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Immunomodulatory Effects of β-1,3/1,6-glucan and Lactobacillus plantarum LM1004 on Atopic Dermatitis Models (아토피 피부염 모델에 대한 β-1,3/1,6-glucan과 Lactobacillus plantarum LM1004의 면역 조절 효과)

  • Kim, In Sung;Kim, Sung Hak;Kim, Jeong A;Yu, Da Yoon;Kim, Gwang Il;Park, Dong-Chan;Lim, Jong Min;Lee, Sang Suk;Choi, In Soon;Cho, Kwang Keun
    • Journal of Life Science
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    • v.28 no.1
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    • pp.17-25
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    • 2018
  • In this study, we examined the efficacy of the immune regulation of ${\beta}$-1,3/1,6-glucan and Lactobacillus plantarum LM1004 on atopic dermatitis models. The oral administration of ${\beta}$-1,3/1,6-glucan and L. plantarum LM1004 on mice significantly decreased the amount of scratching, leakage to evans blue, and concentrations of serum immunoglobulin E (IgE) and histamine compared with the atopic dermatitis - induced group. When atopic dermatitis was induced, the transcription factors (GATA-3, retinoic acid-related orphan receptor ${\gamma}$ T [$ROR{\gamma}T$]) and cytokines (interleukin-4 [IL-4], IL-17) of Th2 and Th17 cells were overexpressed at the transcriptional level, and they significantly decreased with oral administration of ${\beta}$-1,3/1,6-glucan and L. plantarum LM1004. In addition, ${\beta}$-1,3/1,6-glucan and L. plantarum LM1004 were shown to modulate the immune balance by increasing the expression of Th1 and Treg transcription (T-bet, forkhead box p3 [Foxp3]) and cytokines (interferon-${\gamma}$ [IFN-${\gamma}$], transforming growth factor-${\beta}$ [TGF-${\beta}$]). Galectin-9 and filaggrin were significantly lower in the atopic dermatitis - induced group and significantly higher in the ${\beta}$-1,3/1,6-glucan-treated group. In contrast, thymic stromal lymphopoietin (TSLP) was highest in the atopic dermatitis-induced group, while mice that were orally administered ${\beta}$-1,3/1,6-glucan and L. plantarum LM1004 showed similar TSLP levels to the control group. These results indicate that ${\beta}$-1,3/1,6-glucan and L. plantarum LM1004 have immunomodulatory effects and atopic dermatitis improvement effects in an animal model of atopic dermatitis. Therefore, it is expected that ${\beta}$-1,3/1,6-glucan and L. plantarum LM1004 can be used as natural materials in the treatment of atopic dermatitis.

Assessment of Permissible Inflow Load for Water Quality Management in Yeoja Bay, Korea (여자만의 수질관리를 위한 허용유입부하량 산정)

  • Kim, Hyung-Chul;Lee, Won-Chan;Kim, Jong-Gu;Hong, Sok-Jin;Kim, Kyoung-Mi;Cho, Yoon-Sik;Park, Sung-Eun;Kim, Jin-Ho
    • Journal of the Korean Society of Marine Environment & Safety
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    • v.17 no.4
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    • pp.345-356
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    • 2011
  • Based on the consideration of land based pollutant discharges from the basin and seawater quality related carrying capacity and the seawater quality improvement in receiving water bodies of Yeoja Bay where eutrophication and organic pollution are in progress, were evaluated. The permissible inflow loads of BOD, TN and TP by using the geographical features and box modelling method were estimated. As results, it is shown that the reduction rate of discharged BOD and TP loads were 39.3% and 30.8 %, respectively, however, 6.9% was estimated for TN. According to the pollutant loading in each tributary and generated load of the basin, it is given much weight on the land use group, and also was shown in discharged load estimation. This suggests that it is important to control nonpoint source pollutant such as livestock and land use groups as well as point source to contribute the proposition of the water quality improvement plan according to the characteristics of the bay.

