• Journal of the Earthquake Engineering Society of Korea
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• v.9 no.4 s.44
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• pp.11-18
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• 2005

Inelastic seismic analysis is necessary for the seismic design due to the nonlinear behavior of a structure-soil system, and the importance of the performance based design considering the soil-structure interaction is recognized for the reasonable seismic design. In this study, elastic and inelastic seismic response analyses of a single degree of freedom system on the soft soil layer were peformed considering the nonlinearity of the soil for the 11 weak or moderate, and 5 strong earthquakes scaled to the nominal peak acceleration of 0.075g, 0.15g, 0.2g and 0.3g. Seismic response analyses for the structure-soil system were peformed in one step applying the earthquake motions to the bedrock In the frequency domain, using a pseudo 3-D dynamic analysis software. Study results indicate that it is necessary to consider the nonlinear soil-structure interaction effects and to perform the performance based seismic design for the various soil layers rather than to follow the routine procedures specified in the seismic design codes. Nonlinearity of the soft soil excited with the weak earthquakes also affected significantly to the elastic and inelastic responses due to the nonlinear soil amplification of the earthquake motions, and it was pronounced especially for the elastic ones.

• BMB Reports
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• v.53 no.8
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• pp.400-412
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• 2020

The world has witnessed unimaginable damage from the coronavirus disease-19 (COVID-19) pandemic. Because the pandemic is growing rapidly, it is important to consider diverse treatment options to effectively treat people worldwide. Since the immune system is at the hub of the infection, it is essential to regulate the dynamic balance in order to prevent the overexaggerated immune responses that subsequently result in multiorgan damage. The use of stem cells as treatment options has gained tremendous momentum in the past decade. The revolutionary measures in science have brought to the world mesenchymal stem cells (MSCs) and MSC-derived exosomes (MSC-Exo) as therapeutic opportunities for various diseases. The MSCs and MSC-Exos have immunomodulatory functions; they can be used as therapy to strike a balance in the immune cells of patients with COVID-19. In this review, we discuss the basics of the cytokine storm in COVID-19, MSCs, and MSC-derived exosomes and the potential and stem-cell-based ongoing clinical trials for COVID-19.

• Molecules and Cells
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• v.43 no.4
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• pp.360-372
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• 2020

The basal ganglia network has been implicated in the control of adaptive behavior, possibly by integrating motor learning and motivational processes. Both positive and negative reinforcement appear to shape our behavioral adaptation by modulating the function of the basal ganglia. Here, we examined a transgenic mouse line (G2CT) in which synaptic transmissions onto the medium spiny neurons (MSNs) of the basal ganglia are depressed. We found that the level of collaterals from direct pathway MSNs in the external segment of the globus pallidus (GPe) ('bridging collaterals') was decreased in these mice, and this was accompanied by behavioral inhibition under stress. Furthermore, additional manipulations that could further decrease or restore the level of the bridging collaterals resulted in an increase in behavioral inhibition or active behavior in the G2CT mice, respectively. Collectively, our data indicate that the striatum of the basal ganglia network integrates negative emotions and controls appropriate coping responses in which the bridging collateral connections in the GPe play a critical regulatory role.

• Earthquakes and Structures
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• v.11 no.6
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• pp.1101-1121
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• 2016

