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Effects of Ginsenoside Rg3 Epimers on Swine Coronary Artery Contractions

  • Kim, Jong-Hoon;Nah, Seung-Yeol
    • Journal of Ginseng Research
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    • v.29 no.3
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    • pp.119-125
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    • 2005
  • The previous reports demonstrated that ginseng saponins, active ingredient of Panax ginseng, inhibited blood vessel contraction induced by various hormones or high $K^+$. Recently, we demonstrated that 20(R)- and 20(S)-ginsenoside $Rg_3$. regulate ion channel activities with differential manners. The aim of this study was to examine whether ginsenoside $Rg_3$ isomers also show differential effects on swine coronary artery contractionresponses induced by high $K^+$, serotonin (5-HT) or acetylcholine. Treatment of 20(S)- but not 20(R)-ginsenoside $Rg_3$ caused a concentration-dependent relaxation of coronary artery contracted by 25mM KCI. 20(S)- and 20(R)-ginsenoside $Rg_3$ induced significant relaxations of coronary artery contraction induced by 5-HT $(3{\mu}M)$ in the presence of endothelium with concentration-dependent manner and, also in the absence of endothelium only 20(S)-ginsenoside $Rg_3$ induced a strong Inhibition of coronary artery contraction induced by 5-HT in a concentration-dependent manner. 20(S)-ginsenoside $Rg_3$ caused relaxation of coronary artery in the absence and presence of endothelium. In contrast, treatment of 20(S)- and 20(R)-ginsenoside $Rg_3\;(100{\mu}M)$ did not show significant inhibition of coronary artery contraction induced by acetylcholine $(0.01\;to\;30{\mu}M)$ in the presence of endothelium, whereas both isomers caused significant inhibition of coronary artery contraction induced by acetylcholine $(0.01\;to\;30{\mu}M)$ in the absence of endothelium in a concentration-dependent manner. These findings indicate that 20(S)-or 20(R)-ginsenoside $Rg_3$ exhibits differential relaxation eff3cts of swine coronary artery contractions caused by high $K^+$, acetylcholine, and 5-HT treatment and that this differential vasorelaxing effects of ginsenoside $Rg_3$ isomers also might be dependent on endothelium.

The Magnetic Properties of Polycrystalline Yttrium Iron Garnet by Ferromagnetic Resonance (강자성공명 현상을 이용한 YIG의 자기적 특성 연구)

  • 김기현;이대하;김영호
    • Journal of the Korean Magnetics Society
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    • v.9 no.1
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    • pp.7-16
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    • 1999
  • Stoichiometric and nonstoichiometric $Y_{3-x}Fe_{5+x}O_{12})$ polycrystalline samples (x=0.00, 0.05, 0.10, 0.30, -0.05, -0.10, -0.30) were prepared by solid state reaction method. The magnetic properties of the sample were investigated by FMR (ferromagnetic resonance) technique at microwave frequency 5.11 GHz (G-band) and 23.39 GHz (K-band) respectively. The spectroscopic splitting factor g were estimated to be 2.04~2.35 from the derivative absorption lines. As the samples became yttrium $(Y^{3+})$ excess and iron $(Fe^{3+})$ excess, Magnetizations were decreased. But resonance linewidth were increased. To investigate the anisotropy, the angular dependence of resonance magnetic fields were measured. Angular dependence of effective magnetizations were measured by FMR from 77 K to 300 K at K-band microwave frequency (23.39 GHz) and the saturation magnetizations were measured by VSM. The Bloch coefficients B and C were determined by fitting. $M_{eff}(0)$ was obtained by the extrapolation from 80 K. From this result, the spin wave stiffness constant D $(about\; 162~206 \;eV{\AA}^2)$and average square range of exchange interaction $$$(about \;5.84~12.13\;{\AA}^2)$ were determined.

