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Clinical Manifestation and Treatment Outcome of Lupus Nephritis in Children (소아 루프스 신염의 임상양상 및 치료결과)

  • Park Jee-Min;Shin Jae-Il;Kim Pyung-Kil;Lee Jae-Seung
    • Childhood Kidney Diseases
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    • v.6 no.2
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    • pp.155-168
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    • 2002
  • Purpose; Systemic lupus erythematosus(SLE) is an autoimmune disease with multi-system involvement and renal damage is a major cause of morbidity and mortality in children. Renal involvement is more common and severe in children than in adults. Therefore, renal biopsy plays a crucial role in planning effective therapy. In this study, we investigated the clinical and pathological findings of lupus nephritis in children to aid clinical care of the disease. Methods: The clinical and pathological data of 40 patients who were diagnosed as SLE with renal involvement in Shinchon Severance Hospital from Jan. 1990 to Sep. 2002 were analyzed retrospectively. Results: The ratio of male to female patients was 1:3 and the median age at diagnosis was 12.1(2-18) years old. FANA(95.0%), anti-ds DNA antibody(87.5%), malar rash(80.0%) were the most common findings among the classification criteria by ARA. Microscopic hematuria with proteinuria(75.0%), nephrotic syndrome(55.0%), and microscopic hematuria alone(15.0%) were the most common renal presentations in the respective order at diagnosis. There were 27 cases with WHO class IV lupus nephritis confirmed by renal biopsy and 3 cases with pathological changes of WHO class type. Different treatment modalities were carried out : prednisolone only in 5 cases, prednisol-one+azat-hioprine in 9 cases, prednisolone+azathioprine+intravenous cyclophosphamide in 14 cases, prednisolone+cyclosporine A+intravenous cyclophosphamide in 12 cases, plasma exchange in 9 cases and intravenous gamma-globulin in 2 cases. The average follow-up period was $51.8{\pm}40.5$ months. During $51.8{\pm}40.5$ months. During follow-up, 4 patients expired. The risk factors associated with mortality were male, WHO class IV and acute renal failure at diagnosis. Conclusion: Renal involvement was noted in 63.5% of childhood SLE, and 67.5% of renal lesion was WHO class IV lupus nephritis which is known to be associated with a poor prognosis. Therefore aggressive treatment employing immunosuppressant during the early stages of disease could be helpful in improving long-term prognosis. But careful attention should be given to optimize the treatment due to unique problems associated with growth, psychosocial development and gonadal toxicity, especially in children.

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The Basic Data Analysis of Lupus Nephritis in Children (소아 루프스 신염에 대한 기초 조사)

  • Min Jae Hong;Paek Kyung Hoon;Park Kyung Mi;Kim Jung Sue;Ha Il Soo;Cheong Hae Il;Kim Joong Gon;Choi Yong
    • Childhood Kidney Diseases
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    • v.3 no.1
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    • pp.80-87
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    • 1999
  • Purposes : Renal involvement is a potentially serious complication of systemic lupus erythematosus (SLE). There have been only few studies of lupus nephritis in pediatric age. In this study, the clinical manifestations, pathologic findings, response to treatment, and clinical course of lupus nephritis in children were analyzed. And the results will provide basic data for future nation-wide prospective multi-center study. Methods . The medical records of 46 children clinically and pathologically diagnosed to have lupus nephritis at Seoul National University Children's Hospital during 1986 to 1997 were analyzed retrospectively. Results : 1) The median age of diagnosis of lupus nephritis was 12.8 years ($2\;years\~\;15year$ 8months), and the sex ratio was 1:2.5. 2) FANA($85.7\%$), anti-ds-DNA antibody ($78.0\%$), and malar rash ($60.8\%$) were the most common findings among the classification criteria by ARA Decreased C3 was detected in $88.9\%$ of patients. 3) Hematuria ($87.0\%$) was the most common renal symptom, and WHO class IV lupus nephritis was identified in 41 cases by renal biopsy. 4) In most of patients, the disease activity was controlled relatively well with a single or combined therapy of prednisolone, azathioprine, or cyclophosphamide. The response revealed no difference according to the mode of treatment. 5) Infection, especially of Varicella-Zoster virus and candida, was the most common complication during the disease course. Conclusion : The renal involvement was noted in $87.0\%$ of childhood SLE, and $89.1\%$ of renal lesions was WHO class IV lupus nephritis known to associated with poor long-term prognosis. So, aggressive treatment using immunosuppressants in the early disease course may be helpful to increase long-term prognosis of lupus nephritis. A prospective multi-center study is necessary to analyze the therapeutic efficacy of various treatment modalities.

