• 천문학회보
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• 제45권1호
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• pp.38.2-38.2
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• 2020

Horizon Run 5 (HR5) is a cosmological hydrodynamical simulation which captures the properties of the Universe on a Gpc scale while achieving a resolution of 1 kpc. This enormous dynamic range allows us to simultaneously capture the physics of the cosmic web on very large scales and account for the formation and evolution of dwarf galaxies on much smaller scales. Inside the simulation box. we zoom-in on a high-resolution cuboid region with a volume of 1049 × 114 × 114 Mpc3. The subgrid physics chosen to model galaxy formation includes radiative heating/cooling, reionization, star formation, supernova feedback, chemical evolution tracking the enrichment of oxygen and iron, the growth of supermassive black holes and feedback from active galactic nuclei (AGN) in the form of a dual jet-heating mode. For this simulation we implemented a hybrid MPI-OpenMP version of the RAMSES code, specifically targeted for modern many-core many thread parallel architectures. For the post-processing, we extended the Friends-of-Friend (FoF) algorithm and developed a new galaxy finder to analyse the large outputs of HR5. The simulation successfully reproduces many observations, such as the cosmic star formation history, connectivity of galaxy distribution and stellar mass functions. The simulation also indicates that hydrodynamical effects on small scales impact galaxy clustering up to very large scales near and beyond the baryonic acoustic oscillation (BAO) scale. Hence, caution should be taken when using that scale as a cosmic standard ruler: one needs to carefully understand the corresponding biases. The simulation is expected to be an invaluable asset for the interpretation of upcoming deep surveys of the Universe.

• Structural Engineering and Mechanics
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• 제88권2호
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• pp.141-157
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• 2023

In the present paper, the effect of recycled aggregates on the rheological and mechanical properties of self-consolidating concrete is investigated experimentally and numerically. Hence, the specimen with two types of recycled aggregates, i.e., known and unknown resistance origins, are utilized for the studied specimens. The experiments in this study are designed using the Box-Behnken method, which is one of the response surface methods. Input variables in mixtures include silica fume in the range of 5-15% as a percentage substitute for cement weight and recycled coarse and fine aggregates in the range of 0-50% for both series of recycled materials as a substitute for natural materials. The studied responses are slump flow, V funnel, compressive strength, tensile strength, and durability. The results indicate that the increase in the amount of recycled aggregates reduces the rheological and mechanical properties of the mixtures, while silica fume effectively improves the mechanical properties. In addition, the results demonstrate that the fine recycled aggregates affect the total response of the concrete significantly. The results of tensile and compressive strengths indicate that the mixtures including 50% recycled materials with known resistance origin demonstrate better responses up to 8 and 10% compared to the materials with unknown resistance origins, respectively. Recycled materials with a specific resistance origin also show better results than recycled materials with an unknown resistance origin. Durability test results represent those concretes containing recycled coarse aggregates have lower strength compared to recycled fine aggregates. Also, a series of mathematical relationships for all the responses are presented using variance analysis to predict mixtures' rheological and mechanical properties.

• 한국축산식품학회지
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• 제44권1호
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• pp.132-145
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• 2024

Sarcopenia, the age-related muscle atrophy, is a serious concern as it is associated with frailty, reduced physical functions, and increased mortality risk. Protein supplementation is essential for preserving muscle mass, and horse meat can be an excellent source of proteins. Since sarcopenia occurs under conditions of oxidative stress, this study aimed to investigate the potential anti-muscle atrophy effect of horse meat hydrolysate using C2C12 cells. A horse meat hydrolysate less than 3 kDa (A4<3kDa) significantly increased the viability of C2C12 myoblasts against H₂O₂-induced cytotoxicity. Exposure of C2C12 myoblasts to lipopolysaccharide led to an elevation of cellular reactive oxygen species levels and mRNA expression of proinflammatory cytokines, including tumor necrosis factor-α and interleukin 6, and these effects were attenuated by A4<3kDa treatment. Additionally, A4<3kDa activated protein synthesis-related proteins through the protein kinase B/mechanistic target of rapamycin pathway, while decreasing the expression of activity and degradation-related proteins, such as Forkhead box O3, muscle RING finger protein-1, and Atrogin-1 in dexamethasone-treated C2C12 myotubes. Therefore, the natural material A4<3kDa has the potential of protecting against muscle atrophy, while further in vivo study is needed.

