• 한국미생물·생명공학회지
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• 제35권3호
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• pp.255-260
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• 2007

본 연구는 톱밥주원료 버섯폐배지의 효과적 사료화를 위한 균주개발을 목적으로 버섯폐배지로부터 섬유소분해력이 높은 중온성 균주의 분리 동정하고 균주생산을 위한 배지의 최적화 조건 도출을 위하여 실시하였다. Xylanase와 CMCase의 활력이 높으면서 amylase와 pretense의 활력이 낮아 선발된 균은 201-3, 206-3번이며, 동정결과 201-3은 Enteerobacter ludwigii로 동정되어 Ent. ludwigii KU201-3으로, 206-3은 Bacillus cereus로 동정되어 B. cereus KU206-3으로 명명하였다. 균주생산을 위한 적정 액상배양조건은 Ent. ludwigii KU201-3 질소원으로 soybean meal 1%, 탄소원으로 sucrose 3%가, B. cereus KU206-3은 질소원으로 soybean meal 3%, 탄소원으로 molasses 1%인 것으로 나타났다.

• 대한화장품학회지
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• 제43권4호
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• pp.289-295
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• 2017

본 연구에서는 섬오갈피 줄기 추출물 및 용매 분획물의 미백 활성을 검색하고 유효성분을 분리하여 화학구조를 규명하였다. 섬오갈피 줄기 에탄올 추출물 및 용매 분획물의 멜라닌 생성 억제활성을 측정한 결과, 헥산 및 에틸아세테이트 분획물에서 우수한 멜라닌 생성 억제 효과가 있음을 확인하였다. 비교적 세포독성이 적은 헥산 분획물에서 유효성분을 찾고자 크로마토크래피를 실시하여 3개의 화합물을 분리하였으며 $^1H$ 및 $^{13}C$ NMR 데이터 분석 및 문헌 비교를 통하여 화학구조를 동정하였다; kaurenoic acid (1), $16{\alpha}$-hydro-17-isovaleroyloxy-ent-kauran-19-oic acid (2), $16{\alpha}$-hydroxy-17-isovaleroyloxy-ent-kauran-19-oic acid (3). 분리된 화합물에 대한 미백 활성 실험 결과, 화합물 1-3 모두 농도의존적으로 멜라닌 생성을 억제하였다. 또한 세포 내 티로시나제 효소의 활성을 감소시킴을 확인하였으며 이러한 연구 결과를 바탕으로 섬오갈피 줄기 추출물은 기능성 미백 화장품 소재로써 활용 가능할 것이라 사료된다.

• 한국농림기상학회지
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• 제22권2호
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• pp.47-56
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• 2020

본 연구는 기후변화에 따른 소나무 잠재분포변화 예측 및 환경요인과의 관계를 파악하기 위한 목적으로 수행되었다. 입력자료인 종속변수는 1:5,000 임상도에서 추출한 소나무 출현자료를 사용하였으며, 독립변수는 RCP 시나리오 기후자료 및 임상도, 입지도에서 추출한 기후, 입지, 생육환경자료 등 총 14개의 환경요인 변수를 사용하였다. 이러한 입력자료를 바탕으로 생태적 지위 개념을 기반으로 한 종 분포 모형 중 하나인 MaxEnt (Maximum Entropy Modeling) 모형을 구동하여 미래의 소나무 잠재분포를 예측하였다. 분석결과 training AUC (Area Under Curve)가 0.79로 우수한 수준의 정확도를 보였으며 현존 소나무 분포 자료와 유사한 현재 잠재분포 결과를 보였다. RCP 시나리오를 적용한 결과 소나무 잠재분포지는 시간이 지남에 따라 지속적으로 감소할 것으로 나타났으며 RCP8.5 기준으로 2050년과 2070년에 각각 11.1%, 18.7%의 잠재분포지가 줄어들 것으로 예측되었다. 입력자료의 소나무 잠재분포 판단에 대한 기여도는 계절기온, 고도, 겨울철 기온 등이 높게 나타났다. 본 연구의 결과는 기후변화로 인한 소나무림 보전 및 대책 수립을 위한 기초자료로 활용될 것으로 판단된다.

• International journal of advanced smart convergence
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• 제11권4호
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• pp.227-239
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• 2022

Purpose: In our study, in order to find lactic acid bacteria (LAB) with multi-drug resistance to antibiotics, we isolated 140 strains from 15 types of kimchi commercially available in Korea and 20 types of Kimchi made at home from January to December in 2016, and investigated their H₂O₂ generating ability and multi-drug resistance to antibiotics. Methods: In order to observe the H₂O₂ generation ability of LAB, we performed the experiment with methods such as Rabe, Hillier, and Kang. To test the antibacterial susceptibility of LAB, we used the disc agar diffusion method using MRS agar (Difco, USA) according to the CLSI and WHO test methods. There are 18 types of antibiotic discs used. Results: Out of the total numbers of 140 strains, 6 strains of Ent. Faecium, 25 strains of L. plantarum, 1 strain of L. rhamnosus, 3 strains of L. sakei, 1 strain of L. acidophilus, 1 strains St. thermophilus, and 7 of unidentified strains generated H₂O₂. The antibiotic susceptibility of Ent. Faecium indicated SXT, OX, NA, and E; and the antibiotic susceptibility of L. plantarum indicated NA; and the antibiotic susceptibility of St. thermophilus indicated NA, CC, RA, CTT, CM, and P ; and the antibiotic susceptibility of L. rhamnosus indicated SXT, VA, NA and CTT; and the antibiotic susceptibility of 6 strains of L. sakei indicated SXT, OX, NOR, NA, CTT and CIP, all indicating antibiotic resistance. In the case of multi-drug resistance to antibiotics for 53 strains of L. antarum, 8-drug resistance was the most common with 25 strains, followed by 7-drug-resistant strains with 18 strains, 9-drug-resistant strains with 4 strains, 6-drug-resistant strains with 3 strains, 5-drug-resistant strains with 2 strains, and 17-drug-resistant strains with 1 strain. In the case of multi-drug resistance to antibiotics for Ent. Faecium 27 strains, 9-drug resistance was most commonly identified as 9 strains, 8-drug resistance was identified as 6 strains, 7- and 11 drug resistances were identified as 4 strains each, and 4- and 6-drug resistances were identified as 1 strain each. Conclusion: Ent. Faecium, L. plantarum, L. rhamnosus, L. sakei, and St. thermophilus, shown to have anantibacterial activity in previous studies on LAB and shown to have and H₂O₂ generating ability, antibiotic resistance and multi-drug resistance in this study, are expected to be able to play an excellent role for long-term inpatients to use as an alternative to antibiotics and to cope with emerging antibiotic resistance.

