• Journal of Ginseng Research
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• v.48 no.1
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• pp.1-11
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• 2024

Fresh ginseng is prone to spoilage due to its high moisture content. For long-term storage, most fresh ginsengs are dried to white ginseng (WG) or steamed for hours at high temperature/pressure and dried to form Korean Red ginseng (KRG). They are further processed for ginseng products when subjected to hot water extraction/concentration under pressure. These WG or KRG preparation processes affect ginsenoside compositions and also other ginseng components, probably during treatments like steaming and drying, to form diverse bioactive phospholipids. It is known that ginseng contains high amounts of gintonin lysophosphatidic acids (LPAs). LPAs are simple lipid-derived growth factors in animals and humans and act as exogenous ligands of six GTP-binding-protein coupled LPA receptor subtypes. LPAs play diverse roles ranging from brain development to hair growth in animals and humans. LPA-mediated signaling pathways involve various GTP-binding proteins to regulate downstream pathways like [Ca²⁺]_i transient induction. Recent studies have shown that gintonin exhibits anti-Alzheimer's disease and antiarthritis effects in vitro and in vivo mediated by gintonin LPAs, the active ingredients of gintonin, a ginseng-derived neurotrophin. However, little is known about how gintonin LPAs are formed in high amounts in ginseng compared to other herbs. This review introduces atypical or non-enzymatic pathways under the conversion of ginseng phospholipids into gintonin LPAs during steaming and extraction/concentration processes, which exert beneficial effects against degenerative diseases, including Alzheimer's disease and arthritis in animals and humans via LPA receptors.

• Journal of Korea Water Resources Association
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• v.43 no.7
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• pp.657-666
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• 2010

The adjustment processes of mining pits in the disturbed channels by sand or gravel mining were investigated by laboratory experiments in this study. The pit migrated with speed when the river bed was steep. The pit migrated slow and steady when the pit was filling with sand, but the pit migrated with speed after the filling processes was finished. The submerged angle of repose in the pit was nearly constant during the pit was filling. The pit was filled with sand with speed as the channel slope was increased. It took time for the pit to be filled with sand as the pit dimension was increased. This meant that the disturbed channels by sand or gravel mining to adjust the new environment was dependent on the slope of the channels and the dimension of the pits. The dimensionless pit length was short and the dimensionless pit depth was shallow as the time was increased. The dimensionless pit depth was shallow, but the dimensionless pit migration speed was increased as the dimensionless shear velocity and the migration speed of the pit were increased. The dimensionless pit depth was increased with the dimensionless bar migration speed. The shape of the pit was deformed and migrated downstream in accordance with the location and shape of the biased bar front which was developed upstream.

• Journal of Korea Water Resources Association
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• v.48 no.3
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• pp.169-183
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• 2015

As a basic work for river restoration, analysis on fluvial geomorphological characteristics is made using past and present data to understand close-to-nature geomorphic status. The Miho and the Naesung Rivers are targets of this study. Fluvial geomorphic variables including valley-floor width, sinuosity, bankfull width, channel gradient, bed material size, bankfull discharge and unit stream power are evaluated with dominant processes. Though common sand-bed rivers with similar catchment area, the Miho and the Naesung Rivers are different in terms of valley-floor width, channel shape variables and dominant processes related with longitudinal location. In addition, analyses on interrelationship among the geomorphological variables are carried. Bankfull width is shown to be proportional to bankfull discharge, as is in a rough agreement with the previous studies. Relationship of bankfull discharge and channel gradient shows meandering and braiding are prevalent in the Miho River, whereas the most of the sub-reaches of the Naesung River fall to braiding. Relationship of channel gradient with width-depth ratio indicates dune-ripple processes are dominant in the Miho River, while the Naesung River shows longitudinal diversity from braiding in the downstream sub-reaches to riffle-pool and plane-bed along the upper ones. Analyses based on the past data on a river in a close-to-nature status are thought to be rather reasonable in comparison with those on the same river in a engineered condition.

