• Bulletin of the Korean Chemical Society
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• 제32권4호
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• pp.1183-1186
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• 2011

The unique Br signature was utilized for C-terminal amino acid sequencing of model peptides. C-terminal carboxyl group was selectively derivatized in peptides, containing side chain carboxyl group, using 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride (EDC) and Br was introduced using 4-bromophenylhydrazine hydrochloride (BPH) in a one pot reaction. Matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) tandem mass spectra were obtained carrying the Br signature in the y-series ions. The Br signature facilitated C-terminal sequencing and discrimination of C-terminal carboxyl groups in the free acid and amide forms.

• 지적과 국토정보
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• 제53권2호
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• pp.53-66
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• 2023

최근 자율주행 분야에서 실세계와 유사한 디지털트윈 기반의 가상 시뮬레이션 환경 구축에 대한 관심이 크게 증가하고 있다. 디지털트윈 기반의 시뮬레이션 환경에서 자율주행의 성능 및 기능 검증뿐만 아니라, 딥러닝을 위한 가상 학습데이터 생성 연구도 활발히 수행되고 있다. 그러나, 이러한 디지털트윈 기반 자율주행 시뮬레이션 시스템은 고정밀 데이터 구축과 시스템 개발에 많은 시간과 비용을 필요로 하는 문제를 가지고 있다. 이에 본 연구에서는 기 구축된 3차원 입체모형과 정밀도로지도만을 이용하여 디지털트윈 기반의 실시간 자율주행 시뮬레이션 시스템을 신속히 설계하고 구현하기 위한 방안을 제시하고자 한다. 구체적으로 부산 EDC 지역에 대한 FBX의 3D 입체모형과 NGII HD Map을 CARLA에 통합하는 방법과 CARLA 기능을 추가 및 수정하는 방법을 제시한다. 본 연구 결과는 기존의 3D 입체모형과 NGII HD 맵을 활용하면 저렴한 비용으로 신속한 시뮬레이션 시스템의 설계 및 구현이 가능함을 보여준다. 또한, 시뮬레이션 시나리오 구성, 사용자 맞춤형 주행, 실시간 신호등 상태 시뮬레이션 등의 다양한 기능도 지원할 수 있다. 향후 광범위한 지역에 대하여 시스템이 적용되는 경우에 시스템의 활용도가 크게 향상될 것으로 기대된다.

• 한국화재소방학회논문지
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• 제33권2호
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• pp.47-55
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• 2019

건물형태의 공간 내에서 발생한 고체연료 화재에 대해 Fire dynamics simulator (FDS)을 이용하여 설계화재곡선의 예측성능을 실험결과와 비교하여 평가하였다. FDS의 연소모델로서는 EDC 2-step mixing controlled를 적용하였으며 검토된 설계화재곡선들은 기존 연구들에서 제안한 2-stage design fire (TDF) 곡선, Quadratic 및 Exponential design fire 곡선들이다. 시뮬레이션 결과는 건물 내 연기 전파과정이 설계화재곡선에 많은 영향을 받는 것을 확인하였다. 설계화재곡선을 이용한 시뮬레이션은 건물 내 실험온도결과에 대해 합리적으로 예측하고 TDF가 가장 온도를 무난하게 예측하는 것을 확인하였다. 그리고 각 설계화재곡선의 화학종 농도에 대한 예측은 실험과 충분히 예측하지 못하는 것을 확인하였다. 이점은 본 연구에서 사용한 연소모델은 고체연료 화재에 대한 시뮬레이션에 적합하지 않음을 나타내며 고체연료의 예측에 대한 FDS 연소모델에 대한 연구가 추가적으로 필요해 보인다.

• 한국화재소방학회논문지
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• 제28권4호
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• pp.35-43
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• 2014

3개의 난류모델과 3개의 연소모델로 구성된 9개의 모델조합을 이용하여 난류 부분예혼합 제트화염 구조에 대한 수치적 예측성능을 검토하였다. 이용된 난류모델은 표준 ${\kappa}-{\varepsilon}$ 모델(SKE), Realizable ${\kappa}-{\varepsilon}$ 모델(RKE) 및 Reynolds 응력모델(RSM)이며 연소모델들은 Eddy Dissipation Concept 모델(EDC), Steady Laminar Flamelet 모델(SLF)와 Unsteady Laminar Flamelet 모델(ULF)이다. 9개 모델조합의 예측성능을 평가하기 위하여 실험결과가 알려진 Sandia D 화염인 난류 부분예혼합 제트화염을 대상으로 수치계산을 수행하였다. 얻어진 결과로서, 화염길이의 예측은 RSM > SKE > RKE순으로 길게 예측하였으며, RKE 난류모델은 화염길이를 너무 과소 예측하는 것을 확인하였다. RSM + SLF과 RSM + ULF의 조합은 화염길이는 비교적 잘 예측하였지만 하류에서의 화염온도를 과대 예측하였다. 반면에 SKE와 연소모델의 조합에서 SLF 또는 ULF 조합은 화염길이 뿐만 아니라 하류에서의 화염온도도 비교적 잘 예측하였는 것을 확인하였다. 반경방향 화염온도 및 화학종 농도분포를 비교해 본 결과 SKE와 연소모델의 조합이 가장 예측성능이 뛰어났으며 SKE + ULF의 조합이 가장 우수한 예측성능을 갖는 것을 확인하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권12호
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• pp.4809-4813
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• 2014