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Saturated Hydraulic Conductivity of Surface Seals Estimated from Computed Tomography-Measured Porosity (고해상도 X-ray CT 를 이용한 토양표면 피막의 공극율 및 포화수리전도도 측정)

  • Lee, Sang-Soo;Gantzer, C.J.;Thompson, A.L.;Anderson, S.H.;Ketchum, R.A.;Ok, Yong-Sik
    • 한국환경농학회:학술대회논문집
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    • 2011.07a
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    • pp.207-222
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    • 2011
  • Relationships between soil saturated hydraulic conductivity ($K_s$) and porosity (${\phi}$) have been developed over many years; however, use of these relationships for evaluating rain-induced seals is limited mainly because of difficulties in estimating seal pore-size characteristics. The objectives of this study were to evaluate the $K_s$ of soil surface seals over a range of thicknesses, where seal thickness was determined using a High-Resolution-Computed-Tomography (HRCT) scanner, and to investigate relationships between $K_s$ and ${\phi}$ of developing seals in samples with equivalent diameters (e.d.) ${\geq}15\;{\mu}m$. A Mexico silt loam soil was packed to a bulk density (${\rho}_b$) of $1.1\;Mg\;m^{-3}$ in cylinders 160-mm i.d. by 160-mm long and subjected to $61-mm\;h^{-1}$ simulated rainfall having a kinetic energy (KE) of $25\;J\;m^{-2}\;min^{-1}$ for 7.5, 15, 30, and 60 min to create a range in seal development. Thicknesses of the seal layers were determined by analysis of HRCT images of seals. The $K_s$ values of the seals were estimated using an effective $K_s$ value ($K_{s-eff}$). The $K_s-{\phi}$ relationship was described by a Kozeny and Carmen equation, $K_s=B{\phi}^n$; where B and n are empirical constants and n = 31. This approach explained 86% of the variation between $K_s$ and ${\phi}$ within the soil seals. Knowledge of surface seal information and hydraulic conductivity can provide useful information to use in management of sites prone to sealing formation.

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Criticality Safety Analysis of Spent Fuel Storage Facility for Bo-Ri Unit 1 (핵연료 저장시설의 임계 안전성 분석)

  • Dong Ha Kim;Un Chul Lee
    • Nuclear Engineering and Technology
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    • v.14 no.2
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    • pp.86-91
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    • 1982
  • In 1977, spent fuel storage capacity of Ko-Ri Unit 1 was raised to contain 4-2/3 core, by reducing the center-to-center spacing between fuel assemblies from 53.34cm to 36cm. In this paper the adequacy is discussed in detail by examining the previous design analysis report. According to the analytic method presented by Core Performance Branch, study on credible abnormal moderator density condition is performed by using KENO-IV for the redesigned spent fuel storage facility. Result shows that 36cm for the center-to-center spacing between fuel assemblies is not enough to keep the storage safe at water density of 0.1143g/㎤, which gives the maximum $K_{eff}$ 0.9958$\pm$0.0048, which exceeds the CPB regulation limit 0.98. From sensitivity study regarding to the center-to-center spacing, it should be maintained to space greater than 43cm in order to meet the CPB requirements.s.

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POINTWISE CROSS-SECTION-BASED ON-THE-FLY RESONANCE INTERFERENCE TREATMENT WITH INTERMEDIATE RESONANCE APPROXIMATION

  • BACHA, MEER;JOO, HAN GYU
    • Nuclear Engineering and Technology
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    • v.47 no.7
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    • pp.791-803
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    • 2015
  • The effective cross sections (XSs) in the direct whole core calculation code nTRACER are evaluated by the equivalence theory-based resonance-integral-table method using the WIMS-based library as an alternative to the subgroup method. The background XSs, as well as the Dancoff correction factors, were evaluated by the enhanced neutron-current method. A method, with pointwise microscopic XSs on a union-lethargy grid, was used for the generation of resonance-interference factors (RIFs) for mixed resonant absorbers. This method was modified by the intermediate-resonance approximation by replacing the potential XSs for the non-absorbing moderator nuclides with the background XSs and neglecting the resonance-elastic scattering. The resonance-escape probability was implemented to incorporate the energy self-shielding effect in the spectrum. The XSs were improved using the proposed method as compared to the narrow resonance infinite massbased method. The RIFs were improved by 1% in $^{235}U$, 7% in $^{239}Pu$, and >2% in $^{240}Pu$. To account for thermal feedback, a new feature was incorporated with the interpolation of pre-generated RIFs at the multigroup level and the results compared with the conventional resonance-interference model. This method provided adequate results in terms of XSs and k-eff. The results were verified first by the comparison of RIFs with the exact RIFs, and then comparing the XSs with the McCARD calculations for the homogeneous configurations, with burned fuel containing a mixture of resonant nuclides at different burnups and temperatures. The RIFs and XSs for the mixture showed good agreement, which verified the accuracy of the RIF evaluation using the proposed method. The method was then verified by comparing the XSs for the virtual environment for reactor applicationbenchmark pin-cell problem, as well as the heterogeneous pin cell containing burned fuel with McCARD. The method works well for homogeneous, as well as heterogeneous configurations.

