• Biomolecules & Therapeutics
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• v.26 no.1
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• pp.57-68
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• 2018

Nuclear factor E2-related factor 2 (NRF2) plays an important role in redox metabolism and antioxidant defense. Under normal conditions, NRF2 proteins are maintained at very low levels because of their ubiquitination and proteasomal degradation via binding to the kelch-like ECH associated protein 1 (KEAP1)-E3 ubiquitin ligase complex. However, oxidative and/or electrophilic stresses disrupt the KEAP1-NRF2 interaction, which leads to the accumulation and transactivation of NRF2. During recent decades, a growing body of evidence suggests that NRF2 is frequently activated in many types of cancer by multiple mechanisms, including the genetic mutations in the KEAP1-NRF2 pathway. This suggested that NRF2 inhibition is a promising strategy for cancer therapy. Recently, several NRF2 inhibitors have been reported with anti-tumor efficacy. Here, we review the mechanisms whereby NRF2 is dysregulated in cancer and its contribution to the tumor development and radiochemoresistance. In addition, among the NRF2 inhibitors reported so far, we summarize and discuss repurposed NRF2 inhibitors with their potential mechanisms and provide new insights to develop selective NRF2 inhibitors.

• Journal of The Korean Astronomical Society
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• v.43 no.5
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• pp.141-152
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• 2010

UBV I CCD photometry is obtained for the open clusters NGC 4609 and Hogg 15 in Crux. For NGC 4609, CCD data are presented for the first time. From new photometry we derive the reddening, distance modulus and age of each cluster - NGC 4609 : E(B-V ) = $0.37{\pm}0.03$, $V_0-M_V=10.60{\pm}0.08$, log $\tau$= 7.7 $\pm$ 0.1; Hogg 15 : E(B - V ) = 1.13 $\pm$ 0.11, $V_0-M_V$ = 12.50 $\pm$ 0.15, log $\tau$ $\lesssim$ 6.6. The young age of Hogg 15 strongly implies that WR 47 is a member of the cluster. We also determine the mass function of these clusters and obtain a slope $\Gamma$ = -1.2 ($\pm$0.3) for NGC 4609 which is normal and a somewhat shallow slope (${\Gamma}=-0.95{\pm}0.5$) for Hogg 15.

• The Bulletin of The Korean Astronomical Society
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• v.35 no.2
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• pp.73.1-73.1
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• 2010

Using the spectroscopic data secured with the Hamilton Echelle Spectrograph attached to a 3-m telescope at the Lick Observatory, we derived the expansion velocities from various line profiles in the 3600 $\AA$ to 10,000 $\AA$ based on the full width at half maximum and double peak of the high dispersion line profiles. The symmetrical shapes of the permitted line profiles indicate that the permitted line zone is symmetrical e.g., a spherical shell or bipolar + torus structures, which might be evidence of relatively recent ejection from the central star. Most other stronger forbidden lines might be coming from a main shell which appears as a bilateral symmetrical morphology, seen in HST and other ground-based telescopic images. The overall expansion velocities of this main shell structure that are responsible for most lines, seem to show the Hubble type expansion, i.e., accelerating shell. The faster expansion velocities of the permitted OII, NII, NIII and perhaps CII lines that do not suit to the Hubble type expansion, imply the existence of a somewhat smaller inner shell inside the outer main shell. We conclude that the nebular shell consists of a swiftly expanding inner shell and an outer normal shell excited by a central star of about 55,000K. The former compact zone appears to be responsible for the permitted C, N, and O lines while the latter extended shell appears to be responsible for H, He, and forbidden lines. We present some evidence that NGC 6833 be a member of the Galactic halo.

• Advances in materials Research
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• v.6 no.2
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• pp.155-168
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• 2017

The terrorist attacks and dangers by bomb blast have turned into an emerging issue throughout the world and the protection of the people and structures against terrorist acts depends on the prediction of the response of structures under blast and shock load. In this paper, behavior of aluminum and unidirectionally reinforced E-Glass Epoxy composite plates with and without focal circular holes subjected to shock loading has been identified. For isotropic and orthotropic plates (with and without holes) the classical normal mode approach has been utilized as a part of the processing of theoretical results. To obtain the accurate results, convergence of the results was considered and a number of modes were selected for plate with and without hole individually. Using a shock tube as a loading device, tests have been conducted to composite plates to verify the theoretical results. Moreover, peak dynamic strains, investigated by experiments are also compared with the theoretical values and deviation of the results are discussed accordingly. The strain-time histories are likewise indicated for a specific gauge area for aluminum and composite plates. Comparison of dynamic-amplification factors between the isotropic and the orthotropic plates with and without hole has been discussed.