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Analysis of Drying Efficiency for Circulating and Falling Movements on Indirected Drying Process of Food Waste (음식물류폐기물 간접건조과정에서의 순환 및 낙하이동에 따른 건조효율 평가)

  • Kim, Byung Tae
    • Journal of the Korea Organic Resources Recycling Association
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    • v.20 no.4
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    • pp.106-117
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    • 2012
  • Indirected heating dryer is used as one of the food waste treatment technologies for the production of the drier material supplied to the recycling facilities or end user. This study investigated the effect on drying efficiency for the operation of rotating screw with the circulating and falling movements on indirected drying process of food waste. The screw operating condition showed higher drying efficiency despite of the shorter drying time compared to the screw non-operating condition. The moisture content decreased to 14.4% from the initial moisture content of 77.1% after drying 5 hours in the screw operating condition. On the other hand, in the screw non-operating condition, the moisture content decreased slightly to 35.6% after drying 16 hours. During the drying process, variations of the water evaporation rate and particle size showed different tendencies depending on the moisture content regions. In the higher moisture content region above the glue zone(moisture content of about 50%-60%), the particle size increased and the water evaporation rate reached the highest peak. In the range of glue zone, the particle size maximized while the water evaporation rate decreased sharply. In the lower moisture content region below the glue zone, the water evaporation rate and particle size both decreased at the same time. The particle size distribution was widely ranged from 25.0mm to 0.25mm in the screw operating condition while it was narrowly distributed in the screw non-operating condition from 25.0mm to 3.56mm, especially highly concentrated to 25.0mm. It was regarded that the hygroscopic, capillary and gravitational water evaporated more easily from the intra-particle during the circulating and falling movement caused by the rotating of the screw and the difference of the cohesional force of water within intra-particle depending on the moisture content regions. Comparing the effect of the circulating and falling movement on drying efficiency, the water evaporation rates per time and per weight of dry solid in the screw operating condition were higher about 364% and 356%, respectively, than those of the screw non-operating condition.

Effect of Various β-1,3-glucan Supplements on the Performance, Blood Parameter, Small Intestinal Microflora and Immune Response in Laying Hens (β-Glucan 제제들이 산란계의 생산성, 혈액 성상과 소장내 미생물 균총 및 면역 체계에 미치는 영향)

