• Asian Pacific Journal of Cancer Prevention
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• 제15권24호
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• pp.10847-10853
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• 2015

Background: Lapatinib, a dual tyrosine kinase inhibitor that interrupts the epidermal growth factor receptor (EGFR) and HER2/neu pathways, has been indicated to have significant efficacy in treating HER2-positive breast cancer. However, acquired drug resistance has become a very serious clinical problem that hampers the use of this agent. In this study, we aimed to screen small molecule drugs that might reverse lapatinib-resistance of breast cancer by exploring differentially expressed genes (DEGs) via a bioinformatics method. Materials and Methods: We downloaded the gene expression profile of BT474-J4 (acquired lapatinib-resistant) and BT474 (lapatinib-sensitive) cell lines from the Gene Expression Omnibus (GEO) database and selected differentially expressed genes (DEGs) using dChip software. Then, gene ontology and pathway enrichment analyses were performed with the DAVID database. Finally, a connectivity map was utilized for predicting potential chemicals that reverse lapatinib-resistance. Results: A total of 1, 657 DEGs were obtained. These DEGs were enriched in 10 pathways, including cell cycling, regulation of actin cytoskeleton and focal adhesion associate examples. In addition, several small molecules were screened as the potential therapeutic agents capable of overcoming lapatinib-resistance. Conclusions: The results of our analysis provided a novel strategy for investigating the mechanism of lapatinib-resistance and identifying potential small molecule drugs for breast cancer treatment.

• Imaging Science in Dentistry
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• 제44권4호
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• pp.263-271
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• 2014

Purpose: This study aimed to evaluate the use of dental cone-beam computed tomography (CBCT) in the diagnosis of osteoporosis among menopausal and postmenopausal women by using only a CBCT viewer program. Materials and Methods: Thirty-eight menopausal and postmenopausal women who underwent dual-energy X-ray absorptiometry (DXA) examination for hip and lumbar vertebrae were scanned using CBCT (field of view: $13cm{\times}15cm;$ voxel size: 0.25 mm). Slices from the body of the mandible as well as the ramus were selected and some CBCT-derived variables, such as radiographic density (RD) as gray values, were calculated as gray values. Pearson's correlation, one-way analysis of variance (ANOVA), and accuracy (sensitivity and specificity) evaluation based on linear and logistic regression were performed to choose the variable that best correlated with the lumbar and femoral neck T-scores. Results: RD of the whole bone area of the mandible was the variable that best correlated with and predicted both the femoral neck and the lumbar vertebrae T-scores; further, Pearson's correlation coefficients were 0.5/0.6 (p value=0.037/0.009). The sensitivity, specificity, and accuracy based on the logistic regression were 50%, 88.9%, and 78.4%, respectively, for the femoral neck, and 46.2%, 91.3%, and 75%, respectively, for the lumbar vertebrae. Conclusion: Lumbar vertebrae and femoral neck osteoporosis can be predicted with high accuracy from the RD value of the body of the mandible by using a CBCT viewer program.

• 한국항해항만학회지
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• 제34권10호
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• pp.775-780
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• 2010

기계장치에 있어서 브레이크 시스템은 기계의 안전상 동작만큼이나 중요한 부분이다. 기계를 급히 정지시켜야하는 비상시에 기계가 멈추지 않으면 큰 사고로 발전할 수 있기 때문이다. 이것은 모든 기계장치에서 공통된 사항이며, 선박에서 또한 마찬가지이다. 선박에는 2종류의 계류장치가 존재한다. 그 중 하나는 항해하는 선박을 근해에 정박시키기 위해서는 해저에 닻을 내리는 윈드라스 윈치이며, 또 다른 하나는 배를 항구에 계류시키기 위한 무어링 윈치이다. 그 중 기존에 사용하는 무어링 윈치의 경우, 브레이크 밴드가 하나의 철판으로 만들어져 있으며, 브레이크 밴드와 라이닝을 연결하는 볼트의 파손이 발생하게 된다. 본 연구에서는 이 파손을 방지하기 위해 유한요소해석 프로그램을 사용하여 응력이 집중되는 부위를 선정하였고, 이 부위를 분리하여 응력 집중을 해소하였다, 또한 이 분리지점의 각도에 따른 해석을 수행하여 최적의 위치를 선정하였다.

