• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2000년도 춘계학술대회논문집
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• pp.1298-1302
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• 2000

Electrorheological(HER) and magnetorheologica(MR) fluids have a unique ability to increase the dynamic yield stress of the fluid substantially when electric or magnetic field is applied. ER and MR fluid-based dampers are typically analyzed using Bingham-plastic shear flow analysis under Quasi-steady fully developed flow conditions. An alternative perspective, supported by measurements reported in the literature, is to allow for post-yield shear thinning and shear thickening. To model these, the constant post-yield plastic viscosity in Bingham model can be replaced with a power-law model dependent on shear strain rate that is known as the Herschel-Bulkley fluid model. The objective of this paper is to predict the damping forces analytically in a typical ER bypass damper for variable electric field, or yield stress using Herschel-Bulkley analysis.

• IEIE Transactions on Smart Processing and Computing
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• 제1권2호
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• pp.78-87
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• 2012

In this paper, we address the tracking problem caused by camera motion and rolling shutter effects associated with CMOS sensors in consumer handheld cameras, such as mobile cameras, digital cameras, and digital camcorders. A modified particle filtering method is proposed for simultaneously tracking objects and compensating for the effects of camera motion. The proposed method uses an elastic registration algorithm (ER) that considers the global affine motion as well as the brightness and contrast between images, assuming that camera motion results in an affine transform of the image between two successive frames. By assuming that the camera motion is modeled globally by an affine transform, only the global affine model instead of the local model was considered. Only the brightness parameter was used in intensity variation. The contrast parameters used in the original ER algorithm were ignored because the change in illumination is small enough between temporally adjacent frames. The proposed particle filtering consists of the following four steps: (i) prediction step, (ii) compensating prediction state error based on camera motion estimation, (iii) update step and (iv) re-sampling step. A larger number of particles are needed when camera motion generates a prediction state error of an object at the prediction step. The proposed method robustly tracks the object of interest by compensating for the prediction state error using the affine motion model estimated from ER. Experimental results show that the proposed method outperforms the conventional particle filter, and can track moving objects robustly in consumer handheld imaging devices.

• 한국재료학회지
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• 제3권2호
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• pp.185-192
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• 1993

본 연구에서는 분극성을 갖는 미세분말/유전유체 분산계내의 전기유변효과를 mechanism을 중심으로 고찰하였다. 전기유변효과를 일으키는 mechanism을 (1)입자표면전도(surface conductance) (2)입자내부전도(bulk conductance(3) 유도분극(induced polarization)으로 구분하여 설명하였다. 소수성(anhydrous-base)전기유변유체 내의 미세분말 입자간 상호인력을 예측할 수 있도록 유도분극 mechanism을 적용하여 수학적으로 모델화 함으로써 전기유변효과를 향상 시키기 위한 재료선정의 기초로 하였다. 전기유변유체의 미세입자로 이용될 수 있다고 여겨지는 ceramic, ferrite 및 polymer등 7가지 재료를 선정하여 계산한 결과 ceramic및 ferrite입자가 입자간 상호인력이 큰것으로 나타났다.

• Korean Chemical Engineering Research
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• 제60권4호
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• pp.613-619
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• 2022

전도성 입자로 제조된 전기유변(Electrorheological) 유체에서 입자 크기 및 서로 다른 크기의 입자들의 혼합이 전기유변 현상에 어떤 영향을 미치는지 살펴보기 위해 Onsager 이론으로 확장된 Maxwell-Wagner 분극 모델을 이용하여 전산 모사를 수행하였다. 전산 모사 결과 입자의 부피 분율이 같은 경우 단일한 크기의 입자로 구성된 균일한 전기유변 유체의 동적 항복응력은 입자 크기에 무관하였고, 크기가 서로 다른 입자들로 혼합된 비균일 전기유변 유체의 동적 항복응력은 균일한 전기유변 유체에 비해 감소하였다. 입자 부피 분율이 같은 경우 ${\dot{\gamma}}^*$≧0.01인 범위에서 큰 입자로 구성된 균일한 전기유변 유체가 작은 입자로 구성된 균일한 전기유변 유체보다 전단응력이 큰 것으로 나타났으며, ${\dot{\gamma}}^*$≧1인 경우에는 전기유변 유체는 큰 입자의 비율이 증가할수록 전단응력이 증가함을 보였다. 모든 입자 크기 및 조성에 대해 전도성 입자로 제조된 전기유변 유체의 특성인 비제곱 전기유변 현상(∆_𝛕 ∝ Eⁿ, n ≈ 1.55)도 예측하였다.

