• Title/Summary/Keyword: Downstream Processes

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Addendum Surface Modeling in Draw Die Design for Stamping Automotive Panels (자동차 프레스 패널 성형을 위한 드로 금형의 어덴덤 곡면 모델링)

  • Chung, Yunchan
    • Journal of the Korean Society of Manufacturing Technology Engineers
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    • v.22 no.6
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    • pp.1018-1024
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    • 2013
  • In the process of draw die design for stamping automotive press panels, the addendum surfaces generated in metal forming simulation software cannot be used in downstream processes such as machining and making draw dies because simulation tools use simple discrete models for the surface geometry. The downstream processes require more precise and continuous geometric models such as NURBS surfaces. Generally, automotive die engineers manually regenerate the addendum surface geometry using the discrete model. This paper presents an automated geometric modeling process for generating addendum surfaces using draft surface models. The design parameters of the section curve for the addendum surfaces are extracted automatically from the draft geometry. Using the extracted design parameters, smooth addendum surfaces are generated automatically as NURBS surfaces. The generated surfaces are $G^1$ continuous with the part surface and the binder surface, and can be used in downstream processes.

Upstream Regulators and Downstream Effectors of NADPH Oxidases as Novel Therapeutic Targets for Diabetic Kidney Disease

  • Gorin, Yves;Wauquier, Fabien
    • Molecules and Cells
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    • v.38 no.4
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    • pp.285-296
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    • 2015
  • Oxidative stress has been linked to the pathogenesis of diabetic nephropathy, the complication of diabetes in the kidney. NADPH oxidases of the Nox family, and in particular the homologue Nox4, are a major source of reactive oxygen species in the diabetic kidney and are critical mediators of redox signaling in glomerular and tubulointerstitial cells exposed to the diabetic milieu. Here, we present an overview of the current knowledge related to the understanding of the role of Nox enzymes in the processes that control mesangial cell, podocyte and tubulointerstitial cell injury induced by hyperglycemia and other predominant factors enhanced in the diabetic milieu, including the renin-angiotensin system and transforming growth factor-${\beta}$. The nature of the upstream modulators of Nox enzymes as well as the downstream targets of the Nox NADPH oxidases implicated in the propagation of the redox processes that alter renal biology in diabetes will be highlighted.

Experimental Study on the Adjustment Processes of a Series of Mining Pits in the Dredged Channels (준설하천에서 직렬로 배열된 웅덩이의 적응에 관한 실험적 연구)

  • Jang, Chang-Lae;Lee, Gi-Ha
    • Korean Journal of Ecology and Environment
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    • v.44 no.4
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    • pp.385-395
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    • 2011
  • The adjustment processes and responses of a series of mining pits by sand or gravel mining were investigated by laboratory experiments. The filling processes of the two pits were affected by the bars developed in the upstream of the channel. However, the bars were not developed and the bed was degradated in the downstream of the pits due to little sediment flow, which was trapped in the pits. The submerged angle of repose in the pits was nearly constant when the pits were being filled. After the filling processes of the pits were finished, the pit was speedily filled with sediment, and the bed was aggradated and migrated with speed. However, the angle of repose decreased. As the distance between the upstream pit and the downstream pit increased, the bed of the pit downstream was tailcutted and degradated. The migration speed of the pit decreased. However, the dimensionless pit depth increased as the distance between the pits increased. The dimensionless pit depth increased with time.

Ultrafiltration and Diafiltration Processes for Concentration and Formulation of Antibody-based Therapeutics (항체의약품 농축 및 제제화를 위한 한외여과 및 정용여과 공정)

  • Lee, Jieun;Lee, Jiyoon;Baek, Youngbin
    • Membrane Journal
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    • v.30 no.6
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    • pp.373-384
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    • 2020
  • Antibody-based therapeutics have been receiving great attention as a representative biopharmaceutical, in which many researches are also carried out for its commercialization. The downstream process is considered an important part of the manufacturing processes of antibody-based therapeutics since it directly affects the performance and stability of products. Ultrafiltration/diafiltration (UF/DF), mostly performed in final step during downstream process, are used for the final concentration and formulation of antibody-based therapeutics. This paper reviewed the major products of the UF membrane, process characteristics, and recent research trends in UF/DF.

