• Journal of Pharmacopuncture
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• v.4 no.1
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• pp.5-21
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• 2001

The influence of electroacupuncture (EA), a traditional Chinese medical treatment, on type Ⅱ collagen-induced arthritis (CIA) was examined in DBA/1J mice in vivo. Mice were immunized intradermally twice at the 3-week interval with bovine type Ⅱ collagen(C Ⅱ). EA stimulation, begun on the 21 simultaneously with the second immunization, was applied at the acupoint equivalent to GV4 three times a week for 3 weeks. The results showed that EA delayed the onset, attenuated the severity of arthritis, and reduced the anti-collagen antibody level. Furthermore, we investigated the impact of EA on the productions of endogenous $interleukin-1{\Beta}$ (IL-1 beta) and prostaglandin E2 (PGE2), and the levels of IL-1 beta mRNA in splenocytes and synovial tissues from C Ⅱ immunized mice on the 45 and cyclooxygenase-2 (COX-2) mRNA in lipopolysaccharide (LPS)-stimulated macrophages of normal mice by using reverse transcriptase-polymerase chain reaction (RT-PCR). EA stimulation significant inhibited the concentrations of splenic endogenous IL-1 beta and serum PGE2. The expression of IL-1 beta mRNA in spleen cells was obviously down-regulated and that in synovial tissues was modestly affected by EA. COX-2 mRNA was highly expressed in cultured peritoneal macrophages when stimulated with LPS. Previous treatment with EA also reduced LPS-stimulated induction of COX-2 mRNA. These data suggest that EA has an inhibitory effect on murine CIA, and the partial mechanism of its therapeutic result may be attributed to inhibiting the productions of IL-1 beta and PGE2 by suppression the IL-1 beta and COX-2 gene activations.

• Journal of Korean Society for Atmospheric Environment
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• v.18 no.6
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• pp.539-546
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• 2002

The physicochemical properties of solid wastes generated from seven highway service areas, four branch offices, and one construction site were analyzed in concert with air pollutants including heavy metals emitted from near-by small-scale incinerators. The amount of solid wastes generated from highway areas has been increasing with recent increases in the number of highways and passengers. Twelve incinerators examined in this study generally had capacity smaller than 100 kg/hr, most of which were equipped with cyclone for dust removal. It was seen that the concentrations of the gas-phase air pollutants (e.g., SO$_2$, NO$_{x}$, HCl and H$_2$S) were above the acceptable emission standards except one or two sites. CO concentrations at all incinerators were also higher due to incomplete combustion. In addition, particulate matters showed concentration six times higher at their maximum. The results of heavy metal analysis showed that the concentrations of Cu, Cd, and Ni satisfied the emission standards. whereas Pb at one site and Zn at five sites exceeded the standards. Cr measurement results indicated that 9 of 12 incinerators had higher values than the standard; especially one branch office showed nine times higher than normal concentration. In order to satisfy more stringent emission standards in the near future, it is necessary to install air pollution control system and to develop an intensified management plan.n.

• Journal of Korean Society for Atmospheric Environment
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• v.22 no.5
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• pp.614-626
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• 2006

Using the data of three environmental monitoring sites in Pohang area(KME112, KME113, and KME114), statistical forecasting models of the daily maximum and mean values of PM10 have been developed. Since the distributions of the daily maximum and mean PM10 values are skewed, which are similar to the Weibull distribution, these values were log-transformed to increase prediction accuracy by approximating the normal distribution. Three statistical forecasting models, which are regression, neural networks(NN) and support vector regression(SVR), were built using the log-transformed response variables, i.e., log(max(PM10)) or log(mean (PM10)). Also, the forecasting models were validated by the measure of RMSE, CORR, and IOA for the model comparison and accuracy. The improvement rate of IOA before and after the log-transformation in the daily maximum PM10 prediction was 12.7% for the regression and 22.5% for NN. In particular, 42.7% was improved for SVR method. In the case of the daily mean PM10 prediction, IOA value was improved by 5.1% for regression, 6.5% for NN, and 6.3% for SVR method. As a conclusion, SVR method was found to be performed better than the other methods in the point of the model accuracy and fitness views.