On the Source Identification by Using the Sound Intensity Technique in the Radiated Acoustic Field from Complicated Vibro-acoustic Sources (음향 인텐시티 기법을 이용한 복잡한 진동-음향계의 방사 음장에 대한 음원 탐색에 관하여)

  • 강승천;이정권
    • The Journal of the Acoustical Society of Korea
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    • v.21 no.8
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    • pp.708-718
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    • 2002
  • In this paper, the problems in identifying the noise sources by using the sound intensity technique are dealt with for the general radiated near-field from vibro-acoustic sources. For this purpose, a three-dimensional model structure resembling the engine room of a car or heavy equipment is considered. Similar to the practical situations, the model contains many mutually coherent and incoherent noise sources distributed on the complicated surfaces. The sources are located on the narrow, connected, reflecting planes constructed with rigid boxes, of which a small clearance exists between the whole box structure and the reflecting bottom. The acoustic boundary element method is employed to calculate the acoustic intensity at the near-field surfaces and interior spaces. The effects of relative source phases, frequencies, and locations are investigated, from which the results are illustrated by the contour map, vector plot, and energy streamlines. It is clearly observed that the application of sound intensity technique to the reactive or reverberant field, e.g., scanning over the upper engine room as is usually practiced, can yield the detection of fake sources. For the precise result for such a field, the field reactivity should be checked a priori and the proper effort should be directed to reduce or improve the reactivity of sound field.

GLAD법으로 증착한 Smart window용 WO3와 TiO2의 전기변색적 특성 비교

  • Kim, Seong-Han;Song, Pung-Geun
    • Proceedings of the Korean Vacuum Society Conference
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    • 2015.08a
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    • pp.198-198
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    • 2015
  • 전기변색재료는 전압을 인가하였을 때 전계방향에 따라 가역적으로 색이 변화하는 재료를 말한다. 스마트윈도우용 전기 변색재료는 지속적으로 전기를 가해줄 필요 없이 한번 변색되면 색이 지속되는 특징을 가지므로 에너지 효율적으로 우수하여 태양열 차단 창호나 디스플레이 분야에 응용될 것으로 기대된다. 이러한 전기 변색재료에는 산화형 전기 변색 재료, 환원형 전기 변색 재료가 있는데 이중 가장 널리 연구되고 있는 재료는 환원형 전기변색재료이다. 대표적인 재료로 $WO_3$가 쓰이는 데 이는 전기 변색적 특성이 우수하고 또한 내구성이 다른 재료에 비해 우수하다는 장점 때문이다. 그러나, 상용화를 위해서는 내구성의 개선이 요구되고 있다. 한편, $TiO_2$는 안정성이 매우 뛰어나지만 전기변색적 특성이 $WO_3$에 비해 낮은 점이 지적되고 있다. 이러한 $WO_3$$TiO_2$ 박막은 스퍼터링 또는 sol-gel법 등으로 제작되고 있는데, 일반적으로 스퍼터링의 경우 치밀한 박막이 형성되기 때문에 Porous 한 박막을 얻기 힘들다. 따라서 본 연구에서는 기판에 입사하는 스퍼터 입자들의 각도를 조절하여 shadowing 효과로 인해 박막의 구조가 porous해지는 Glancing angle deposition을 도입하였다. 이러한 증착법을 이용하여 $WO_3$$TiO_2$를 각도를 조절하여 증착하고 $TiO_2$$WO_3$ 박막의 특성을 비교하여 본다. 두께 300 nm를 가지는 $WO_3$$TiO_2$ 박막은 GLAD RF 마그네트론 스퍼터링법을 이용하여 Corning glass(corning E-2000)기판 위에 증착하였다. 기판 입사 각도는 $0^{\circ}$, $30^{\circ}$, $45^{\circ}$, $60^{\circ}$로 증착하였고 직경 3 in의 $TiO_2$, $WO_3$ 타겟을 사용하였다. 또한 스퍼터링 파워는 400 W, 작업압력 1.0 Pa, 그리고 스퍼터링 가스는 O2/Ar+O2 유량 10%에서 30%로 증착을 상온에서 진행하였다. 전기화학적 특성을 평가하기 위하여 $TiO_2$$WO_3$ 박막을 100 nm 두께의 ITO/glass 위에서 증착하였다. 박막의 미세구조는 XRD와 SEM을 통해 확인하였고, 전기화학적 특성은 Ar 분위기의 Glove box안에서 parstat 2273을 통해 측정하였다. 전해질은 1 M $LiPF_6/PC$로 진행하였고, 대향 전극는 Pt전극을, 참고 전극은 칼로멜 전극을 사용하였다. Potential 범위는 2 V에서 4 V로 진행하였고, scan rate는 50 mV/s로 측정하였다. 투과도는 UV/VIS spectrometer로 측정하였다. 전기변색 특성의 상관관계 및 에 대해서는 학회 당일 발표할 예정이다.