A Study on the Improving Construction Processes through the Cooperative Design (협력설계를 통한 건설 프로세스 개선 방안)

  • Na Kyung-Chul;Kim Chang-Duk
    • Korean Journal of Construction Engineering and Management
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    • v.2 no.4 s.8
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    • pp.144-156
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    • 2001
  • This study aims at improving the limitations of current construction processes. Previous solutions to improve construction processes have been focused on the improvement of local processes. This paper proposes a method to improve global effectiveness of construction processes through ascertainment of communication among the process participants. This paper provides two case studies: Deck plate installation processes and Duct installation processes. The case study illustrates a way to improve global effectiveness by incorporating downstream participants such as specialty contractors in upstream construction processes such as design and planning.

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Formation Processes of Myeonsan Wetland in Bongwa (봉화 면산습지의 형성과정)

  • Son, Myoung Won;Baek, Chung-Yeol
    • Journal of The Geomorphological Association of Korea
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    • v.23 no.1
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    • pp.35-45
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    • 2016
  • Aiming to elucidate the formation processes of Myeonsan wetland around the ridge from Myeonsan peak to Seokgae pass, this paper analyzes the geomorphic, physical and chemical characteristics of the wetland. The results are as follow: Firstly, resistant bedrock and big boulders distributed on the riverbed of the small channel from the wetland to Seokgaecheon have played a role as a temporary base level. At the upstream part above this point, a wide and shallow depression was formed and developed into a wetland. There was a gorge covered with boulders at downstream part. Secondly, owing to the obstacles at the outlet of wetland, deposits on bed tend to be downstream coarsening. Finally, deposits show weak acidity of pH 5.0~5.7. The source of wetland water is groundwater containing rich Ca and Na. Trees in the wetland help much more Ca accumulated. And deposit biotite and amphibole contained rich Mg have been weathered in the wetland.

Drying Techniques of Microalgal Biomass: A Review

  • Kim, Gyu Min;Kim, Young-Kee
    • Applied Chemistry for Engineering
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    • v.33 no.2
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    • pp.145-150
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    • 2022
  • Microalgae are attracting attention as a resource for the production of biofuels, food nutrients, biochemicals, and bioplastics. Among a wide range of sources of the biomass, microalgae have been highlighted due to relatively easy cultivation, ability to eliminate carbon dioxide, and low culturing cost. Despite the great potential of microalgal biomass as a biological material, the complexity and relatively expensive downstream processes have inhibited the commercial use of microalgae. In this study, we reviewed recent techniques for microalgal drying for the production of microalgal based products. As drying processes comprise the largest portion of microalgae processing cost, an efficient drying technique is key to the utilization of microalgal biomass.

Numerical simulation of coextrusion process of viscoelastic fluids using the open boundary condition method

  • Park, Seung-Joon;Ahn, Kyung-Hyun;Lee, Seung-Jong
    • Korea-Australia Rheology Journal
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    • v.13 no.1
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    • pp.37-45
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    • 2001
  • Numerical simulation of coextrusion process of viscoelastic fluids within a die has been carried out. In the coextrusion process velocity profile at the outflow boundary is not known a priori, which makes it difficult to impose the proper boundary condition at the outflow boundary. This difficulty has been avoided by using the open boundary condition (OBC) method. In this study, elastic viscous stress splitting (EVSS) formulation with streamline upwind (SU) method has been used in the finite element method. In order to test the validity of the OBC method, comparison between the results of fully developed condition at the outlet and those of OBC has been made for a Newtonian fluid. In the case of upper convected Maxwell (UCM) fluid, the effect of outflow boundary condition on the interface position has been investigated by using two meshes having different downstream lengths. In both cases, the results with the OBC method showed reasonable interface shape. In particular, for the UCM fluid the interface shape calculated with OBC was independent of the downstream length, while the results with the zero traction condition showed oscillation of interface position close to the outlet. Viscosity difference was found to be more important than elasticity difference in determining the final interface position. However, the overshoot of interface position near the con-fluent point increased with elasticity.

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Comparisons of Reverse Osmosis and Pervaporation Membrane Processes I. Theoretical Interpretations

  • Rhim, Ji-Won;Lee, Kew-Ho;Huang, Y.M.
    • Proceedings of the Membrane Society of Korea Conference
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    • 1991.10a
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    • pp.47-48
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    • 1991
  • The pressure in RO leads to a concentration difference across the membrane, while the concentration difference in PVAP across the membrane is achieved by applying a vacuum to the downstream compartment. Therefore, it could be possible to compare this two processes using the solution-diffusion mechanism.

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