• The Journal of Korean Institute of Information Technology
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• v.16 no.11
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• pp.133-144
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• 2018

IEC 62278, the Railway System Safety Standard, requires for hazard analysis to prevent or control the hazard that the railway system may have. If hazard analysis is not performed sufficiently, there is a high probability that accidents will occur. For this reason, hazard analysis methods are actively studied. In this paper, we propose the hybrid hazard analysis method to combine two representative hazard analysis methods: reliability-based and system-theoretic. As the proposed method is complementary to existing ones, it covers both the hazard caused by failure of components and the hazard occurred from the unintended control between components. It applies to the development of a safety protection mechanism for multiple cruise control system that automatically control the speed of trains to avoid the collision among trains. As a result, we drive more safety requirements than the existing analysis methods and it turns out that the safety requirements protect the trains with respect to the identified hazards.

• Journal of Microbiology and Biotechnology
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• v.29 no.8
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• pp.1288-1298
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• 2019

Bacterial ATP synthases drive ATP synthesis by a rotary mechanism, and play a vital role in physiology and cell metabolism. Corynebacterium glutamicum is well known as an industrial workhorse for amino acid production, and its ATP synthase operon contains eight structural genes and two adjacent genes, cg1360 and cg1361. So far, the physiological functions of Cg1360 (GenBank CAF19908) and Cg1361 (GenBank CAF19909) remain unclear. Here, we showed that Cg1360 was a hydrophobic protein with four transmembrane helices (TMHs), while no TMH was found in Cg1361. Deletion of cg1360, but not cg1361, led to significantly reduced cell growth using glucose and acetic acid as carbon sources, reduced F1 portions in the membrane, reduced ATP-driven proton-pumping activity and ATPase activity, suggesting that Cg1360 plays an important role in ATP synthase function. The intracellular ATP concentration in the ${\Delta}cg1360$ mutant was decreased to 72% of the wild type, while the NADH and NADPH levels in the ${\Delta}cg1360$ mutant were increased by 29% and 26%, respectively. However, the ${\Delta}cg1361$ mutant exhibited comparable intracellular ATP, NADH and NADPH levels with the wild-type strain. Moreover, the effect of cg1360 deletion on L-valine production was examined in the L-valine-producing V-10 strain. The final production of L-valine in the $V-10-{\Delta}cg1360$ mutant reached $9.2{\pm}0.3g/l$ in shake flasks, which was 14% higher than that of the V-10 strain. Thus, Cg1360 can be used as an effective engineering target by altering energy metabolism for the enhancement of amino acid production in C. glutamicum.

• Biomolecules & Therapeutics
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• v.31 no.2
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• pp.161-167
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• 2023

Despite the various medications used in clinics, the efforts to develop more effective treatments for depression continue to increase in the past decades mainly because of the treatment-resistant population, and the testing of several hypotheses- and target-based treatments. Undesirable side effects and unresponsiveness to current medications fuel the drive to solve this top global health problem. In this study, we focused on neuroinflammatory response-mediated depression which represents a cluster of depression etiology both in animal models and humans. Several meta-analyses reported that proinflammatory cytokines such as interleukin 6 (IL-6) and tumor necrosis factor-α (TNF-α) were increased in major depressive disorder patients. Inflammatory mediators implicated in depression include type-I interferon and inflammasome pathways. To elucidate the molecular mechanisms of neuroinflammatory cascades underlying the pathophysiology of depression, we introduced hycanthone, an antischistosomal drug, to check whether it can counteract depressive-like behaviors in vivo and normalize the inflammation-induced changes in vitro. Lipopolysaccharide (LPS) treatment increased proinflammatory cytokine expression in the murine microglial cells as well as the stimulation of type I interferon-related pathways that are directly or indirectly regulated by Janus kinase-signal transducer and activator of transcription (JAK-STAT) activation. Hycanthone treatment attenuated those changes possibly by inhibiting the JAK-STAT pathway and inflammasome activation. Hycanthone also ameliorated depressive-like behaviors by LPS. Taken together, we suggest that the inhibitory action of hycanthone against the interferon pathway leading to attenuation of depressive-like behaviors can be a novel therapeutic mechanism for treating depression.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.36 no.10
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• pp.1115-1130
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• 2012

In nuclear power plants, the reactor pressure vessel (RPV) upper head control rod drive mechanism (CRDM) penetration nozzles are fabricated using J-groove weld geometry. Recently, the incidences of cracking in Alloy 600 CRDM nozzles and their associated welds have increased significantly. The cracking mechanism has been attributed to primary water stress corrosion cracking (PWSCC), and it has been shown to be driven by welding residual stresses and operational stresses in the weld region. The weld-induced residual stress is the main factor contributing to crack growth. Therefore, an exact estimation of the residual stress is important for ensuring reliable operation. This study presents the residual stress computation performed for an RPV CRDM penetration nozzle in Korea. Based on two and three dimensional finite element analyses, the effect of welding variables on the residual stress variation is estimated for sensitivity analysis.