• IMMUNE NETWORK
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• 제22권3호
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• pp.21.1-21.21
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• 2022

As far the current severe coronavirus disease 2019 (COVID-19), respiratory disease is still the biggest threat to human health. In addition, infectious respiratory diseases are particularly prominent. In addition to killing and clearing the infection pathogen directly, regulating the immune responses against the pathogens is also an important therapeutic modality. Sirtuins belong to NAD+-dependent class III histone deacetylases. Among 7 types of sirtuins, silent information regulator type-1 (SIRT1) played a multitasking role in modulating a wide range of physiological processes, including oxidative stress, inflammation, cell apoptosis, autophagy, antibacterial and antiviral functions. It showed a critical effect in regulating immune responses by deacetylation modification, especially through high-mobility group box 1 (HMGB1), a core molecule regulating the immune system. SIRT1 was associated with many respiratory diseases, including COVID-19 infection, bacterial pneumonia, tuberculosis, and so on. Here, we reviewed the latest research progress regarding the effects of SIRT1 on immune system in respiratory diseases. First, the structure and catalytic characteristics of SIRT1 were introduced. Next, the roles of SIRT1, and the mechanisms underlying the immune regulatory effect through HMGB1, as well as the specific activators/inhibitors of SIRT1, were elaborated. Finally, the multitasking roles of SIRT1 in several respiratory diseases were discussed separately. Taken together, this review implied that SIRT1 could serve as a promising specific therapeutic target for the treatment of respiratory diseases.

• IMMUNE NETWORK
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• 제20권5호
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• pp.36.1-36.13
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• 2020

Hippo signaling pathways are evolutionarily conserved signal transduction mechanisms mainly involved in organ size control, tissue regeneration, and tumor suppression. However, in mammals, the primary role of Hippo signaling seems to be regulation of immunity. As such, humans with null mutations in STK4 (mammalian homologue of Drosophila Hippo; also known as MST1) suffer from recurrent infections and autoimmune symptoms. Although dysregulated T cell homeostasis and functions have been identified in MST1-deficient human patients and mouse models, detailed cellular and molecular bases of the immune dysfunction remain to be elucidated. Although the canonical Hippo signaling pathway involves transcriptional co-activator Yes-associated protein (YAP) or transcriptional coactivator with PDZ motif (TAZ), the major Hippo downstream signaling pathways in T cells are YAP/TAZ-independent and they widely differ between T cell subsets. Here we will review Hippo signaling mechanisms in T cell immunity and describe their implications for immune defects found in MST1-deficient patients and animals. Further, we propose that mutual inhibition of Mst and Akt kinases and their opposing roles on the stability and function of forkhead box O and β-catenin may explain various immune defects discovered in mutant mice lacking Hippo signaling components. Understanding these diverse Hippo signaling pathways and their interplay with other evolutionarily-conserved signaling components in T cells may uncover molecular targets relevant to vaccination, autoimmune diseases, and cancer immunotherapies.

• Smart Structures and Systems
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• 제33권3호
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• pp.189-199
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• 2024

To properly extract the strain components under varying operational conditions is very important in bridge health monitoring. The abnormal sensor readings can be correctly identified and the expected operational performance of the bridge can be better understood if each strain components can be accurately quantified. In this study, strain components under varying load conditions, i.e., temperature variation and live-load variation are evaluated based on field strain measurements collected from a real concrete box-girder bridge. Temperature-induced strain is mainly regarded as the trend variation along with the ambient temperature, thus a smoothing technique based on the wavelet packet decomposition method is proposed to estimate the temperature-induced strain. However, how to effectively extract the vehicle-induced strain is always troublesome because conventional threshold setting-based methods cease to function: if the threshold is set too large, the minor response will be ignored, and if too small, noise will be introduced. Therefore, an autoencoder framework is proposed to evaluate the vehicle-induced strain. After the elimination of temperature and vehicle-induced strain, the left of which, defined as the model error, is used to assess the operational performance of the bridge. As empirical techniques fail to detect the degraded state of the structure, a clustering technique based on Gaussian Mixture Model is employed to identify the damage occurrence and the validity is verified in a simulation study.