• Journal of Korean Society of Environmental Engineers
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• v.34 no.1
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• pp.1-6
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• 2012

Down Stream K River has high COD (4-10 mg/L) and high $NH_3$-N concentration (3.5 mg/L during winter period). Although $NH_3$-N itself is not reported harmful at this level, it must be removed to meet drinking water standard (0.5 mg/L). We constructed a pilot plant modifying the processes of conventional drinking water facilities. Prechlorination and powdered activated carbon (PAC) dechlorination was adopted prior to a flocculation tank to remove ammonia and prevent disinfection byproducts (DBPs) formation. Also, GAC processes was included after sand filter to remove residual DOC. This pilot having a capacity of 36 ton/day was operated for one year. The GAC processes were successful to remove ammonia and many organic pollutants (DOC, MBAS, UV-254 nm absorbance, etc). Influent DOC concentrations were very high as 3~6 mg/L throughout the plant operation. It was impossible to achieve 1.0 mg/L effluent DOC, indicating that bed depth (2 m) should be increased to achieve more strict DOC quality standards. When $Cl_2$ dose was well controlled ($Cl_2/NH_3$-N ratio 10~11 on a weight basis), $NH_3$-N removal was 98% and THMs was very low possibly due to low free residual chlorine and PAC dechlorination.

• THE INTERNATIONAL COMMERCE & LAW REVIEW
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• v.38
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• pp.229-262
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• 2008

With the introduction of supply chain management concept, the nature of a firm is fundamentally changed. Control is no longer based on direct control of the business processes, but rather based on integration across member organizations in the supply chain. Firms are trying to achieve a competitive edge by managing their supply chain performance to gain advantages in cost and service differentiation. The supply chain elements of a sea port involves ILSP (Inbound Logistics Service Provider) at the input side and OLSP (Outbound Logistics Service Provider) at the output side. The goal of sea port is to satisfy the needs of different parties, both upstream and downstream, in the chain with greater effectiveness and efficiency than it's competitors. In this context, the purpose of this paper is to derive conceptualization of the SCP (Supply Chain Performance) in the sea port from literature review on the previous researches and to tackle their theoretical and practical implications. The paper deals with conceptualizing SCP in sea port using the SCOR (Supply Chain Operation Reference) model. It incorporates both the effectiveness and efficiency aspects of performance measurement. And it also recognizes customer related reasons for measuring performance.

• Bulletin of the Korean Chemical Society
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• v.29 no.6
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• pp.1137-1140
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• 2008

M1 RNA, the catalytic subunit of Escherichia coli RNase P, is an essential ribozyme that processes the 5' leader sequence of tRNA precursors (ptRNAs). Using KS2003, an E. coli strain generating only low levels of M1 RNA, which showed growth defects, we examined whether M1 RNA is involved in polycistronic mRNA processing or degradation. Microarray analysis of total RNA from KS2003 revealed six polycistronic operon mRNAs (acpP-fabF, cysDNC, flgAMN, lepAB, phoPQ, and puuCBE) showing large differences in expression between the adjacent genes in the same mRNA transcript compared with the KS2001 wild type strain. Model substrates spanning an adjacent pair of genes for each polycistronic mRNA were tested for RNase P cleavage in vitro. Five model RNAs (cysNC, flgMN, lepAB, phoPQ, and puuBE) were cleaved by RNase P holoenzyme but not by M1 RNA alone. However, the cleavages occurred at non-ptRNA-like cleavage sites, with much less efficiency than the cleavage of ptRNA. Since cleavage products generated by RNase P from a polycistronic mRNA can have different in vivo stabilities, our results suggest that RNase P cleavage may lead to differential expression of each cistron.

