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Effect of N-Methyl-D-Aspartate Glutamate Receptor Antagonist, Memantine, on Alcohol Intake in C57BL/6 Mice (N-methyl-D-aspartate glutamate 수용체 길항제 memantine의 투여가 C57BL/6형 생쥐의 알코올 섭취량에 미치는 영향)

  • Kim, Hyeun-Kyeung;Kim, Sung-Gon;Kim, Ji-Hoon;Shin, Su-Mi;Lee, Sang-Shin;Bae, So-Hyun;Kim, Ho-Chan
    • Journal of Life Science
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    • v.19 no.4
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    • pp.532-537
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    • 2009
  • Previous studies reported that the N-methyl-D-aspartate (NMDA) receptor is related to alcohol dependence in terms of developing withdrawal or tolerance, however, it is controversial whether NMDA receptor antagonists are effective in preventing relapse in alcohol-dependent patients or not. The purpose of this study was to investigate the effect of memantine, an NMDA receptor antagonist, on alcohol intake in C57BL/6 mice, which prefer drinking hereditarily. Using limited access procedures in C57BL/6 mice in the state of alcohol dependence, vehicle, naltrexone 1.0 mg/kg or, memantine 5, 25, or 50 mg/kg i.p. was administered respectively for twelve days. Medication effects on 2-hours alcohol, 22-hour water, and 24-hour food intake and body weight were studied. Using repeated measure ANOVA, the naltrexone 1 mg/kg, memantine 5, 25, or 50 mg/kg, and vehicle groups showed significant medication by day interaction (naltrexone, df=4, F=11.827, p<0.01, memantine 5 mg/kg, df=4, F=7.999, p<0.01; memantine 25 mg/kg, df=4, F=6.199, p<0.05; memantine 50 mg/kg, df=4, F=10.522, p<0.01) in 2-hour alcohol intake. In 3 memantine groups, there was no significant medication by day interaction with the vehicle group in 22-hour water intake, 24-hour food intake, or body weight. The naltrexone and vehicle groups showed significant medication by day interaction in body weight, but not in 22-hour water or 24-hour food intake. From these results, it is suggested that memantine treatment can affect alcohol intake in mice. Therefore, it is possible that a pure NMDA receptor antagonist is effective in preventing relapse in alcohol-dependent patients.

A study on OHIP-14 and EQ-5D of residents in some rural areas (일부 농촌지역 주민들의 OHIP-14와 EQ-5D에 관한 연구)