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New Gain Function Based on Attenuation Characteristics of Ballast Track for GPR Analysis (GPR 분석을 위한 자갈궤도 자갈의 감쇄특성을 이용한 이득함수 개발)

  • Shin, Jihoon;Choi, Yeongtae;Jang, SeungYup
    • Journal of the Korean GEO-environmental Society
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    • v.18 no.4
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    • pp.13-21
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    • 2017
  • Ballasted track has been used as track system for more than 100 years. Ballasted track has advantages of low construction cost, flexible maintenance, low noise and vibration, and so on. However, ballasted track leads to continuous settlement which causes maintenance. Recently, increase in speed, traffic volume, and weight of train requires more frequent maintenance. Fouling, well-known phenomenon of accumulation of fine materials due to intrusion of subgrade and breakage of ballast materials, expedites the settlement (i.e., irregular settlement) of track. Ground Penetrating Radar (GPR) can be one of non-destructive tools that can evaluate fouling level of ballast. In this paper, a gain function based on the attenuation characteristics of ballast material is suggested in conjunction with Hilbert transform. Lab box tests and full-scale tests indicate that the suggested method reasonably classifies clean, fouled layers, and subgrade. However, additional study to eliminate effect of sleeper and to include the scattering features of the electromagnetic wave in ballast voids should be required in order to enhance the accuracy.

Ultrastructure of the Eyes of Menemerus fulvus (Araneae: Salticidae) (흰수염깡충거미(Menemerus fulvus) (거미목, 깡충거미과)시각기의 미세구조)

  • 김주필;권중균
    • The Korean Journal of Soil Zoology
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    • v.5 no.2
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    • pp.101-112
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    • 2000
  • Spiders usually have poor vision but not the jumping spiders. Their eight eyes are located on its distinctive box-shaped head and relatively well developed. The Spiders were fixated with 3% glutaraldehyde and thin section was performed with ultra-microtome. The specimens were observed with light microscopy, transmission and scanning electron microscopy. Eye area of jumping spider is competed of three rows. The first eye row comprise four eyes. Among them, two anterior median eyes are the largest and two anterior lateral eyes are relatively small. The former are main-eyes and have excellent vision. The second row, which has the two smallest eyes, is located about midway between the first and third rows. The third row is about half-way back on the thorax and eyed of which are middle size. To investigate ultrastructure of salticid spiders'eye, Menemerus fulvus was chosen. All of Menemerus fuvus's eyes are composed of cornea, lens, vitreous body and retina in histologically. Cornea layer, linked to exocuticle of exoskeleton. is regular layer structure without any cell tripe. Lenses are biconvex type. Retinas comprise well developed microvilli-shape rhabdomeres, unpigmented supporting cells, and pigmented cell. Retinas of anterior median eyes are surrounded by circular cylinder-shaped vitreous body, photoreceptor, i.e. rhabdomeres, of it is irregularly arranged compared to the other eyes.

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Effect of Annealing in a Nitrogen Atmosphere on the Properties of In2O3 Films Deposited with RF Magnetron Sputtering (RF 마그네트론 스퍼터로 증착된 In2O3 박막의 질소분위기 열처리에 따른 특성변화)

  • Kong, Young-Min;Lee, Young-Jin;Heo, Sung-Bo;Lee, Hak-Min;Seo, Min-Su;Kim, Yu-Sung;Kim, Dae-Il
    • Korean Journal of Materials Research
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    • v.22 no.1
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    • pp.24-28
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    • 2012
  • $In_2O_3$ films were deposited by RF magnetron sputtering on a glass substrate and then the effect of post deposition annealing in nitrogen atmosphere on the structural, optical and electrical properties of the films was investigated. After deposition, the annealing process was conducted for 30 minutes at 200 and $400^{\circ}C$. XRD pattern analysis showed that the as deposited films were amorphous. When the annealing temperature reached 200-$400^{\circ}C$, the intensities of the $In_2O_3$ (222) major peak increased and the full width at half maximum (FWHM) of the $In_2O_3$ (222) peak decreased due to the crystallization. The films annealed at $400^{\circ}C$ showed a grain size of 28 nm, which was larger than that of the as deposited amorphous films. The optical transmittance in the visible wavelength region also increased, while the electrical sheet resistance decreased. In this study, the films annealed at $400^{\circ}C$ showed the highest optical transmittance of 76% and also showed the lowest sheet resistance of $89{\Omega}/\Box$. The figure of merit reached a maximum of $7.2{\times}10^{-4}{\Omega}^{-1}$ for the films annealed at $400^{\circ}C$. The effect of the annealing on the work-function of $In_2O_3$ films was considered. The work-function obtained from annealed films at $400^{\circ}C$ was 7.0eV. Thus, the annealed $In_2O_3$ films are an alternative to ITO films for use as transparent anodes in OLEDs.

