• Review of Culture and Economy
• /
• v.20 no.1
• /
• pp.81-104
• /
• 2017

This study aims to examine the transformation of the heroic narrative in the successful Korean Wave drama. In this study, TV drama "Descendants of the Sun" which gained tremendous popularity at home and abroad was considered to be an example of the heroic narrative model proposed by Vogler. Further, two analysis points were identified as the critical factor of success: modern transformation and global transformation. Modern transformation is about distinct characteristics of Korea, found in three primary factors of the work: the setting up of a character, the development of events and the background set-up. Global transformation features universal value to attract foreign viewers by lowering cultural discount. In "Descendants of the Sun", humanism is considered to broaden the horizon of the work by affecting above three factors. In conclusion, It is the proper combination of these dual transformations that globalize Korean drama. In this regard, this study will be a meaningful attempt to shed light on the storytelling strategy of Korean dramas in terms of the heroic narrative.

• 재활복지
• /
• v.22 no.3
• /
• pp.41-68
• /
• 2018

The purpose of this study was to verify the causal relations among related factors of job and life satisfaction among 805 wage workers with disabilities. The study conducted a path analysis using the $8^{th}$ Panel survey of Employment for the Disabled data. The results are as follows. Firstly, the life satisfaction scale was categorized into the human relationship satisfaction and the material environment satisfaction by an explorative factor analysis. These two satisfactions are directly affected by Job Satisfaction (JS) and Job Involvement (JI), not directly affected by Job Engagement (JE). Secondly, JS and JI have a complete mediated effect on the path from JE to these two satisfactions. Thirdly, an indirect effect in the path reaching JS was shown to be significant in a dual mediating effect through JS and JI. Based on this study, it is recommended the way of vocational rehabilitation counseling and the related supporting strategies and programs devise toward a JS of wage workers with disabilities, vocational rehabilitation field practitioners and professionals should consider properly intervening job factors.

• Korea Journal of Hospital Management
• /
• v.24 no.3
• /
• pp.11-26
• /
• 2019

Objectives: The purpose of this study was to investigate the effect of the perception on the quality of nosocomial infection control on perceived risk, trust, and the intention to revisit among the medical consumers. Method: 361 patients and their guardians who were hospitalized in women's hospital, Gangnam-gu, Seoul, participated in this study. The data was analyzed using SPSS Statistics 21.0. Results: The perception on the quality of nosocomial infection control had a negative(-) effect on perceived risk, a positive(+) effect on trust, a positive(+) effect on the intention to revisit. The perceived risk had a negative(-) effect on trust, a negative(-) effect on the intention to revisit. The trust had a positive(+) effect on the intention to revisit. The perceived risk was partially mediated by the perception on the quality of nosocomial infection control and the intention to revisit, while the trust was fully mediated by the perception on the quality of nosocomial infection control and the intention to revisit. Thus, it indicated that the perceived risk and trust had dual mediated effects as well as full mediated effects in the relationship between the perception on the quality of nosocomial infection control and the intention to revisit. Conclusions: The nosocomial infection control can be an important factor to contribute to hospital management by attract the loyal medical customers, not just cost-expenditure. The nosocomial infection control can help hospital revenue and customer management strategy. Thus, it will contribute to the effective marketing strategy in the medical field.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.33 no.1
• /
• pp.56-62
• /
• 2019

To investigate the effect of Bombycis Corpus on male osteoporosis, we performed Dual Energy X-Ray Absorptiometry(DEXA) and histochemical methods. The animals were used ICR-based male mice of 8 weeks and 50 weeks, respectively. ICR male mice at 8 weeks were used in the control group, and ICR male mice at 50 weeks were used in aging group and Bombycis Corpus group(BC group). In the aging group, 0.5 ml of distilled water was administered once a day for 6 months. In BC group, Bombycis Corpus(0.78g/kg) was dissolved in distilled water for 6 months once a day. As a result, Bombycis Corpus decreased bone loss, increased bone density by reducing the loss of bone matrix in the femur due to aging, and increased osteoblast - induced osteopontin(OPN) and osteocalcin(OPC) positivite reaction. In addition, administration of Bombycis Corpus decreased Reaction of activation of nuclear factor kappa B ligand(RANKL) positive reaction, increased osteoprotegerin(OPG) positive reaction, and decreased matrix metalloproteinase-3(MMP-3) and 8-hydroxy-2'-deoxyguanosine(8-OHdG) positivite reaction. Taken together, Bombycis Corpus increases the activity of osteoblasts, inhibits osteoclast function, promotes osteoblast function, inhibits bone tissue degradation, and inhibits bone loss due to oxidative stress. It was observed that Bombycis Corpus reduced bone loss and increased bone density caused by aging to improve male osteoporosis. Therefore, Bombycis Corpus may be used as a preventive and therapeutic agent for male osteoporosis.

