 편의의 문제를 해결하기 위한 방법들과 그 한계점이 논의되었다.

• Biomolecules & Therapeutics
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• 제31권6호
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• pp.661-673
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• 2023

Treatment of colorectal cancer (CRC) has always been challenged by the development of resistance. We investigated the antiproliferative activity of licochalcone H (LCH), a regioisomer of licochalcone C derived from the root of Glycyrrhiza inflata, in oxaliplatin (Ox)-sensitive and -resistant CRC cells. LCH significantly inhibited cell viability and colony growth in both Ox-sensitive and Ox-resistant CRC cells. We found that LCH decreased epidermal growth factor receptor (EGFR) and AKT kinase activities and related activating signaling proteins including pEGFR and pAKT. A computational docking model indicated that LCH may interact with EGFR, AKT1, and AKT2 at the ATP-binding sites. LCH induced ROS generation and increased the expression of the ER stress markers. LCH treatment of CRC cells induced depolarization of MMP. Multi-caspase activity was induced by LCH treatment and confirmed by Z-VAD-FMK treatment. LCH increased the number of sub-G1 cells and arrested the cell cycle at the G1 phase. Taken together LCH inhibits the growth of Ox-sensitive and Ox-resistant CRC cells by targeting EGFR and AKT, and inducing ROS generation and ER stress-mediated apoptosis. Therefore, LCH could be a potential therapeutic agent for improving not only Ox-sensitive but also Ox-resistant CRC treatment.