• Genomics & Informatics
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• v.19 no.1
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• pp.2.1-2.10
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• 2021

BRAF inhibitors (e.g., vemurafenib) are widely used to treat metastatic melanoma with the BRAF V600E mutation. The initial response is often dramatic, but treatment resistance leads to disease progression in the majority of cases. Although secondary mutations in the mitogen-activated protein kinase signaling pathway are known to be responsible for this phenomenon, the molecular mechanisms governing acquired resistance are not known in more than half of patients. Here we report a genome- and transcriptome-wide study investigating the molecular mechanisms of acquired resistance to BRAF inhibitors. A microfluidic chip with a concentration gradient of vemurafenib was utilized to rapidly obtain therapy-resistant clones from two melanoma cell lines with the BRAF V600E mutation (A375 and SK-MEL-28). Exome and transcriptome data were produced from 13 resistant clones and analyzed to identify secondary mutations and gene expression changes. Various mechanisms, including phenotype switching and metabolic reprogramming, have been determined to contribute to resistance development differently for each clone. The roles of microphthalmia-associated transcription factor, the master transcription factor in melanocyte differentiation/dedifferentiation, were highlighted in terms of phenotype switching. Our study provides an omics-based comprehensive overview of the molecular mechanisms governing acquired resistance to BRAF inhibitor therapy.

• 제어로봇시스템학회:학술대회논문집
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• 2003.10a
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• pp.269-272
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• 2003

Industry is now seeing a dramatic increase in robot simulation and off-line programming. In order to use off-line programming effectively, the simulated workcell has to be identical to the real workcell. This requires an efficient and accurate method for the workcell calibration. Currently used techniques in the industry, however, are typically time-consuming, expensive and therefore not suitable for in-process application. This is because most of these techniques are based on the so-called “absolute calibration” method. In contrast to absolute method, relative calibration only measures the difference of an interested object relative to a standard reference. Owing to the small measurement range requirement, relative calibration method is very cheap and can achieve very high accuracy. In this paper the relative method is applied to calibrate an entire grinding workcell. Linear gauge is the only measurement device used. This workcell calibration includes tool center point (TCP) calibration and work object frame calibration. Due to the efficiency of the calibration algorithm and the simplicity of the calibration setup, the described calibration procedure can be done in process.

• Proceedings of the KIPE Conference
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• 2005.07a
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• pp.149-151
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• 2005

Recently, power supply-demand instability due to the dramatic increase in power usage suchas air-conditioning load at summertime has brought forecasts of decrease in power supply capability. Therefore improving the load factor through systematic load management, in other words, Direct Load Control became necessary. Direct Load Control(DLC) system is kind of a load management program for stabilization of electric power supply-demand. It's purpose is limiting the demand of the demand side selected at peak load or other time periods. The paper presented a Design of Direct Load Controller for control the amount of power demand in demand side. The proposed Controller is cheaper and has ability of storing more power data than pre-existing device.

• 한국정보디스플레이학회:학술대회논문집
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• 2007.08a
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• pp.737-740
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• 2007

The buffer layer was spin-coated on the dielectric layer of OTFTs to introduce the hydrophobicity for enhancing the device performance. this functional layer contains the water-proof ingredient to reduce the surface energy and more importantly, does not harm the dielectric property of the dielectric layer. With the help of proposed hydrophobic layer, the transistor showed dramatic improvement at electrical performance which was almost 20 times higher mobility compared to the non-treated case. And on/off ratio was also guaranteed as $10^{5{\sim}6}$.

• Vacuum Magazine
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• v.1 no.4
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• pp.21-24
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• 2014

Thermolectric devices could convert temperature gradient into electricity (Seebeck effect) and electric power into temperature gradient across the themoelectric element (Peltier effect). $Bi_2Te_3$ has been widely used as thermoelectric material for more than 40 years, due to the superior thermoelctric characteristics. However, Bi and Te materials are predicted to face supply shortage, giving strong necessity for the development of new thermoelctric materials. Based on the theoretical prediction, nanostructure are expected to give dramatic enhnacement of thermoelectirc characteristics by controlling phonon propagation. Thus, silicon, which had been considered as improper material for thermoelectricity, is now being considered as strong cadidate material for thermoelectricity. This review will focus on the nanotechnology applied research activities in silicon as thermoelectric materials.