• 지능정보연구
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• 제20권4호
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• pp.155-169
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• 2014

다양한 빅데이터 기술이 발전함에 따라, 기업의 전략결정에 있어서 과거에는 의사결정자의 직관이나 경험에 의존하는 경향이 있었다면, 현재는 데이터를 활용한 과학적이고 분석적인 접근이 이루어지고 있다. 이에 많은 기업들이 경영정보시스템 중의 하나인 비즈니스 인텔리전스 (Business Intelligence) 시스템의 예측분석 기능을 활용하고 있다. 하지만, 이러한 시스템이 미래의 경영환경 변화를 예측하고 기업의 의사결정을 돕는 조언자 (Advisor)로서 역할을 한다고 가정할 때, 시스템에서 제공하는 분석결과가 의사결정자에게 도움을 주는 조언 (Advice) 의 역할을 하지 못하는 경우가 많은 실정이다. 따라서, 본 연구에서는 미래예측의 문제에 있어 의사결정자가 시스템의 조언을 따르는데 영향을 미치는 요소들과 영향력에 대해 분석하고, 그 결과를 바탕으로 데이터 기반의 의사결정을 보다 적극적으로 지원하는 시스템 환경을 제시하고자 한다. 좀 더 구체적으로는 예측 과정에 대한 자세한 설명이나 근거 제시가 시스템의 예측결과에 대한 의사결정자의 수용정도에 미치는 영향을 연구하였다. 이를 위하여 193명의 실험자를 대상으로 영화의 개봉 주 매출액을 예측하는 업무를 수행하고, 예측에 대한 설명의 길이와 조언자의 유형(사람과 시스템의 조언 비교)뿐 아니라 의사결정자의 개인 특성이 의사결정자의 조언 수용정도에 미치는 영향을 분석하였다. 시스템에서 제공하는 조언 내용인 예측결과와 설명에 대해 의사결정가가 느끼는 유용성, 신뢰성, 만족도가 조언의 수용에 미치는 영향도 분석하였다. 본 연구는 시스템의 분석결과를 조언으로 보고 조언자와 조언에 관한 의사결정학 분야의 선행연구를 접목시켜 경영정보시스템 연구 분야를 확장하였다는 점에서 연구의 의의가 있고, 실무적으로도 데이터 기반의 의사결정을 보다 적극적으로 지원할 수 있는 시스템 환경을 만들기 위해서 고려해야 할 점들을 제시함으로써 시스템 활용을 위한 정책결정에도 도움을 줄 수 있을 것으로 본다.

• 한국전자거래학회지
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• 제19권3호
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• pp.125-141
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• 2014

인터넷에서 매 순간 발생하는 데이터의 홍수는 사용자가 필요로 하는 유용한 정보를 검색하는데 어려움을 초래한다. 그래서 많은 사용자들이 자신이 원하는 정보를 쉽게 찾기 위한 기법을 고안하고 이를 지원하는 도구를 개발하게 되었다. 이런 유용한 도구 중 하나인 추천시스템은 기존의 사용자 정보를 분석하여 사용자가 원하는 제품이나 정보를 추천하는 것이다. 본 논문에서는 추천시스템을 활용하여 원하는 정보를 제안하는데 인구통계학적인 기법을 사용한다. 인구통계학 기반 추천시스템은 나이, 성별과 같은 인구통계학적인 특성을 사용하여 유용한 정보를 추출한다. 본 연구는 영화 선택 시 중요한 요소인 사용자 평점을 분석하고 이를 활용할 수 있는 방법을 제시하였다. 이를 위해 Internet Movie Database(IMDB) 웹 사이트에 있는 영화의 사용자 평점을 인구통계학적 요인으로 분석하였다. 본 논문에서는 인구통계학적 분석을 위해 사용자를 성별과 연령대로 분류하였고, 각 영화를 22개 장르로 나눈 IMDB 기준에 따라 사용자 평점을 분석하였다. 각 장르별 영화에 대해 사용자 그룹의 평균 평점을 F-테스트와 T-테스트를 수행하여 그 장르 영화 평점과 동일한 결과를 나타내는 대표 그룹을 찾아내었다. 인구통계학적 분석 결과인 대표 그룹은 새로운 영화가 개봉될 때 대표 그룹에 대한 프로모션과 추천을 통해 영화 홍보를 할 수 있는 대상을 찾아내는데 유용하다.

