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Nutritional Intervention Through Ketogenic Diet in GLUT1 Deficiency Syndrome

  • Young-Sun Kim;Woojeong Kim;Ji-Hoon Na;Young-Mock Lee
    • Clinical Nutrition Research
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    • v.12 no.3
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    • pp.169-176
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    • 2023
  • Glucose transporter type 1 (GLUT1) deficiency syndrome (DS) is a metabolic brain disorder caused by a deficiency resulting from SLC2A1 gene mutation and is characterized by abnormal brain metabolism and associated metabolic encephalopathy. Reduced glucose supply to the brain leads to brain damage, resulting in delayed neurodevelopment in infancy and symptoms such as eye abnormalities, microcephaly, ataxia, and rigidity. Treatment options for GLUT1 DS include ketogenic diet (KD), pharmacotherapy, and rehabilitation therapy. Of these, KD is an essential and the most important treatment method as it promotes brain neurodevelopment by generating ketone bodies to produce energy. This case is a focused study on intensive KD nutritional intervention for an infant diagnosed with GLUT1 DS at Gangnam Severance Hospital from May 2022 to January 2023. During the initial hospitalization, nutritional intervention was performed to address poor intake via the use of concentrated formula and an attempt was made to introduce complementary feeding. After the second hospitalization and diagnosis of GLUT1 DS, positive effects on the infant's growth and development, nutritional status, and seizure control were achieved with minimal side effects by implementing KD nutritional intervention and adjusting the type and dosage of anticonvulsant medications. In conclusion, for patients with GLUT1 DS, it is important to implement a KD with an appropriate ratio of ketogenic to nonketogenic components to supply adequate energy. Furthermore, individualized and intensive nutritional management is necessary to improve growth, development, and nutritional status.

Eating habits and dietary supplement utilization according to food-related lifestyle among Korean adults: a cross-sectional study

  • EunJung Lee;Jin A Jang;Ji-Myung Kim
    • Korean Journal of Community Nutrition
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    • v.29 no.4
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    • pp.253-264
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    • 2024
  • Objectives: This study investigated the association between eating habits and the utilization of dietary supplements (DSs) according to food-related lifestyle (FRL) among Korean adults. Methods: This study included a total of 300 participants (150 men and 150 women) in their 20s to 60s living in Seoul and Gyeonggi Province. We identified two groups by factor and cluster analysis: an 'active pursuit' group and a 'passive pursuit' group. Differences in eating habits and DS utilization between the two groups were analyzed by chi-square test and t-test. Logistic regression analysis was used to analyze the effect of variables on DS consumption according to FRL. Results: There were significant differences between the two groups in terms of age, alcohol drinking frequency, total dietary score, change in DS consumption after coronavirus disease 2019, and current DS consumption (P < 0.05). The proportion who perceived many health benefits of DSs was higher in the 'active pursuit' group than in the 'passive pursuit' group (P = 0.003). The most commonly consumed type of DSs was multivitamins & minerals for the 'active pursuit' group, and omega-3 fatty acids for the 'passive pursuit' group. The 'an active pursuit' group consumed DSs 2.93 times more (95% confidence interval [CI]: 1.44-5.97) compared to the 'passive pursuit' group, after adjusting for confounders. In the 'active pursuit' group, the health pursuit (odds ratio [OR] = 6.54, 95% CI: 1.44-29.61) and rational consumption pursuit factors (OR = 0.26, 95% CI: 0.08-0.83) were associated with DS consumption, whereas only the health pursuit factor had a significant association (OR = 5.37, 95% CI: 2.08-13.88) within the 'passive pursuit' group. However, total dietary score and DSs consumption did not show a relationship. Conclusions: By understanding the consumption characteristics of DSs according to FRL, this can serve as basic data necessary for promoting health through the utilization of DSs and healthy behaviors.

PERIODONTOPATHIC BACTERIA IN DOWN'S SYNDROME (다운증후군 환자의 치주질환 원인균의 출현율)

