• Journal of Preventive Medicine and Public Health
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• 제46권4호
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• pp.201-209
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• 2013

Objectives: The goal of this study was to perform an economic analysis of a primary stenting with drug-eluting stents (DES) compared with bare-metal stents (BMS) in patients with acute myocardial infarction (AMI) admitted through an emergency room (ER) visit in Korea using population-based data. Methods: We employed a cost-minimization method using a decision analytic model with a two-year time period. Model probabilities and costs were obtained from a published systematic review and population-based data from which a retrospective database analysis of the national reimbursement database of Health Insurance Review and Assessment covering 2006 through 2010 was performed. Uncertainty was evaluated using one-way sensitivity analyses and probabilistic sensitivity analyses. Results: Among 513 979 cases with AMI during 2007 and 2008, 24 742 cases underwent stenting procedures and 20 320 patients admitted through an ER visit with primary stenting were identified in the base model. The transition probabilities of DES-to-DES, DES-to-BMS, DES-to-coronary artery bypass graft, and DES-to-balloon were 59.7%, 0.6%, 4.3%, and 35.3%, respectively, among these patients. The average two-year costs of DES and BMS in 2011 Korean won were 11 065 528 won/person and 9 647 647 won/person, respectively. DES resulted in higher costs than BMS by 1 417 882 won/person. The model was highly sensitive to the probability and costs of having no revascularization. Conclusions: Primary stenting with BMS for AMI with an ER visit was shown to be a cost-saving procedure compared with DES in Korea. Caution is needed when applying this finding to patients with a higher level of severity in health status.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2019년도 학술발표회
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• pp.149-149
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• 2019

Gross Primary production (GPP) and evapotranspiration (ET) are the two critical components of carbon and water cycle respectively, linking the terrestrial surface and ecosystem with the atmosphere. The ratio between GPP to ET is called ecosystem water use efficiency (EWUE) and its quantification at the forest site helps to understand the impact of climate change due to large scale anthropogenic activities such as deforestation and irrigation. This study was conducted at the FLUXNET forest site CN-Qia (2003-2005) using Community land model (CLM 5.0). We simulated carbon and water fluxes including GPP, ecosystem respiration (ER), and ET using climatic variables as forcing dataset for 30 years (1981-2010). Model results were validated with the FLUXNET tower observations. The correlation showed better performance with values of 0.65, 0.77, and 0.63 for GPP, ER, and ET, respectively. The model underestimated the results with minimum bias of -0.04, -1.67, and -0.40 for GPP, ER, and ET, respectively. Effect of climate 'CLIM' and '$CO_2$' were analyzed based on EWUE and its trend was evaluated in the study period. The positive trend of EWUE was observed in the whole period from 1981-2010, and the trend showed further increase when simulated with rising $CO_2$. The time period were divided into two parts, from 1981-2000 and from 2001 to 2010, to identify the warming effect on EWUE. The first period showed the similar increasing trend of EWUE, but the second period showed slightly decreasing trend. This might be associated with the increase in ET in the wet temperate forest site due to increase in climate warming. Water use efficiency defined by transpiration (TR) (TWUE), and inherent-TR based WUE (IT-WUE) were also discussed. This research provides the evidence to climate warming and emphasized the importance of long term planning for management of water resources and evaporative demand in irrigation, deforestation and other anthropogenic activities.

• 한국소음진동공학회논문집
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• 제16권12호
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• pp.1286-1293
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• 2006

This paper presents force-feedback control performance of a haptic device in virtual environment of minimally invasive surgery(MIS). As a first step, based on an electrorheological (ER) fluid and spherical geometry, a new type of master device is developed and integrated with a virtual environment of MIS such as a surgical tool and human organ. The virtual object is then mathematically formulated by adopting the shape retaining chain linked(S-chain) model. After evaluating reflection force, computational time, and compatibility with real time control, the virtual environment of MIS is formulated by interactivity with the ER haptic device in real space. Tracking control performances for virtual force trajectory are presented in time domain.

• 한국지능시스템학회:학술대회논문집
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• 한국퍼지및지능시스템학회 2004년도 추계학술대회 학술발표 논문집 제14권 제2호
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• pp.373-376
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• 2004

최근에 뇌파를 이용하여 컴퓨터와 통신하거나 기기를 제어할 수 있는 이른바 뇌-컴퓨터 인터페이스BCI(Brain-Computer Interface)에 대한 연구가 대두되고 있다. 이러한 BCI 연구의 궁극적 목표는 다양한 정신상태에 따른 뇌파의 특성을 파악하여 컴퓨터나 기기 등을 제어하는 것이다. 본 논문에서는 움직임과 관련 있는 10～12Hz의 mu파 영역에서의 ERD/ERS를 계산하였고, 그 결과 왼쪽과 오른쪽 손의 움직임을 상상할 때에 운동과 관련된 기능이 집중되어 있는 일차운동영역(primary motor area)의 mu파에서 ERD/ERS의 차이가 나타남을 발견하였다 또한, RLS방법을 사용한 Adaptive Autoregressive Model 계수의 특징을 추출을 하였으며, 이를 신경망으로 학습시켜 인식률을 비교하였다.