• Molecules and Cells
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• 제38권10호
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• pp.851-858
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• 2015

Disturbed blood flow with low-oscillatory shear stress (OSS) is a predominant atherogenic factor leading to dysfunctional endothelial cells (ECs). Recently, it was found that disturbed flow can directly induce endoplasmic reticulum (ER) stress in ECs, thereby playing a critical role in the development and progression of atherosclerosis. Ursodeoxycholic acid (UDCA), a naturally occurring bile acid, has long been used to treat chronic cholestatic liver disease and is known to alleviate endoplasmic reticulum (ER) stress at the cellular level. However, its role in atherosclerosis remains unexplored. In this study, we demonstrated the anti-atherogenic activity of UDCA via inhibition of disturbed flow-induced ER stress in atherosclerosis. UDCA effectively reduced ER stress, resulting in a reduction in expression of X-box binding protein-1 (XBP-1) and CEBP-homologous protein (CHOP) in ECs. UDCA also inhibits the disturbed flow-induced inflammatory responses such as increases in adhesion molecules, monocyte adhesion to ECs, and apoptosis of ECs. In a mouse model of disturbed flow-induced atherosclerosis, UDCA inhibits atheromatous plaque formation through the alleviation of ER stress and a decrease in adhesion molecules. Taken together, our results revealed that UDCA exerts anti-atherogenic activity in disturbed flow-induced atherosclerosis by inhibiting ER stress and the inflammatory response. This study suggests that UDCA may be a therapeutic agent for prevention or treatment of atherosclerosis.

• 한국환경보건학회지
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• 제47권5호
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• pp.462-471
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• 2021

Background: The number of synthesized chemicals has rapidly increased over the past decade. For many chemicals, there is a lack of information on toxicity. With the current movement toward reducing animal testing, the use of toxicity big data and deep learning could be a promising tool to screen potential toxicants. Objectives: This study identified potential chemicals related to reproductive and estrogen receptor (ER)-mediated toxicities for 1135 cleaning products and 886 laundry products. Methods: We listed chemicals contained in cleaning and laundry products from a publicly available database. Then, chemicals that potentially exhibited reproductive and ER-mediated toxicities were identified using the European Union Classification, Labeling and Packaging classification and ToxCast database, respectively. For chemicals absent from the ToxCast database, ER activity was predicted using deep learning models. Results: Among the 783 listed chemicals, there were 53 with potential reproductive toxicity and 310 with potential ER-mediated toxicity. Among the 473 chemicals not tested with ToxCast assays, deep learning models indicated that 42 chemicals exhibited ER-mediated toxicity. A total of 13 chemicals were identified as causing reproductive toxicity by reacting with the ER. Conclusions: We demonstrated a screening method to identify potential chemicals related to reproductive and ER-mediated toxicities utilizing chemical toxicity big data and deep learning. Integrating toxicity data from in vivo, in vitro, and deep learning models may contribute to screening chemicals in consumer products.

• Structural Engineering and Mechanics
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• 제81권4호
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• pp.411-428
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• 2022

This paper presents the Campbell diagram analysis of the rotordynamic system using the full order model (FOM) and the reduced order model (ROM) techniques to determine the critical speeds, identify the stability and reduce the computational time. Due to the spin-speed-dependent matrices (e.g., centrifugal stiffening matrix), several model order reduction (MOR) techniques may be considered, such as the modal superposition (MS) method and the Krylov subspace-based MOR techniques (e.g., Ritz vector (RV), quasi-static Ritz vector (QSRV), multifrequency quasi-static Ritz vector (MQSRV), multifrequency/ multi-spin-speed quasi-static Ritz vector (MMQSRV) and the combined Ritz vector & modal superposition (RV+MS) methods). The proposed MMQSRV method in this study is extended from the MQSRV method by incorporating the rotational-speed-dependent stiffness matrices into the Krylov subspace during the MOR process. Thus, the objective of this note is to respond to the question of whether to use the MS method or the Krylov subspace-based MOR technique in establishing the Campbell diagram of the shaft-disc-blade assembly systems in three-dimensional (3D) finite element analysis (FEA). The Campbell diagrams produced by the FOM and various MOR methods are presented and discussed thoroughly by computing the norm of relative errors (ER). It is found that the RV and the MS methods are dominant at low and high rotating speeds, respectively. More precisely, as the spinning velocity becomes large, the calculated ER produced by the RV method is significantly increased; in contrast, the ER produced by the MS method is smaller and more consistent. From a computational point of view, the MORs have substantially reduced the time computing considerably compared to the FOM. Additionally, the verification of the 3D FE rotordynamic model is also provided and found to be in close agreement with the existing solutions.