  • Kim, Seon-Mi;Yang, Kyu-Ho;Choi, Nam-Ki;Oh, Jong-Suk;Kang, Mi-Sun
    • Journal of the korean academy of Pediatric Dentistry
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    • v.32 no.4
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    • pp.717-725
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    • 2005
  • It is widely known that individuals with Down's syndrome(DS) often develop early onset severe periodontal diseases. In this study, We examined the prevalence of periodontopathic bacteria in DS patients to compare controls with mental disabilities(MD) The subjects were 27 DS patients (7 to 19 years old) and 27 age-matched controls with MD. Plaque index and gingival index were measured. And 5 pathogens, Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Fusobacterium nucleatum, were surveyed in subgingival plaque samples using a polymerase chain reaction. No significant difference in plaque index and gingival index were observed between the DS and control group. The prevalence in DS was 96.3% for F. nucleatum, 74.1% for T. forsythia, 63.0% for P. gingivalis, 55.6% for A. actinomycetemcomitans. 40.7% for T. denticola. No significant differences were observed in the prevalence of periodontopathic bacterias between the DS and control. Prevalence of P.g(16.7%) at age $7{\sim}10$ is lower than other age group in DS, but its prevalence increased with age. Prevalence of A.a(83.3%) is peak at age $7{\sim}10$ in DS. These results suggest that various periodontopathic pathogens can colo nize in the very early childhood of DS and MD patients. But no significant difference was observed in the prevalence of periodontopathic bacterias between the DS and control.

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Adaptive Closed-Loop Power Control Algorithm in DS/CDMA system (DS/CDMA 시스템의 적응형 폐쇄루프 전력 제어 알고리즘)

  • 감두열;박상규
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.25 no.3A
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    • pp.383-390
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    • 2000
  • In this paper, an adaptive power control algorithm in the DS/CDMA system is proposed. The currently used transmitter/receiver based on IS-95 and the radio propagation channel under mobile communication environments are modeled. Theses are the key features for the simulation to analyse the performance of power control. the distribution of the received SIR(signal to interference ratio)and the bit error probability are the required parameters for the performance analysis. Furthermore the influence of the power control command error on the above parameters are analyzed. By using the performance analysis of IS-95 and the occurrence of burst errors that is characteristic for wireless channels. the new power control algorithm is proposed. The proposed power control algorithm increases the SIR which results in a better service quality and an enhancement in the system capacity.

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A Study on Channel Equalization for DS-CDMA System in Fast Fading Environment (Fast Fading 환경에서 DS-CDMA 시스템에 대한 채널 등화에 관한 연구)

  • 김원균;박노진;강철호
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.26 no.7B
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    • pp.937-943
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    • 2001
  • fast fading 채널 특성을 갖는 DS-CDMA 다중 사용자 환경에서 Normalized CMA(Constant Modulus Algorithm)와 Newton 방식을 이용한 CMA를 이용하여 빠른 수렴속도와 작은 평균 자승 오차(Mean Square Error)를 동시에 개선할 수 있는 등화 방법을 제안하였다. Normalized CMA는 Newton 방식을 이용한 CMA에 비해 작은 평균 자승오차를 갖지만 수렴속도가 느리다는 단점이 있다. 반면 Newton 방식을 이용한 CMA는 Normalized CMA에 비해 수렴속도는 빠르지만 큰 평균 자승 오차를 갖는다는 단점이 있다. 따라서 빠른 수렴 속도와 작은 평균 자승 오차를 동시에 얻기 위한 구조를 제안하였으며, 이 구조는 각각의 알고리즘을 사용하는 방법과는 달리 두 개의 알고리즘을 동시에 이용한다. 모의 실험 결과, 제안한 기법이 Normalized CMA보다 약 320번, Newton 방식을 이용한 CMA보다는 170번 정도 빠른 수렴 속도를 나타냈으며, 동시에 수렴시의 평균 자승 오차는 Newton 방식을 이용한 CMA보다 약 0.6dB, Normalized CMA보다 약 0.4dB 정도 낮은 수치를 나타내는 것을 확인할 수 있었다.

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On-line self-tuning PID power controller using fuzzy logic for CDMA cellular systems (퍼지 논리를 이용한 온라인 자기동조기능을 갖는 CDMA 셀룰러 시스템용 PID 전력제어기)

  • 김상민;한진욱;김성중
    • 제어로봇시스템학회:학술대회논문집
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    • 1997.10a
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    • pp.211-214
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    • 1997
  • This paper applies fuzzy self-tuning PID controller in DS/CDMA cellular system. Power control is essential in DS/CDMA to compensate for the differing received powers due to both the slowly varying long-term and fast varying short-term fading processes and co-channel interference. The controller proposed is adaptable for the variations of the system dynamics and especially for the variable time delay which exists in mobile radio systems. Accordingly the results is the smaller power control error, that is, the smaller average transmitting power of mobile compared with the conventional control schemes. Because interferences to the other mobiles are reduced, the capacity of CDMA can be increased.

