• Title/Summary/Keyword: EB

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A Toxicogenomic Study to Assess Methylmercury-induced Neurotoxicity

  • Kim, Youn-Jung;Yun, Hye-Jung;Ryu, Jae-Chun
    • Proceedings of the Korea Society of Environmental Toocicology Conference
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    • 2003.10a
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    • pp.177-177
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    • 2003
  • Methylmercury (MeHg) is a well-known neurotoxicant that causes severe damage to the central nervous system in humans. Many reports have shown that MeHg is poisonous to human body through contaminated foods and has released into the environment. Despite many studies on the pathogenesis of MeHg-induced central neuropathy, no useful mechanism of toxicity has been established so far. In this study, suppressive subtractive hybridization (SSH) was performed to identify differentially expressed genes on human neuroblastoma cell line, SH-SY5Y treated with DMSO and MeHg (6.25 uM) for 6 hr. Differentially expressed cDNA clones were sequenced and were screened by dot blot to eliminate false positive clones. 13 of 35 screened genes were confirmed using real time RT-PCR. These genes include EB1,90-kDa heat-shock protein, chromosome condensation-related SMC-associated protein and brain peptide Al, etc. Analysis of these genes may provide an insight into the neurotoxic effects of MeHg in human neuronal cells and a possibility to develop more efficient and exact monitoring system of heavy metals as ubiquitous environmental pollutants.

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Stereoscopic Depth Fidelity: New Reference For Making Effective and Natural Stereoscopic 3D Content (효과적인 3D 콘텐츠 제작을 위한 참조지표 - 입체충실도)

  • Park, Byung-Jin;Jung, Jae-Woo;Park, Sung-Hwan
    • Proceedings of the Korean Society of Broadcast Engineers Conference
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    • 2012.11a
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    • pp.92-95
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    • 2012
  • 대한민국에서 3DTV 방송서비스는 더 이상 '미래방송서비스'가 아니다. EBS는 올해 4월 지상파 DTV 주파수에서 세계최초로 2D/3D 혼용방송서비스를 실시하였으며, 오는 10월 15일에는 APC(Automatic Program Controller)와 연동하여 방송스케줄에 따라 자동으로 3D 방송을 송출하는 시스템을 구축하여 2차 시범방송을 진행할 예정이다. 이렇게 3D 방송을 위한 기술적 준비는 차근차근 이루어지고 있음에 반하여, 3D 방송서비스에 대한 시청자의 호응은 그다지 크지 않다. 이것은 방송되는 3D 콘텐츠의 양과 질이 부족하기 때문으로 풀이된다. 이 같은 3D 방송서비스의 장애요소에 착안하여, 본 논문에서는 3D 콘텐츠 제작효율을 높이고, 만들어지는 3D 방송콘텐츠의 품질을 높이기 위한 하나의 방법으로서, 제작현장에서 활용할 수 있는 3D 콘텐츠 제작과 밀접한 관련이 있는 새로운 참조지표인 '입체충실도(Depth Fidelity)'를 정의하여 제안하고자 한다. 입체충실도를 도출하기 위해 우선 양안식(兩眼式) 3D 입체영상의 특징을 분석하였고, 시청자 체감 가상깊이를 계산하여 활용하였다. 또한 연구를 통해 도출한 입체충실도 계산 알고리즘이 적용된 EBS 입체계산기(Stereoscopic Calculator) 애플리케이션을 개발하여 안드로이드 스마트폰에서 이용할 수 있도록 함으로써, 카메라감독과 프로듀서 등 방송제작 현업 스태프들이 연구결과를 활용할 수 있도록 했다.

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A Study on Couplant Medium Improvement for Ultrasonic Inspection System with Water Immersion to Detect Weld Defects (용접결함 검사용 수침식초음파탐상기의 매질개선연구)

  • Jung, Dal-Woo;Choi, Nak-Sam;Park, Yong-Bae
    • Transactions of the Korean Society of Automotive Engineers
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    • v.16 no.5
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    • pp.8-14
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    • 2008
  • For nondestructive inspection of electron beam (EB) welding part in automotive power transmission assembly, a pulse-echo ultrasonic testing apparatus in water immersion has been applied using the ultrasonic waves with a frequency of 10MHz. However various problems have appeared during the ultrasonic inspection, which led to some significant mistakes in automatic quality evaluation of the welding parts. Experimental study showed that the state of water couplant medium containing some amount of contaminants, rusts and anti-corrosion agents had considerable influences on the reduction of ultrasonic amplitudes during wave propagation. The amplitude reduction depending on the coupling medium state could bring about some mis-diagnoses for defects in the welding parts. The results proposed that for a reliable inspection of defects in welds the state of water medium should be kept in about 15 volume fractions (vol.%) of anti-corrosion agents and in minimized contaminants.

