• Tuberculosis and Respiratory Diseases
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• v.66 no.3
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• pp.198-204
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• 2009

Background: First-line drugs, if sensitive, are the most potent drugs in the treatment of multidrug-resistant tuberculosis (MDR-TB). This study examined the frequency and risk factors associated with acquired drug resistance to first-line drugs during a standardized treatment using first-line drugs in patients with MDR-TB. Methods: This study included patients who were diagnosed with MDR-TB at the National Masan Tuberculosis Hospital between January 2004 and May 2008, treated with standardized first-line drugs, and for whom the preand post-treatment results of the drug susceptibility test were available. Their medical records were reviewed retrospectively. Results: Of 41 MDR-TB patients, 14 (34.1%) acquired additional resistance to ethambutol (EMB) or pyrazinamide (PZA). Of 11 patients initially resistant to isoniazid (INH) and rifampicin (RFP), 3 (27.3%) acquired additional resistance to both EMB and PZA, and 3 (27.3%) to PZA. Of 18 patients initially resistant to INH, RFP and EMB, 6 (33.3%) acquired additional resistance to PZA. Of 6 patients initially resistant to INH, RFP and PZA, 2 (33.3%) acquired additional resistance to EMB. Ten of the 41 MDR-TB patients (24.4%) changed from resistant to susceptible. No statistically significant risk factors associated with acquired resistance could be found. Conclusion: First-line drugs should be used cautiously in the treatment of MDR-TB in Korea considering the potential acquisition of drug resistance.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.10
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• pp.581-588
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• 2020

This study examined a brake pad wear compensation method for an Electro-Mechanical Brake (EMB) using the braking test device. A three-phase Interior Permanent Magnet Synchronous Motor (IPMSM) was applied to drive the actuator of an EMB. Current control, speed control, and position control were used to control the clamping force of the EMB. The wear compensation method was performed using a software algorithm that updates the motor model equation by comparing the motor output torque current with a reference current. In addition, a simple first-order motor model equation was applied to estimate the output clamping force. The operation time to the maximum clamping force increased within 0.1 seconds compared to the brake pad in its initial condition. The experiment verified that the reference operating time was within 0.5 seconds, and the maximum value of the clamping force was satisfied under the wear condition. The wear compensation method based on the software algorithm in this paper can be performed in the pre-departure test of rolling stock.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.9
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• pp.596-603
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• 2020

'Electro-Mechanical Brake (EMB) is a novel braking system for automobiles and railway vehicles, and research in this area is actively underway. The current braking system for railway vehicles generates a braking force using a pneumatic cylinder, but the EMB system generates the force through a combination of an electric motor and gears. In this study, the design of an EMB system that meets the domestic standards was conducted through the finite element modeling and fatigue analysis of an eccentric rotating shaft-based EMB system capable of generating a high clamping force. At this time, to improve the accuracy of fatigue analysis, three types of fatigue test specimens, which were subjected to the same heat treatment as the materials used in the prototype, were produced, and the fatigue tests were performed for each material. The fatigue properties (S-N curves) were obtained from the fatigue test results for each material and reflected in the analysis model. The results of fatigue analysis confirmed that the design of the EMB prototype could satisfy the maximum commercial braking/relaxation of 530,000 times, which was the endurance life condition for domestic railway vehicles. In addition, based on this design, a prototype will be manufactured, and endurance testing will be completed to demonstrate the durability characteristics of the developed prototype.

• Microbiology and Biotechnology Letters
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• v.33 no.3
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• pp.169-177
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• 2005

This study focuses on investigating roles of microorganisms in decontamination of reed rhizosphere in Sunchon Bay, Korea, which is considered one of the marsh and mud environment severely affected by human activities such as agriculture and fisheries. In general, the bay is known to play the role of the buffering zone to reduce the sudden impact or change by environmental stresses. In our initial efforts to elucidate the microbial functions in decontamination process in reed rhizosphere, pure bacteria capable of degrading aromatic hydrocarbons were isolated from reed (Phragmites communis) rhizosphere of Sunchon bay by enrichment culture using either benzene, toluene, ethylbenzene, or xylene (BTEX) as a sole source of carbon and energy. Measurement of the rates of BTEX degradation and cell growth during the incubation in BTEX media under several temperature conditions demonstrated maximized degradation of BTEX at $37^{\circ}C$ in both strains. Both strains were also resistant to all the heavy metals and antibiotics tested in this study, as well as they grew well at $42^{\circ}C$. Identification of the isolates based on 16S rRNA gene sequences, and a variety of phenotypic and morphologic properties revealed that the two strains capable of BTEX catabolism were among Microbacterium sp., and Rhodococcus sp. with over $95{\%}$ confidence, designated Microbacterium sp. EMB-1 and Rhodococcus sp. EMB-2, respectively This result suggested that in the rhizosphere of reed, one of major salt marsh plants they might play an important roles in decontamination process of reed rhizosphere contaminated with petroleum such as BTEX.

