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Effects of Prunellae Spica Extract on LT4-induced Hyperthyroidism in Rats through the Regulation of Heat and Cold Imbalance (하고초추출물의 갑상선기능항진증 랫트모델에서의 한열조절작용에 의한 개선효능 연구)

  • Kang, An Na;Kang, Seok Yong;Meng, Xianglong;Ma, Junnan;Park, Jong Hun;Park, Yong-Ki
    • The Korea Journal of Herbology
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    • v.33 no.4
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    • pp.77-85
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    • 2018
  • Objective : This study was intended to examine the effects of water extract of Prunellae Spica (PS), which is a herb with 'cold' nature based on hot and cold theory of traditional Korean medicine. Methods : Hyperthyroidism was induced in SD rats by LT4 (0.5 mg/kg, i.p.) daily for four weeks. After 2 weeks of LT4 injection, rats were divided randomly into four groups; normal, LT4-induced hyperthyroid control, PS extract (500 mg/kg, p.o.)-treated group, and propylthiouracil (PTU, 10 mg/kg, s.c.)-treated positive group. After 2 weeks of drug treatment, all rats were sacrificed and harvested blood samples and thyroid tissues. The changes of body weight, food and water intake, and body temperature were measured weekly. Serological markers were analyzed in sera using an enzyme-based assay, and thyroid tissues were stained with Hematoxylin & Eosin (H&E). Brain and dorsal root ganglion (DRG) tissues were isolated and analyzed the expression of transient receptor potential (TRP) channels by Western blot. Results : PS extract administration attenuated the loss of body weight and the increase of body temperature in LT4-induced hyperthyroidism rats. PS extract increased the level of thyroid stimulating hormone (TSH) and decreased tiiodothyronine (T3) and tetraiodothyronine (T4). In action mechanism, PS extract regulated the expression of transient receptor potential channel subfamily V member 1 (TRPV1) and transient Receptor Potential channel subfamily M member 8 (TRPM8), the thermoregulators. Conclusion : To conclude, PS extract can improve the symptoms of hyperthyroidism through regulation of the thyroid hormones imbalance and thermoregulation via TRP channels.

The Influence of Vacuum Packaging of Hot-Boned Lamb at Early Postmortem Time on Meat Quality during Postmortem Chilled Storage

  • Zhao, Yingxin;Chen, Li;Bruce, Heather L.;Wang, Zhenyu;Roy, Bimol C.;Li, Xin;Zhang, Dequan;Yang, Wei;Hou, Chengli
    • Food Science of Animal Resources
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    • v.42 no.5
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    • pp.816-832
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    • 2022
  • To evaluate the effects of early postmortem vacuum packaging (VP) on meat quality during postmortem chilled storage, hot-boned lamb was vacuum-packaged at 1, 6, 12, 24, and 48 h postmortem and stored around 2℃ until 168 h postmortem, with lamb packaged in plastic wrap as the control (aerobic packaging). Intramuscular pH decline was delayed when lamb was vacuum packaged at 1, 6, and 12 h postmortem (p<0.05). The lamb vacuum-packaged at 1 h postmortem (VP-1h group) had significantly lower shear force values and purge losses accompanied by lower free thiol group values than other treatments during postmortem storage and was also higher in extractable calpain-1 activity by 6 h postmortem (p<0.05). Free thiol group concentrations were significantly higher after VP at 6 and 12 h postmortem (p<0.05). Packaging lamb under vacuum very early postmortem produced the lowest shear force and purge loss, likely by slowing heat loss and muscle temperature decline, implying that lamb quality is improved by VP when applied very early postmortem. This was at the expense of protein oxidation, which was unrelated to other meat quality measurements, most likely because potential contracture during hot boning confounded its impact. Further research is required to understand the implications of the interaction between protein oxidation, VP, and hot boning on the acceptability of lamb.

