• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.20
• /
• pp.8759-8763
• /
• 2014

Background: Non-hodgkin lymphoma (NHL) is a diverse group of disease encompassing divergent tumor types with contrasting clinical behaviors. We aimed to evaluate the usefulness of Ki67 index in segregating indolent from aggressive NHL and its association with clinical parameters. Materials and Methods: During a study period of 4.5 years, a total of 215 cases of lymphomas were diagnosed among of which 172 cases were NHL. Ki67 immunohistochemical staining was performed by the DAKO envision method. Average proportion of tumor cells stained was calculated to determine the proliferative index. Results: The mean age at diagnosis was 46.2 years +19.8 (3-81) with a male to female ratio of 1.5:1. Mean Ki67 index for indolent NHL included 23% for small cell, 25% for mantle cell, 28.5% for marginal zone and 34.6% for follicular lymphoma. On the other hand, mean Ki67 index for aggressive lymphomas were 66.4%, 66.9%, 80.3%, 83.3% and 94.4% for diffuse large B cell, T cell (NOS), anaplastic large cell, lymphoblastic and burkitts lymphoma respectively. No significant correlation was found between Ki67 index and other clinical parameters like age and extra nodal involvement. Conclusions: Ki67 index is a valuable IHC marker to distinguish indolent from aggressive lymphomas especially in small needle biopsies where exact typing may not be possible.

• Asian Pacific Journal of Cancer Prevention
• /
• v.16 no.4
• /
• pp.1443-1448
• /
• 2015

To investigate the significance of FOXO3a and Ki67 in human lung adenocarcinomas. Envision immunohistochemical staining and Western blotting were used to examine the protein expression of FOXO3a in 127 cases of human lung adenocarcinoma specimens. The positive rate in lung adenocarcinoma (55.9%) was lower than that in normal tissues (80%). We found that the expression of FOXO3a was closely related with the degree of differentiation, TNM staging, lymph node metastasis and survival. In addition, significant differences in the different pathological types of lung adenocarcinoma cases (P<0.01). The FOXO3a positive rate of the acini as the main type (APA) (86.7%) and the lepidic as the main type (LPA) (82.4%) was higher than the solid as the main type (SPA) (50.0%), the papilla as the main type (PPA) (42.9%) and the micropapilla as the main type (MPA) (9.4%). Moreover, the expression of FOXO3a was negatively related with Ki67 expression. Our results suggested that the expression of FOXO3a is closely correlated with the aggressiveness of lung adenocarcinoma. It was indicated that disregulation of FOXO3a might play key roles in the occurrence and development of lung a denocarcinoma and joint detection of the two markers might play an important role in diagnosing tumors.

• Journal of the Korean Society of Clothing and Textiles
• /
• v.35 no.7
• /
• pp.721-735
• /
• 2011

This study: 1) identifies differences in consumers' perceived similarity of extended products to their parent product in terms of brand attributes, 2) identifies the influence of the perceived similarity on consumer's attitude toward and purchase intention of extended products (i.e., brand extension effect), and 3) examines the moderating effect of Brand Relationship Quality (BRQ) on brand extension effects. A survey questionnaire was distributed to a convenience sample of individuals aged 20-39. A total of 576 valid responses were used for the final analysis. The results showed that: 1) the consumers perceived more similarity in the extended products when the extended products maintain more consistent attributes with their parent product, 2) the higher the perceived similarity was then the higher the brand extension effect, and 3) brand relationship quality moderated the influence of perceived similarity on attitude and purchase intention. When consumers build a high relationship quality with a brand, then the brand extension effect is likely to be high regardless of the perceived similarity of the extended products. This study consequently has its own contribution in that it empirically examined the brand extension effect in the fashion field and evidenced the role of BRQ in brand extension.