• The Transactions of the Korean Institute of Electrical Engineers B
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• v.50 no.3
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• pp.107-114
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• 2001

Electro-mechanical battery (EMB) consists of a high-speed fly wheel with an integral motor/ generator suspended on magnetic bearings and in an evacuated housing. Permanent magnet (PM) machines as the EMB motor/ generator are a popular choice, since there are no excitation losses which means substantial increase in the efficiency. In this paper we present the comparison of conventional slotted and slotless ring-wound types, aimed at EMB and other high-speed drives. We firstly discuss the topology of each machine for this particular application. these machines are primarily designed as 1kW two-pole PM generator with the rated speed of 40000 rpm. the motoring torque of 0.51 Nm has to be enough to accelerate the flywheel to the rated speed. We then present the comparison of the open-circuit field, the armature reaction field and winding inductance. next we analyze the induced voltage and the developed torque per unit stack length and unit weight of different machines. Finally, we estimate and compare the losses and the efficiency at motoring and generating modes.

• The Transactions of the Korean Institute of Power Electronics
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• v.15 no.4
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• pp.335-341
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• 2010

The electric braking system obtains its braking force by a motor instead of the hydraulic brake which has been used in conventional automobile systems. Electric braking system is consisted of fewer numbers of components than hydraulic braking system, and it has effects of improved response and reduced braking distance for the ABS(Anti-lock Brake System) and ESC(Electronic Stability Control). This paper presents the BLAC motor drive system for Electro-Magnetic Brake(EMB). Proposed control system consists of the power converter for driving a motor and the digital control system for speed control, and the vector control is applied for fast torque response. It is verified through the simulation using Matlab/Simulink and experiment that the proposed BLAC drive system can be applied to EMB.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.12
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• pp.237-246
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• 2019

The Electro-Mechanical Brake (EMB) is the next generation braking system for automobiles and railway vehicles. Current brake systems for high-speed trains generate a braking force using a pneumatic cylinder, but EMB systems produce that force through a combination of an electric motor and a gear. In this study, an EMB operation mechanism capable of generating a high braking force was proposed, and structural and vibration analyses of the gears and shafts, which are the core parts of the mechanisms, were performed. Dynamic structural analysis confirmed that the maximum stress in the analysis model was within the yield strength of the material. In addition, the design that maximizes the diameter of the motor shaft was found to be advantageous in strength, and large shear stress could be generated in the bolt fixing the gear and eccentric shaft. In addition, a test apparatus that can reproduce the mechanism of the analytical model was fabricated to measure the strain of the fixed bolt part, which is the most vulnerable part. The strain measurement results showed that the error between the analysis and measurement was within 10%, which could verify the accuracy of the analytical model.

• The Transactions of the Korean Institute of Electrical Engineers B
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• v.48 no.8
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• pp.400-407
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• 1999

This paper treated the design, manufacture and the performance characteristics under each mode of high speed motor/generator for an electro-mechanical battery(EMB). This machine is employed as an integral part of a flywheel energy storage system(FESS), i.e., a modular flywheel system to be used as a device for storing electrical or mechanical energy. In this machine, the magnetic field system is constructed by using special magnet array, dipole Halbach array with 16 permanent magnet segments and the armature is composed of a plastic bobbin and multi-phase windings with Litz wire. The magnet array produces a highly uniform dipole field without back iron. The motor/generator is 3-phase machine in which the dipole Halbach array surrounding the winding is rotating. Since there are no iron laminations, this field system offers some unique advantages for the simplicity of the design and the theoretical prediction of characteristics of a high speed electric machine. This paper describes the results obtained when EMB system was tested in the laboratory.

• The Korean Journal of Zoology
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• v.16 no.4
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• pp.211-217
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• 1973

Mitomycin C, chemically reactive antibiotics derived from Streptomyces caespitosus, was introduced to Chinese hamster, Cricetulus griseus, (2n=22) cells (22Emb. ♀5PSP ♂, to carry out an analysis of the chromosome aberration. It was found that regions 5 and 7 of chromosomes 1 and 2, and secondary constriction of chromosome X showed the most striking effect of Mitomycin C. The relationship between Mitomycin C and secondary contriction was discussed.

• Tuberculosis and Respiratory Diseases
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• v.83 no.1
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• pp.20-30
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• 2020

Tuberculosis (TB) remains a threat to public health and is the leading cause of death globally. Isoniazid (INH) is an important first-line agent for the treatment of TB considering its early bactericidal activity. Resistance to INH is now the most common type of resistance. Resistance to INH reduces the probability of treatment success and increases the risk of acquiring resistance to other first-line drugs such as rifampicin (RIF), thereby increasing the risk of multidrug-resistant-TB. Studies in the 1970s and 1980s showed high success rates for INH-resistant TB cases receiving regimens comprised of first-line drugs. However, recent data have indicated that INH-resistant TB patients treated with only firs-tline drugs have poor outcomes. Fortunately, based on recent systematic meta-analyses, the World Health Organization published consolidated guidelines on drug-resistant TB in 2019. Their key recommendations are treatment with RIF-ethambutol (EMB)-pyrazinamide (PZA)-levofloxacin (LFX) for 6 months and no addition of injectable agents to the treatment regimen. The guidelines also emphasize the importance of excluding resistance to RIF before starting RIF-EMB-PZA-LFX regimen. Additionally, when the diagnosis of INH-resistant TB is confirmed long after starting the first-line TB treatment, the clinician must decide whether to start a 6-month course of RIF-EMB-PZA-LFX based on the patient's condition. However, these recommendations are based on observational studies, not randomized controlled trials, and are thus conditional and based on low certainty of the effect estimates. Therefore, further work is needed to optimize the treatment of INH-resistant TB.