• Development and Reproduction
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• v.6 no.1
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• pp.31-35
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• 2002

The major urinary proteins(MUPs) of mice that bind hydrophobic molecules known as pheromones are regulated in part by the actions of growth hormone. The expression of the MUPs was therefore investigated in transgenic mice that express a human growth hormone-releasing factor gene from a metallothionein gene promoter(MT-GRF) and as a result have elevated growth hormone levels. MUPs were severely down-regulated in the urine of these animals compared to normal mice or to control transgenic mice expressing another gene(the inhibin a subunit) from the same metallothionein promoter(MT-Inh) and more MUPs disappeared in male mice than female ones. MUPs were also down-regulated in the urine of the UT-GRF-injected mice. In addition, it was observed that the urine of the MT-GRF mice included a high molecular weight protein that co-migrates with the major serum protein albumin, indicating an impairment in glomerular filtration within the kidney. The urinary loss of serum proteins was more severe in male MT-GRF mice than female ones. Thus the overexpression of human GRF mimics changes observed in MUP protein expression and glomerular function in other models of growth hormone hypersecretion with sex-dependent differential effects.

• Economic and Environmental Geology
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• v.25 no.3
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• pp.351-358
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• 1992

The gravity measurement has been conducted at 327 station with an interval of 25 m along the survey lines of 1.6 km and 1.7 km traversing Hyungsan river and of 2.35 km and 2.42 km running N-S direction near Heunghae-eup in Pohang basin. Bouguer gravity anomalies were obtained, and geologic structure along four survey lines were interpreted by applying Fourier series and Talwani methods for two demensional body. A fault is in existence along the Hyungsan river, and northern block of it is displaced down by 150 m to 200 m relative to southern one. The thicknesses of Yeonil Group vary from 250 m to 550 m and from 150 m to 300 m in the northern and southern blocks of the fault, respectively. Another fault is in existence running E-W direction near Heunghae-eup, and its southern block is displaced down by about 250 m relative to its northern block. The thicknesses of Yeonil Group vary from 200 m to 400 m and from 500 m to 700 m in the southern and northern blocks of the fault, respectively. Above two faults are normal faults and make a graben structure, which results the age of rocks in the central region between the faults is younger than those of outside regions. This result coincides with that of paleontological study.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.13 no.12
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• pp.6214-6242
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• 2019

Routing in mobile ad hoc networks is performed in a distributed fashion where each node acts as host and router, such that it forwards incoming packets for others without relying on a dedicated router. Nodes are mostly resource constraint and the users are usually inclined to conserve their resources and exhibit selfish behaviour by not contributing in the routing process. The trust and reputation models have been proposed to motivate selfish nodes for cooperation in the packet forwarding process. Nodes having bad trust or reputation are detected and secluded from the network, eventually. However, due to the lack of proper identity management and use of non-persistent identities in ad hoc networks, malicious nodes can pose various threats to these methods. For example, a malicious node can discard the bad reputed identity and enter into the system with another identity afresh, called whitewashing. Similarly, a malicious node may create more than one identity, called Sybil attack, for self-promotion, defame other nodes, and broadcast fake recommendations in the network. These identity-based attacks disrupt the overall detection of the reputation systems. In this paper, we propose a reputation-based scheme that detects selfish nodes and deters identity attacks. We address the issue in such a way that, for normal selfish nodes, it will become no longer advantageous to carry out a whitewash. Sybil attackers are also discouraged (i.e., on a single battery, they may create fewer identities). We design and analyse our rationale via game theory and evaluate our proposed reputation system using NS-2 simulator. The results obtained from the simulation demonstrate that our proposed technique considerably diminishes the throughput and utility of selfish nodes with a single identity and selfish nodes with multiple identities when compared to the benchmark scheme.