Endocrine-disrupting chemicals (EDCs) have been reported to interfere with estrogen signaling. Exposure to these chemicals decreases the immune response and causes a wide range of diseases in animals and humans. Recently, many studies showed that licorice (Glycyrrhiza glabra) root extract (LRE) commonly called "gamcho" in Korea exhibits antioxidative, chemoprotective, and detoxifying properties. This study aimed to investigate the mechanism of action of LRE and to determine if and how LRE can alleviate the toxicity of EDCs. LRE was prepared by vacuum evaporation and freeze-drying after homogenization of licorice root powder that was soaked in 80% ethanol for 72 h. We used 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) as a representative EDC, which is known to induce tumors or cancers; MCF-7 breast cancer cells, used as a tumor model, were treated with TCDD and various concentrations of LRE (0, 50, 100, 200, $400{\mu}g/mL$) for 24, 48, and 72 h. As a result, TCDD stimulated MCF-7 cell proliferation, but LRE significantly inhibited TCDD-induced MCF-7 cell proliferation in a dose- and time-dependent manner. The expression of TCDD toxicity-related genes, i.e., aryl hydrocarbon receptor (AhR), AhR nuclear translocator, and cytochrome P450 1A1, was also down-regulated by LRE in a dose-dependent manner. Analysis of cell cycle distribution after treatment of MCF-7 cells with TCDD showed that LRE inhibited the proliferation of MCF-7 cells via G2/M phase arrest. Reverse transcription-polymerase chain reaction and Western blot analysis also revealed that LRE dose-dependently increased the expression of the tumor suppressor genes p53 and p27 and down-regulated the expression of cell cycle-related genes. These data suggest that LRE can mitigate the tumorigenic effects of TCDD in breast cancer cells by suppression of AhR expression and cell cycle arrest. Thus, LRE can be used as a potential toxicity-alleviating agent against EDC-mediated diseases.

• Asian Pacific Journal of Cancer Prevention
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• 제15권13호
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• pp.5117-5121
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• 2014

Endocrine-disrupting chemicals (EDCs) have been reported to interfere with estrogen signaling. Exposure to these chemicals decreases the immune response and causes a wide range of diseases in animals and humans. Recently, many studies showed that licorice (Glycyrrhiza glabra) root extract (LRE) commonly called "gamcho" in Korea exhibits antioxidative, chemoprotective, and detoxifying properties. This study aimed to investigate the mechanism of action of LRE and to determine if and how LRE can alleviate the toxicity of EDCs. LRE was prepared by vacuum evaporation and freeze-drying after homogenization of licorice root powder that was soaked in 80% ethanol for 72 h. We used 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) as an EDC, which is known to induce tumors or cancers; MCF-7 breast cancer cells were used as a tumorigenic model. These were treated with TCDD and various concentrations of LRE (0, 50, 100, 200, $400{\mu}g/mL$) for 24, 48, and 72 h. As a result, TCDD stimulated MCF-7 cell proliferation, but LRE significantly inhibited TCDD-induced MCF-7 cell proliferation in a dose- and time-dependent manner. Expression of TCDD toxicity-related genes, i.e., aryl hydrocarbon receptor (AhR), AhR nuclear translocator, and cytochrome P450 1A1, were subsequently down-regulated by LRE in a dose-dependent manner. Analysis of cell cycle distribution after treatment of MCF-7 cells with TCDD and various concentrations of LRE showed that LRE inhibited the proliferation of MCF-7 cells via G2/M phase arrest. Reverse transcription-polymerase chain reaction and Western blot analyses also revealed that LRE dose-dependently increased the expression of the tumor suppressor genes p53 and p27 and down-regulated the expression of cell cycle-related genes. These data suggest that LRE can mitigate the tumorigenic effects of TCDD in breast cancer cells by suppression of AhR expression and cell cycle arrest. Thus, LRE can be used as a potential toxicity-alleviating agent against EDC-mediated disease.