• 한국정보과학회논문지:데이타베이스
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• 제30권2호
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• pp.176-183
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• 2003

질의 최적화에 사용하기 위한 선택도 추정 방법은 히스토그램, 샘플링 그리고 패러미터에 의한 요약 방법 등이 제시되고 있다. 히스토그램을 이용한 선택도 추정은 상용 데이타베이스 시스템에서 가장 보편적으로 사용되는 방법이지만, 이동 객체를 위한 시공간 데이타베이스에서는 데이타 분포가 지속적으로 변화함으로써 기존의 히스토그램 방법을 이용하는 것은 제한이 많게 된다. 특히 미래 질의를 위해서는 데이타 갱신을 반영하는 동적 관리가 가능하며, 정화도를 유지할 수 있는 다른 접근 방법이 필요하다. 따라서 시공간 객체를 위한 선택도 추정 방법은 질의 술어가 요구하는 데이타 분포에 대한 히스토그램이 필요하며, 본 논문에서는 미래의 시공간 영역 질의 술어에 대하여 신속히 히스토그램을 생성할 수 있도록 쌍대성과 한계 분포 방법을 이용한 히스토그램을 제안한다. 쌍대 공간에서 이동 객체에 대한 데이타 시놉시스를 이용하여 구성된 시공간 히스토그램은 이동 궤적의 선형성이 유지하는 시간 동안 정확성을 보장하면서 빠른 시간에 생성이 가능하다. 또한 동적 갱신을 점증적으로 지원함으로써 효율적으로 갱신된 정보를 반영할 수 있고 추정 결과의 정확성을 향상시킬 수 있다.

• Molecules and Cells
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• 제37권9호
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• pp.664-671
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• 2014

MiR-217 can function as an oncogene or a tumour suppressor gene depending on cell type. However, the function of miR-217 in lung cancer remains unclear to date. This study aims to evaluate the function of miR-217 in lung cancer and investigate its effect on the sensitivity of lung cancer cells to cisplatin. The expression of miR-217 was detected in 100 patients by real-time PCR. The effects of miR-217 overexpression on the proliferation, apoptosis, migration and invasion of SPC-A-1 and A549 cells were investigated. The target gene of miR-217 was predicted by Targetscan online software, screened by dual luciferase reporter gene assay and demonstrated by Western blot. Finally, the effects of miR-217 up-regulation on the sensitivity of A549 cells to cisplatin were determined. The expression of miR-217 was significantly lower in lung cancer tissues than in noncancerous tissues (p < 0.001). The overexpression of miR-217 significantly inhibited the proliferation, migration and invasion as well as promoted the apoptosis of lung cancer cells by targeting KRAS. The up-regulation of miR-217 enhanced the sensitivity of SPC-A-1 and A549 cells to cisplatin. In conclusion, miR-217 suppresses tumour development in lung cancer by targeting KRAS and enhances cell sensitivity to cisplatin. Our results encourage researchers to use cisplatin in combination with miR-217 to treat lung cancer. This regime might lead to low-dose cisplatin application and cisplatin side-effect reduction.

• 한국산학기술학회논문지
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• 제11권5호
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• pp.1702-1707
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• 2010

본 논문은 무선을 통해 전송하고자 하는 데이터의 양이 점점 늘어나면서 기존 20MHz의 무선랜(WLAN) 채널을 두 개 결합해 사용하는 802.11n에 대한 관심 및 적용이 늘어나고 있는 추세이다. 802.11n은 2.4GHz 대역과 5.8GHz의 듀얼밴드를 사용하여 기존의 2GHz 인근 대역의 무선 통신에 의한 간섭 회피 효과가 있어 대용량 무선 전송 방식으로 기대되고 있다. 이러한 802.11n 무선방식을 사용하여 정보를 전송하므로 주변의 전파환경에 영향을 받을 수밖에 없다. 특히 실내 환경과 실외 환경은 서로 다른 모델링으로 정의될 만큼 무선 통신에 미치는 영향이 다르다고 할 수 있다. 본 논문에서는 실내와 실외환경에서의 802.11n RF 특성 및 Network 특성 비교를 통해 이러한 실내외 환경의 차이가 802.11n의 RF 특성에 미치는 영향을 비교하고 아울러 RF 특성과 Network 특성간의 상호 관계를 규명하고자 한다.

