• International Journal of Aerospace System Engineering
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• v.1 no.1
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• pp.10-15
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• 2014

This study presents technical description of the operating program development that operates the test bench for functional test of EECU. The test bench is capable of testing, simulation and adjustment of the EECU software using the operating program. The test bench is for the Development Project of the EECU platform for FADEC system. The operating program is consists of 3 modules which are the test bench operating module, cockpit simulator module and SILS module. The operating module mainly carries out the EECU test with manual operation and operating scenarios. Also that record and process the test data. The cockpit simulator module is capable of implementation of virtual cockpit control input and engine status display. The SILS module can simulate engine and EECU operation in software environment.

• Journal of Life Science
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• v.29 no.4
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• pp.410-420
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• 2019

Citrus unshiu peel extracts possess a variety of beneficial effects, and studies on their anticancer activity have been reported. However, the exact mechanisms underlying this activity remain unclear. In the current study, the apoptotic effect of ethanol extract of C. unshiu peel (EECU) on human breast adenocarcinoma MDA-MB-231 cells and related mechanisms were investigated. The results showed that the survival rate of MDA-MB-231 cells treated with EECU was significantly inhibited in a concentration-dependent manner, which was associated with the induction of apoptosis. EECU-induced apoptosis was associated with the activation of caspase-8 and caspase-9, which initiate extrinsic and intrinsic apoptosis pathways, respectively, and caspase-3, a representative effect caspase. EECU suppressed the expression of the inhibitor of apoptosis family of proteins, leading to an increased Bax/Bcl-2 ratio and proteolytic degradation of poly (ADP-ribose) polymerase. EECU also enhanced the loss of the mitochondrial membrane potential and cytochrome c release from the mitochondria to the cytosol, along with truncation of Bid. In addition, EECU activated AMP-activated protein kinase (AMPK), and compound C, an AMPK inhibitor, significantly weakened EECU-induced apoptosis and cell viability reduction. Furthermore, EECU promoted the generation of reactive oxygen species (ROS), which acted as upstream signals for AMPK activation as pretreatment of cells, with the antioxidant N-acetyl cysteine reversing both EECU-induced AMPK activation and apoptosis. Collectively, these findings suggest that EECU inhibits MDA-MB-231 adenocarcinoma cell proliferation by activating intrinsic and extrinsic apoptotic pathways, which was mediated through ROS/AMPK-dependent pathways.

• Journal of Aerospace System Engineering
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• v.8 no.2
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• pp.27-32
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• 2014

From the flight safety and the performance point of views, a new engine installation impacts an helicopter development or upgrade program significantly. More than a close relationship between an aircraft manufacturer and an engine manufacturer is necessary for the best integration work from the program initiation phase. In this paper, technical cooperation between aircraft and engine companies, and technical supports by the engine manufacturer for the T700/701K engine during the Surion development program are summarized. The applications of official technical program documents, US Mil-spec, France airworthiness regulations as the standard of the engine installation work, and engineering activities at each phase such as contract, design and manufacturing, flight clearance, ground and flight tests are described. This paper would be a cornerstone for the future domestic helicopter development program.