• 통상정보연구
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• 제10권4호
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• pp.533-551
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• 2008

Export Credit Agency(ECA) plays a role of importance in international trade and investment flows. The first ECA, the Export Credits Guarantee Department(ECGD) of the United kingdom, was established in 1919. Its original purpose was to encourage and support exports that would not otherwise have taken. Similar motivations led to the establishment, most of those in operation today. Their traditional role is to support and encourage exports and outward investment by insuring international trade and investment transactions, and in some cases by providing trade finance directly. ECA come in all shapes and sizes, and there in no such thing as a typical ECA model. Most of them insure both political and commercial risks on exports and until the last decade. They operated as government entities or on the account of their government, and many of them have changed and are still changing. This study focuses and analyzes the changes of those four major countries' ECAs, which are the U.S.A.(EXIM), France(COFACE), Japan(JBIC), and Canada(EDC).

• 한국방송∙미디어공학회:학술대회논문집
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• 한국방송∙미디어공학회 2022년도 추계학술대회
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• pp.26-29
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• 2022

The diffuse sound field plays a crucial role in the perceptual quality of the auralization of virtual scenes. Diffuse Rain is a geometrical scattering model which enables the simulation of diffuse fields that is compatible with acoustic ray tracing, but is often computationally expensive. We develop a novel method that can reduce this cost by rendering the large number of Diffuse Rain data in Ambisonics format. The proposed method is evaluated in a shoebox scene simulation run on MATLAB, in reference to a more faithful method of rendering the Diffuse Rain data ray-by-ray. The EDC and IACC of the binaural output show that the simulated diffuse field can be rendered in Ambisonics with only minimal deviations in energy decay and spatial quality, even with 1^st-order Ambisonics.

• 한국환경독성학회:학술대회논문집
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• 한국환경독성학회 2003년도 춘계학술대회
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• pp.149-149
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• 2003

To understand environmental paths of the transport and accumulation of endocrine disrupting chemicals (EDCs), a single cell multimedia fate model has been constructed and evaluated. The EDCs of concern were PAHs, Organochlorine Pesticides (OCPs), PCBs, Alkyl phenols, and phthalates. An evaluation model was designed for the multimedia distribution, including air, water, soil, sediment and vegetation. This model was verified using reported values and via monitoring data. Based on collected data, the distribution trends of EDCs with respect to environmental media were analyzed. Those results have applied to the model for the prediction of the spatial and temporal distribution of EDCs in Seoul. Especially, phenol compound, phthalates, PAHs, PCBs and organochlorine pesticides were estimated and the model was verified. This model was successfully conducted to environmental media, such as air (vapor and suspended particles), soils (forest soil, bare soil, and cement-concrete covered soil), water (dissolved and suspended solids), sediment, trees (deciduous and coniferous). The discrepancies between the model prediction and the measured data are approximately within or near a factor of 10 for the PAHs of three rings through that of six rings, implying that multimedia distribution of the PAHs could be predicted with a factor of 10. Concerning about the air equilibrium may be assumed, a fugacity at steady state is similar in all environmental media. Considering the uncertainties of this model, the use of equilibrium models may be sufficient for assessing chemical fates. In this study, a suggestion was made that modeling and estimation of chemicals in environmental multimedia be rigorously evaluated using the measured flux data. In addition, these data should be obtained, for example, from the precise and standardized inventory of the target chemicals. The model (EDC Seoul) will be refined in an on-going research effort and will be used to support decision-making concerning the management of EDCs.

• 한국화재소방학회논문지
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• 제32권3호
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• pp.42-50
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• 2018

Large Eddy Simulation (LES) 기반의 Fire Dynamics Simulator (FDS) Version(5와 6)에 따른 아격자 난류 및 연소모델의 변화가 헵탄 풀화재의 평균 화염높이에 미치는 영향이 검토되었다. 화재시뮬레이션을 위한 열발생률은 동일한 조건에서 수행된 실험을 통해 제공되었으며, FDS Version에 따른 평균 화염높이의 예측성능은 기존 상관식과의 비교를 통해 평가되었다. FDS 5와 6에 각각 적용된 Smagorinsky 및 Deardorff 난류 모델은 평균 유동장, 화염형상 및 화염높이에 큰 영향을 주지 않는다. 그러나 평균 화염높이를 포함한 풀화재 특성 차이는 주로 FDS 5와 6에 각각 적용된 혼합분율 및 Eddy Dissipation Concept (EDC) 연소모델 차이로 인하여 발생됨을 확인하였다. 마지막으로 FDS 6에 비해 FDS 5는 상당히 긴 화염높이의 예측결과를 제공하며, 기존 상관식과 보다 일치하는 평균 화염높이 예측이 가능함을 확인하였다.