• Proceedings of the Korea Water Resources Association Conference
• /
• 2015.05a
• /
• pp.429-429
• /
• 2015

면적감소계수(ARF)는 면적강우에 대한 지점강우의 비로 정의되며, 과거 면적확률강우량 산정시 유역 내의 여러 지점강우량을 티센기법, Kriging 기법 등을 통해 공간보정을 실시하고 면적강우량을 산정하였다. 하지만 이러한 방법은 강우의 시공간분포 특성을 정확히 반영하지 못하는 단점이 있기 때문에, 최근에는 많은 연구에서 레이더 강우를 활용한 ARF를 산정한다. 기존의 연구에서 이중편파레이더를 사용하여 낙동강 유역의 호우중심형 ARF를 산정한 바 있기 때문에, 본 연구에서는 산정된 ARF 값을 적용한 설계홍수량은 분석해보고자 한다. 대상유역은 낙동강 유역내의 유역들을 대상으로 하고자 한다. 낙동강 유역에는 약 $175km^2{\sim}2000km^2$의 다양한 면적의 유역들이 존재함을 확인하였다. 따라서 면적별로 대표적인 유역을 선정하여 설계홍수량을 산정하기에 적합한 지역이라 판단된다. 설계홍수량을 산정하기 방법으로는 강우-유출 모형을 이용하고자 한다. 이용할 모형은 호주에서 개발된 IHACRES 모형으로써, 개념적인 모형으로 장기 및 단기 강우사상을 모두 모의할 수 있는 특징을 갖고 있다. 따라서 낙동강 내의 선정된 유역들을 실제 강우자료를 통해 각 유역의 매개변수를 산정하고, 확률강우량과 Huff분포를 이용한 지속시간 24시간의 설계강우량을 산정하고자 한다. 산정된 설계강우량에 앞서 소개한 이중편파레이더 ARF를 적용하여 설계홍수량을 산정하고, ARF를 적용하지 않고 산정한 설계홍수량, 두 값의 차이를 통해 ARF를 통해 감소된 설계강우량의 비와 ARF 적용 유무에 따른 설계홍수량 차이의 비를 비교하여 이중편파레이더 ARF가 면적별로 미치는 영향을 알아보고자 한다.

• Journal of Gastric Cancer
• /
• v.22 no.4
• /
• pp.319-338
• /
• 2022

Purpose: Gastric cancer (GC) has high morbidity and mortality, the cure rate of surgical treatment and drug chemotherapy is not ideal. Therefore, development of new treatment strategies is necessary. We aimed to identify the mechanism underlying Sp1 regulation of GC progression. Methods and Methods: The levels of Sp1, β-catenin, SET domain bifurcated 1 (SETDB1), and 15-hydroxyprostaglandin dehydrogenase (HPGD) were detected by quantitative reverse transcription polymerase chain reaction and western blot analysis. The targets of SETDB1 were predicted by AnimalTFDB, and dual-luciferase reporter assay was used for confirming the combination of Sp1, β-catenin, and SETDB1. HGC27 or AGS cells (1×10⁶ cells/mouse) were injected into mice via the caudal vein for GC model establishment. The level of Ki67 was detected using immunohistochemistry, and hematoxylin and eosin staining was performed for evaluating tumor metastasis in mice with GC. Results: HPGD was inhibited, while the protein levels of Sp1, β-catenin, and SETDB1 were up-regulated in GC tissues and cell lines. HPGD overexpression or SETDB1 silencing inhibited the proliferation, invasion, and migration of GC cells, and Sp1 regulated the proliferation, invasion, and migration of GC cells in a β-catenin-dependent manner. Furthermore, HPGD served as a target of SETDB1, and it was negatively regulated by SETDB1; additionally, Sp1 and β-catenin bound to the SETDB1 promoter and negatively regulated HPGD expression. We proved that Sp1 regulated GC progression via the SETDB1/HPGD axis. Conclusions: Our findings revealed that Sp1 transcriptionally inhibited HPGD via SETDB1 in a β-catenin-dependent manner and promoted the proliferation and metastasis of GC cells.

• Biomolecules & Therapeutics
• /
• v.31 no.2
• /
• pp.200-209
• /
• 2023

Patients with non-small-cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) amplification or sensitive mutations initially respond to the tyrosine kinase inhibitor gefitinib, however, the treatment becomes less effective over time by resistance mechanism including mesenchymal-epithelial transition (MET) overexpression. A therapeutic strategy targeting MET and EGFR may be a means to overcoming resistance to gefitinib. In the present study, we found that picropodophyllotoxin (PPT), derived from the roots of Podophyllum hexandrum, inhibited both EGFR and MET in NSCLC cells. The antitumor efficacy of PPT in gefitinib-resistant NSCLC cells (HCC827GR), was confirmed by suppression of cell proliferation and anchorage-independent colony growth. In the targeting of EGFR and MET, PPT bound with EGFR and MET, ex vivo, and blocked both kinases activity. The binding sites between PPT and EGFR or MET in the computational docking model were predicted at Gly772/Met769 and Arg1086/Tyr1230 of each ATP-binding pocket, respectively. PPT treatment of HCC827GR cells increased the number of annexin V-positive and subG1 cells. PPT also caused G2/M cell-cycle arrest together with related protein regulation. The inhibition of EGFR and MET by PPT treatment led to decreases in the phosphorylation of the downstream-proteins, AKT and ERK. In addition, PPT induced reactive oxygen species (ROS) production and GRP78, CHOP, DR5, and DR4 expression, mitochondrial dysfunction, and regulated involving signal-proteins. Taken together, PPT alleviated gefitinib-resistant NSCLC cell growth and induced apoptosis by reducing EGFR and MET activity. Therefore, our results suggest that PPT can be a promising therapeutic agent for gefitinib-resistant NSCLC.

