Molecules and Cells

Korean Society for Molecular and Cellular Biology (한국분자세포생물학회)
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Dynamic Changes in the Bridging Collaterals of the Basal Ganglia Circuitry Control Stress-Related Behaviors in Mice

  • Lee, Young (Department of Life Sciences, Korea University) ;
  • Han, Na-Eun (Department of Life Sciences, Korea University) ;
  • Kim, Wonju (Department of Life Sciences, Korea University) ;
  • Kim, Jae Gon (Department of Life Sciences, Korea University) ;
  • Lee, In Bum (Department of Life Sciences, Korea University) ;
  • Choi, Su Jeong (Department of Physiology and Neuroscience, Dental Research Institute, Seoul National University School of Dentistry) ;
  • Chun, Heejung (Cognitive Glioscience Group, Center for Cognition and Sociality, Institute for Basic Science (IBS)) ;
  • Seo, Misun (Center for Neuroscience, Brain Science Institute, Korea Institute of Science and Technology (KIST)) ;
  • Lee, C. Justin (Cognitive Glioscience Group, Center for Cognition and Sociality, Institute for Basic Science (IBS)) ;
  • Koh, Hae-Young (Center for Neuroscience, Brain Science Institute, Korea Institute of Science and Technology (KIST)) ;
  • Kim, Joung-Hun (Department of Life Sciences, Pohang University of Science and Technology (POSTECH)) ;
  • Baik, Ja-Hyun (Department of Life Sciences, Korea University) ;
  • Bear, Mark F. (The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology) ;
  • Choi, Se-Young (Department of Physiology and Neuroscience, Dental Research Institute, Seoul National University School of Dentistry) ;
  • Yoon, Bong-June (Department of Life Sciences, Korea University)
  • Received : 2019.11.19
  • Accepted : 2019.12.17
  • Published : 2020.04.30
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Abstract

The basal ganglia network has been implicated in the control of adaptive behavior, possibly by integrating motor learning and motivational processes. Both positive and negative reinforcement appear to shape our behavioral adaptation by modulating the function of the basal ganglia. Here, we examined a transgenic mouse line (G2CT) in which synaptic transmissions onto the medium spiny neurons (MSNs) of the basal ganglia are depressed. We found that the level of collaterals from direct pathway MSNs in the external segment of the globus pallidus (GPe) ('bridging collaterals') was decreased in these mice, and this was accompanied by behavioral inhibition under stress. Furthermore, additional manipulations that could further decrease or restore the level of the bridging collaterals resulted in an increase in behavioral inhibition or active behavior in the G2CT mice, respectively. Collectively, our data indicate that the striatum of the basal ganglia network integrates negative emotions and controls appropriate coping responses in which the bridging collateral connections in the GPe play a critical regulatory role.

Keywords

References

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