• 제목/요약/키워드: Downstream Processes

검색결과 166건 처리시간 0.02초

자동차 프레스 패널 성형을 위한 드로 금형의 어덴덤 곡면 모델링 (Addendum Surface Modeling in Draw Die Design for Stamping Automotive Panels)

  • 정연찬
    • 한국생산제조학회지
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    • 제22권6호
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    • pp.1018-1024
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    • 2013
  • In the process of draw die design for stamping automotive press panels, the addendum surfaces generated in metal forming simulation software cannot be used in downstream processes such as machining and making draw dies because simulation tools use simple discrete models for the surface geometry. The downstream processes require more precise and continuous geometric models such as NURBS surfaces. Generally, automotive die engineers manually regenerate the addendum surface geometry using the discrete model. This paper presents an automated geometric modeling process for generating addendum surfaces using draft surface models. The design parameters of the section curve for the addendum surfaces are extracted automatically from the draft geometry. Using the extracted design parameters, smooth addendum surfaces are generated automatically as NURBS surfaces. The generated surfaces are $G^1$ continuous with the part surface and the binder surface, and can be used in downstream processes.

Upstream Regulators and Downstream Effectors of NADPH Oxidases as Novel Therapeutic Targets for Diabetic Kidney Disease

  • Gorin, Yves;Wauquier, Fabien
    • Molecules and Cells
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    • 제38권4호
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    • pp.285-296
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    • 2015
  • Oxidative stress has been linked to the pathogenesis of diabetic nephropathy, the complication of diabetes in the kidney. NADPH oxidases of the Nox family, and in particular the homologue Nox4, are a major source of reactive oxygen species in the diabetic kidney and are critical mediators of redox signaling in glomerular and tubulointerstitial cells exposed to the diabetic milieu. Here, we present an overview of the current knowledge related to the understanding of the role of Nox enzymes in the processes that control mesangial cell, podocyte and tubulointerstitial cell injury induced by hyperglycemia and other predominant factors enhanced in the diabetic milieu, including the renin-angiotensin system and transforming growth factor-${\beta}$. The nature of the upstream modulators of Nox enzymes as well as the downstream targets of the Nox NADPH oxidases implicated in the propagation of the redox processes that alter renal biology in diabetes will be highlighted.

준설하천에서 직렬로 배열된 웅덩이의 적응에 관한 실험적 연구 (Experimental Study on the Adjustment Processes of a Series of Mining Pits in the Dredged Channels)

  • 장창래;이기하
    • 생태와환경
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    • 제44권4호
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    • pp.385-395
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    • 2011
  • 본 연구는 하천준설 및 골재채취로 인하여 2개의 웅덩이가 직렬로 발생하였을 때, 이동상 실내실험을 수행하여 웅덩이의 적응과정과 응답특성을 분석하였다. 웅덩이의 되메우기 과정은 웅덩이 상류에서 발달한 사주의 영향을 받지만, 웅덩이 하류에서는 웅덩이에서 유사가 포착되어 사주가 발달되지 않았으며, 하상이 지속적으로 저하되었다. 웅덩이의 되메우기가 진행될 때, 웅덩이의 이동속도는 거의 일정하며, 웅덩이의 수중 안식각은 일정하게 유지되었다. 그러나 웅덩이의 되메우기가 거의 완료되면서, 웅덩이의 이동속도는 증가하고, 웅덩이에서 수중 안식각은 작아졌다. 웅덩이와 웅덩이의 이격거리가 증가하면, 2차 웅덩이 하류에서 미부침식이 크게 발생하였다. 또한 웅덩이의 이격거리가 증가할수록 웅덩이의 이동속도는 감소하였다. 이것은 웅덩이가 되메워지는 데 시간이 증가하고, 웅덩이 하류하천에 미치는 영향이 크다는 것을 의미한다. 시간이 증가함에 따라, 무차원 웅덩이의 깊이는 지속적으로 감소하지만, 웅덩이의 이격 거리가 증가할수록, 무차원 웅덩이 깊이는 증가하였다. 그러나 무차원 웅덩이의 길이는 시간이 증가함에 따라서 전체적으로 감소하지만, 웅덩이와 웅덩이의 이격 거리가 증가할수록, 무차원 웅덩이의 길이가 증가하는 경향을 보여주었다.

항체의약품 농축 및 제제화를 위한 한외여과 및 정용여과 공정 (Ultrafiltration and Diafiltration Processes for Concentration and Formulation of Antibody-based Therapeutics)

  • 이지은;이지윤;백영빈
    • 멤브레인
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    • 제30권6호
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    • pp.373-384
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    • 2020
  • 바이오의약품 중에서도 항체의약품의 수요가 증가함에 따라 항체를 상업용으로 개발하기 위한 연구가 활발히 진행되고 있다. 항체의약품의 제조공정 중 downstream 공정은 의약품 성능에 직접적으로 영향을 미치기 때문에 중요하게 다뤄지며, 본 총설은 그 중에서도 농축 및 제제화를 목적으로 행해지는 한외여과 및 정용여과 공정에서 사용되는 한외여과막의 주요 제품 및 공정 특성을 살펴보고, 최근 연구 동향에 대해 소개하고자 한다.