Microwave drying characteristics of squash slices

  • Lee, Dongyoung;So, Jung Duk;Jung, Hyun Mo;Park, Sung Hyun;Lee, Seung Hyun
    • Korean Journal of Agricultural Science
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    • v.45 no.4
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    • pp.847-857
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    • 2018
  • Recently, customers' demand and attention to dried agricultural products or foods have increased due to their convenience and nutritional values. Conventional drying methods such as solar drying and hot air drying have been most widely used for producing a large amount of dried agricultural products; however, those methods require quite a long time and high energy consumption. To compensate for these issues associated with conventional methods, dielectric heating such as microwave and radio frequency heating has been used as a supplemental method in the drying procedure. This study investigated the microwave drying characteristics of squash slices with different thicknesses under different microwave power intensities and determined the best drying model that could precisely describe the experimental drying curves of the squash slices. The squash was cut into slices with two different thicknesses (5 and 10 mm), and then, they were dried under different microwave power intensity ranges between 90 and 900 W with an increase interval of 90 W. Six drying models were tested to evaluate the fit to the experimental drying data, and the effective moisture diffusivity ($D_{eff}$) values of the squash slices under microwave drying were determined. The results clearly show that as the microwave power was increased, the drying time of both squash slices was significantly decreased, and the slope of the drying rate increased. The effective moisture diffusivity was also significantly related with the microwave power intensities and thicknesses of the slices. In addition, the Page model was most suitable to delineate the drying curves of both squash slices under different microwave power intensities.

Physical nature of the eclipsing δ Scuti star AO Serpentis

  • Park, Jang-Ho;Lee, Jae Woo;Hong, Kyeongsoo;Koo, Jae-Rim;Kim, Chun-Hwey
    • The Bulletin of The Korean Astronomical Society
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    • v.44 no.1
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    • pp.86-86
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    • 2019
  • We present BV photometric observations and high-resolution spectra of AO Ser, which were obtained at the Mt. Lemmon Optical Astronomy Observatory (LOAO) and the Bohyunsan Optical Astronomy Observatory (BOAO), respectively, in 2017. The radial velocities (RVs) for both components were measured, and the effective temperature of the primary star was found to be $T_{eff,1}=8,820{\pm}62K$ by a comparison of the observed spectra and the Kurucz models. A unique set of fundamental parameters of AO Ser were derived for the first time by a simultaneous analysis of the light and RV curves. The results indicate that our program target is a semi-detached eclipsing system with values of $M_1=2.06{\pm}0.11M_{\odot}$ and $M_2=0.41{\pm}0.03M_{\odot}$, $R_1=1.54{\pm}0.03R_{\odot}$ and $R_2=1.30{\pm}0.02R_{\odot}$, and $L_1=12.9{\pm}0.2L_{\odot}$ and $L_2=0.9{\pm}0.3L_{\odot}$. We applied multiple frequency analyses to the eclipse-subtracted light residuals. As a result, two frequencies of $f_1=21.85151days^{-1}$ and $f_2=23.48405days^{-1}$ were detected and their pulsation constants were calculated to $Q_1=0.0344days$ and $Q_2=0.0320days$. The pulsational characteristics and the position in the HR diagram demonstrate that the primary star is a ${\delta}$ Sct pulsator.

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ESTIMATION OF NITROGEN-TO-IRON ABUNDANCE RATIOS FROM LOW-RESOLUTION SPECTRA