Groundwater control measures for deep urban tunnels (도심지 대심도 터널의 지하수 변동 영향 제어 방안)

  • Jeong, Jae-Ho;Kim, Kang-Hyun;Song, Myung-Kyu;Shin, Jong-Ho
    • Journal of Korean Tunnelling and Underground Space Association
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    • v.23 no.6
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    • pp.403-421
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    • 2021
  • Most of the urban tunnels in Korea, which are represented by the 1st to 3rd subways, use the drainage tunnel by NATM. Recently, when a construction project that actively utilizes large-scale urban space is promoted, negative effects that do not conform to the existing empirical rules of urban tunnels may occur. In particular, there is a high possibility that groundwater fluctuations and hydrodynamic behavior will occur owing to the practice of tunnel technology in Korea, which has mainly applied the drainage tunnel. In order to solve the problem of the drainage tunnel, attempts are being made to control groundwater fluctuations. For this, the establishment of tunnel groundwater management standard concept and the analysis of the tunnel hydraulic behavior were performed. To prevent the problem of groundwater fluctuations caused by the construction of large-scale tunnels in urban areas, it was suggested that the conceptual transformation of the empirical technical practice, which is applied only in the underground safety impact assessment stage, to the direction of controlling the inflow in the tunnel, is required. And the relationship between the groundwater level and the inflow of the tunnel required for setting the allowable inflow when planning the tunnel was derived. The introduction of a tunnel groundwater management concept is expected to help solve problems such as groundwater fluctuations, ground settlement, depletion of groundwater resources, and decline of maintenance performance in various urban deep tunnel construction projects to be promoted in the future.

Effect of the Multisensory on the Stress-relieving for Vehicle Driver (운전자 스트레스 저감을 위한 다감각 자극의 효과)

  • Kim, Young-Joo;Kim, Hyejin;Lee, Hyunwoo;Jo, Youngho;Whang, Mincheol
    • Science of Emotion and Sensibility
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    • v.24 no.4
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    • pp.107-116
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    • 2021
  • This study aims to investigate the effect of multisensory stimulation on relieving the stress experienced by drivers. The photoplethysmograms (PPGs) of 30 healthy subjects were measured, and their subjective response to stressful situations and normal driving were evaluated. The subjects underwent nonstimulation and multisensory stimulation in stressful driving situations. Heart rate estimation from the PPG was collected via an ear-type sensor to reduce movement noise. The signals acquired were sampled at 200 Hz using BIOPAC PPG100C. Heart rate variability (HRV) was analyzed to compare the effect of multisensory stimulation on stress situations. In the multisensory stimulation, blue, green, and yellow were used for the visual sensory system; white, pink, and brown noises were used for the auditory sensory system; and lavender, lemon, and rosemary were used for the olfactory sensory system. No difference was observed in the subjective evaluation; however, the HRV results showed an increased HF (%) and decreased LF (%) and LF/HF (%) in the multisensory stimulation (e.g., green, pink noise, and rosemary) when compared to the nonstimulation.

An Analysis of Students' Mathematical Communication Competency focused on Fraction Division (분수의 나눗셈에 대한 초등학생의 수학적 의사소통 능력 분석)

  • Pang, Jeong Suk;Kim, Yoon Young;Sunwoo, Jin
    • Education of Primary School Mathematics
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    • v.25 no.2
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    • pp.179-195
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    • 2022
  • Mathematical communication competency, one of the six mathematical competencies emphasized in the latest mathematics curriculum, plays an important role both as a means and as a goal for students to learn mathematics. Therefore, it is meaningful to find instructional methods to improve students' mathematical communication competency and analyze their communication competency in detail. Given this background, this study analyzed 64 sixth graders' mathematical communication competency after they participated in the lessons of fraction division emphasizing mathematical communication. A written assessment for this study was developed with a focus on the four sub-elements of mathematical communication (i.e., understanding mathematical representations, developing and transforming mathematical representations, representing one's ideas, and understanding others' ideas). The results of this study showed that students could understand and represent the principle of fraction division in various mathematical representations. The students were more proficient in representing their ideas with mathematical expressions and solving them than doing with visual models. They could use appropriate mathematical terms and symbols in representing their ideas and understanding others' ideas. This paper closes with some implications on how to foster students' mathematical communication competency while teaching elementary mathematics.