• Convergence Security Journal
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• v.21 no.1
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• pp.55-62
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• 2021

Recently, the use of sensor devices is gradually increasing. As various sensor device emerge and the related technologies advance, there has been a dramatic increase in the interest in heterogeneous wireless sensor networks (WSNs). While sensor device provide us many valuable benefits, automatically and remotely supported services offered and accessed remotely through WSNs also exposes us to many different types of security threats. Most security threats were just related to information leakage and the loss of authentication among the involved parties: users, sensors and gateways. An user authentication protocol for wireless sensor networks is designed to restrict access to the sensor data only to user. In 2019, Chen et al. proposed an efficient user authentication protocol. However, Ryu et al. show that it's scheme still unstable and inefficient. It cannot resist offline password guessing attack and session key attack. In this paper, we propose an improved protocol to overcome these security weaknesses by storing secret data in device. In addition, security properties like session-key security, perfect forward secrecy, known-key security and resistance against offline password attacks are implied by our protocol.

• Journal of the Institute of Electronics and Information Engineers
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• v.52 no.8
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• pp.18-26
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• 2015

Measuring the heart rate during exercise is important to properly control the amount of exercise. With the recent advent of smart device usage, there is a dramatic increase in interest in devices for the real-time measurement of the heart rate during exercise. During intensive exercise, accurate heart rate estimation from wrist-type photoplethysmography (PPG) signals is a very difficult problem due to motion artifact (MA). In this study, we propose an efficient algorithm for an accurate estimation of the heart rate from wrist-type PPG signals. For the twelve data sets, the proposed algorithm achieves the average absolute error of 1.38 beat per minute (BPM) and the Pearson correlation between the estimates and the ground-truth of heart rate was 0.9922. The proposed algorithm presents the strengths in an accurate estimation together with a fast computation speed, which is attractive in application to wearable devices.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.39C no.11
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• pp.1167-1176
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• 2014

In this paper, a relay communication scheme for enhancing the WiMedia network performance by device's mobility is proposed. WiMedia protocol is suitable for the application that supports the real-time multimedia service in Ship Area Network since it supports high speed data transfer. However, the device's mobility is caused the dramatic change of link state and network topology, and is occurred the degradation of network performance. Therefore, a relay communication scheme for WiMedia network is proposed in this paper. The proposed technique can intelligently treat the change of link state, and solve the degradation of network performance.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.39C no.11
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• pp.1159-1166
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• 2014

In this paper, a resource management scheme for enhancing the network connectivity and reliability in wireless USB system is proposed. Wireless USB protocol is suitable for the application that supports the real-time multimedia service in Ship Area Network since it supports high speed data transfer. However, the device's mobility is caused the dramatic change of link state and network topology, and is occurred the degradation of network performance. Therefore, a resource management scheme for wireless USB system is proposed in this paper. The proposed technique can intelligently treat the change of link state, and solve the degradation of network performance. The simulation results show that proposed protocol can enhance the throughput and delay performance by selecting relay device with better link state.

• 한국정보디스플레이학회:학술대회논문집
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• 2007.08b
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• pp.1103-1107
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• 2007

Highly efficient organic electroluminescent devices (OLEDs) based on 4,7- diphenyl-1, 10- phenanthroline (BPhen) as the electron transport layer (ETL), tris (8-hydroxyquinoline) aluminum ($Alq_3$) as the emission layer (EML) and N,$\acute{N}$-bis-[1-naphthy(-N,$\acute{N}$diphenyl-1,1´-biphenyl-4,4´-diamine)] (NPB) as the hole transport layer (HTL) were developed. The typical device structure was glass substrate/ ITO/ NPB/$Alq_3$/ BPhen/ LiF/ Al. Since BPhen possesses a considerable high electron mobility of $5\;{\times}\;10^{-4}\;cm^2\;V^{-1}\;s^{-1}$, devices with BPhen as ETL can realize an extremely high luminous efficiency. By optimizing the thickness of both HTL and ETL, we obtained a highly efficient OLED with a current efficiency of 6.80 cd/A and luminance of $1361\;cd/m^2$ at a current density of $20\;mA/cm^2$. This dramatic improvement in the current efficiency has been explained on the principle of charge balance.