• Biomolecules & Therapeutics
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• 제28권6호
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• pp.561-568
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• 2020

We examined the anticancer effects of a novel sirtuin inhibitor, MHY2256, on HCT116 human colorectal cancer cells to investigate its underlying molecular mechanisms. MHY2256 significantly suppressed the activity of sirtuin 1 and expression levels of sirtuin 1/2 and stimulated acetylation of forkhead box O1, which is a target protein of sirtuin 1. Treatment with MHY2256 inhibited the growth of the HCT116 (TP53 wild-type), HT-29 (TP53 mutant), and DLD-1 (TP53 mutant) human colorectal cancer cell lines. In addition, MHY2256 induced G0/G1 phase arrest of the cell cycle progression, which was accompanied by the reduction of cyclin D1 and cyclin E and the decrease of cyclin-dependent kinase 2, cyclin-dependent kinase 4, cyclin-dependent kinase 6, phosphorylated retinoblastoma protein, and E2F transcription factor 1. Apoptosis induction was shown by DNA fragmentation and increase in late apoptosis, which were detected using flow cytometric analysis. MHY2256 downregulated expression levels of procaspase-8, -9, and -3 and led to subsequent poly(ADP-ribose) polymerase cleavage. MHY2256-induced apoptosis was involved in the activation of caspase-8, -9, and -3 and was prevented by pretreatment with Z-VAD-FMK, a pan-caspase inhibitor. Furthermore, the autophagic effects of MHY2256 were observed as cytoplasmic vacuolation, green fluorescent protein-light-chain 3 punctate dots, accumulation of acidic vesicular organelles, and upregulated expression level of light-chain 3-II. Taken together, these results suggest that MHY2256 could be a potential novel sirtuin inhibitor for the chemoprevention or treatment of colorectal cancer or both.

• 디지털콘텐츠학회 논문지
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• 제15권4호
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• pp.481-489
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• 2014

본 논문에서는 차단전력문턱치에 의해 대기전력을 감소시키는 자동대기전력 차단콘센트를 구현하였다. 여기서 대기전력은 사용하고 있지 않은 전자제품에 콘센트가 꽂아져 있는 경우, 흐르는 전력을 뜻한다. 제안한 콘센트의 경우 PC(Personal Computer)나 모바일 폰과 같은 스마트 기기로 실시간 전력량을 확인 할 수 있을 뿐만 아니라 차단전력문턱치를 직접 제어할 수 있기 때문에 어떤 전자기기든 각 대기 전력에 맞게 차단전력문턱치를 설정하여 확실하게 대기전력을 차단할 수 있다. 소프트웨어는 비주얼 스튜디오, 코드 비젼, SN8 C 스튜디오로 코딩을 했으며, 하드웨어는 크게 ATmega128, SN8F27E93S, USB to UART, 릴레이로 구성되어 있다. 모의실험결과, 제안된 방법과 기존 방법에서 먼저 휴대폰을 비교해보면 대기전력값이 큰 차이가 없지만 컴퓨터, 에어컨, 특히 셋톱박스의 경우에는 기존 방법에 의한 대기 전력이 제안된 시스템에 의한 대기전력보다 많은 소모됨을 알 수 있다. 따라서 제안된 차단콘센트는 대기전력 측면에서 우수한 성능을 나타냄을 알 수 있다.