An Experimental Study on Relationship Between Half-Cell Potential and Corrosion Current Density of Chloride-Induced Corroded Steel in Concrete (염해에 따라 콘크리트 속에서 부식된 철근의 반전지전위와 부식전류밀도의 상관관계에 관한 실험적 연구)

  • Jo, Sang-Hyeon;Kim, Dong-Won;Kee, Seong-Hoon
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.26 no.6
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    • pp.1-13
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    • 2022
  • This study aims to investigate the feasibility of the half-cell potential (HCP) measurements on the concrete surface for evaluation of corrosion rate (or corrosion levels) of reinforcing steel in concrete. A series of experimental study is performed to measure HCP (or corrosion potential, Ecorr) and corrosion current density (icorr) of reinforcing steel in concrete cube specimens, with a side length of 200 mm. Various corrosion levels in a range of 0% to 20% of the test specimens are accelerated by impressing current to the reinforcing steel in concrete immersed in 3.0 % NaCl solution. HCP is measured in accordance with ASTM C876-15, and corrosion current density is determined by using the Stern-Geary equation and measured polarization resistance measured by electrochemical impedance spectroscopy (EIS). As a result, a numerical formula that relates HCP and icorr in the test specimen is established by a regression analysis of the measured data in this study. It is observed that HCP is linearly correlated with log(icorr) with a R2 greater than 0.87, which is less affected by the experimental variables such as concrete mixture proportion, diameter of reinforcing steel and the amount of applied current in this study. These results exhibit that HCP measurements could be effective for evaluation of corrosion rate (or corrosion levels) of reinforcing steel in concrete in the case of exposed to a certain consistent environment.

Correlation Analysis of Load-carrying Capacity by Safety Inspection Indicators in Bridges (교량 안전점검 지표별 내하성능 상관관계 분석)

  • Jung, Kyu San;Seo, Dong Woo;Kim, Jae Hwan;Cho, Han Min;Park, Ki Tae;Shin, Yeon-Woo
    • Journal of Korean Society of Disaster and Security
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    • v.15 no.3
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    • pp.89-99
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    • 2022
  • Bridges are a key infrastructure that underpins economic and social activities. In Korea, bridges began to be built with economic development in the 1970s and were built intensively in the 1980s and 1990s. In recent years, as the number of bridges with a service life of more than 30 years is increasing, continuous maintenance is required to ensure the safety of the bridges. In particular, in order to cope with the aging of bridges, research on technology development such as maintenance using ICT technology, preventive maintenance, life cycle cost reduction, and long life bridge is being actively promoted. This paper presents the results of correlation analysis based on the safety evaluation data of bridges as part of the research on the development of a model for estimating load-carrying capacity of bridges. As a analysis result, indicators highly correlated with the load-carrying capacity of the bridge was derived.

Gentiana straminea supplementation improves feed intake, nitrogen and energy utilization, and methane emission of Simmental calves in northwest China

  • Xie, K.L.;Wang, Z.F.;Guo, Y.R.;Zhang, C.;Zhu, W.H.;Hou, F.J.
    • Animal Bioscience
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    • v.35 no.6
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    • pp.838-846
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    • 2022
  • Objective: Native plants can be used as additives to replace antibiotics to improve ruminant feed utilization and animal health. An experiment was conducted to evaluate the effects of Gentiana straminea (GS) on nutrient digestibility, methane emissions, and energy metabolism of Simmental calves. Methods: Thirty-two (5-week-old) male Simmental clves, with initial body weight (BW) of 155±12 kg were fed the same basal diet of concentrates (26%), alfalfa hay (37%), and oat hay (37%) and were randomly separated into four treatment groups according to the amount of GS that was added to their basal diet. The four different groups received different amounts of GS as a supplement to their basal diet during whole experiment: (0 GS) 0 mg/kg BW, the control; (100 GS) 100 mg/kg BW; (200 GS) 200 mg/kg BW; and (300 GS) 300 mg/kg BW. Results: For calves in the 200 GS and 300 GS treatment groups, there was a significant increase in dry matter (DM) intake (p<0.01), average daily gain (ADG) (p<0.05), organic matter intake (p<0.05), DM digestibility (p<0.05), neutral detergent fibre (NDF) digestibility (p<0.05), and acid detergent fibre (ADF) digestibility (p<0.05). Dietary GS supplementation result in quadratic increases of DM intake (p<0.01), ADG (p<0.05), NDF intake (p<0.05), and ADF intake (p<0.05). Supplementing the basal diet with GS significantly increased nitrogen (N) retention (p<0.001) and the ratio of retention N to N intake (p<0.001). Supplementing the basal diet with GS significantly decreased methane (CH4) emissions (p<0.01), CH4/BW0.75 (p<0.05) and CH4 energy (CH4-E) (p<0.05). Dietary GS supplementation result in quadratic increases of CH4 (p<0.01) and CH4/DM intake (p<0.01). Compared with 0 GS, GS-supplemented diets significantly improved their gross energy intake (p<0.05). The metabolizable energy and digestive energy intake were significantly greater for calves in the 100 GS and 200 GS calves than for 0 GS calves (p<0.05). Conclusion: From this study, we conclude that supplementing calf diets with GS could improve utilization of feed, energy, and N, and may reduce CH4 emissions without having any negative effects on animal health.