  • Kim, Changmin;Lee, Young Sun;Beers, Timothy C.;Masseron, Thomas
    • Journal of The Korean Astronomical Society
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    • v.55 no.2
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    • pp.23-36
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    • 2022
  • We present a method to determine nitrogen abundance ratios with respect to iron ([N/Fe]) from molecular CN-band features observed in low-resolution (R ~ 2000) stellar spectra obtained by the Sloan Digital Sky Survey (SDSS) and the Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST). Various tests are carried out to check the systematic and random errors of our technique, and the impact of signal-to-noise (S/N) ratios of stellar spectra on the determined [N/Fe]. We find that the uncertainty of our derived [N/Fe] is less than 0.3 dex for S/N ratios larger than 10 in the ranges Teff = [4000, 6000] K, log g = [0.0, 3.5], [Fe/H] = [-3.0, 0.0], [C/Fe] = [-1.0, +4.5], and [N/Fe] = [-1.0, +4.5], the parameter space that we are interested in to identify N-enhanced stars in the Galactic halo. A star-by-star comparison with a sample of stars with [N/Fe] estimates available from the Apache Point Observatory Galactic Evolution Experiment (APOGEE) also suggests a similar level of uncertainty in our measured [N/Fe], after removing its systematic error. Based on these results, we conclude that our method is able to reproduce [N/Fe] from low-resolution spectroscopic data, with an uncertainty sufficiently small to discover N-rich stars that presumably originated from disrupted Galactic globular clusters.

Enhancement and optimization of gamma radiation shielding by doped nano HgO into nanoscale bentonite

  • Allam, Elhassan A.;El-Sharkawy, Rehab M.;El-Taher, Atef;Shaaban, E.R.;RedaElsaman, RedaElsaman;Massoud, E. El Sayed;Mahmoud, Mohamed E.
    • Nuclear Engineering and Technology
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    • v.54 no.6
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    • pp.2253-2261
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    • 2022
  • In this study, nano-scaled shielding materials were assembled and fabricated by doping different weight percentages of Nano-mercuric oxide (N-HgO) into Nano-Bentonite (N-Bent) based on using (100-x% N-Bent + x% N-HgO, x = 10, 20, 30, and 40 wt %). The fabricated N-HgO/N-Bent nanocomposites were characterized by FT-IR, XRD, and SEM and evaluated to evaluate their shielding properties toward gamma radiation by using four different γ-ray energies form three point sources; 356 keV from 133Ba, 662 keV from 137Cs as well as 1173, and 1332 keV from 60Co. The γ-rays mass attenuation coefficients were plotted as a function of the doped N-HgO concentrations into N-HgO/N-Bent nanocomposites. The computed values of mass attenuation coefficients (µm), effective atomic number (Zeff) and electron density (Nel) by the as-prepared samples were found to increase, while the half value layer (HVL) and mean free path (MFP) were identified to decrease upon increasing the N-HgO contents. It was concluded also that the increase in N-HgO concentration led to a direct increase in the mass attenuation coefficient from 0.10 to 0.17 cm2/g at 356 keV and from 0.08 to 0.09 cm2/g at 662 keV. However, a slight increase was observed in the identified mass attenuation coefficients at (1172 and 1332 keV).

Sensitivity and uncertainty quantification of neutronic integral data in the TRIGA Mark II research reactor

  • Makhloul, M.;Boukhal, H.;Chakir, E.;El Bardouni, T.;Lahdour, M.;Kaddour, M.;Ahmed, Abdulaziz;Arectout, A.;El Yaakoubi, H.
    • Nuclear Engineering and Technology
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    • v.54 no.2
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    • pp.523-531
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    • 2022
  • In order to study the sensitivity and the uncertainty of the Moroccan research reactor TRIGA Mark II, a model of this reactor has been developed in our ERSN laboratory for use with the N-Particle MCNP Monte Carlo transport codes (version 6). In this article, the sensitivities of the effective multiplication factor of this reactor are evaluated using the ENDF/B-VII.0, ENDF/B-VII.1 and JENDL-4.0 libraries and in 44 energy groups, for the cross sections of the fuel (U-235 and U-238) and the moderator (H-1 and O-16). However, the quantification of the uncertainty of the nuclear data is performed using the nuclear code NJOY99 for the generation and processing of covariance matrices. On the one hand, the highest uncertainty deviations, calculated using the ENDFB-VII.1 and JENDL4.0 evaluations, are 2275, 386 and 330 pcm respectively for the reactions U235(n, f), $ U_{235}(n\bar{\nu})$ and H1(n, γ). On the other hand, these differences are very small for the neutron reactions of O-16 and U-238. Regarding the neutron spectra, in CT-mid plane, they are very close for the three evaluations (ENDF/B-VII.0, ENDF/B-VII.1 and JENDL-4.0). These spectra present two peaks (thermal and fission) around the energies 0.05 eV and 1 MeV.