• Korean Journal of Agricultural Science
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• v.3 no.1
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• pp.95-104
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• 1976

This study was conducted to test the harvesting operation of two kinds of rice varieties such as Milyang #15 and Tong-il with a imported two furrow Japanese combine and was performed to find out the operational accuracy of it, the adaptability of this machine, and the feasibility of supplying this machine to rural area in Korea. The results obtained in this study are summarized as follows; 1. The harvesting test of the Milyang #15 was carried out 5 times from the optimum harvesting operation was good regardless of its maturity. The field grain loss ratio and the rate of unthreshed paddy were all about 1 percent. 2. The field grain loss of Tong-il harvested was increased from 5.13% to 10.34% along its maturity as shown in Fig 1. In considering this, it was needed that the combine mechanism should be improved mechanically for harvesting of Tong-il rice variety. 3. The rate of unthreshed paddy of Tong-il rice variety of which stem was short was average 1.6 percent, because the sample combine used in this study was developed on basisof the long stem variety in Japan, therefore some ears owing to the uneven stem of Tong-il rice could nat reach the teeth of the threshing drum. 4. The cracking rates of brown rice depending mostly upon the revolution speed of the threshing drum(240-350 rpm) in harvesting of Tong-il and Milyang #15 were all below 1 percent, and there was no significance between two varieties. 5. Since the ears of Tong-il rice variety covered with its leaves, a lots of trashes was produced, especially when threshed in raw materials, and the cleaning and the trashout mechanisms were clogged with those trashes very often, and so these two mechanisms were needed for being improved. 6. The sample combine of which track pressure was $0.19kg/cm^2$ could drive on the soft ground of which sinking was even 25cm as shown in Fig 3. But in considering the reaping height adjustment, 5cm sinking may be afford to drive the combine on the irregular sinking level ground without any readjustment of the resaping height. 7. The harvesting expenses per ha. by the sample combine of which annual coverage area is 4.7 ha. under conditions that the yearly workable days is 40, percentage of days being good for harvesting operation is 60%, field efficiency is 56%, working speed is 0.273m/sec, and daily workable hours is 8 hrs is reasonable to spread this combine to rural area in Korea, comparing to the expenses by the conventional harvesting expenses, if mechanical improvement is supplemented so as to harvest Tong-il rice. 8. In order to harvest Tong-il rice, the two furrow combine should be needed some mechanical improvements that divider can control not to touch ears of paddy, the space between the feeding chain and the thrshing drum is reduced, trash treatment apparatus must be improved, fore and rear adjust-interval is enlarged, and width of track must be enlarged so as to drive on the soft ground.

• Journal of the Korean Vacuum Society
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• v.18 no.1
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• pp.66-72
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• 2009

The detection methods are required to monitor and diagnose the abnormality on the insulation condition inside a gas-insulated switchgear (GIS). Due to a good sensitivity to the products decomposed by partial discharges (PDs) in $SF_6$ gas, the development of a SWNT gas sensor is actively in progress. However, a few numerical studies on the diffusion mechanism of the $SF_6$ decomposition products by PD have been reported. In this study, we modeled $SF_6$ decomposition process in a chamber by calculating temperature, pressure and concentration of the decomposition products by using a commercial CFD program in conjunction with experimental data. It was assumed that the mass production rate and the generation temperature of the decomposition products were $5.04{\times}10^{-10}$ [g/s] and over 773 K respectively. To calculate the concentration equation, the Schmidt number was specified to get the diffusion coefficient functioned by viscosity and density of $SF_6$ gas instead rather than setting it directly. The results showed that the drive potential is governed mainly by the gradient of the decomposition concentration. A lower concentration of the decomposition products was observed as the sensors were placed more away from the discharge region. Also, the concentration increased by increasing the discharge time. By installing multiple sensors the location of PD is expected to be identified by monitoring the response time of the sensors, and the information should be very useful for the diagnosis and maintenance of GIS.