• 자원환경지질
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• 제26권4호
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• pp.519-539
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• 1993

A total of 264 independently oriented core samples were collected from 26 sites in the southwestern part (the Naktong Trough) of the Cretaceous $Ky{\check{o}}ngsang$ Basin in south Korea. The sampled formations comprise the sedimentary Shindong and the Hayang Groups of the Lower Cretaceous age. Alternating field and thermal demagnetizations were conducted. Characteristic remanent magnetization (ChRM) was relatively easily isolated in each formation except in the Chinju formation, from which only remagnetization circles were observed. Even though an extensive use of the fold test was not possible due to the nearly homoclinal nature of the strata in the area, we believe that the ChRM of each formation is of primary origin based on the following grounds: The in-situ ChRM direction of each formation is different from the present geomagnetic field direction. Fisherian precision parameter becomes enhanced through the tilt correction in all formations, closely to the values required for a positive fold test. Three out of the five studied formations pass the reversal test. The mean palaeomagnetic pole position from the studied area is found to be statistically different from the contemporary pole from the Chinese block exclusive of the Shandong area. The difference in magnetic declination suggests a $14.5^{\circ}$ (${\pm}10.5^{\circ}$) clockwise rotation of the studied area relative to the Chinese block comprising the west of the Tan-Lu fault. On the other hand, any significant difference in magnetic inclination and concurrent palaeolatitude is not observed between the studied area and China as well as the other area (Taegu-Andong area) in the $Ky{\check{o}}ngsang$ Basin. The dual nature of the magnetic polarity confirmed in all formations suggests an older than 124 Ma (Neocomian or older) age of the studied sedimentary strata.

• 한국표면공학회지
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• 제42권3호
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• pp.128-132
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• 2009

Transparent conducting thin films of indium tin oxide(ITO) co-sputtered with aluminum-doped zinc oxide(AZO) were deposited on glass substrate by dual magnetron sputtering. It was found that the electrical properties and structural characteristics of the films are significantly changed according to the sputtering power of the AZO target. The IAZTO film prepared with D.C power of ITO at 100 W and R.F power of AZO at 50 W shows an electrical resistivity of $4.6{\times}10^{-4}{\Omega}{\cdot}cm$ and a sheet resistance of $30{\Omega}/{\square}$ (for 150 nm thick). Besides of the improvement of the electrical properties, compared to the ITO films deposited at the same process conditions, the IAZTO films have very smooth surface, which is due to the amorphous nature of the films. However, the electrical conductivity of the IAZTO films was found to be deteriorated along with the crystallization in case of the high temperature deposition (above $310^{\circ}C$). In this work, high quality amorphous transparent conductive oxide layers could be obtained by mixing AZO with ITO, indicating possible use of IAZTO films as the transparent electrodes in OLED and flexible display devices.

• 멤브레인
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• 제30권4호
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• pp.213-227
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• 2020

재생 불가능한 에너지 자원이 수년에 걸쳐 고갈됨에 따라, 재생 에너지 생산을 위한 보다 효과적인 방법에 대한 연구가 증가되었다. 연로전지 개발의 한 분야인 미생물 연료전지(MFC)는 이중 성능의 잠재력 덕분에 발전하였다. MFC는 박테리아와 같은 전극 감소 생물에서 전력을 모아서 전기 에너지를 생산한다. MFC는 폐수를 연료로 사용하여 에너지를 생산하고 폐수를 정화한다. 양성자 교환막(PEM)은 양극과 음극 챔버의 분리막으로, 양성자만 효과적으로 통과할 수 있게 하는 중요한 역할을 한다. Nafion은 MFC에 상업적으로 사용되는 PEM이지만 비용, 생산 시간, 양성자 전도성 차원에서 보완할 점들이 많다. 본 리뷰 논문에는 Nafion을 대체할 수 있는 새로 개발된 PEM 몇 가지를 논의하였다. 또한, PEM, 혼합 PEM 및 복합 PEM에 기반한 MFC를 요약하고자 한다.

• 드라이브 ㆍ 컨트롤
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• 제15권3호
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• pp.14-20
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• 2018

Wet clutches in an automatic transmission enable the transmission of the engine power by the frictional torque experienced and noted between disk and plates. Since the clutch frictional torque considerably affects the shift quality of an automatic transmission as well as the durability of the machinery, its friction characteristics must be carefully examined to meet the design requirements. The SAE No. 2 friction test machine is a well-known standard to evaluate mainly the friction characteristics of plate clutches along with the required automatic transmission fluids. This paper reviews the experimental analysis of the wet clutch friction characteristics by using the exclusively developed clutch test machine which is capable of controlling the clutch test procedure, in accordance with the applicable test standard and processing of the experimental data automatically. As the clutch test machine is designed for the accommodation of dual clutches which is applied to the real transmission, it can evaluate not only the clutch friction characteristics, but also an actuation performance of a measured clutch piston. In respect to friction characteristics involving dynamic friction coefficients, the energy absorbed in a clutch disk and the recorded temperatures of clutch plates during braking actions and procedures are also investigated. Additionally, the change of friction coefficients by the use of the repeated clutch application is also observed with the endurance test functions of an accurately calibrated and dedicated clutch test machine.