• Korean Journal of Veterinary Research
• /
• v.44 no.1
• /
• pp.15-21
• /
• 2004

This paper describes the development of $^{99m}Tc$ tricarbonyl cysteine as potential renal function diagnostic radiopharmaceutical and evaluation of its biological characteristics using experimental animals. l-Cysteine was labeled efficiently with $^{99m}Tc$ tricarbonyl precursor $([^{99m}Tc(CO)_3(H_2O)_3)]^{+})$ under 30 min heating at ${75^{\circ}C}$. Labeling yield and stability were analyzed by high performance liquid chromatography (HPLC). The biodistribution property of $^{99m}Tc$ tricarbonyl cysteine in mice and its dynamic imaging profiles in rabbits were carried out. To investigate the excretion mechanism of $^{99m}Tc$ tricarbonyl cysteine, tubular transport inhibition test with probenecid was adopted. $^{99m}Tc$ tricarbonyl cysteine was obtained with a high labeling yield under the moderate condition. The results of biodistribution experiments of $^{99m}Tc$ tricarbonyl cysteine in ICR mice at 3 and 90 min provided that $^{99m}Tc$ tricarbonyl cysteine was very highly accumulated in the kidney and bladder, thereby almost 99% of $^{99m}Tc$ tricarbonyl cysteine was excreted within 90 min post injection. The same results were confirmed by the whole body dynamic images for 30 minutes and static images in rabbits at given time intervals after injection. Renogram of $^{99m}Tc$ tricarbonyl cysteine in rabbits showed that its $T_{max}$ and $T_{1/2}$ of $^{99m}Tc$ tricarbonyl cysteine were $2.33{\pm}0.56$ and $4.30{\pm}0.79$ min, respectively. The $T_{max}$ of $^{99m}Tc$ tricarbonyl cysteine with probenecid pretreatment was $2.30{\pm}0.17$ min, whereas $T_{1/2}$ of that with probenecid pretreatment was $17.0{\pm}32.47$ min. $T_{1/2}$ of $^{99m}Tc$ tricarbonyl cysteine with probenecid pretreatment was significantly different, as compared to the result without probenecid (p<0.0001). The results showed that the excretion of $^{99m}Tc$ tricarbonyl cysteine was extremely affected by probenecid. Therefore, $^{99m}Tc$ tricarbonyl cysteine was rapidly excreted from the kidney principally by the tubular secretion.

• Journal of the Korean Geotechnical Society
• /
• v.20 no.4
• /
• pp.89-102
• /
• 2004

The generated blasting pressure wave initiated under decoupled-charge condition is a function of peak blasting pressure, rise time, and wave-shape function. The peak blasting pressure and the rise time are also the function of explosive and rock properties. The probabilistic distributions of explosive and rock properties are derived from the results of their property tests. Since the probabilistic distributions of explosive and rock properties displayed a normal distribution, the peak blasting pressure and the rise time can also be regarded as a normal distribution. Parameter analysis and uncertainty analysis were performed to identify the most influential parameter that affects the peak blasting pressure and the rise time. Even though the explosive properties were found to be the most influential parameters on the peak blasting pressure and the rise time from the parameter analyses, the result of uncertainty analysis showed that rock properties constituted major uncertainties in estimating the peak blasting pressure and the rise time rather than explosive properties. Damage and overbreak of the remaining rock around the excavation line induced by blasting were evaluated by dynamic numerical analysis. A user-subroutine to estimate the rock damage was coded based on the continuum damage mechanics. This subroutine was linked to a commercial program called 'ABAQUS/Explicit'. The results of dynamic numerical analysis showed that the rock damages generated by the initiation of stopping hole were larger than those from the initiation of contour hole. Several methods to minimize those damages were proposed such as relocation of stopping hole, detailed subdivision of rock classification, and so on. It was found that fracture probability criteria and fractured zones could be distinctively identified by applying fuzzy-random probability.

• Journal of the Korean Association of Geographic Information Studies
• /
• v.11 no.2
• /
• pp.38-50
• /
• 2008

The site-specific seismic responses and corresponding seismic hazards are influenced mainly by the subsurface geologic and geotechnical dynamic characteristics. To estimate reliably the seismic responses in this study, a geotechnical information system (GTIS) within GIS framework was developed by introducing new concepts, which consist of the extended area containing the study area and the additional site visit for acquiring surface geo-knowledge data. The GIS-based GTIS was built for Gyeongju area, which has records of abundant historical seismic hazards reflecting the high potential of future earthquakes. At the study area, Gyeongju, intensive site investigations and pre-existing geotechnical data collections were performed and the site visits were additionally carried out for assessing geotechnical characteristics and shear wave velocity ($V_S$) representing dynamic property. Within the GTIS for Gyeongju area, the spatially distributed geotechnical layers and $V_S$ in the entire study area were reliably predicted from the site investigation data using the geostatistical kriging method. Based on the spatial geotechnical layers and $V_S$ predicted within the GTIS, a seismic zoning map on site period ($T_G$) from which the site-specific seismic responses according to the site effects can be estimated was created across the study area of Gyeongju. The spatial $T_G$ map at Gyeongju indicated seismic vulnerability of two- to five-storied buildings. In this study, the seismic zonation based on $T_G$ within the GIS-based GTIS was presented as regional efficient strategy for seismic hazard prediction and mitigation.