협력설계를 통한 건설 프로세스 개선 방안 (A Study on the Improving Construction Processes through the Cooperative Design)

  • 나경철;김창덕
    • 한국건설관리학회논문집
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    • 제2권4호
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    • pp.144-156
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    • 2001
  • 본 연구에서는 종래 건설 프로세스 상의 한계점을 분석한 후, 그 개선방안을 제시하였다. 본 연구에서 제시하는 개선방안은 설계도서의 철저한 사전검토를 통한 협력 업체의 공정계획 조기참여 방안이다. 이를 통해서 커뮤니케이션이 활성화되어 사전의견조정의 극대화를 확보할 수 있다. 본 연구에서는 데크플레이트 설치 프로세스와 덕트 설치 프로세스를 대상으로 사례연구를 수행하였다. 사례연구 결과, 협력업체의 조기투입과 설계도서 사전 검토를 통하여 체계적으로 건설 프로세스를 개선할 수 있었고, 구성원들의 사전의견조정을 통하여 건설생산 효율성을 제고할 수 있었다.

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봉화 면산습지의 형성과정 (Formation Processes of Myeonsan Wetland in Bongwa)

  • 손명원;백충렬
    • 한국지형학회지
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    • 제23권1호
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    • pp.35-45
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    • 2016
  • Aiming to elucidate the formation processes of Myeonsan wetland around the ridge from Myeonsan peak to Seokgae pass, this paper analyzes the geomorphic, physical and chemical characteristics of the wetland. The results are as follow: Firstly, resistant bedrock and big boulders distributed on the riverbed of the small channel from the wetland to Seokgaecheon have played a role as a temporary base level. At the upstream part above this point, a wide and shallow depression was formed and developed into a wetland. There was a gorge covered with boulders at downstream part. Secondly, owing to the obstacles at the outlet of wetland, deposits on bed tend to be downstream coarsening. Finally, deposits show weak acidity of pH 5.0~5.7. The source of wetland water is groundwater containing rich Ca and Na. Trees in the wetland help much more Ca accumulated. And deposit biotite and amphibole contained rich Mg have been weathered in the wetland.

Drying Techniques of Microalgal Biomass: A Review

  • Kim, Gyu Min;Kim, Young-Kee
    • 공업화학
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    • 제33권2호
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    • pp.145-150
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    • 2022
  • Microalgae are attracting attention as a resource for the production of biofuels, food nutrients, biochemicals, and bioplastics. Among a wide range of sources of the biomass, microalgae have been highlighted due to relatively easy cultivation, ability to eliminate carbon dioxide, and low culturing cost. Despite the great potential of microalgal biomass as a biological material, the complexity and relatively expensive downstream processes have inhibited the commercial use of microalgae. In this study, we reviewed recent techniques for microalgal drying for the production of microalgal based products. As drying processes comprise the largest portion of microalgae processing cost, an efficient drying technique is key to the utilization of microalgal biomass.

Numerical simulation of coextrusion process of viscoelastic fluids using the open boundary condition method

  • Park, Seung-Joon;Ahn, Kyung-Hyun;Lee, Seung-Jong
    • Korea-Australia Rheology Journal
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    • 제13권1호
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    • pp.37-45
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    • 2001
  • Numerical simulation of coextrusion process of viscoelastic fluids within a die has been carried out. In the coextrusion process velocity profile at the outflow boundary is not known a priori, which makes it difficult to impose the proper boundary condition at the outflow boundary. This difficulty has been avoided by using the open boundary condition (OBC) method. In this study, elastic viscous stress splitting (EVSS) formulation with streamline upwind (SU) method has been used in the finite element method. In order to test the validity of the OBC method, comparison between the results of fully developed condition at the outlet and those of OBC has been made for a Newtonian fluid. In the case of upper convected Maxwell (UCM) fluid, the effect of outflow boundary condition on the interface position has been investigated by using two meshes having different downstream lengths. In both cases, the results with the OBC method showed reasonable interface shape. In particular, for the UCM fluid the interface shape calculated with OBC was independent of the downstream length, while the results with the zero traction condition showed oscillation of interface position close to the outlet. Viscosity difference was found to be more important than elasticity difference in determining the final interface position. However, the overshoot of interface position near the con-fluent point increased with elasticity.

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Comparisons of Reverse Osmosis and Pervaporation Membrane Processes I. Theoretical Interpretations

  • Rhim, Ji-Won;Lee, Kew-Ho;Huang, Y.M.
    • 한국막학회:학술대회논문집
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    • 한국막학회 1991년도 추계 총회 및 학술발표회
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    • pp.47-48
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    • 1991
  • The pressure in RO leads to a concentration difference across the membrane, while the concentration difference in PVAP across the membrane is achieved by applying a vacuum to the downstream compartment. Therefore, it could be possible to compare this two processes using the solution-diffusion mechanism.

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