• Korean Journal of Radiology
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• 제25권6호
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• pp.511-517
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• 2024

Objective: To prospectively investigate the influence of the menstrual cycle on the background parenchymal signal (BPS) and apparent diffusion coefficient (ADC) of the breast on diffusion-weighted MRI (DW-MRI) in healthy premenopausal women. Materials and Methods: Seven healthy premenopausal women (median age, 37 years; range, 33-49 years) with regular menstrual cycles participated in this study. DW-MRI was performed during each of the four phases of the menstrual cycle (four examinations in total). Three radiologists independently assessed the BPS visual grade on images with b-values of 800 sec/mm² (b800), 1200 sec/mm² (b1200), and a synthetic 1500 sec/mm² (sb1500). Additionally, one radiologist conducted a quantitative analysis to measure the BPS volume (%) and ADC values of the BPS (ADC_BPS) and fibroglandular tissue (ADC_FGT). Changes in the visual grade, BPS volume (%), ADC_BPS, and ADC_FGT during the menstrual cycle were descriptively analyzed. Results: The visual grade of BPS in seven women varied from mild to marked on b800 and from minimal to moderate on b1200 and sb1500. As the b-value increased, the visual grade of BPS decreased. On b800 and sb1500, two of the seven volunteers showed the highest visual grade in the early follicular phase (EFP). On b1200, three of the seven volunteers showed the highest visual grades in EFP. The BPS volume (%) on b800 and b1200 showed the highest value in three of the six volunteers with dense breasts in EFP. Three of the seven volunteers showed the lowest ADC_BPS in the EFP. Four of the seven volunteers showed the highest ADC_BPS in the early luteal phase (ELP) and the lowest ADC_FGT in the late follicular phase (LFP). Conclusion: Most volunteers did not exhibit specific BPS patterns during their menstrual cycles. However, the highest BPS and lowest ADC_BPS were more frequently observed in EFP than in the other menstrual cycle phases, whereas the highest ADC_BPS was more common in ELP. The lowest ADC_FGT was more frequent in LFP.

• Journal of Pharmaceutical Investigation
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• 제37권2호
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• pp.95-99
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• 2007

To develop topical nitroglycerin (NTG) preparation far chronic anal fissure treatment, the release rate of NTG should be controlled carefully. For this, microemulsion was prepared from the phase diagram construction with Cremophor ELP, ethanol and Labrafil $M1944CS^{(R)}$ and the topical gel was prepared by dispersing NTG containing microemulsion into hydrophilic polymers. in viかo release characteristics were evaluated with Franz diffusion cell using cellulose membrane and compared with control hydrogels. The release rate of NTG was followed $1^{st}$ order kinetics and, when comparing the NTG release from control hydrogel with that from the microemulsion-based hydrogel, the NTG release rate was controlled by the content of polymers within continuous phase and the concentration of dispersed phase.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2011년도 제40회 동계학술대회 초록집
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• pp.188-188
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• 2011

Recently, scaling down of ULSI (Ultra Large Scale Integration) circuit of CMOS (Complementary Meta Oxide Semiconductor) based electronic devices, the electronic devices, become much faster and smaller size that are promising property of semiconductor market. However, very narrow interconnect line width has some disadvantages. Deposition of conformal and thin barrier is not easy. And metallization process needs deposition of diffusion barrier and glue layer for EP/ELP deposition. Thus, there is not enough space for copper filling process. In order to get over these negative effects, simple process of copper metallization is important. In this study, Cu-V alloy layer was deposited using of DC/RF magnetron sputter deposition system. Cu-V alloy film was deposited on the plane SiO2/Si bi-layer substrate with smooth surface. Cu-V film's thickness was about 50 nm. Cu-V alloy film deposited at $150^{\circ}C$. XRD, AFM, Hall measurement system, and AES were used to analyze this work. For the barrier formation, annealing temperature was 300, 400, $500^{\circ}C$ (1 hour). Barrier thermal stability was tested by I-V(leakage current) and XRD analysis after 300, 500, $700^{\circ}C$ (12 hour) annealing. With this research, over $500^{\circ}C$ annealed barrier has large leakage current. However vanadium-based diffusion barrier annealed at $400^{\circ}C$ has good thermal stability. Therefore thermal stability of vanadium-based diffusion barrier is desirable for copper interconnection.