Stray Light Analysis of a Compact Imaging Spectrometer for a Microsatellite STSAT-3 (과학기술위성3호 부탑재체 소형영상분광기 미광 해석)

  • Lee, Jin Ah;Lee, Jun Ho
    • Korean Journal of Optics and Photonics
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    • v.23 no.4
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    • pp.167-171
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    • 2012
  • This paper reports on the stray light analysis results of a compact imaging spectrometer (COMIS) for a microsatellite STSAT-3. COMIS images Earth's surface and atmosphere with ground sampling distances of 27 m at the 18~62 spectral bands (0.4 ~ 1.05 ${\mu}m$) for the nadir looking at an altitude of 700 km. COMIS has an imaging telescope and an imaging spectrometer box into which three electronics PCBs are embedded. The telescope images a $27m{\times}28km$ area of Earth surface onto a slit of dimensions $11.8{\mu}m{\times}12.1mm$. This corresponds to a ground sampling distance of 27 m and a swath width of 28 km for nadir looking posture at an altitude of 700 km. Then the optics relays and disperses the slit image onto the detector thereby producing a monochrome image of the entrance slit formed on each row of detector elements. The spectrum of each point in the row is imaged along a detector column. The optical mounts and housing structures are designed in order to prevent stray light from arriving onto the image and so deteriorating the signal to noise ratio (SNR). The stray light analysis, performed by a non-sequential ray tracing software (LightTools) with three dimensional housing and lens modeling, confirms that the ghost and stray light arriving at the detector plane has the relative intensity of ${\sim}10^{-5}$ and furthermore it locates outside the concerned image size i.e. the field of view of the optics.

Evaluation of Static Strength of Group Stud Shear Connection in Precast Concrete Deck Bridges (프리캐스트 콘크리트 바닥판 교량의 그룹 스터드 전단연결부 강도평가)

  • Shim, Chang Su;Jeon, Seung Min;Kim, Dong Wook
    • Journal of Korean Society of Steel Construction
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    • v.20 no.2
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    • pp.333-345
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    • 2008
  • concrete deck bridges are increasingly aplied to twin- girder bridges and open-stel box girder bridges.One of the most dificult isues in the design of shear conect ors is the mater of achieving ful composite action. Many connectors in smal area require a significant section los of precast decks resulting in difficult reinforcement details. In this closer spacing than the required minimum spacing in the design codes was evaluated through static tests. Test results s howed that the ultimate strength decreased as the conector spacing was reduced. The strength enhancement was observed due to aditional reinforcement for precast slabs or for shear pockets. Thus, the design of group stud shear connection needs to anticipate failure modes and the conector failure should be induced. Based on the test results, an empirical equation consi dering stud spacing was proposed to evaluate the ultimate strength of group stud shear conection. Fatigue tests showed n o reduction in fatigue life of the group stud shear conection in the range of this research. Details of the precast decks wer e enhanced using the findings of the study.

Interpolation and Reconstruction of the Holocene Sea-levels Using Inverse Fractal Interpolation functions (프랙탈 내삽함수 역산법을 이용한 홀로세 해수면의 내삽 및 재구성)

  • CHUNG, SANG YONG;KIM, DAE CHOUL;YI, HI-IL
    • 한국해양학회지
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    • v.29 no.3
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    • pp.228-238
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    • 1994
  • The change of sea-level is a good indicator of the change of climate during the Quaternary period. The sea-levels in the world have been changing very irregularly during that time. The pattern of the Quaternary sea-level change was assumed to be a stochastic fractal in this study. We measured fractal dimensions of the Holocene sea-levels of the Hudson river estuary and the Delaware coast. A box counting method gave almost the same values. i.e., D=1.358 for the Hudson sea-level changes and D+1.346 for the Delaware sea-level changes. the ability of the inverse method of fractal interposea-levels. IFIF reproduction the realistic sea-levels for the both of them. The delaware sea-level data made less statistical errors for the interpolation of IFIF than the Hudson and the Delaware sea-levels. IFIF reproduction the realistic sea-levels for the both of them. The Delaware sea-level data made less statistical errors for the interpolation of IFIF than the Hudson sea-level data. This suggests that the Delaware sea-level data are more reliable than the Hudson sea-level data was calculated from the fractal dimension of the Delaware sea-level data. Fractal interpolation functions (FIF) was used to reconstruct the peleosea-levels of the Korean coasts and the Atlantic Ocean coasts of the United States. The Korean Peleosea-level change generacted by FIF is different from the peleosea-level change of the eastern U.S.. The Korean peleosea-levels are much higher than the eastern U.S. Paleosea-levels, comparing to each other from the present to 8,000 BP.

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