• Clean Technology
• /
• v.18 no.3
• /
• pp.295-300
• /
• 2012

Synthesis of well-defined particle with tunable size, shape, and functionalities is strongly emphasized for various applications such as chemistry, biology, material science, chemical engineering, medicine, and biotechnology. This study presents micromolding method for the fabrication of anisotropic particles with elegant control of curvature of covex roof. For the demostration of rapid fabrication of the particles, we have applied polydimethylsiloxane (PDMS) micromold as structure guiding template and wetting fluid to control curvature of roof of the particles. Based on this approach, we can control the radius of curvature from $20{\mu}m$ to $70{\mu}m$ with different aspect ratio of mold. In addition, wetting fluids with different wetting properties can also modulate the height and radius of curvature of the particles. We envision that this methodology is promising tool for precise control of particle shape in 3-dimensional space and new synthetic route for anisotropic particles with cost effective, simple, easy, and fast procedure.

• Education of Primary School Mathematics
• /
• v.3 no.1
• /
• pp.1-36
• /
• 1999

The case of four classrooms analyzed in this study point to many commonalities in the challenges of reforming mathematics teaching in Korea and the U. S. In both national contexts we have seen the need fur a clear distinction between implementing new student-centered social practices in the classroom, and providing significant new loaming opportunities for students. In particular, there is an important need to distinguish between attending to the social practices of the classroom and attending to students conceptual development within those social practices. In both countries, teachers in the less successful student-centered classes tended to abdicate responsibility fur sense making to the students. They were more inclined to attend to the literal statements of their students without analyzing their conceptual understanding (Episodes KA5 and UP 2). This is easy to do when the rhetoric of reform emphasizes student-centered social practices without sufficient attention to psychological correlates of those social practices. The more successful teachers tended to monitor the understanding of the students and to take proactive measures to ensure the development of that understanding (Episodes KO5 and UN3). This suggests the usefulness of constructivism as a model (or successful student-centered instruction. As Simon(1995) observed, constructivist teachers envision a hypothetical learning trajectory that constitutes their plan and expectation for students learning from the particular if the trajectory is being followed. If not, the teacher adjusts or supplements the task to obtain a more satisfactory result, or reconsider her or his assumptions concerning the hypothetical learning trajectory. In this way, the teacher acts proactively to try to ensure that students are progressing in their understanding in particular ways. Thus the more successful student-centered teacher of this study can be seen as constructivist in their orientation to student conceptual development, in comparison to the less successful student-centered teachers. It is encumbant on the authors of reform in Korea and the U. S. to make sure that reform is not trivialized, or evaluated only on the surface of classroom practices. The commonalities of the two reform endeavores suggest that Korea and the U. S. have much to share with each other in the challenges of reforming mathematics teaching for the new millennium.

• The Journal of the Korea Contents Association
• /
• v.6 no.11
• /
• pp.302-309
• /
• 2006

This paper propose a practical algorithm to reuse and expand the objects. This algorithm is based on the Motion Path Modification rules. We focus on reusing of the existing motions for synthesizing new motions for the objects. Both the linear and the nonlinear curve-fitting algorithm are applied to modify an animation by keyframe interpolation and to make the motion appear realistic. We also proposes a framework of the scenario-based 3D image synthesizing system that allows common users, who envision a scenario in their minds, to realize it into segments of a cool animation. The framework is useful in building a 3D animation in game programming with a limited set of 3D objects.

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.40 no.10
• /
• pp.1900-1911
• /
• 2015

In this paper, we introduce backscatter communication for power-limited sensors to enable long-range transmission in wireless sensor networks, and envision a way to avoid doubly near-far problem in wireless-powered communication network (WPCN) with this technology. In backscatter based WPCN, users harvest energy from both the signal broadcasted by the hybrid access point and the carrier signal transmitted by the carrier emitter in the downlink, and then transmit their own information in a passive way via the reflection of the carrier signal using frequency-shift keying modulation in the uplink. We characterize the energy-free condition and the signal-to-noise ratio (SNR) outage zone in backscatter based WPCN. Further, we propose backscatter based harvest-then-transmit protocol to maximize the sum-throughput of the backscatter based WPCN by optimally allocating time for energy harvesting and information transmission. Numerical results demonstrate that the backscatter based WPCN increases significantly the transmission range and diminishes greatly the SNR outage zone.