• 한국정밀공학회지
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• 제9권3호
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• pp.61-66
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• 1992

This paper addresses on the determination of damping coefficients of an infinitely long squeeze film damper operating with an electro-rheological (ER) fluid. The ER fluid behaves as Bingham fluid with an electric field dependent yield shear stress. AS phenomenological model of the fluid is adopted for the relationship between the yield shear and the intensity of the electric field imposed on the fluid domain. The model is then incorporated with the governing equation and associated boundary conditions of the squeeze film damper executing a circula centered orbit for the expression of dimension- less damping coefficients. Numerical simulation is performed to evaluate the performance improvement of the proposed squeeze film damper.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2000년도 춘계학술대회논문집
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• pp.251-256
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• 2000

This paper presents dynamic modeling and controller design of a tracked vehicle installed with the double-rod type ERSU(electro-rheological suspension unit). A 16 DOF(degree-of-freedom) model for the tracked vehicle is established by Lagrangian method. After showing the spring and damping characteristics of the proposed ERSU, equivalent 2 DOF 1/12 tracked vehicle model is then formulated by regarding the spring and viscous damping coefficients under the static state as constant values. A robust LSDP(loop-shaping design procedure) $H_{\infty}$ controller compensating spring and damping parameter variations is then designed in order to suppress unwanted vibration of the vehicle. The control responses such as vertical and pitch acceleration are presented in time domain.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1997년도 추계학술대회
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• pp.375-379
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• 1997

Pulsed Er:YAG and $CO_2$ lasers induced temperature rise of tissue are studied using axisymmetric, two-dimensional, and transient Pennes' bio-heat equation or the implications of skin resurfacing. Model results indicate that Er:YAG laser induced temperature has much higher but more shallow distribution in tissue than that of the $CO_2$ laser because of its higher absorption coefficient. The increase of repetition rate does not affect the temperature rise too much because these laser modalities have much shorter heat diffusion time than the temporal length of each off-pulse. This model works as a tool to understand the photothermal effect in the laser-tissue interaction.

• Toxicological Research
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• 제33권1호
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• pp.71-77
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• 2017

Hormone replacement therapy (HRT) consists of highly effective prescription medications for treating menopausal symptoms; however, these agents have exhibited side effects including the risk of estrogen-induced carcinogenesis. Therefore, interest in phytotherapy-based materials as a natural source of alternatives to estrogen therapy has increased. However, some of these herbal medicines have been reported to increase the risk of estrogen-induced cancer. Herbal formulations composed of a combination of Cynanchum wilfordii Hemsley (CW), Phlomis umbrosa Turczaninow (PU), and Angelica gigas Nakai (AG) extracts (CPAE) have been used for treating menopausal symptoms. Therefore, in this study, we aimed to examine the safety of CPAE by determining its potential adverse estrogenic activity using the Organization for Economic Cooperation and Development (OECD) test guideline 455 (TG455) in a stably transfected transcriptionally activated human estrogen receptor ${\alpha}$ ($hER{\alpha}$)-HeLa9903 cell model. We found that CPAE did not how any estrogenic activity or stimulate promoters containing estrogen response elements in MCF-7 cells. In addition, CPAE showed no significant selective activity against $hER{\alpha}$ and $hER{\beta}$, non-selective activity against the ER, or effects on ER target gene expression. Furthermore, CPAE did not significantly induce MCF-7 cell proliferation and uterine weight increase in ovariectomized rats. These results demonstrate that CPAE can be used as beneficial herbal drug for prevention and therapeutic intervention of estrogen carcinogenesis in menopausal women.

• BMB Reports
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• 제52권11호
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• pp.647-652
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• 2019

G protein-coupled estrogen receptor (GPER) is known to play an important role in hormone-associated cancers. G-1, a novel synthetic GPER agonist, has been reported to exhibit anti-carcinogenic properties. However, the chemotherapeutic mechanism of GPER is yet unclear. Here, we evaluated GPER expression in human gastric cancer tissues and cells. We found that G-1 treatment attenuates GPER expression in gastric cancer. GPER expression increased G-1-induced antitumor effects in mouse xenograft model. We analyzed the effects of knockdown/overexpression of GPER on G-1-induced cell death in cancer cells. Increased GPER expression in human gastric cancer cells increased G-1-induced cell death via increased levels of cleaved caspase-3, -9, and cleaved poly ADP-ribose polymerase. Interestingly, during G-1-induced cell death, GPER mRNA and protein expression was attenuated and associated with ER stress-induced expression of PERK, ATF-4, GRP-78, and CHOP. Furthermore, PERK-dependent induction of ER stress activation increased G-1-induced cell death, whereas PERK silencing decreased cell death and increased drug sensitivity. Taken together, the data suggest that the induction of ER stress via GPER expression may increase G-1-induced cell death in gastric cancer cells. These results may contribute to a new paradigm shift in gastric cancer therapy.

• Nuclear Engineering and Technology
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• 제54권9호
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• pp.3516-3525
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• 2022

The high capture cross-section (𝜎_c) of Gadolinium (Gd-155 and Gd-157) causes reactivity penalty and swing at the initial stage of fuel burnup in Pressurized Water Reactor (PWR). The present study is concerned with the feasibility of the combination of mixed burnable poison with both low and high 𝜎_c as an approach to minimize these effects. Two considered reference designs are fuel assemblies with 24 IBA rods of Gd₂O₃ and Er₂O₃ respectively. Models comprise nuclear fuel with a homogeneous mixture of Er₂O₃, AmO₂, SmO₂, and HfO₂ with Gd₂O₃ as well as the coating of PaO₂ and ZrB₂ on the Gd₂O₃ pellet's outer surface. The infinite multiplication factor was determined and reactivity was calculated considering 3% neutron leakage rate. All models except Er₂O₃ and SmO₂ showed expected results namely higher values of these parameters than the reference design of Gd₂O₃ at the early burnup period. The highest value was found for the model of PaO₂ and Gd₂O₃ followed by ZrB₂ and HfO₂. The cycle burnup, discharge burnup, and cycle length for three batch refueling were calculated using Linear Reactivity Model (LRM). The pin power distribution, energy-dependent neutron flux and Fuel Temperature Coefficient (FTC) were also studied. An optimization of model 1 was carried out to investigate effects of different isotopic compositions of Gd₂O₃ and absorber coating thickness.