  • Lee, Eun-Gyeong;Park, Jeong-Hee;Park, Jeong-Ran;Park, Jae-Yong
    • Journal of Korean society of Dental Hygiene
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    • v.11 no.2
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    • pp.197-211
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    • 2011
  • Objectives : OHIP-14 and EQ-5D were used, targeting the residents of farming communities to identify the elements that influence oral cavity's health and quality of life due to health and to identify the importance of oral cavity's health in order to increase health of adults' oral cavity and quality of life via improved health. Methods : This research was conducted from July 17th, 2010 to August 16th, 2010 targeting 600 residents in Goryeong-gun, Gyeongsangbuk-do, aging over 40. The data has been analyzed using Mann-Whitney U test, Kruskal-Wallis test and hierarchical multiple regression through SPSS Win Program 18.0 version. Results : 1. OHIP-14 and EQ-5D based on general characteristics showed lower oral health-related quality of life and health-related quality of life on the following cases: women (p=0.004, p<0.001), older (p<0.001, p<0.001), lower scholastic ability (p<0.001, p<0.001), lower average of average spending money (p<0.001, p<0.001), higher number of chronic disease (p<0.001, p<0.001), less drinking (p=0.012, p=0.008), lower perceived oral health and health status (p<0.001, p<0.001) and non smoking showed only EQ-5D (p<0.001). 2. OHIP-14 and EQ-5D based on oral health behavior showed lower oral health-related quality of life and health-related quality of life on the following cases: no periodic oral check-up (p<0.001, p<0.001), less experience of oral health education (p<0.001, p<0.001), horizontal tooth-brushing method(p<0.001, p<0.001) and lower frequency of tooth-brushing showed only OHIP-14 (p=0.042). OHIP-14 and EQ-5D based on oral health status and subjective oral symptom showed lower oral health-related quality of life and health-related quality of life on following cases: number of existing tooth less than 20 (p<0.001, p<0.001), the number of missing teeth more than 9 (p<0.001, p=0.044), DMFT (Decay, Missing, Filling Teeth) index more than 18 (p<0.001, p<0.001), wears denture (p<0.001, p<0.001), edentulous (p<0.001, p=0.002), have xerostomia (p<0.001, p<0.001) and have chewing discomfort (p<0.001, p<0.001). 3. Factors affecting OHIP-14 were gender, age, perceived oral health status, perceived health status, number of existing teeth, dental status, xerostomia and chewing discomfort, and the of reliability (how well it explains) the final model was 48.7%. EQ-5D showed relevance on gender, age, presence of chronic disease, perceived health status, xerostomia, chewing discomfort and oral health-related quality of life, and the reliability of the final model was 42.9%. Conclusions : In order to improve the quality of life of ruralists, oral health needs to be improved or remained by increasing the rate of possession of the existing teeth and preventing the loss of teeth. In order to do so, improvement of accessibility of dental clinic, change of direction from treatment-centered to prevention-centered health care system, development of oral health education program and various oral health care policies which would vitalize continuous oral health care system are considered to be necessary.

Model Development of Affecting Factors on Health Behavior and Juvenile Delinquency of Adolescents (청소년의 건강행위와 비행의 영향 요인에 관한 모형 구축)

  • Kim, Hyeon Suk;Kim, Hwa Jung
    • Journal of the Korean Society of School Health
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    • v.11 no.2
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    • pp.171-187
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    • 1998
  • In recent years, adolescent issues including smoking, drinking, drug abuse, juvenile delinquency, deviant sexual behavior, mental health problems, high suicide rate, juvenile delinquency and absence without due notice, etc are emerging as serious social problems and the debate on these controversial issues is heating up. The previous studies on adolescent health behavior and social juvenile delinquency such as run-away from home and absence without due notice have been conducted mostly by cause analysis utilizing social demographic factors or biological factors. In other words, the main factors analyzed were demographic and economic factors or parent's educational level, etc, which were the fixed environmental ones that were unable to cause the change in the health behavior. Accordingly, the purpose of this study is to analyze factors which are changeable and fixable among the factors influencing the adolescent's health behavior and misconducts and, eventually influencing factors which can be used as the basis to establish health policies and health promotion program to reduce the health risk behavior and misconducts of adolescents. The study subjects were selected by dividing senior high school student in Seoul by region and through random sampling. The 890 subjects were selected from 10 schools including the preparatory school, vocational schools and institutional schools. The duration of the study was for July 1-5, 1997 for the first survey and the second one, for August 25-September 10. Regarding the analysis method, the SAS program was used. The adoptablity of theoretical model was tested through covariance structural analysis utilizing PC-LISREL 8.12 Program. The major findings of the study are as follows: As a result of establishing the model of factors influencing health behavior and juvenile delinquency, in case of male students as the health behavior self-efficacy, education level of fathers, economic level, self-control and the health interest of parent were higher, students were more likely to practice the health promoting behavior. Juvenile delinquency and health risk behavior were prevalent among those with the less shyness, the lower health behavior self-efficacy, lower self-control, lower self-assertiveness, lower economic level. The self-control was the most powerful factor. In case of female students, those with higher health behavior self-efficacy were more likely to practice the health promoting behavior whereas those with lower health behavior self-efficacy, lower self-control, lower self- assertiveness, less shyness were more likely to practice health risk behavior and juvenile delinquency. In case of prep schools, those with higher health behavior self-efficacy and better perceived health status were more likely to practice the health promoting behavior while those with less shyness, lower health behavior self-efficacy and lower academic achievement were more likely to engage in health risk behavior and juvenile delinquency. In case of vocational schools, as health behavior self-efficacy and economic level were higher, the practice rate of health promoting behavior was higher. As the self-control, shyness, self-assertiveness, health behavior self-efficacy were lower, the rate of health risk behavior and juvenile delinquency were higher. In case of social institutional schools, as, the health behavior self-efficacy, social support and economic level, health interest of parents were higher, the rate of health promoting behavior were higher. As the self-control, shyness, self-assertiveness, health behavior self-efficacy and social support were lower, the rate of health risk behavior and juvenile delinquency were higher. So the health promoting behavior was positively related to the health behavior self-efficacy, health interest of parents, social support, education level of fathers, level of perceived health status, economic level. The health risk behavior and juvenile delinquency were higher with the lower health behavior self-efficacy, self-control and self-assertiveness, lower health locus control, less shyness and loneliness, lower economic level and academic achievement. In conclusion, the health risk behavior and juvenile delinquency can be reduced by enhancing self-control, self-assertiveness, health behavior self-efficacy and social support. According to the final model drawn by connecting health behavior and juvenile delinquency, the reduction of health risk behavior can greatly contribute to decreasing social juvenile delinquency as the process of juvenile delinquency was extended from common behaviors to problem behaviors and further into juvenile delinquency.