• Journal of Korea Society of Industrial Information Systems
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• v.18 no.5
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• pp.81-92
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• 2013

The satellite includes many release mechanisms such as solar array deployment, antenna deployment, cover to protect contamination in scientific equipment, pyro value of the propulsion subsytem, and bypass device in Li-Ion cell module. A drive the initiators is a critical to the successful mission because the initiators of release mechanism driving by the pyrotechnic circuit is operated in single short. The pyrotechnic circuit has to provide switching network for safety. A typical switching network has defect consisting of high current rating fire switch to handle switching transient current during fire the initiator. The pyrotechnic circuit is required some form of power conditioning to reduce the peak power demanded from the bus if the initiators are to be fired from the main bus. This paper design a pyrotechnic circuit synchronized to the fire-command to activate the fire switch to overcome use high current rating fire switch to handle switching transient current during fire the initiator. The pyrotechnic circuit provides a current limited widow pulse for fire current synchronized to the fire-command to insure that fire switch will only carry the current but never switch it. The current limited widow pulse for fire current can be possible to use low current rating and light mass switch in switching network. The current limit function in the pyrotechnic circuit reduces supply voltage to initiator and provides the effect of power conditioning function to reduce peak bus power. The pyrotechnic circuit to apply satellite development on geostationary orbit is verified the function by test in development model.

• Cartoon and Animation Studies
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• s.33
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• pp.55-78
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• 2013

The issues on the representation of digital images, the uncanny is not considered aesthetically but must be overcome. It seems that the future of visual media using digital images, depends on the development and advancement of the digital technology. However, the Brothers Quay regarded as unique and experimental animators, focus their attention towards the past rather than the future. They trace back to the origin of the media, reproducing, manipulating, and representing gestures in oder to restore the shock and thrill delivered in film and animation. The Brothers Quay explore the uncanny of gestures through the mechanism of medium. They work in a wide range of genres, from animation, live action to dance film. The creaking spasms, which create the feeling that the movement does not belong to this world, and the strange gestures, reveals the flicker of the still projection and make audiences recognize gestures in the true meaning of the word. While they animate live actors and dead objects like automata, the hidden desires are revealed over screen. In this paper, focusing on the works of Brothers Quay, I tried to explore the uncanny of gesture based on Freud's and Jentsch' theory of uncanny.

• Journal of the Korean Geotechnical Society
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• v.29 no.10
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• pp.39-48
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• 2013

This paper presents an equation to depict the penetration behavior during the standard penetration test (SPT) in sandy deposits. An energy balance approach is considered and the driving mechanism of the SPT sampler is conceptually modeled as that of a miniature open-ended steel pipe pile into sands. The equation consists of three sets of input parameters including hyperbolic parameters (m and ${\lambda}$) which are difficult to determine. An iterative technique is thus applied to determine the optimized values of m and ${\lambda}$ using three measured values from a routine SPT data. It is verified from a well-documented record that the simulated penetration curves are in good agreement with the measured ones. At a given depth, the increase in m results in the decrease in ${\lambda}$ and the increase in the curvature of the penetration curve as well as the simulated N-value. Generally, the predicted penetration curve becomes nearly straight for the portion of exceeding the seating drive zone, which is more pronounced as soil density increases. Thus, the simulation method can be applied to extrapolating a prematurely completed test data, i.e., to determining the N value equivalent to a 30 cm penetration. A simple linear equation is considered for obtaining similar results.

• Journal of Satellite, Information and Communications
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• v.1 no.2
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• pp.95-100
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• 2006

The COMS(Communication, Ocean and Meteorological Satellite) EPS(Electrical Power Subsystem) is derived from an enhanced Eurostar 3000 version. Eurostar 3000 EpS is fully autonomous operation in nominal conditions or in the event of a failure and provides a high level of reconfigure capability. This paper introduces the COMS EPS preliminary design result. COMS EPS consists of a battery, a solar arrat wing, a PSR(Power Supply Regulator), a PRU(Pyrotechnic Unit), a SDAM(Solar Array Drive Mechanism) and relay and fuse brackets. COMS EPS can offer a bus power capability of 3 kW. The solar array is made of a deployable wing with two panels. One type fo solar cells is selected ad GaAs/Ge triple junction cells. Li-ion battery is base lined with ten series cell module of five cells in parallel. PSR associated to battery and solar array wing generates a power bus fully regulated at 50 V. Power bus os centralized protection and distribution by relay and fuse brackets. PRU provides power for firing actuarors devices. The solar array wing is rotated by the SADM under control of the attitude orbit control subsystem. The control and monitoring of the EPS, especially of the battery, is performed by the PSR in combination with the on-board software.