Analysis of Structural Relationship between Science Academic Achievement, Learning Support from Teachers, Students' Attitude toward Science, and School Life from TIMSS 2019, and National Assessment of Educational Achievement (TIMSS 2019와 국가수준 학업성취도 평가에 나타난 과학성취도와 교사의 학습 지원, 과학에 대한 태도, 학교 생활의 구조적 관계 비교 분석)

  • Rho, Jaehee;Ryoo, Ji Hoon
    • Journal of The Korean Association For Science Education
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    • v.42 no.1
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    • pp.149-160
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    • 2022
  • Comparative studies using large-scale data such as TIMSS, PIRLS, and PISA inform us of the effectiveness of each educational system. Even though samples in the large-scale studies were representative, admitting potential discrepancy when applying the findings of the large-scale studies to local educational system is still needed. This study examines the structural relationship among students' attitude towards science, learning support from teachers, school life, and science academic achievement with both large-scale data and local comparative study data utilizing same variables. Responses on the TIMSS 2019 of 5,554 Korean seventh-grade students and National Assessment of Educational Achievement (NAEA) 2019 of 6,365 third-grade middle school students were used. The results indicate that: a) school life did not affect the science achievements in both data. However, in NAEA 2019, students' attitude mediated the relationship between school life and science achievement; b) learning support from teachers had a significant impact on TIMSS science achievements, and also had positive effect on achievement through students' attitude in TIMSS. On the other hand, learning support had a positive effect on achievement only when student's attitude mediated the relationship in NAEA; c) students 'attitude toward science had positive effect on science achievement on both data; d) the impact of gender was different on school life, academic achievement, students 'attitude towards science, and learning support from teachers on both data; and e) the impact of the number of books differed as well. There were differences in results between the international and domestic research, which inform us that we need to pay attention when interpreting the domestic environment through the results of international research.

Application of chemical treatment for cattle and chicken carcasses for the control of livestock infectious diseases (가축 전염병 발생에 따른 소와 닭 사체의 화학적 처리 방법의 적용)

  • Lee, Taek Geun;Oh, Yeonsu;Ko, Young-Seung;Bae, Da-Yun;Tark, Dong-Seob;Rim, Chaekwang;Cho, Ho-Seong
    • Korean Journal of Veterinary Service
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    • v.45 no.2
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    • pp.117-124
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    • 2022
  • In the event of an outbreak of a livestock epidemic, it has been considered that the existing burial-centered carcass disposal method should be improved ecofriendly for prevention of leachate and odors from burial basically in regard of pathogen inactivation. Therefore, the aim of this study is whether it was possible to treat the carcass of cattle and chickens using the chemical carcass treatment method. It was conducted to establish detailed treatment standards for the chemical treatment method of cattle and chicken carcasses based on the results of the proof of the absence of infectious diseases in cattle chickens. After inoculating cattle carcass with 10 pathogens (foot and mouth disease virus, bovine viral diarrhea virus, Mycobacterium bovis, Mycobacterium avium subsp. Paratuberculosis, Brucella abortus, Bacillus anthracis, Clostridium chauvoei, Clostridium perfringens, Escherichia coli, and Salmonella Typhimurium) and chicken carcasses with low pathogenic avian influenza virus, Clostridium perfringens type C, E. coli and Salmonella Typhimurium, these were treated at 90℃ for 5 hours in a potassium hydroxide liquid solution corresponding to 15% of the body weight. This method liquefies all cadaveric components and inactivates all inoculated pathogens by PCR and culture. Based on these results, it was possible to prove that chemical treatment of cattle and chicken carcasses is effective in killing pathogens and is a safe method without the risk of disease transmission. The chemical treatment method of livestock carcasses can be suggested as an alternative to the current domestic burial-centered livestock carcass treatment method, preventing environmental pollution, and contributing to public health.