  • Park, K.W.;Rhee, A.R.;Lee, I.Y.;Kim, M.K.;Paik, I.K.
    • Korean Journal of Poultry Science
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    • v.35 no.2
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    • pp.183-190
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    • 2008
  • This study was conducted to investigate the effect of feeding diets supplemented with ${\beta}-glucan$ products on the performance, small intestinal microflora and immune response in laying hens. The ${\beta}-glucan$ products used in the experiment were $BetaPolo^{(R)}$ ; soluble ${\beta}-glucan$ of microbial cell wall origin, $HiGlu^{(R)}$ ; microbial cell wall origin, $OGlu^{(R)}$ ; oat origin, $BGlu^{(R)}$ ; barley origin. A total of 720 Hy-Line Brown laying hens of 40wks old were divided into 5 dietary treatments : T1 ; Control( C), T2 ; $BetaPolo^{(R)}$, T3 ; $HiGlu^{(R)}$, T4 ; $OGlu^{(R)}$, T5 ; $BGlu^{(R)}$. Each treatment was replicated 4 times with 36 birds/replicate housed in 2 bird cages, and arranged according to completely randomized block design. Feeding trial lasted 40ds under 16 h lighting regimens. There were significant differences among treatments in hen-house egg production feed intake and feed conversion. HiGlu treatment was significantly higher than OGlu treatments in hen-house egg production. ${\beta}-glucan$ supplemented treatments were lower than the control in feed intake and feed conversion ratio. All ${\beta}-glucan$ supplemented treatments were significantly higher than the control in eggshell strength. Eggshell color and Haugh unit tended to be lower in the supplemented group than the control. IgY concentration was not significantly affected by treatments. At $5^{th}$ week of experiment, however, IgY concentration tended to increase in the supplemented groups. Among the leucocytes parameters, WBC, heterophil, lymphocytes, monocyte and eosinophil concentration were lower in the supplemented groups than those of the control. Among erythrocytes, HCT(hematocrit) and MCV(mean corpuscular volume) were significantly affected by treatment. MCV of supplemented groups were higher than that of the control. Immunoglobulin concentrations in the birds were not significantly different among treatments. However, IgA concentration tended to be low in the supplemented groups than the control. The cfu of small intestinal microflora were not significantly different among treatments, but that of Cl. perfringens tended to be lower than the control. The result of this experiment indicateted that feeding ${\beta}-glucan$ to laying hens improve feed conversion ratio and eggshell strength. Also intestinal microflora and immune responses are modified.

Productivity of $F_1$ Hybrid Maize and of $F_2$ Material Derived from by Multiplication (옥수수 잡종이세대의 건물생산과 수량구성요소)

  • 박병훈;박병식
    • Journal of The Korean Society of Grassland and Forage Science
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    • v.6 no.1
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    • pp.49-52
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    • 1986
  • The objective of this study was to find out the productivity of F_2 material derived from F_1 hybrid Maize (Zea mays L.) by multiplication and their response to plant population. Suweon 19 and Junju-Ok were grown at three population densities. Populations were ca. 8.3, 10.4 and 13.9 thousand plants per 10a. The results are summarized as follows; 1. The number of barren plants differed significantly for the two generations but other yield components comparisons were not significant at P(0.05). 2. Ear and TDN yield were higher from the $F_1$ hybird of Suweon 19 than from the F_2 material, while yields of Jinju-Ok and stover yield of both hybrids were not affected by generation. 3. Plant and ear height were not affected by population density but barren plants were increased at high population. Length and weight of a ear, and ear (including cobs)-to-stover ratio decreased with increased population. 4. Increasing population density resulted in significant decrease in ear and TDN yield, while stover yield not decreased.

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Estimation of Agricultural Water Quality Using Classification Maps of Water Chemical components in Seonakdong River Watershed (수질성분 분포도를 이용한 서낙동강 수계 농업용수 수질평가)

  • Ko, Jee-Yeon;Lee, Jae-Sang;Kim, Choon-Song;Jeong, Ki-Yeol;Choi, Young-Dae;Yun, Eul-Soo;Park, Seong-Tae;Kang, Hwang-Won;Kim, Bok-Jin
    • Korean Journal of Environmental Agriculture
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    • v.25 no.2
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    • pp.138-146
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    • 2006
  • To understand the status of water quality and work out a suitable countermeasures in Seonakdong watershed which has poor agro- environmental condition because of severe point and non-point source pollution by popularized city and near sea, we investigated the pollution sources and water quality from '03 and '05 and the result were mapped with GIS and RS for end-users's convenient comprehense and conjunction of water quality and geological data. The most degraded tributary was Hogeo stream which was affected directly by highly popularized Gimhae city, the main pollution source of the watershed. The pollution of tributaries in watershed increased the T-N of main body that reached over 4 mg/L during dry season. Pyeonggang stream and the lower part of main water way were suffered from high salt contents induced near sea and the EC value of those area were increased to 2.25 dS/m. The delivered loads of T-N and T-P were largest in Joman river as 56% and 61% of total delivered loads 1mm tributaries because of lots of stream flow. When Management mandate for irrigation water in Seonakdong river watershed was mapped for estimating integrated water quality as the basis of classification of EC and T-N contents in water, Hogeo and Shineo catchments were showed the requiring countermeasures none against nutrients hazard and Pyeonggang catchment was the vulnerable zone against nutrients and salts hazard. As the result, Seonakdong watershed had very various status of water quality by characteristics of catchments and countermeasures for improving water quality and crop productivity safely should changed depend on that.