• Journal of Pharmaceutical Investigation
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• 제37권5호
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• pp.291-295
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• 2007

Prostaglandin $E_1\;(PGE_1)$ was formulated as two self-microemulsifying drug delivery systems (SMEDDS) composed of Cremophor $EL^{(R)}$ or Cremophor $ELP^{(R)}$ as a surfactant, ethanol as a cosurfactant and Labrafac $CC^{(R)}$ as an oil to develop liquid preparation for the treatment of erectile dysfunction. In pseudo-ternary phase diagram, viscous gel area and microemulsion area were defined. In the measurement of viscosity, the viscosity of two formulations increased gradually upon the addition of water and it decreased from the water contents over 40%. With excessive water, the present systems formed a microemulsion spontaneously. From these results, rte could expect that the present liquid $PGE_1$ SMEDDS formulations might stay within the urethra in the viscous state when contacting the moisture of the urethra and can be easily eliminated by urination. In long-term stability study, we could select one formulation more stable at the shelf storage condition of $4^{\circ}C$.

• 제어로봇시스템학회논문지
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• 제22권6호
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• pp.483-489
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• 2016

This paper proposes a repeat-back jamming signal detection scheme that utilizes a combined pseudo random noise signal that is effective for processing a global positioning system (GPS) repeat-back jamming signal with the early minus late phase scheme to alleviate any existing multipath signal detection. The proposed scheme uses the combined pseudo random noise signal to treat repeat-back jamming signals like similar multipath signals and can effectively detect a repeat-back jamming signal by applying the early minus late phase scheme to a combined pseudo random noise signal. Through a Monte-Carlo simulation, the detection probability of the proposed scheme is better than the one of the conventional scheme under low jamming to signal power ratio.

• 대한지리학회지
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• 제49권5호
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• pp.716-727
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• 2014

연암의 관찰법을 활용한 자연사물 글쓰기는 자연환경 관찰력을 배양하는 데 일조할 수 있다. 이에 본 연구에서는 연암의 "열하일기" 글을 대상으로 하여 연암이 활용했던 관찰법을 분석하였다. 연암의 관찰법의 특징은 다음과 같이 정리해 볼 수 있다. 첫째, 연암의 관찰법은 구체적이고 세부적인 관찰이다. 둘째, 오감을 활용한 관찰과 오감 활용의 위험성과 한계 인식이다. 셋째, 자연과 인간에 대한 평등 의식을 지닌 관찰이다. 연암은 자연을 인간과 같은 위치에서 바라보았다. 넷째, 부분적으로 관찰한 것들을 형상화 기법을 활용하여 생동감있게 그리고 현장감있게 묘사하는 방법을 활용하였다. 다섯째, 다양한 관점을 활용한 다양성 발견 관찰이었다. 이러한 연암의 자연사물 글쓰기의 원천은 자연사물에 대한 세부적 관찰과, 교감, 형상화, 다양한 관점과 다양성 발견에 기반하고 있다.

• Archives of Pharmacal Research
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• 제28권9호
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• pp.1097-1102
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• 2005

An O/W microemulsion system was developed to enhance the skin permeability of ace-clofenac. Of the oils studied, Labrafil? M 1944 CS was chosen as the oil phase: of the microemulson, as it showed a good solubilizing capacity. Pseudo-ternary phase diagrams were constructed to obtain the concentration range of oil, surfactant, Cremophor ELP, and co-surfactant, ethanol, for micoemulsion formation. Eight different formulations with various values of oil of $6-30\%$, water of $0-80\%$, and the mixture of surfactant and co-surfactant (at the ratio of 2) of $14-70\%$. The in vitro transdermal permeability of aceclofenac from the microemulsions was evaluated using Franz diffusion cells mounted with rat skin. The level of aceclofenac permeated was analyzed by HPLC and the droplet size' of the microemulsions was characterized using a Zetasizer Nano-ZS. Terpenes were added to the microemulsions at a level of $5\%$, and their effects on the skin permeation of aceclofenac were investigated. The mean diameters of the microemulsions ranged between approximately $10\~100nm$, and the skin permeability of the aceclofenac incorporated into the microemulsion systems was 5-fold higher than that of the ethanol vehicle. Of the various terpenes added, limonene had the best enhancing ability. These results indicate that the microemulsion pystem studied is a promising tool for the percutaneous delivery of aceclofenac.