• Geomechanics and Engineering
• /
• v.32 no.1
• /
• pp.49-68
• /
• 2023

The three-dimensional failure criterion is essential for maintaining wellbore stability and sand production problem. The convenient factor for a stable wellbore is mud weight and borehole orientation, i.e., mud window design and selection of borehole trajectory. This study proposes a new three-dimensional failure criterion with linear relation of three in-situ principal stresses. The number of failure criteria executed to understand the phenomenon of rock failure under in-situ stresses is the Mohr-Coulomb criterion, Hoek-Brown criterion, Mogi-Coulomb criterion, and many more. A new failure criterion is the extended Mohr-Coulomb failure criterion with the influence of intermediate principal stress (σ₂). The influence of intermediate principal stress is considered as a weighting of (σ₂) on the mean effective stress. The triaxial compression test data for eleven rock types are taken from the literature for calibration of material constant and validation of failure prediction. The predictions on rock samples using new criteria are the best fit with the triaxial compression test data points. Here, Drucker-Prager and the Mogi-Coulomb criterion are also implemented to predict the failure for eleven different rock types. It has been observed that the Drucker-Prager criterion gave over prediction of rock failure. On the contrary, the Mogi-Coulomb criterion gave an equally good prediction of rock failure as our proposed new 3D failure criterion. Based on the yield surface of a new 3D linear criterion it gave the safest prediction for the failure of the rock. A new linear failure criterion is recommended for the unique solution as a linear relation of the principal stresses rather than the dual solution by the Mogi-Coulomb criterion.

• The Korean Journal of Nuclear Medicine Technology
• /
• v.27 no.2
• /
• pp.95-98
• /
• 2023

Purpose: The precision error of a bone density meter reflects the equipment and reproducibility of results by an examiner. Precision error values can be expressed as coefficient of variation (CV), CV%, and root mean square-SD (RMS-SD). The International Society for Clinical Densitometry (ISCD) currently recommends using RMS-SD as the precision error value. When a 95% confidence interval is applied, the least significant change (LSC) value is calculated by multiplying the precision error value by 2.77. Exceeding the LSC value reflects a significant difference in measured bone density. Therefore, the LSC value of a bone density equipment is an essential factor for accurately determining a patient's bone density. Accordingly, we aimed to calculate the LSC value of a bone density meter (Lunar iDXA, GE) and compare it with the value recommended by the ISCD. We also assessed whether the value measured by the iDXA equipment was below the LSC value recommended by ISCD. Material and Methods: The bone densities of the lumbar spine and thighs of 30 participants were measured twice, and the LSC values were calculated using the precision calculation tool provided by the ISCD (http://www.iscd.org). To check the reproducibility of the measurement, patients were asked to completely dismount from the equipment after the first measurement; the patient was then repositioned before proceeding with the second measurement. Results: The LSC values derived using the CV% values recommended by the ISCD were 5.3% for the lumbar spine and 5.0% for the thigh. The LSC values measured using our bone density equipment were 2.47% for the lumbar spine and 1.61% for the thigh. The LSC value using RMS-SD was 0.031 g/cm² for the lumbar spine and 0.017 g/cm² for the thigh. Conclusion: that the findings confirm that the CV% value measured using our bone density meter and the LSC value using RMS-SD were maintained very stably. This can be helpful for obtaining accurate measurements during bone density follow-up examinations.

• Information Systems Review
• /
• v.18 no.3
• /
• pp.31-50
• /
• 2016

This study investigates the impact of social-face sensitivity of smartphones on the adoption of iPhone in China. Social-face sensitivity is divided into three dimensions, namely, other-directed sensitivity, self-directed sensitivity, and formality-directed sensitivity. We surveyed 218 university students in China through an online survey site. The results showed that formality-directed and other-directed sensitivity have significant impacts on iPhone preferences. Self-directed sensitivity was not significant. We investigated two moderate variables, namely, financial ability and brand sensitivity. Both variables showed significantly moderate impacts on the intention to purchase iPhone. The impact of social-face sensitivity on iPhone preferences implies that the iPhone has dual characteristics to the Chinese, namely, as utility and luxury goods. This finding offers managerial implications for Apple and other mobile service companies in terms of production and marketing strategies.