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Changes of Nitrifying Bacteria Depending on the Presence and Absence of Organic Pollutant in Nak-Dong River (낙동강에서의 유기성 오염 유무에 따른 질화세균의 변화)

  • Jin, Seon-Yeong;Lee, Young-Ok
    • Korean Journal of Microbiology
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    • v.49 no.2
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    • pp.137-145
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    • 2013
  • This study was performed at 2 sites of Nak-Dong River to investigate the changes of nitrifiers depending on the presence and absence of organic pollutants (due to the effluents of domestic wastewater treatment plant, WWTP). Conventional chemical parameters such as T-N, $NH_4$-N, $NO_2$-N, $NO_3$-N were measured and the quantitative nitrifiers at the 2 sites were analyzed comparatively by fluorescent in situ hybridization (FISH) with NSO190 and NIT3, after checking the presence of gene amoA of ammonia oxidizing bacteria (AOB) and 16S rDNA signature sequence for Nitrobacter sp. that belongs to nitrite oxidizing bacteria (NOB). Also ${\alpha}{\cdot}{\beta}{\cdot}{\gamma}$-Proteobacteria were detected using FISH to get a glimpse of the general bacterial community structure of the sites. Based on the distribution structure of the ${\alpha}{\cdot}{\beta}{\cdot}{\gamma}$-Proteobacteria and the measurement of nitrogen in different phases, it could be said that the site 2 was more polluted with organics than site 1. Corresponding to the above conclusion, the average numbers of AOB and NOB detected by NSO160 and NIT3, respectively, at site 2 [AOB, $9.3{\times}10^5$; NOB, $1.6{\times}10^6$ (cells/ml)] was more than those at site 1 [AOB, $7.8{\times}10^5$; NOB, $0.8{\times}10^6$ (cells/ml)] and also their ratios to total counts were higher at site 2 (AOB, 27%; NOB, 34%) than those at site 1 (AOB, 18%; NOB, 23%). Thus, it could be concluded that the nitrification at site 2 was more active due to continuous loading of organics from the effluents of domestic WWTP, compared to site 1 located closed to raw drinking water supply and subsequently less polluted with organics.