• Nuclear Engineering and Technology
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• 제43권6호
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• pp.547-556
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• 2011

Two computational methods for determining equilibrium states for the Mark-IV electrorefiner (ER) have been assessed to improve the current computational electrorefiner model developed at University of Idaho. Both methods were validated against measured data to better understand their effects on the calculation of the equilibrium compositions in the ER. In addition, a sensitivity study was performed on the effect of specific unknown activity coefficients-including sodium in molten cadmium, zirconium in molten cadmium, and sodium chloride in molten LiCl-KCl. Both computational methods produced identical results, which stayed within the 95% confidence interval of the experimental data. Furthermore, sensitivity to unavailable activity coefficients was found to be low (a change in concentration of less than 3 ppm).

• IMMUNE NETWORK
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• 제12권6호
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• pp.253-260
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• 2012

${\alpha}$-Mangostin is a xanthon derivative contained in the fruit hull of mangosteen (Garcinia mangostana L.), and the administration of ${\alpha}$-Mangostin inhibited the growth of transplanted colon cancer, Her/CT26 cells which expressed Her-2/neu as tumor antigen. Although ${\alpha}$-Mangostin was reported to have inhibitory activity against sarco/endoplasmic reticulum $Ca^{2+}$ ATPase like thapsigargin, it showed different activity for autophagy regulation. In the current study, we found that ${\alpha}$-Mangostin induced autophagy activation in mouse intestinal epithelial cells, as GFP-LC3 transgenic mice were orally administered with 20 mg/kg of ${\alpha}$-Mangostin daily for three days. However, the activation of autophagy by ${\alpha}$-Mangostin did not significantly increase OVA-specific T cell proliferation. As we assessed ER stress by using XBP-1 reporter system and phosphorylation of $eIF2{\alpha}$, thapsigargin-induced ER stress was significantly reduced by ${\alpha}$-Mangostin. However, coadministration of thapsigargin with ${\alpha}$-Mangostin completely blocked the antitumor activity of ${\alpha}$-Mangostin, suggesting ER stress with autophagy blockade accelerated tumor growth in mouse colon cancer model. Thus the antitumor activity of ${\alpha}$-Mangostin can be ascribable to the autophagy activation rather than ER stress induction.

• Experimental and Molecular Medicine
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• 제50권11호
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• pp.10.1-10.11
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• 2018

Although early studies suggested that bladder cancer (BCa) is more prevalent in men than in women, muscle-invasive rates are higher in women than in men, suggesting that sex hormones might play important roles in different stages of BCa progression. In this work, we found that estrogen receptor beta ($ER{\beta}$) could increase BCa cell proliferation and invasion via alteration of miR-92a-mediated DAB2IP (DOC-2/DAB2 interacting protein) signals and that blocking miR-92a expression with an inhibitor could partially reverse $ER{\beta}$-enhanced BCa cell growth and invasion. Further mechanism dissection found that $ER{\beta}$ could increase miR-92a expression at the transcriptional level via binding to the estrogen-response-element (ERE) on the 5' promoter region of its host gene C13orf25. The $ER{\beta}$ up-regulated miR-92a could decrease DAB2IP tumor suppressor expression via binding to the miR-92a binding site located on the DAB2IP 3' UTR. Preclinical studies using an in vivo mouse model also confirmed that targeting this newly identified $ER{\beta}$/miR-92a/DAB2IP signal pathway with small molecules could suppress BCa progression. Together, these results might aid in the development of new therapies via targeting of this $ER{\beta}$-mediated signal pathway to better suppress BCa progression.