Physiological and Ecological Studies on Prolongation of the Green Perido in Korean Lawn (잔디의 녹색기간연장에 관한 생리 생태학적 연구)

  • 장남기;김형기
    • Journal of The Korean Society of Grassland and Forage Science
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    • v.6 no.3
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    • pp.131-137
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    • 1986
  • Korean lawn, Zoysia japonica STEUD, is the type of a perennial warm-season lawn grass that has a naturally green period during 5 months from May to September. This study was carried out to detect the effects of N-P-K fertilization, regrowth capacity after mowing and chlorophyll contents on prolongation of the green period in Zoysia japonica grasslands. The results obtained are summarized as follows: 1. The effects of nitrogen fertilizer application on Zoysia japonica grasslands were affected on regrowth capacity after mowing, green color of leaf canopies and chlorophyll contents, respectively. 2. A the experimental plots which applied 45g/$m^2$/10 weeks of $N_3$ fertilizer, there were high significant effects on prolongation of the green period and the plots of phosphorus and potassium had additive effects. 3. Prolongation of the green period to the last ten days of October was obviously possible by slow degrees in proportion to increment of N-P-K fertilization. 4. However, it is interpreted that more prolongation of the green period is impossible with N-P-K fertilization and irrigation treatments, unless the intermediate turfgrasses between $C_3$ and $C_4$ plants must be found and bred.

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Analysis of Redcell and Blood Protein Typing in Mongolian Horse (몽고말의 적혈구항원형 및 혈액단백질형 분석)

  • Cho, G.J.;Cho, B.W.
    • Journal of Animal Science and Technology
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    • v.46 no.6
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    • pp.887-896
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    • 2004
  • The present study was carried out to investigate the blood markers of Mongolian horses. The blood redcell types and blood protein types(biochemical polymorphisrns) were tested from 19 Mongolian horses by serological and electrophoretic procedure, and their phenotypes and gene frequencies were estimated. The blood group and biochemical polymorphism phenotypes observed with high frequency were $A^{af}$(42.1%), $C^a$(89.5%), $K^-$(84.2%), $U^a$(63.2%), $P^a$(42.1%) $P^-$42.1%), $Q^c$(31.6%) $Q^-$(31.6%), $AL^{AB}$((52.6%), AI$B^K$(89.5%), $ES^1$(63.2%), $GC^F$(78.9%), $HB^BI$1(68.4%), PG$D^F$(84.2%), $TF^{FIR}$(21.1%), $TF^{F2R}$(21.1%)(21.1%), and genotypes $D^{cgm/dghm}$(15.8%), $D^{dghm/dghm}$(15.8%), $D^{ad/dghm}$(10.5%), $D^{ade/dghm}$(10.5%), in Mongolian horses, respectively. Alleles observed with high frequency were $A^a$(0.4211), $C^a$(0.8947), $K^-$(0.8421), $U^a$(0.6316), $P^a$(0.4474), $Q^c$(0.4474), $D^{dghm}$(0.4211), $AL^B$(0.6579), $AIB^K$(0.9211), $ES^I$(0.7895), $GC^F$(0.8947), $HB^{BI}$(0.7895), $PGD^F$(0.8421) and $TF^R$(0.3421) in Mongolian horses. These results present basic information for estimating the genetic relationships between the Korean native horse, and developing a system for parentage verification and individuals identification in Mongolian horse.