Base isolation, one of the popular seismic protection approaches proven to be effective in practical applications, has been widely applied worldwide during the past few decades. As the techniques mature, it has been recognised that, the biggest issue faced in base isolation technique is the challenge of great base displacement demand, which leads to the potential of overturning of the structure, instability and permanent damage of the isolators. Meanwhile, drain, ventilation and regular maintenance at the base isolation level are quite difficult and rather time- and fund- consuming, especially in the highly populated areas. To address these challenges, a number of efforts have been dedicated to propose new isolation systems, including segmental building, additional storey isolation (ASI) and mid-storey isolation system, etc. However, such techniques have their own flaws, among which whipping effect is the most obvious one. Moreover, due to their inherent passive nature, all these techniques, including traditional base isolation system, show incapability to cope with the unpredictable and diverse nature of earthquakes. The solution for the aforementioned challenge is to develop an innovative vibration isolation system to realise variable structural stiffness to maximise the adaptability and controllability of the system. Recently, advances on the development of an adaptive magneto-rheological elastomer (MRE) vibration isolator has enlightened the development of adaptive base isolation systems due to its ability to alter stiffness by changing applied electrical current. In this study, an innovative semi-active storey isolation system inserting such novel MRE isolators between each floor is proposed. The stiffness of each level in the proposed isolation system can thus be changed according to characteristics of the MRE isolators. Non-dominated sorting genetic algorithm type II (NSGA-II) with dynamic crowding distance (DCD) is utilised for the optimisation of the parameters at isolation level in the system. Extensive comparative simulation studies have been conducted using 5-storey benchmark model to evaluate the performance of the proposed isolation system under different earthquake excitations. Simulation results compare the seismic responses of bare building, building with passive controlled MRE base isolation system, building with passive-controlled MRE storey isolation system and building with optimised storey isolation system.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.35 no.5
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• pp.1025-1037
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• 2015

Flexible base isolation bearings that separate superstructure from ground have been widely used in the construction field because they make a significant contribution to increasing the fundamental period of the structure, thereby decreasing response acceleration transmitted into the superstructure. However, the established bearing devices installed to uphold the whole building give rise to some problems involved with failure and collapse due to lack of the capacity as modern structures are getting more massive and higher. Therefore, this study suggests new isolation bearings assembled with additional restrainers enabled to reinforcing and recentering, and then evaluates their performance to withstand the seismic load. The superelastic shape memory alloy (SMA) bars are installed into the conventional lead-rubber bearing (LRB) devices in order to provide recentering forces. These new systems are modeled as component spring models for the purpose of conducting nonlinear dynamic analyses with near fault ground motion data. The LRB devices with steel bars are also designed and analyzed to compare their responses with those of new systems. After numerical analyses, ultimate strength, maximum displacement, permanent deformation, and recentering ratio are compared to each model with an aim to investigate which base isolation models are superior. It can be shown that LRB models with superelastic SMA bars are superior to other models compared to each other in terms of seismic resistance and recentering effect.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.36 no.1
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• pp.33-44
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• 2000

Ships in a seaway will encounter dangerous situation, such as slamming, stranding, and capsizing. The number of capsizing is small, but the loss due to them is very large from the viewpoint of human life, property, and the environmental pollution. The number of capsizing of fishing vessels is about 62% of total number of capsizing, and the half of them is originated from the operational mistake in a seaway. So the dynamics and the capsizing phenomena are to be studied, and the guide for the safe operation of a fishing vessel in a seaway are to be specified. The hydrodynamic forces consist of radiation forces (which are due to the motion of a ship), Froude-Krylov forces (which is due to the incoming waves), and diffraction forces (which is due to the wave and ship interaction). These forces are calculated by well-known strip method. Using the calculated forces, the motion of a ship in a regular sea is obtained. In the real seaway, the waves are very irregular, therefore the statistical analysis is very helpful. In this paper, using the results of the motion in a regular seaway and the wave spectrum, the motion in a irregular seaway are obtained and analyzed.

