• Molecules and Cells
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• v.37 no.4
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• pp.302-306
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• 2014

Myostatin represses muscle growth by negatively regulating the number and size of muscle fibers. Myostatin loss-of-function can result in the double-muscling phenotype and increased muscle mass. Thus, knockout of myostatin gene could improve the quality of meat from mammals. In the present study, zinc finger nucleases, a useful tool for generating gene knockout animals, were designed to target exon 1 of the myostatin gene. The designed ZFNs were introduced into porcine primary fibroblasts and early implantation embryos via electroporation and microinjection, respectively. Mutations around the ZFNs target site were detected in both primary fibroblasts and blastocysts. The proportion of mutant fibroblast cells and blastocyst was 4.81% and 5.31%, respectively. Thus, ZFNs can be used to knockout myostatin in porcine primary fibroblasts and early implantation embryos.

• Journal of Oriental Medical Thermology
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• v.4 no.1
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• pp.29-38
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• 2005

Purpose: We intended to observe the relations between Chiljehyangbuhwan and abdominal temperature according to primary dysmenorrhea severity. Methods: We selected the 100 primary dysmenorrhea patients by the screening tests (first screening test-inquiry, second screening test-clinical test, additionally WHR (Waist-to-Hip ratio) by Inbody 2.0). By the fixed blocked randomization and double blind method, Chiljehyangbuhwan or placebo was administered for 1 menstration period. Finally, 69 patients remainded. Before and after administration, we measured 4 points abdominal temperature (Chon-jung(CV17), Chung-wan(CV12), Kwan-won(CV4), Chung-guk(CV3)) by DITI (DOREX Inc., USA). And then we checked the difference of temperature $({\Delta}T)$ between CV17 and CV12 / CV17 and CV4 / CV17 and CV3 / CV12 and CV4 / CV12 and CV3. After that, we compared ${\Delta}T$ with primary dysmenorrhea severity evaluated by VRS (verbal rating scale) and MVRS (multidimensional verbal rating scale). In dysmenorrhea severity, we standardized scale score and 3-group-severity by score (mild, moderate, severe). For statistics, we used Pearson correlations and Spearman's rho correlations, SPSS 11.0 for windows. Results: In case of MVRS, Chiljehyangbuhwan was correlated to ${\Delta}T$ (CV12 and CV3 / CV12 and CV4). In case of VRS, Chiljehyangbuhwan was not correlated to ${\Delta}T$. Statistically they showed significant result (p<0.05). Conclusion: The primary dysmenorrhea patients showed that severity by MVRS was connected with ${\Delta}T$ (CV12 and CV3 / CV12 and CV4) after Chiljehyangbuhwan administration. So we can consider Chiljehyangbuhwan effects the abdominal temperature according primary dysmenorrhea severity.

• Journal of Electrical Engineering and Technology
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• v.13 no.2
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• pp.677-687
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• 2018

This paper presents a novel power decoupling control scheme with the bidirectional buck-boost converter for primary-side regulation photovoltaic (PV) micro-inverter. With the proposed power decoupling control scheme, small-capacitance film capacitors are used to overcome the life-span and reliability limitations of the large-capacitance electrolytic capacitors. Then, an improved flyback PV inverter is employed in continuous conduction mode with primary-side regulation for the PV power conditioning. The proposed power-decoupling controller shares the reference for primary side current regulation of the flyback PV inverter. The decoupling controller shapes the input current of the bidirectional buck-boost converter. The shared reference eliminates the phase-delay between the input current to the bidirectional buck-boost converter and the double frequency current at the PV primary current. The elimination of the phase-delay in dynamic response enhances the ripple rejection capability of the power decoupling buck-boost converter even with small film capacitor. With proposed power decoupling control scheme, the additional advantage of the primary-side regulation of flyback PV inverter is that there is no need to have an extra current sensor for obtaining the ripplecurrent reference of the decoupling current-controller of the power-decoupling buck-boost converter. Therefore, the proposed power decoupling control scheme is cost-effective as well as the size benefit. A new transient analysis is carried out which includes the source voltage dynamics instead of considering the source voltage as a pure voltage source. For verification of the proposed control scheme, simulation and experimental results are presented.

• Journal of electromagnetic engineering and science
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• v.10 no.3
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• pp.86-91
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• 2010

In this paper, a double-layered frequency selective surface(FSS) superstrate was built and tested. The unit cell of the proposed FSS consists of a ring slot and a dipole-shaped structure and shows a complementary frequency response. Each unit cell is printed on two sides of a substrate. By using these double-layered structures, the first resonant frequency of the pass-band can be lowered. As a result, the size of the unit cell is minimized and the spacing between the other cells is reduced. The proposed FSS-dipole composite antenna is designed for the gain enhancement of wide-band code division multiple access(WCDMA) frequency bands(1.92~2.17 GHz) with a low quality factor(Q=0.17). To verify the gain enhancement performance of the FSS, an FSS-dipole composite antenna was created. Although the FSS layer enhances the gain of the primary radiation source of the dipole antenna, the FSS-dipole complex antenna cannot show a uniform gain over the entire desired frequency band. The experimental results show a gain enhancement of 3 dBi with an FSS superstrate in the WCDMA frequency band.