Studies on the Nutri-Culture of Major Wild Vegetable Ligularia fischeri Turcz I. Growth and Yield of Ligularia fischeri Turcz. by Media, Amount of Media and Planting Density in Nutri-Culture (곰취의 양액재배 기술 개발 I. 배지종류 , 배지량 , 재식밀도에 따른 곰취의 생육 및 수량)

  • 홍정기
    • Korean Journal of Plant Resources
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    • v.10 no.4
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    • pp.401-410
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    • 1997
  • This experiment was conducted to investigate the opimum media, media amount and planting density of nutri-culture for the high quality and yield of wild vegetable, Liguliaria fischeri Turez. The fried rice hull was recognized best media among perlite, sand and fried rice hull for nutri-culture of Ligularia fischeri Turcz. The yield on fried rice hull media at early growing stage was lower, but higher than in other media at late growing stage. Therefore, total yield in fried rice hull media was 15-29% higher than that of the existing perlite media. Growth and yield of Ligularia fischeri Turcz. were not significantly different between medium amounts, therefore considering economical efficiency and stability, the optimum medium amount was 105 $\iota/m^3$, Yield by planting density increased in the high density and 50 plants/$m^2$ was considered as proper planting density in nutri-culture of Liguliaria fishcheri Turcz.

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Comparison of Plant Community Structures in Cut and Uncut Areas at Burned Area of Mt. Gumo-san (금오산(金烏山)의 산화지(山火地)에서 벌목지(伐木地)와 비벌목지(非伐木地)의 식물(植物) 군집구조(群集構造) 비교(比較))

  • Che, Sang-Hoon;Kim, Woen
    • Journal of Korean Society of Forest Science
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    • v.86 no.4
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    • pp.509-520
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    • 1997
  • This is a report on the early vegetation, plant community structure, and secondary succession of cut and uncut sites of burned areas in Mt. Gumo-sun. The forest fire occurred on April, 1994 and the pine forest and its floor vegetation were burned down. The investigation was carried out from April, 1995 to October, 1996. The results are summarized as follows : The floristic composition of cut and uncut sites of burned area and unburned area were composed of 32, 36, and 34 kinds of vascular plants respectively. The biological spectra showed the $H(G)-D_1-R_5-e$ type, $H(M)-D_1-R_5-e$ and $M(N)-D_1-R_5-e$ in cut, uncut, and unburned site respectively. The dominant species based on $SDR_3$ of the cut site were Miscanthus sinensis var. purpurascens(100.00). Caret humilis(52.27), Quercus serrata(51.19) and Lysimachia clethroides(39.40), however, in the uncut sites the dominant species were Quercus acutissima(56.91), Pinus densiflora(26.83) in the tree layer, Quercus serrata(50.43), Lindera glauca(40.51), Lespedeza bicolor(37.85) in the shrub layer, and Miscanthus sinensis var. purpurascens(72.27), Pteridium aquilium var. latiusculum(60.92), Carex humilis(63.63) in the herb layer. Pinus densiflora(99.88), Miscanthus sinensis var. purpurascens(82.74), Quercus serrata(77.47) and Carex humilis(74.02) were dominant in the unburned site. The species diversity(H) and evenness index(e) were 1.05, 0.70 and 1.32, 0.85 in the cut and uncut site, respectively and 0.22, 0.63 in the unburned site. Dominance index(C) was 0.15, 0.06 and 0.96 in the cut, uncut site and unburned site, respectively. Degree of succession(DS) was 345.19, 747.47 and 674.34 in cut, uncut and unburned site, respectively. The index of similarity(CCs) was 0.66 between cut and uncut sites, 0.50 between unburned and cut sites and 0.61 between unburned and uncut sites. The amount of exchangeable sodium, calcium, magnesium and soil pH were increased, but the amount of organic matter, available phosphous, total nitrogen, total carbon and exchangeable potassium were decreased in cut site after fire.

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