Relations between Emotional Labor and Sleep Health according to the Personality Types of Dental Hygienists (일부지역 치과위생사의 성격유형에 따른 감정노동과 수면건강과의 관계)

  • Yoon, Song-Uk;Nam, In-Suk
    • Journal of dental hygiene science
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    • v.11 no.3
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    • pp.243-249
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    • 2011
  • Under the goal of investigating relations between emotional labor and sleep health according to the personality types of dental hygienists, who provide high quality medical service at dental clinics, this study surveyed 220 dental hygienists in Gumi city from July 2 to 21, 2010. The surveyed dental hygienists scored average 2.75 in emotional labor, which means their emotional labor was higher than average. Their emotional labor was in statistically significant relations with such general characteristics as educational background, place of work, salary, and drinking(p<0.05). The means of their emotional labor in six items were analyzed according to the personality types. As a result, personality type A had higher means in emotional labor than personality type B with statistical significance(p<0.05). The more stress they had from emotional labor, the worse their sleep health became. As for the relations between emotional labor and sleep health according to the personality types, the bad sleep health group accounted for 88.1% and recorded 2.85 mean scores in emotional labor, which was statistically significant(p<0.05), in personality type A. The regression analysis results of emotional labor in personality type A and sleep health indicate that the more emotional labor in personality type A they had, the worse their sleep health became. As for causality between personality type A and emotional labor, "difficulty with sleeping," "a feeling of lack of sleep when waking up," and "taking sleeping pills" had significant influences on the emotional labor of personality type A. Dental hygienist who owns the characteristics of personality type A, the more emotional labor, emotional stress of personality type A labor is high and unhealthy sleep affects the results were derived.

The Effect of Commercially Available Mouth Rinsing Solution and Alkaline Ionized Water on the Oral Bacteria (시판되는 구강 양치액과 알칼리 이온수가 구강 내 세균에 미치는 효과)

  • Park, Seon-Nyeo;Jeong, Soon-Jeong;Jeong, Moon-Jin;Ahn, Yong-Soon;Choi, Yoo-Seok;Lim, Do-Seon
    • Journal of dental hygiene science
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    • v.13 no.2
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    • pp.213-221
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    • 2013
  • The mouth rinsing solution currently on the market is used for oral hygiene and reduction of halitosis, and alkaline ionized water is used for drinking purposes. The aim of this germiculture and observation through a microscope is to investigate the effect they have on the oral bacteria, and the results are as follows. 1. The change in the number of cultivated bacteria before and after the use of gargle was most dramatic for Hexamedin. It showed the highest rate of decrease in bacteria by 71.29%, followed by Listerine with 62.25%, Caregargle with 42.26%, Garglin with 33.52%, saline solution with 21.62%, alkaline ionized water with 16.08% and distilled water with 7.67%. 2. After careful analysis of statistics, Hexamedin was found to result in a significant decrease in the number of bacteria after gargling (p<0.05). 3. From observing through an light microscope after gram staining, it was evident that both a number of cocci and a few of filamentous were present before the use of gargle, whereas mostly cocci was present after the use of gargle. 4. The difference in the pH of oral rinses and alkaline ionized water had no significant influence on the number of oral bacteria. In conclusion, Hexamedin and Listerine, with the rate of decrease of bacteria of co71.29% and 62.25% respectively, have proven to be highly effective when applied before dental treatment. Other oral rinses and alkaline ionized water are relatively less efficient in decreasing the number of oral bacteria. Also, the decrease of bacteria is more affected by the antibacterial component of oral rinses than by the change in pH.