• Journal of Wetlands Research
• /
• v.16 no.3
• /
• pp.327-336
• /
• 2014

Submerged thin walls are extreme case of submerged rectangular blocks, and could be used for many purposes in rivers or coastal zones, e.g. to tsunami. To understand flow characteristics including flow and pressure fields around a specific submerged thin wall a numerical model was applied which includes computation of hydrodynamic pressure on ${\sigma}$-coordinate. ${\sigma}$-coordinate has strong merits for simulation of subcritical flow over mild-sloped beds. On the other hand ${\sigma}$-coordinate is quite poor to treat sharp structures on the bed. There have been a few trials to incorporate dynamic pressure in ${\sigma}$-coordinate by some researchers. One of the previous approaches includes process of sloving the Poisson equation. However, the above method includes many high-order terms, and requires long cpu for simulation. Another method SOLA was developed by Hirt et al. for computation of dynamic pressure, but it was valid for straight grid system only. Previous SOLA was modified for ${\sigma}$-coordinate for the present purpose and was adopted in a model system, CST3D. Computed flow field shows reasonable behaviour including vorticity is much stronger than the upstream and downstream of the structure. The model was verified to laboratory experiments at a 2DV flume. Time-average flow vectors were measured by using one-dimensional electro-magnetic velocimeter. Computed flow field agrees well with the measured flow field within 10 % error from the speed point of view at 5 profiles. It is thought that the modified SOLA scheme is useful for ${\sigma}$-coordinate system.

• The Korean Journal of Financial Management
• /
• v.25 no.4
• /
• pp.183-212
• /
• 2008

The purpose of this paper is to analyze the efficiency change and determinants of the korean non-life insurance companies. we use DEA (Data Envelopment Analysis) model to measure company efficiency change and use GLS, Tobit model, FIixed effect model, Random effect model, GMM to measure efficiency determinants. we utilize ten non-life insurance companies in korea and the panel data for five from 2001 to 2005. The empirical results show the following findings. First, technical efficiency shows that approximately 15.5% of inefficiency exists on the non-life insurance companies and it reveals that the cause for technical inefficiency is due to scale inefficiency. Second, Dea Window results show that the stable dissimilarity by standard deviation, LDP of CCR. Third, the results of efficiency determinants show that increase efficiency is depend on the premium income and real estates.

• Journal of KIISE:Computer Systems and Theory
• /
• v.31 no.8
• /
• pp.432-444
• /
• 2004

In this paper, we construct the TMO-based object group model on distributed environment, and analyze and evaluate the executability for distributed real-time service of our object group model by developing the distributed real-time application simulator applying the model. The Time-triggered Message-triggered Object(TMO) is a real-time server object having real-time property itself. The TMO-based object group is defined as a set of objects which logically reconfigured the physically distributed one or more TMOs on network by a given distributed application. For supporting group management of the server objects, the TMO-based object group we suggested provides the functions which register and withdraw the solver objects as a group member to an arbitrary object group, and also provides the functions which insert and delete the access rights of server objects from clients. Also, our model was designed and implemented to support the appropriate object selection and dynamic binding service for a single TMO as well as the duplicated TMOs, and to support the real-time scheduling service for the clients which are requesting the service. Finally, we developed the Defence System against Invading Enemy Planes(DSIEP) simulator as a practical example of distributed real-time application by applying our model, and evaluated the adaptability of distributed service strategies for the group components and the executability of real-time services that the TMO-based object group model provides.

• Journal of the Korean Geotechnical Society
• /
• v.23 no.1
• /
• pp.39-49
• /
• 2007

In this study, quantitative sensitivity analysis on rockfill material influencing the dam crest settlement of CFRD (Concrete-Faced Rockfill Dam) subjected to earthquake loading was carried out. The purpose of this study is to indicate the most important input parameter from the results of sensitivity analysis, to show the quantitative variation of settlement at the crest of CFR type dam during earthquake with this input parameter, and to recommend the approximate estimation method of the settlement on the crest of CFRD subjected to earthquake loading. The statistic characteristics of rockfill parameters which were obtained from large triaxial tests were evaluated. The total 108 dynamic numerical analyses (2 input earthquake, 2 magnitudes for each earthquake, 27 rockfill material property combinations) on CFRD were conducted. The global sensitivity analysis was carried out using the results of numerical analysis. From the sensitivity analysis, It was found that the crest settlement of the CFRD subjected to earthquake was absolutely affected by the shear modulus of rockfill material irrespective of the input earthquakes and the magnitude of input acceleration. On the contrary, it was found that the effect of cohesion and friction angle of rockfill was negligible. From the results of sensitivity analysis and numerical analysis, the approximate estimation method of the settlement on the crest of CFRD subjected to earthquake loading was recommended on condition that the rockfill shear modulus and simple dam information was known.