• Mass Spectrometry Letters
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• v.2 no.1
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• pp.1-7
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• 2011

China's rapid economic growth has resulted in significant environmental side effects. Therefore, China has been interested in reducing her dependence on foreign oil and gas by developing technologies needed for hydrogen, in addition to her increasing energy mix of nuclear and renewable energy form, such as solar and wind power. There are three isotopes of hydrogen, i.e. protium (P or H), deuterium (D), and tritium (T). Both deuterium and tritium are important materials in nuclear fuel cycle industry. Tritium is one of the critical radioactive nuclides. Planning for and implementing contamination control as a part of normal operation and maintenance activities is an important function in any hydrogen facility, especially tritium facility. The development of hydrogen isotopes analysis is the key issues in this area. Mass spectrometry (MS) with medium (about 600) and high resolution (> 1,400) is commercially available; however, the routine analysis of hydrogen isotopes is done with low-resolution MS (< 200) in China. This paper summarizes the progress of MS measurement technology for hydrogen isotope abundance in China, focusing on our lab's research program and technical status. An analyzing method has been introduced for accurate measurement of tritium abundance in the H.D.T system by low resolution MAT-253 MS. The quotient of compression ratio coefficient is determined by building up equipment for laboratory-scale preparation of secondary standard gases and by considering the difference in sensitivity between hydrogen isotopes. The results show that the measured value is reproducible within the relative error range of 0.8% for gas samples of different tritium abundance.

• Journal of KIISE:Software and Applications
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• v.33 no.2
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• pp.252-266
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• 2006

Many problems in computer vision are mainly based on mathematical models. Their optimal solutions can be found by estimating the parameters of each model. However, provided an input data set is involved outliers which are relative]V larger than normal noises, they lead to incorrect results. RANSAC is a representative robust algorithm which is used to resolve the problem. One major problem with RANSAC is that it needs priori knowledge(i.e. a percentage of outliers) of the distribution of data. To solve this problem, we propose a FRANSAC algorithm which improves the rejection rate of outliers and the accuracy of solutions. This is peformed by categorizing all data into good sample set, bad sample set and vague sample set using a fuzzy classification at each iteration and sampling in only good sample set. In the experimental results, we show that the performance of the proposed algorithm when it is applied to the linear regression and the calculation of a homography.

• Genomics & Informatics
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• v.7 no.2
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• pp.122-130
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• 2009

A systems biology approach for the identification of perturbed molecular functions is required to understand the complex progressive disease such as breast cancer. In this study, we analyze the microarray data with Gene Ontology terms of molecular functions to select perturbed molecular functional modules in breast cancer tissues based on the definition of Gene ontology Functional Code. The Gene Ontology is three structured vocabularies describing genes and its products in terms of their associated biological processes, cellular components and molecular functions. The Gene Ontology is hierarchically classified as a directed acyclic graph. However, it is difficult to visualize Gene Ontology as a directed tree since a Gene Ontology term may have more than one parent by providing multiple paths from the root. Therefore, we applied the definition of Gene Ontology codes by defining one or more GO code(s) to each GO term to visualize the hierarchical classification of GO terms as a network. The selected molecular functions could be considered as perturbed molecular functional modules that putatively contributes to the progression of disease. We evaluated the method by analyzing microarray dataset of breast cancer tissues; i.e., normal and invasive breast cancer tissues. Based on the integration approach, we selected several interesting perturbed molecular functions that are implicated in the progression of breast cancers. Moreover, these selected molecular functions include several known breast cancer-related genes. It is concluded from this study that the present strategy is capable of selecting perturbed molecular functions that putatively play roles in the progression of diseases and provides an improved interpretability of GO terms based on the definition of Gene Ontology codes.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.28 no.3
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• pp.234-238
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• 2002

Photodynamic therapy (PDT) is based on a photochemical reaction which is initiated by light activation of a photosensitizer. The photosensitizer accumulates more in tumor tissues than in normal tissues and is activated with specific wavelength of light, usually laser. The photochemical reaction produces highly reactive oxygen products causing cytotoxiciy and vascular shutdown to the tumor. The advantages of PDT are its relative selective tumor destruction and tissue healing by regeneration, which can maintain important structures with very good functional and esthetic results. Therefore, PDT is considered as an alternative modality for cancers of the head and neck. In this article, we will report three cases of photodynamic therapy for treatment of oral leukoplakia, squamous cell carcinoma, and basal cell carcinoma of head and neck. It was observed that premalignant and malignant lesions responded well to the photodynamic therapy with Aminolevulinic acid (ALA) and $Foscan^{(R)}$. Photodynamic therapy can be considered as a new treatment method for the premalignant and malignant tumors in Oral and Maxillofacial Surgery.