Comparative Study on Dietary Life and Nutrient Intakes of Elderly Persons at Nursing Home or Their Home in Chungnam (충남지역 일부 시설노인과 재가노인의 식생활 및 영양섭취상태 비교)

  • Song, Eun-Sook;Kim, Eun-Jin;Kim, Myung-Hee;Choi, Mi-Kyeong
    • Journal of the East Asian Society of Dietary Life
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    • v.21 no.5
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    • pp.649-660
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    • 2011
  • The purpose of this study was to compare the dietary life and nutrient intakes among elderly persons residing at nursing homes and their homes in order to provide fundamental data for improved foodservice and dietary management. We recruited 150 subjects at a nursing home stay and 150 home stay elderly persons for a survey. The results were as follows. There was no significant difference in frequency of napping between the two groups. The frequency of going out was higher in the home stay subjects, but regular exercise was higher in nursing home stay subjects. Subjects possessed the following diseases: dementia and digestive disorders for nursing home stay elderly men, blood vessel disorder and diabetes for home stay elderly men, digestive and blood vessel disorders for nursing home stay elderly women, and blood vessel and heart disease for home stay elderly women. In a health-related assessment, smoking, drinking, and teeth condition of nursing home stay subjects were not higher than those of home stay subjects. The ratio of subjects who ate meals everyday was higher in nursing home stay elderly women than in home stay women. While most nursing home subjects ate adequate amount of meals, home stay subjects ate until they were full. The daily energy intakes of men and women were 2,229.9 kcal and 2,302.1 kcal for nursing home subjects and 1,894.0 kcal and 1,885.9 kcal for home subjects, respectively. Nutrient intake was also higher in nursing home than home stay subjects. In summary, the dietary life of elderly persons residing in a nursing home was higher than that of elderly persons residing at their home from the view point of meal frequency, meal intake, and nutrient intakes. Therefore, systematic assessment and management of nutrition for elderly staying at a nursing home or at home alone should be conducted continually.

Comparison of Biofilm Formed on Stainless Steel and Copper Pipe Through the Each Process of Water Treatment Plant (정수처리 공정 단계별 스테인리스관과 동관에 형성된 생물막 비교)

  • Kim, Geun-Su;Min, Byung-Dae;Park, Su-Jeong;Oh, Jung-Hwan;Cho, Ik-Hwan;Jang, Seok-Jea;Kim, Ji-Hae;Park, Sang-Min;Park, Ju-Hyun;Chung, Hyen-Mi;Ahn, Tae-Young;Jheong, Weonhwa
    • Korean Journal of Microbiology
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    • v.49 no.4
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    • pp.313-320
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    • 2013
  • Biofilm formed on stainless and copper in water treatment plant was investigated for sixteen weeks. Biofilm reactor was specially designed for this study. It was similar to that of a real distribution pipe. Raw water, coagulated, settled, filtered and treated water were used in this study. The average number of heterotrophic bacteria counts was $1.6{\times}10^4CFU/ml$, $5.8{\times}10^3CFU/ml$, $1.8{\times}10^3CFU/ml$, $1.3{\times}10^2CFU/ml$, 1 CFU/ml, respectively. Density of biofilm bacteria formed on stainless and copper pipes in raw, coagulated and settled water increased above $2.9{\times}10^3CFU/cm^2$ within second weeks while more biofilm bacteria counts were found on the stainless pipe than on the copper pipe. In case of filtered water (free residue chlorine 0.44 mg/L), there was no significant difference in the number of biofilm bacteria on both pipes and biofilm bacteria below $18CFU/cm^2$ were detected on both pipe materials after fifth weeks. Biofilm bacteria were not detected on both pipe materials in treated water (free residue chlorine 0.88 mg/L). According to the results of DGGE analysis, Sphingomonadacae was a dominant species of biofilm bacteria formed on the stainless pipe while the copper pipe had Bradyrhizobiaceae and Sphingomonadaceae as dominant bands. In case of filtered water, a few bands (similar to Propionibacterium sp., Sphingomonas sp., Escherichia sp., and etc.) that have 16S rRNA sequences were detected in biofilm bacteria formed on both pipes after fifth weeks. Stainless pipe had higher species richness and diversity than the copper pipe.