• Journal of the Korean Geotechnical Society
• /
• v.23 no.5
• /
• pp.111-129
• /
• 2007

The standard construction manual of the SDA(Separated Doughnut Auger) piling method was proposed so that the resisting capacity of the augered piles could work effectively. 405 dynamic pile load tests and 30 static pile load tests were performed for 265 test piles, which were installed by the SDA piling method in 33 sites in Korea. The results of the pile load tests showed that the end bearing capacity of the SDA augered piles depended on the property of various soil stratums and did not agree with ones estimated by the existing formula based on several standard design codes. On the basis of the pile load test results, four formulas were presented according to bearing stratums to estimate quantitatively the unit end bearing capacity of the SDA augered piles. The formulas for the unit end bearing capacity of piles on soils or weathered rocks were related to N-value given by SPT(Standard Penetration Test), while the unit end bearing capacity on bedrock was suggested to be more than 1500 $tf/m^2$. The presented formulas were compared with the existing formulas, which were presented by several standard design codes to design the augered piles. In order to use correctly the presented formulas, the quality of Standard Penetration Test should be controlled precisely. Also it is desirable to choose a pilot construction site, where both dynamic and static pile load tests are performed.

• Journal of the Korean Geotechnical Society
• /
• v.26 no.12
• /
• pp.5-17
• /
• 2010

Coarse granular material is used as important fill material in most of large embankments such as railway, road, dam and so on. Therefore, the accurate design parameters of the coarse granular material are necessarily required in design and construction. The behavior of the coarse granular material was not well understood because of the lack of large testing equipment capable of coarse granular material. A large triaxial testing system was developed in this research, capable of large specimens of 500 mm, 300 mm and 150 mm in diameter. In the new large triaxial testing system, the load cell is installed inside the triaxial cell and axial displacement is measured locally on a specimen in order to improve control and measurement in small strain level. Urethane specimens of 300 mm and 50 mm in diameter were prepared. The large triaxial tests were performed on the 300 mm diameter urethane specimens while RC/TS and impact echo tests on the 50 mm diameter urethane specimens to verify this testing system. In this verification test results, we could ascertain the reasonable test results of the KRRI large triaxial testing system.

• Macromolecular Research
• /
• v.9 no.4
• /
• pp.197-205
• /
• 2001

Platelet adhesion onto elastic polymeric biomaterials was tested in vitro by perfusing human whole blood at a shear rate of 100 sec$\^$-1/ for possible verification of mechanisms of initial platelet adhesion perfusion of blood on the polymeric substrates was performed after treatments either with or without pre-adsorption of 1% blood plasma, and either with or without residence of the protein-preadsorbed substrate in phosphate buffered solution. The surfaces employed were elastic polymers such as poly(ether urethane urea), poly(ether urethane), silicone urethane copolymer, silicone rubber and poly(ether urethane) with the anti-calcifying agent hydroxyethane bisphosphate. Each polymer surface treated was exposed in vitro to the dynamic, heparinized whole blood perfused for upto 6 min and the surface area of platelets initially adhered was measured by employing in situ epifluorescence video microscopy. The blood perfusion was performed on the surfaces treated at the following three different conditions: directly on the bare surfaces, after protein pre-adsorption and after residence in buffer for 3 days of the surfaces protein pre-adsorbed for 2 h. The effects of blood plasma pre-adsorption on the initial platelet adhesion was surface-dependent. The amount of the adsorbed fibrinogen and the surface coverage area of the adhered platelets were dependent on the surface conditions whether substrates were bare surfaces or protein pre-adsorbed ones. To test an effect of possible morphological (re)orientations of the adsorbed proteins on the initial platelet adhesion, the polymeric substrate pre-adsorbed with 1% blood plasma was immersed in phosphate buffered solution for 3 days and then exposed to physiological blood perfusion. The surface area of the platelets adhered on these surfaces was significantly different from that of the surfaces treated with protein pre-adsorption only. These results indicated that platelet adhesion was dependent on the surface property itself and pre-treatment conditions such as blood perfusion without any pre-adsorption of proteins, and blood perfusion either after protein pre-adsorption or after subsequent substrate residence in buffer of the substrate pre-adsorbed with proteins. Understanding of these results may guide for better designs of blood-contacting materials based on protein behaviors.