• Asian Pacific Journal of Cancer Prevention
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• 제16권14호
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• pp.5741-5747
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• 2015

Purpose: To understand the epidemiology of different upper gastrointestinal (UGI) tract related abnormalities through endoscopic data analysis. Materials and Methods: A retrospective study of three years from January 2009 to December 2011 was conducted with data from endoscopic surveillance of upper GI tract problems, collected from the Gastroenterology Unit, Osmania General Hospital, Hyderabad. MS excel and Medcalc software (comparison of proportions) were used for data analysis. Results: A total of 10,029 (6,468 in males and 3,561 in females) endoscopies were performed during this three-year period. The male to female ratio was 1.8:1. Overall, ~30% of endoscopies evaluated showed patients with acid peptic disorders, 13.6% with vascular-related abnormalities, 10.6% showed structural abnormalities, followed by 6.3% with malignancies. Burden of malignancies was mostly observed in the older age group (60-69 years). Esophageal cancer cases decreased (p=0.0001) whereas stomach cancers increased over this period (p=0.0345). We also observed an increased incidence of acid peptic disease (APD) (p=0.0036) and gastroesophageal reflux disease (GERD) (p=0.0002) cases during this period. Conclusions: Endoscopic diagnosis is useful for early detection of UGI anomalies and helpful for physicians to manage and treat varied kinds of UGI disorders. Analysis of data revealed changing trends in the incidence of various pathologies of the UGI tract. Functional dyspepsia and GERD definitely reduce the quality of life of the individual. The role of our diverse dietary habits and lifestyle associated with these problems have not yet been established, though there have been reports on the effect of coffee, spicy food, wheat-based diet, screening of UGI pathologies along with collection of complete personal and medical history details, can h elp in correlating the patients' condition with various aspects of lifestyle and diet.

• Journal of Animal Science and Technology
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• 제62권3호
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• pp.293-305
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• 2020

The difference in the breeding programs and population history may have diversely shaped the genomes of Korean native cattle breeds. In the absence of phenotypic data, comparisons of breeds that have been subjected to different selective pressures can aid to identify genomic regions and genes controlling qualitative and complex traits. In this study to decipher genetic variation and identify evidence of divergent selection, 3 Korean cattle breeds were genotyped using the recently developed high-density GeneSeek Genomic Profiler F250 (GGP-F250) array. The three Korean cattle breeds clustered according to their coat color phenotypes and breeding programs. The Heugu breed reliably showed smaller effective population size at all generations considered. Across the autosomal chromosomes, 113 and 83 annotated genes were identified from Hanwoo-Chikso and Hanwoo-Heugu comparisons, respectively of which 16 genes were shared between the two pairwise comparisons. The most important signals of selection were detected on bovine chromosomes 14 (24.39-25.13 Mb) and 18 (13.34-15.07 Mb), containing genes related to body size, and coat color (XKR4, LYN, PLAG1, SDR16C5, TMEM68, CDH15, MC1R, and GALNS). Some of the candidate genes are also associated with meat quality traits (ACSF3, EIF2B1, BANP, APCDD1, and GALM) and harbor quantitative trait locus (QTL) for beef production traits. Further functional analysis revealed that the candidate genes (DBI, ACSF3, HINT2, GBA2, AGPAT5, SCAP, ELP6, APOB, and RBL1) were involved in gene ontology (GO) terms relevant to meat quality including fatty acid oxidation, biosynthesis, and lipid storage. Candidate genes previously known to affect beef production and quality traits could be used in the beef cattle selection strategies.

• 한국지역지리학회지
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• 제19권4호
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• pp.787-804
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• 2013

본 연구는 '월드카페형 대화법' 토의 수업이 집단지성 구현을 위한 토의 수업으로서의 가능성이 있는지를 모색해 보는데 목적이 있다. 이를 위해 '월드카페형 대화법' 토의 수업을 대학 교양 수업 '발표와 토론'수업의 지구적 이슈 학습 영역에 적용해 보았다. '월드카페형 대화법' 토의 수업의 집단지성 구현 효과를 찾아보기 위해 실험 수업에 참여한 학생들의 설문 반응 결과와 토의 내용을 분석하였다. 설문 반응 분석에서는 학습에의 참여도를 분석하였고 토의 내용 분석에서는 토의 주제에 대한 논의 전개 양상을 분석하였다. 전체 학생의 85.4% 학생이 수업에 적극적으로 참여하였다고 응답하였다. 그 이유로는 자유로운 토의 분위기, 생각의 연결에서 오는 즐거움, 조 간 경쟁 심리의 배제 등이 있었다. 학생들의 학습 주제에 대한 논의 전개 정도 분석에서는 주제에 대해 제시된 의견 수, 제시된 의견을 중심으로 전개된 논의의 정도가 통제 집단 학생들의 일반적인 토의 수업 진행 결과와 비교해 볼 때, 더 많은 의견 수와 심층적인 논의 전개 양상을 보여 주었다. 이러한 결과는 '월드카페형 대화법' 토의 수업이 개인의 적극적인 참여를 이끌어 낼 수 있다는 장점을 갖고 있으며 동시에 개인의 적극적인 의견 제시와 상호 의견 개진을 통해 더 깊이 있는 논의를 전개함으로써 집단지성 구현의 가능성을 담고 있음을 보여주었다.