• International Journal of Highway Engineering
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• v.8 no.4 s.30
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• pp.115-124
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• 2006

The objectives of this paper are to develop the structural condition evaluation technique using Falling Weight Deflectometer deflections and propose the structural condition criteria for asphalt pavements. To figure out correlation between surface deflections and critical pavement responses, the synthetic database has been established using the finite element pavement structural analysis program. A regression approach was adopted to develop the pavement response model that can be used to compute the stresses and strains within pavement structure using the FWD deflections. Based on the pavement response model, the procedure for assessing the structural condition of pavement layers was proposed in this study. To validate the condition evaluation procedure for asphalt pavements, the FWD test, dynamic cone penetrometer test, and repeated triaxial compression test were conducted on 11 sections of national highway and 8 sections of local road. Test results indicate that the tensile strain at the bottom of AC layer and AC elastic modulus were good indicators for estimating the stiffness characteristics of AC layer. For subbase layer, the BDI value and compressive strain on top of the subbase layer were appropriate to predict the structural capacity of subbase layer. The BCI value and compressive strain on top of the subgrade were found to be good indicators for evaluating the structural condition of the subgrade. The evaluation criteria for structural condition in asphalt pavements was also proposed in this paper.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.11 no.5
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• pp.1863-1872
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• 2010

Researches recently made in advanced countries into entrepreneurship found that various resources and information are mainly provided to ventures through social capital, which is a resource capital based on a network, and through corporate entrepreneurship. This research is an exploratory study on the effects of social capital and corporate entrepreneurship of new ventures upon their corporate performance, conducted from the standpoint of dynamic capability. For that purpose, a questionnaire investigation was made of 171 venture entrepreneurs in Korea, and the following are the results of an empirical analysis of responses to the questionnaire. First, it was found that social capital, which is a resource capital based on a network, had a significant effect on corporate entrepreneurship. Second, social capital also had a significant effect on ventures corporate performance. Third, corporate entrepreneurship had a significant effect on corporate performance. These results imply that social capital and corporate entrepreneurship have a significant effect on the corporate performance of ventures, which have innate disadvantages concerning the supply of resources. On the other hand, ventures, which encounter relatively more intense demands for change and renovation, can be managed in a sustainable manner just when they adequately accumulate their social capital and utilize their external resources and appropriately conduct their corporate entrepreneurship activities.

• Journal of the Earthquake Engineering Society of Korea
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• v.9 no.2 s.42
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• pp.37-46
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• 2005

To date, many viable smart base isolation systems have been proposed and investigated. In this study, a novel friction pendulum system (FPS) and an MR damper are employed as the isolator and supplemental damping device, respectively, of the smart base isolation system. A fuzzy logic controller (FLC) is used to modulate the MR damper because the FLC has an inherent robustness and ability to handle non linearities and uncertainties. A genetic algorithm (GA) is used for optimization of the FLC. The main purpose of employing a GA is to determine appropriate fuzzy control rules as well to adjust parameters of the membership functions. To this end, a GA with a local improvement mechanism is applied. This method is efficient in improving local portions of chromosomes. Neuro fuzzy models are used to represent dynamic behavior of the MR damper and FPS. Effectiveness of the proposed method for optimal design of the FLC is judged based on computed responses to several historical earthquakes. It has been shown that the proposed method can find optimal fuzzy rules and the GA optimized FLC outperforms not only a passive control strategy but also a human designed FLC and a conventional semi active control algorithm.

• The Journal of the Acoustical Society of Korea
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• v.35 no.6
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• pp.480-490
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• 2016

As wind turbines become larger and lighter, they are likely to respond sensitively by dynamic loads applied on them. Since the responses at resonances are particularly interested, it is required to be able to predict natural frequencies of wind turbines reliably at early design stage. To achieve this, the foundation-soil analysis is needed to be carried out and a finite element approach is adopted in general. However, the finite element approach would not be appropriate in early design stage because it demands heavy efforts in pile-soil modelling and computing facilities. On the contrary, theoretical approaches adopting linear approximations for soils are relatively simple and easy to handle. Therefore, they would be a useful tool in predicting a pile-soil interaction, particularly in early design stage. In this study an analysis for a pile inserted in soil is performed. The pile and soil are modelled as a beam and continuum medium, respectively, within an elastic range. In this analysis, influence factors at the pile head for lateral loads are predicted by means of this continuum approach for various length-diameter ratios of the pile. The influence factors predicted are validated with those reported in literature, proposed from a finite element analysis.