• Journal of the Korea Society of Computer and Information
• /
• v.18 no.10
• /
• pp.183-192
• /
• 2013

This paper examines the impact of the strategic leadership of CEOs after M&A on resistance to change and on perceived performance. Most M&A research has focused on the strategic, financial and economic aspects, while studies on leadership and employee behavior have been limited. CEO leadership is critical to a successful M&A. Recently, strategic leadership has been attracting more attention. Strategic leadership can be defined as a person's ability to anticipate, envision, maintain flexibility, think strategically and to work with others to initiate changes that will create a viable future for an organization. It can also reduce resistance and improve perceived performance. So this paper used empirical studies from the IT industry after M&A.

• Hwankyungkyoyuk
• /
• v.23 no.4
• /
• pp.82-95
• /
• 2010

The Water Environmental Education Program Using Streams(WEES) is developed to help the teachers increase their professionalism of incorporating a local environment into their inquiry teaching. The purpose of this study is inquiry about the 'Baig Cheon' stream with the perspective of environmental studies for WEES. Through these studies, we tried to get the background information in 'Baig Cheon' and profound insights into application of WEES. The 'Baig Cheon' was examined from the perspective of environmental studies through literature study, field study, and water quality monitoring. The results revealed the characteristics of the 'Baig Cheon' that ran across a rural area in terms of the watershed boundaries, water systems, and water usage. The changes to the water quality items were observed according to the spatial distribution at the measuring points across the watershed for six months from March to August, 2007. The results indicate that the water quality of the 'Baig Cheon' could well be affected not only by the natural and environmental conditions such as the geological features, but also by the human activities including the land uses in the surrounding roads, rice fields and farms and the water supply and usage. The inquiry of the 'Baig Cheon' from the perspective of environmental studies will hopefully make the education and inquiry process of WEES more meaningful and in-depth and contribute to providing better environmental education that properly reflects the nature of inquiry from the perspective of environmental studies.

• Journal of Information Processing Systems
• /
• v.10 no.1
• /
• pp.103-118
• /
• 2014

Over the last couple of years, traditional VANET (Vehicular Ad Hoc NETwork) evolved into VANET-based clouds. From the VANET standpoint, applications became richer by virtue of the boom in automotive telematics and infotainment technologies. Nevertheless, the research community and industries are concerned about the under-utilization of rich computation, communication, and storage resources in middle and high-end vehicles. This phenomenon became the driving force for the birth of VANET-based clouds. In this paper, we envision a novel application layer of VANET-based clouds based on the cooperation of the moving cars on the road, called CaaS (Cooperation as a Service). CaaS is divided into TIaaS (Traffic Information as a Service), WaaS (Warning as a Service), and IfaaS (Infotainment as a Service). Note, however, that this work focuses only on TIaaS and WaaS. TIaaS provides vehicular nodes, more precisely subscribers, with the fine-grained traffic information constructed by CDM (Cloud Decision Module) as a result of the cooperation of the vehicles on the roads in the form of mobility vectors. On the other hand, WaaS provides subscribers with potential warning messages in case of hazard situations on the road. Communication between the cloud infrastructure and the vehicles is done through GTs (Gateway Terminals), whereas GTs are physically realized through RSUs (Road-Side Units) and vehicles with 4G Internet access. These GTs forward the coarse-grained cooperation from vehicles to cloud and fine-grained traffic information and warnings from cloud to vehicles (subscribers) in a secure, privacy-aware fashion. In our proposed scheme, privacy is conditionally preserved wherein the location and the identity of the cooperators are preserved by leveraging the modified location-based encryption and, in case of any dispute, the node is subject to revocation. To the best of our knowledge, our proposed scheme is the first effort to offshore the extended traffic view construction function and warning messages dissemination function to the cloud.