Application of Nano Fe°-impregnated Biochar for the Stabilization of As-contaminated Soil (비소 오염토양의 안정화를 위한 나노 Fe° 담지 바이오차 적용 연구)

  • Choi, Yu-Lim;Angaru, Ganesh Kumar Reddy;Ahn, Hye-Young;Park, Kwang-Jin;Joo, Wan-Ho;Yang, Jae-Kyu;Chang, Yoon-Young
    • Journal of Environmental Impact Assessment
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    • v.29 no.5
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    • pp.350-362
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    • 2020
  • In this study, nano Fe°-impregnated biochar (INPBC) was prepared using pruning residues and one-pot synthetic method and evaluated its performance as an amendment agent for the stabilization of arsenic-contaminated soil. For the preparation of INPBC, the mixture of pruning residue and Fe (III) solution was heated to 220℃ for 3hr in a teflon-sealed autoclave followed by calcination at 600℃ under N2 atmosphere for 1hr. As-prepared INPBC was characterized using FT-IR, XRD, BET, SEM. For the stabilization test of as-prepared INPBC, As-contaminated soils (Soil-E and Soil-S) sampled from agricultural sites located respectively near E-abandoned mine and S-abandoned mine in South Korea were mixed with different of dosage of INPBC and cultivated for 4 weeks. After treatment, TCLP and SPLP tests were conducted to determine the stabilization efficiency of As in soil and showed that the stabilization efficiency was increased with increasing the INPBC dosage and the concentration of As in SPLP extractant of Soil-E was lower than the drinking water standard level of Ministry of Environment of South Korea. The sequential fractionation of As in the stabilized soils indicated that the fractions of As in the 1st and 2nd stages that correspond liable and known as bioavailable fraction were decreased and the fractions of As in 3rd and 4th stages that correspond relatively non-liable fraction were increased. Such a stabilization of As shows that the abundant nano Fe° on the surface of INPBC mixed with As-contaminated soils played the co-precipitation of As leaching from soil by surface complexation with iron. The results of this study may imply that INPBC as a promising amendments for the stabilization of As-contaminated soil play an important role.

The Analysis of Program Preferences for the Development of Forest Therapy Program (산림치유 프로그램 개발을 위한 프로그램 선호도 분석)

  • Kim, Youn-Hee
    • Korean Journal of Environment and Ecology
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    • v.30 no.1
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    • pp.118-129
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    • 2016
  • The purpose of this study was to offer the preliminary data for the development of forest therapy program. This exploratory study is about the development of forest healing program by identifying what is the forest healing program preferences of potential consumers and would be an important basis for the operation. The survey of interests and needs of 620 people on the forest therapy was analyzed. Using SPSS 21.0 program, statistical analysis, frequency analysis, T-test, One-way ANOVA, we looked at the differences in forest healing program preferences according to gender, age, occupation. Forest therapy program preference was found to vary depending on sex, age and job. First, according to gender, men preferred athletic in the forest and camping compared to women, and women showed a higher preference than men in the overall program. Second, depending on age, as compared to other age, for 20s; stress assessment & diagnosis, cooking in the forest, photo therapy in the forest, for 30s; walking in the forest, counseling, listening to lectures(stress-related or interpersonal relationships-related), communication-related lectures and vision quest, for 40s; meditation, viewing the forest, forest bathing wind bathing sun bathing, walking on barefoot in the forest, for 50s; breathing breathing exercises, yoga, mountaineering, climbing in silence, eating wild food, respectively, each of those programs were especially favored. Third, the forest healing program preference in accordance with the job is as follows. For students; stress assessment & diagnosis, cooking in the forest, etc., for teachers; walking in the forest, mountaineering, reading in the forest, viewing the forest, forest bathing wind bathing sun bathing, camping etc., for housewives; yoga, listening to the sound of water flowing, drinking herbal tea, eating wild food, for specialist researcher; breathing breathing exercises, climbing in silence, meditation, sleeping in the forest, respectively, each of those programs were especially favored. We expect the results of this study to be utilized as basic data for the development of forest therapy program targeting on adults.