• The Journal of Korean Medicine
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• v.23 no.4
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• pp.151-160
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• 2002

Background: Nowadays asthma is considered to be an inflammatory disease characterized by airway hyperresponsiveness and pulmonary eosinophilia. Production of cytokines by bronchial epithelial cells may contribution to the local accumulation of inflammatory cells in patients with bronchial asthma. In many recent studies molecular biological methods have been used to investigate the role of cytokines in pathogenesis and new therapeutic targets of asthma. Objectives: We aimed to identify the clinical effects of Chuongsangboha-tang and the effects of Chuongsangboha-tang on serum cytokines in asthmatic patients. Materials and Methods: The subjects consisted of 36 patients with asthma who had been treated with Chuongsangboha-tang for four weeks. Chuongsangboha-tang is an herbal decoction which has been used of the traditional therapeutic agent of asthma. PFT, Quality of Life Questionnaire for Adult Korean Asthmatics (QLQAKA), blood eosinophil, serum IgE, Serum IL-4, IL-5, IFN- were checked before and 4 weeks after treatments. Results: Treatment with Chuongsangboha-tang for four weeks resulted in significant increase in FEV1.0%, PEFR%, QLQAKA. The blood eosinophil, serum IgE, IL-4 and IL-5 in asthmatic patients increased significantly compared to the normal control group, while the serum IFN-decreased significantly. Conclusions: This study shows that Chuongsangboha-tang has effects on improvement of pulmonary function and quality of life in asthmatic patients. Obviously, further research concerning this is still necessary.

• Asian-Australasian Journal of Animal Sciences
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• v.5 no.1
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• pp.45-49
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• 1992

Bovine drumstick of neutrophil leucocytes was studied on the quantitative and morphological characteristics and was evaluated as a diagnostic measure for bovine freemartin in newborn calves. Nuclear area of neutrophil (A, ${\mu}m^2$) and drumstick area (B, ${\mu}m^2$) were significantly correlated with average diameter of drumstick (ADD, ${\mu}m$) and following regression equations were obtained : $A=45({\pm}3)$ ADD-8, r = 0.74, $s.e.{\pm}0.6$, p < 0.01, $B=1.72({\pm}0.05)$ ADD-0.98, r = 0.93, $s.e.{\pm}0.1$, p < 0.01 Eight female siblings of heterosexual multiplets were diagnosed as freemartin from the results of chromosome analysis. Heterosexual multiplets had a very low frequency of drumstick in the nucleus of neutrophils irrespective of genetic sex. Diameters of drumstick fund in freemartin and male cotwin did not differ from those of normal cows. Examinations of drumstick in 800 neutrophils for both female and male siblings are concluded to be the best way to aid the detection of freemartinism of heterosexual twins at early life.

• Journal of the Korean Society of Clothing and Textiles
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• v.14 no.4 s.36
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• pp.292-304
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• 1990

The surface change of upperarm and shoulder blade area are caused by the extensive upper limb movement, thus it is necessary to measure the amount of change for constructing the clothing. Moire photography was taken after plastic casters of upperarm and shoulder blade area was prepared. 1. For the shoulder blade area, subjects showed the same change of surface area for the various limb positions, wherease, for the upperarm only at the $0^{\circ}\;and\;180^{\circ}$ limb position, same change was observed. 2. As the movement of the upperarm was increased, surface area of axillary part was increased and that of shoulder part was decreased. 3. To make a bodice pattern, the minimum size of the back with the ease were $\frac{B}{4}$+3.13 cm R for normal wear and $\frac{B}{4}$+5.75 cm for active wear. 4. As the movement of the arm was increased, the cross section for the upperarm were changed to elliptical shape. 5. For each horizontal basic line, there was a positive correlation between the amount of change of shoulder blad area and that of upperarm area.

• Journal of the Korean Vacuum Society
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• v.18 no.5
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• pp.394-401
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• 2009

This paper reports the structural and optical properties of ZnO/glass thin films grown by radio-frequency magnetron sputtering with a powder target. In contrast to ZnO ceramic target typically used, a ZnO raw powder target was sputtered in this study. ZnO grew with the (0002) preferred orientation along the surface normal direction. Initially, the surface of ZnO thin films was flat considerably and then it became rougher as the thickness increased. The optical transmittance was as high as 88% in the range of 400-1000 nm. The bandgap energy of 3.23 eV at the 220 nm thick sample was estimated.

• Korean Journal of Materials Research
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• v.13 no.6
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• pp.398-403
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• 2003

Shallow $p^{＋}$ n junction was formed using a ULE(ultra low energy) implanter. Deactivation phenomena were investigated for the shallow source/drain junction based on measurements of post-annealing time and temperature following the rapid thermal annealing(RTA) treatments. We found that deactivation kinetics has two regimes such that the amount of deactivation increases exponentially with annealing temperature up to $850^{\circ}C$ and that it decreases linearly with the annealing temperature beyond that temperature. We believe that the first regime is kinetically limited while the second one is thermodynamically limited. We also observed "transient enhanced deactivation", an anomalous increase in sheet resistance during the early stage of annealing at temperatures higher than X$/^{\circ}C$. Activation energy for transient enhanced deactivation was measured to be 1.75-1.87 eV range, while that for normal deactivation was found to be between 3.49-3.69 eV.

• Journal of Biomedical Engineering Research
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• v.16 no.4
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• pp.447-456
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• 1995

As a part of electro-mechanical totally implantable artificial heart (TIAH) program, a transcut- aneous energy transmission system has been developed. By mutual magnetic induction between the first coil on the skin and the subcutaneously implanted second coil, the system transfers elctrical power through the skin. This research aimed at minimizing the size of the implanted part as well as maximizing the transfer efficiency. Using class I amplifier, we achieved above 75% power transfer efficiency at average 40W power transfer level which is required for normal TIAH operation. In vivo performance of the developed system and bio-compatibility of the material used in Implanted parts were evaluated through animal experiments.