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Fast 3D CT/CTA Image Registration and its Application to DS-CTA (고속 3차원 CT/CTA 영상 정합 기법 및 DS-CTA 응용)

  • 권성민;김용선;김태성;김동익;나종범
    • Proceedings of the IEEK Conference
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    • 2003.07c
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    • pp.2697-2700
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    • 2003
  • 이 논문에서는 3 차원 CT/CTA 영상 데이터에 대하여 고속 자동 정합 기법을 제안한다. 제안하는 기법은 다해상도 (multi-resolution) 구조의 정규 상호 정보량(normalized mutual information) 을 최대화하는 정합 방식에서, 정합 유사도를 계산하는 볼륨 영역을 효율적으로 줄여 정합 속도를 증가시키는 방법이다. 제안된 정합방식을 CT/CTA (CT angiography) 팬텀 데이터와 7 세트의 실제 CT/CTA 임상 데이터에 적용하여 테스트하였다. 이로부터 제안하는 방식이, 정합 정확도를 유지하는 동시에 정합 속도를 10 ∼ 60% 로 감소시킴을 확인 할 수 있었다. 또한 제안된 정합 방식을 DS-CTA (digital subtraction CT angiography) 에 적용하여, CT/CTA 영상으로부터 혈관 영상을 성공적으로 추출하였다.

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Adaptive Step-size Algorithm for the AIC in the Space-time Coded DS-CDMA System (시공간부호화된 DS-CDMA 시스템에서 적응스텝크기 알고리듬을 적용한 간섭제거수신기)

  • Yi, Joo-Hyun;Lee, Jae-Hong
    • Proceedings of the IEEK Conference
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    • 2004.06a
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    • pp.265-268
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    • 2004
  • In this paper. we propose an adaptive step-size algorithm for the adaptive interference canceller (AIC) in the space-time trellis coded DS-CDMA system. In the AIC, the performance of the blind LMS algorithms that updates the tap-weight vector of the AIC is heavily dependent on the choice of step-size. To improve the performance of the fixed step-size AIC (FS-AIC), the regular adaptive step-size algorithm is extended in complex domain and applied to the joint AIC and ML decoder scheme. Simulation results show that the joint adaptive step-size AIC (AS-AIC) and ML decoder scheme using the proposed algorithm has boner performance than not only the conventional ML decoder but also the joint FS-AIC and ML decoder scheme without much increase of the decoding delay and complexity.

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Blind Adaptive Interference Suppression Using CMA for Multipath DS-CDMA Channels (다중 경로 DS-CDMA 채널을 위한 CMA 기반의 블라인드 적응 간섭 제거)

  • 김병주;신요안
    • Proceedings of the IEEK Conference
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    • 2000.09a
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    • pp.33-36
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    • 2000
  • DS-CDMA (direct sequence-code division multiple access) 시스템에서 여러 사용자가 동일 주파수 대역을 공유함으로써 다중 접속 간섭 (multiple access interference; MAI)이 발생하고 시스템의 성능을 크게 제한한다. 이러한 다중 접속 간섭을 제거하여 전송 신호의 질을 높이고 용량을 증대시키는 중요한 신호 처리 기술 가운데 하나가 적응 간섭 억제 기술이다. 적응 간섭 억제 기술 가운데 CMA (constant modulus algorithm) 기반의 블라인드 적응 간섭 억제기는 훈련수열을 필요로 하지 않고 빠른 수렴을 통하여 간섭을 효과적으로 제거할 수 있으나, 다중 경로 환경에서 심벌간 간섭 (intersymbol interference; ISI)이 증대되어 기존의 적응 수신기보다 악화된 성능을 보인다. 본 논문에서는 CMA를 기반으로 훈련 수열 없이 빠른 수렴을 하며 MAI와 ISI를 효과적으로 제거하기 위한 다이버시티 결합기 구조의 적응 간섭 억제기를 제한한다. 다중 경로 페이딩 채널 환경에서 기존의 블라인드 적응간섭 억제기와의 성능 비교 결과, 제안된 방식이 다중경로에 의한 ISI의 영향을 효과적으로 제거하여 우수한 성능을 얻을 수 있음을 확인하였다.

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Novel soft switching FB DC-DC converter (새로운 소프트 스위칭 FB DC-DC 컨버터)

  • 김은수;최해영;조기연;계문호;김윤호
    • Proceedings of the KIPE Conference
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    • 1997.07a
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    • pp.251-255
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    • 1997
  • The conventional high frequency phase-shifted full bridge dc/dc converter has a disadvantage that a circulating current flows through transformer and switching devices during the freewheeling interval. Due to this circulating current, RMS current stress, conduction losses of transformer and switching devices are increased. To alleviate this problem, this paper provides a circulating current free type high frequency soft switching phase-shifted full bridge (FB) dc/dc converter with energy recovery snubber (ERS) attached at the secondary side of transformer. The energy recovery snubber (ERS) adopted in this study is consisted of three fast recovery diode(Ds1, DS2, Ds3), two resonant capacitor (Cs1, Cs2)

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