• Korean Journal of Agricultural Science
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• v.38 no.2
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• pp.315-324
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• 2011

Riparian vegetation distribution patterns and diversity relative to various fluvial geomorphic channel patterns, stream bank stabilization methods, and stream flow processes are described and interpreted for selected nature-friendly small stream bank protection of Goesan, central Korea. Idong Stream Pilot Project, which began in May 2003 and finished in December 2003, was selected to develop effective methods which was nature-friendly stream bank protection. The project aim to maintain or increase stream bank stabilization ecosystem goods and services while protecting downstream and stream bank ecosystem. A number of protecting methods which were a Flight of fieldstone, Vegetation block, Green river block, Stone net, Green environment block, Eco friendly cobble, Vegetation mat and Geo-green cell and Firefly block were applied on the bank of Idong stream. The stream sites have been monitored about vegetation conditions each method in 2007. We selected six points to separately investigate in left and right bank. The main purpose of this study was to find out suitable methods and to improve stream restoration techniques for ecosystem. On the stream bank, H environment block method (9.7) was the highest average of vegetation coverage and Firefly block method (3.87) was the lowest average in applied methods.

• BMB Reports
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• v.32 no.3
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• pp.215-225
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• 1999

Phytochromes (with gene family members phyA, B, C, D, and E) are a wavelength-dependent light sensor or switch for gene regulation that underscore a number of photo responsive developmental and morphogenic processes in plants. Recently, phytochrome-like pigment proteins have also been discovered in prokaryotes, possibly functioning as an auto-phosphorylating/phosphate-relaying two-component signaling system (Yeh et al., 1997). Phytochromes are photochromically convertible between the light sensing Pr and regulatory active Pfr forms. Red light converts Pr to Pfr, the latter having a "switch-on" conformation. The Pfr form triggers signal transduction pathways to the downstream responses including the expression of photosynthetic and other growth-regulating genes. The components involved in and the molecular mechanisms of the light signal transduction pathways are largely unknown, although G-proteins, protein kinases, and secondary messengers such as $Ca^{2+}$ ions and cGMP are implicated. The 124-127 kDa phytochromes form homodimeric structures. The N-terminal half contains the tetrapyrrolic phytochromobilin for red/far-red light absorption. The C-terminal half includes both a dimerization motif and regulatory box where the red light signal perceived by the chromophore-domain is recognized and transduced to initiate the signal transduction cascade. A working model for the inter-domain signal communication within the phytochrome molecule is proposed in this Review.

• BMB Reports
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• v.43 no.2
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• pp.127-132
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• 2010

Phosphatidylinositol (3,4,5)-triphosphate ($PIP_3$) is a lipid second messenger that employs a wide range of downstream effector proteins for the regulation of cellular processes, including cell survival, polarization and proliferation. One of the most well characterized cytoplasmic targets of $PIP_3$, serine/threonine protein kinase B (PKB)/Akt, promotes cell survival by directly interacting with nucleophosmin (NPM)/B23, the nuclear target of $PIP_3$. Here, we report that nuclear $PIP_3$ competes with Akt to preferentially bind B23 in the nucleoplasm. Mutation of Arg23 and Arg25 in the PH domain of Akt prevents binding to $PIP_3$, but does not disrupt the Akt/B23 interaction. However, treatment with phosphatases PTEN or SHIP abrogates the association between Akt and B23, indicating that nuclear $PIP_3$ regulates the Akt/B23 interaction by controlling the concentration and subcellular dynamics of these two proteins.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.22 no.5
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• pp.661-671
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• 1998

It is unavoidable that the fuel spray impinges on the wall of piston cavity in a compact high-pressure D.I. diesel engine. Therefore the characteristics of impinging spray are the very significant information on the consideration and the simulation of its combustion processes including the formation mechanism of exhaust emission and the design of the combustion chamber. In this paper, the numerical simulation was performed to study the characteristics of impinging spray. The spray-wall impingement model used is Watkins and Park's model. Calculation parameters are the inclination angles and the ambient pressures. As the inclination angle increases, the impinging spray develops mainly to the direction of the downstream and scarcely flows to that of the upstream. The shape on the wall of the impinging spray is the circle in the case of the normal impingement, while it is the ellipse in that of the oblique impingement. As the ambient pressure increases, the growth of impinging spray on the wall in the radial direction decreases owing to the increase in the resistance of the ambient.