Performance Comparison of Turbo Codes at Various Puncturing Rates (다양한 부호율로 펑처링된 터보 부호의 성능 비교)

  • 권이경;송홍엽
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.24 no.7A
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    • pp.1074-1079
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    • 1999
  • In this paper, the concept of puncturing is introduced to turbo code in order to implement various code as code rate varies.rates. First, several different puncturing matrices are applied into rate 1/3 encoder in order to produce various rate 1/2 turbo codes. By analyzing and comparing these results, we can show which puncturing pattern should be selected in order to maintain good performance. Second, we select some appropriate puncturing patterns which provide the best performance of turbo codes of various rates from 1/3 to 2/3 among all the possible candidates. Finally, we provide the change of required Eb/No at $P_b=10^{-4}$ as code rate varies.

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Correlation Between Skin Irritation and Cytotoxicity of Anti-wrinkle Agents (화장품 원료의 피부자극성과 세포독성의 관련성)

  • 이은희;이종권;김용규;박기숙;안광수
    • YAKHAK HOEJI
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    • v.45 no.3
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    • pp.310-319
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    • 2001
  • To compare skin irritation and cytotoxicity of anti-wrinkle agents, we examined skin irritation of six anti-wrinkle agents (ascorbic acid, glycolic acid, all trans-retinoic acid, ginseng extract, retinol, EB) in New Zealand white rabbit. Cytotoxicity of these agents was determined by MTT [tetrazolium salt 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide] at multi-time points in cultured HaCaT cell, a human immortalized keratinocyte cell. We then analyzed correlation between skin irritation and cytotoxicity by spearman's rank correlation analysis. All trans-retinoic acid showed the highest primary irritation index (0.92) in skin irritation test. Being all the six agents not irritant, retinal showed the most cytotoxic agents. The correlation between skin irritation and cytotoxicity ($IC_{50}$/ at different time point was 0.814, 0.757, 0.814 and 0.7 at 3, 24, 48 and 72 h, respectively. We also fecund that IC$_{20}$ and IC$_{80}$ of these agents showed similar correlation with skin irritation. These results therefore demonstrated that there is close correlation between skin irritation and cytotoxicity $IC_{50}$/ value by MTT in HaCaT cell at early time points by anti-wrinkle agents or IC$_{20}$ value. $IC_{50}$/ at earily time point or IC$_{20}$ values may be reliable alternative determinant of skin irritation.n.

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Selective Coordination of Silver Ions to Poly(styrene-b-(ethylene-co-butylene)-b-styrene) and its Influence on Morphology and Facilitated Olefin Transport

  • Lee, Dong-Hoon;Kang, Yong-Soo;Kim, Jong-Hak;Kang, Sang-Wook
    • Macromolecular Research
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    • v.16 no.8
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    • pp.676-681
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    • 2008
  • The $\pi$-complex membranes of poly(styrene-b-(ethylene-co-butylene)-b-styrene) (SEBS) of two silver salts of $AgBF_4$ and $AgCF_3SO_3$ were prepared and tested for the separation of the propylene/propane mixtures. The Fourier-transform infrared (FT-IR) spectra of these complexes showed that the silver salts were dissolved in SEBS up to a silver mole fraction of 0.14, due to $\pi$-complexation between the aromatic C=C bonds of styrene blocks and silver ions. Above this solubility limit, ion pairs and high-order ionic aggregates began to form, so that silver salts were distributed unselectively in both the EB and PS blocks. The domain size of the PS blocks was enlarged up to this critical concentration with increasing silver concentration without structural transitions, as confirmed by small angle x-ray scattering (SAXS). These structural properties of the SEBS/silver salt complexes may explain the lower separation properties for propylene/propane mixtures compared to poly(styrene-b-butadiene-b-styrene)(SBS)/silver salt complex membranes.