• 대한핵의학회:학술대회논문집
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• 대한핵의학회 1967년도 제6회 학술대회
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• pp.100.1-100.1
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• 1967

• 콘크리트학회지
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• 제23권6호
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• pp.43-47
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• 2011

• 농업과학연구
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• 제38권2호
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• pp.219-225
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• 2011

Changes in biota, species distribution range shift and catastrophic climate influence due to recent global warming have been observed during the last century. Since global warming affects various sectors, such as agriculture and vegetation, it is important to predict more accurate impact of future climate change. The purpose of this study is to examine the observed distribution of Abeliophyllum distichum in the Korean peninsula. For this purpose, two period (present and future) climate data were used. Mean data between 1950 and 2000, were used as the present value and the year 2050 and 2080 data from A1B senario in IPCC SRES were used for the future value. Potential habitation is analyzed by MaxEnt(Maximum Entropy model), and Abeliophyllum distichum's coordinates data were used as a dependent variable and independent variables are composed of environmental data such as BioClim, altitude, aspect and slope. The result of six types GCM mean calculation, the potential habitability decreased by 40-60% of the average existing distribution. The methodogies and results of this research can be applicable to the climate changing adaptation stratiegies for the biodiversity conservation.

• Asian Pacific Journal of Cancer Prevention
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• 제16권8호
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• pp.3539-3542
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• 2015

Background: Retrospective data on 165 patients who presented with a parotid mass and underwent surgery in our clinics during 2000-2009 were examined. The obtained data (demographic data, surgical procedures, histopathological diagnoses) were compared to similar studies to make contributions to the literature. Materials and Methods: Patients were classified according to their histopathological diagnosis. Surgical procedures and patient follow-up were clarified. The results are presented as means and standard deviations. Results: Of the 165 masses, 134 (81.3%) were benign and 31 (18.7%) were malignant. Pleomorphic adenoma was the most common benign tumour (79 patients, 59%). Lymphoma and adenoid cystic carcinoma were equally common and were the most common malignant parotid gland tumours (both 6 patients, 19.3%). The most frequent surgical procedure was superficial parotidectomy (92 patients, 55.7%), and the most commonly encountered surgical complication was facial paralysis (12 patients, 7.2%). Conclusions: Our data are generally in line with the literature but lymphoma was more common than in most previous reports. Although the number of cases was low, the high incidence of parotid gland lymphoma was remarkable.

• Asian Pacific Journal of Cancer Prevention
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• 제15권14호
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• pp.5645-5651
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• 2014

Whether cyclin D1 (CCND1) gene variants increase susceptibility to head and neck cancer (HNC) is undetermined. Therefore, we performed the present meta-analysis to systematically assess any possible association between CCND1 variants (G870A and G1722C) and HNC risk. Seventeen studies for CCND1 G870A and three studies for CCND1 G1722C were included. Overall, CCND1 polymorphisms (G870A and G1722C) had no association with increased HNC risk (p>0.05). In the subgroup analysis by smoking status, significantly increased HNC risk was found among smokers under allele contrast, homozygous comparison and recessive models (p<0.05), smoking carriers of A allele and AA genotype appearing at elevated risk. In conclusion, while there was overall a lack of any association between CCND1 polymorphisms (G870A and G1722C) and HNC risk, smokers carrying the A allele and AA genotype of the CCND1 G870A polymorphism may be susceptible to HNC development.

• 대한기관식도과학회:학술대회논문집
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• 대한기관식도과학회 1972년도 춘계종합 학술대회 초록집
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• pp.17.2-17
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• 1972

현재 일반적으로 Neurilemmoma 또는 Schwannoma라고 부르는 일련의 종양들은 1908年 Verocay에 의해 처음으로 기술되었으며, 1910년 그는 이것을 "Neurinoma"라고 명명하였다. Neurilemmoma라는 명칭은 1935년 Stoutdp 의하여 처음으로 소개되었다. Neurilemmoma는 신경초(Newe Sheath)를 소유하고 있는 어떤 신경에서나 발생할 수 있는 종양으로서 비교적 희유한 양성종양이며 연령, 성병, 그리고 발생장소에 따른 어떤 우월성은 없었으나 이 종양의 약 25% 이상이 두경부에 발생한다. 다른 부위로 전이를 일으키지 않으며 완전 제거 후에는 재발되지 않으며 방사선에 대한 감수성은 거의 없었다. 저자들은 과거 5년간 본 병원 이비인후과령역에서 수술제거한 5예의 Neurilemmoma를 문헌고찰과 함께 보고하는 바이다.