A Study on the Optimal XML/EDl Method for the Port and Logistics Industry (항만물류산업에 적합한 XML/EDl 방안 연구)

  • 박남규;최형림;김현수;이창섭
    • Proceedings of the Korean Institute of Navigation and Port Research Conference
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    • 2002.03a
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    • pp.59-71
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    • 2002
  • Korean government, port and logistics companies have given a lot of their efforts to exchange electronic documents between themselves and their partners. As the results of them, Korean EDI(Electronic Data Interchange) standards were made by Korean EDIFACT committee and the standards have been used by companies and governmental organizations in Korea. However, Korean port and logistics EDI system is based on YAN(Value Added Network) and one VAN company has monopolistic right to relay EDI documents to Korean HOMAF(Ministry of Maritime Affairs & Fisheries) and Customs Service. Therefore it leads to a lot of problems such as inconvenient software, expensive transmission fee, insufficient improvement of business process and the difficulty of connection with the in-house systems of user companies. For solving these problems, this study is aimed to progress for XML and XML-based electronic commerce framework. This paper shows a optimal XML/EDl method using XML/EDl, BizTalk Framework, ebXML Framework. Fer improving extant problems in port and logistics industry, this paper proposed XML/EDl system based on system architectural level, support technical level, business infrastructure level.

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A study on the Korea's global e-Trade marketing spreading strategy (글로벌 전자무역 마케팅 확산전략에 대한 연구)

  • Park, Yong-Hwan;Lee, Seung-Kwan
    • The Journal of Information Technology
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    • v.7 no.3
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    • pp.99-112
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    • 2004
  • Internet is changing all of the commercial practices and customs on international business transaction. So called e-Trade in global marketing is expected to dominate the global trade in 21st century and thus is being introduced as a major mission assignment for exporting countries. e-Trade has the potential to accelerated existing threads and introduce new ways of carrying out global trade. It is especially important in Korea, which has a high dependency rate on trade. Trade efficiency through the channel of e-Trade is an alternative to strengthen international competition of korean small and medium sized global trading firm.

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The performance Simulation of OFDM/HL-16QAM System for Data and Image Transmission in Multipath Fading Channel (다중경로 페이딩 채널에서 데이터와 영상전송을 위한 OFDM/HL-16QAM 시스템의 성능 시뮬레이션)

  • 곽재민;박기식;조성언;김춘길;조성준
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.26 no.10A
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    • pp.1772-1781
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    • 2001
  • 본 논문에서는 OFDM/HL-16QAM 시스템의 성능을 구하였다. OFDM/HL-16QAM은 계층적 16QAM을 채용하는 OFDM 시스템으로서 열악한 다중경로 페이딩 환경에서 고품질의 고속 데이터 전송이 가능하고 서로 다른 품질의 두 가지 데이터 서비스를 동시에 제공할 수 있는 시스템이다. 성능평가를 위한 무선 채널로서는 AWGN과 다중경로 페이딩이 존재하는 무선 환경을 고려했다. 각각의 채널환경에서의 시뮬레이션을 통해 데이터 전송시의 OFDM/HL-16QAM 시스템에 대해 Eb/No와 반송파 수에 따른 BER 성능을 구해냈고, 이로부터 고품질과 저품질의 데이터 서비스를 모두 만족시키기 위해 요구되는 최소 평균 SNR 값을 제시했다. 이미지 전송에 응용하기 위한 방안으로는, 영상 압축을 위해 DCT 기반의 고정길이 부호기법을 채용하는 OFDM/HL-16QAM 시스템을 제안하고, 수신 영상의 PSNR(Peak Signal to Noise power Ratio)을 최대화시키는 최적 계층 변조 파라미터를 구했다. 또한, 최적화된 계층 변조 파라미터를 사용하는 경우, 제안한 시스템을 통한 수신 영상 품질이 기존의 OFDM/16QAM 시스템보다 우수하다는 것을 보였고, 시뮬레이션을 통해 수신 영상에 대한 PSNR의 상한과 하한을 구해냈다. 성능분석 결과들로부터 제안한 OFDM/HL-16QAM 시스템이 데이터와 이미지 전송에 적합한 시스템이라는 것을 알 수 있다.

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Three Common Subunits in Editing Domains of Class Ia tRNA Synthetases

  • Lee, Keun-Woo;Kwon, Yong-Jung;Briggs, James M.
    • Bulletin of the Korean Chemical Society
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    • v.28 no.2
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    • pp.207-210
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    • 2007
  • To identify structural or functional common subunit(s) in the CP1 (editing) domains of class Ia tRNA synthetases, five available structures were compared and analyzed. Through the sequence alignments and structural overlapping of the CP1 domains, three conserved regions were identified near the amino acid binding site in the editing domain. Structural overlapping of the three subunits clearly showed the existence of three common structural subunits in all of the five editing RS structures. Based on the established experimental results and our modeling results, it is proposed that subunits 1 and 3 accommodate the incoming amino acid binding, while subunit 2 contributes to the interactions with the adenosine ring of the A76 to stabilize the overall tRNA binding. Since these subunits are critical for the editing reaction, we expect that these key structures should be conserved through the most class Ia editing RSs.