• Journal of Chest Surgery
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• v.34 no.11
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• pp.854-857
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• 2001

Double-outlet left ventricle(DOLV) is a rare congenital cardiac malformation, defined as the origin of both the aorta and the pulmonary artery being entirely or predominantly above the morphologically left ventricle, which is difficult to diagnose accurately. A 3-year old male was admitted for cyanosis and dyspnea. At the age of 2 months, he had undergone pulmonary artery banding and coarctoplasty. He was diagnosed as DOLV with subaortic ventricular septal defect(VSD). Biventricular repair was achieved by patch closure of VSD, primary closure of PFO, and pulmonary trunk translocation from left ventricle to right ventricle. The advantages of this procedure using native tissue for right ventricular outflow tract reconstruction are growth potential and preserved valve function, which contribute to a decreased likelihood of reoperation related to the right ventricular dysfunction related to pulmonary insufficiency.

• Journal of Chest Surgery
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• v.37 no.2
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• pp.184-187
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• 2004

The synchronous double cancer of the esophagus and lung is rare. Right lower lobectomy and Ivor Lewis procedure were performed simultaneously in a 75 year-old male patient who had synchronous double primary squamous cell carcinoma of the thoracic esophagus and right lower lobe of the lung, Left upper lobectomy was performed in a 69 year-old male patient who had squamous cell carcinoma of the left upper lobe of the lung, and four months later we performed Ivor Lewis procedure for the squamous cell carcinoma that occurred in the thoracic esophagus. The above two patients were doing well 10 months and 24 months after the operation respectively without recurrence. We treated the two cases of synchronous double cancer of the esophagus and lung with complete resection, and report this with review of literature.

• Earthquakes and Structures
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• v.11 no.6
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• pp.983-1000
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• 2016

To date the engineering community has seen facade systems as non-structural elements with high aesthetic value and a barrier between the outdoor and indoor environments. The role of facades in energy use in a building has also been recognized and the industry is also witnessing the emergence of many energy efficient facade systems. This paper will focus on using exterior skin of the double skin facade system as a dissipative movable element during earthquake excitation. The main aim of this study is to investigate the potential of the facade system to act as a damper system to reduce earthquake-induced vibration of the primary structure. Unlike traditional mass dampers, which are usually placed at the top level of structures, the movable/smart double skin facade systems are distributed throughout the entire height of building structures. The outer skin is moveable and can act as a multi tuned mass dampers (MTMDs) that move and dissipate energy during strong earthquake motions. In this paper, using a three dimensional 10-storey building structure as the example, it is shown that with optimal choice of materials for stiffness and damping of brackets connecting the two skins, a substantial portion of earthquake induced vibration energy can be dissipated which leads to avoiding expensive ductile seismic designs. It is shown that the engineering demand parameters (EDPs) for a low-rise building structures subjected to moderate to severe earthquakes can be substantially reduced by introduction of a smart designed double skin system.

• Nuclear Engineering and Technology
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• v.48 no.4
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• pp.1022-1035
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• 2016

A double-tube once-through steam generator (DOTSG) consisting of an outer straight tube and an inner helical tube is studied in this work. First, the structure of the DOTSG is optimized by considering two different objective functions. The tube length and the total pressure drop are considered as the first and second objective functions, respectively. Because the DOTSG is divided into the subcooled, boiling, and superheated sections according to the different secondary fluid states, the pitches in the three sections are defined as the optimization variables. A multi-objective optimization model is established and solved by particle swarm optimization. The optimization pitch is small in the subcooled region and superheated region, and large in the boiling region. Considering the availability of the optimum structure at power levels below 100% full power, we propose a new operating scheme that can fix the boundaries between the three heat-transfer sections. The operation scheme is proposed on the basis of data for full power, and the operation parameters are calculated at low power level. The primary inlet and outlet temperatures, as well as flow rate and secondary outlet temperature are changed according to the operation procedure.

• International Journal of High-Rise Buildings
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• v.2 no.4
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• pp.293-314
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• 2013

Double-Skin Façade (DSF), which is a kind of passive indoor environmental control technique, is effective way to control environmental loads while maintaining the transparency especially in perimeter zone and hence the adoption example of DSF keep increasing recently. The objective of this study was to perform a field survey of air quality environment with natural ventilation through DSF and thermal environment within office building with six stories during a mild climate period in Japan. Moreover, to understand the comprehensive environmental performance of the target building, questionnaire survey was conducted to subjectively evaluate the productivity and satisfaction with the environmental factors in office space. In this field measurement, there was a positive correlation between the DSF internal ventilation flow and the amount of solar radiation on the DSF normal surface; the primary driving force for ventilation in the DSF was considered to be the buoyancy force caused by solar radiation. The results of questionnaire survey with regard to productivity level indicated the need for improvement in the thermal (temperature) and spatial environment (room size and furniture placement).

• Journal of Power Electronics
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• v.18 no.1
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• pp.289-299
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• 2018

Electric-field coupled power transfer (ECPT) systems employ a high frequency electric field as an energy medium to transfer power wirelessly. Existing ECPT systems have made great progress in terms of increasing the transfer distance. However, the topologies of these systems are complex, and the transfer characteristics are very sensitive to variations in the circuit parameters. This paper proposes an ECPT system with a double-sided LC network, which employs a parallel LC network on the primary side and a series LC network on the secondary side. With the same transfer distance and output power, the proposed system is simpler and less sensitive than existing systems. The expression of the optimal driving voltage for the coupling structure and the characteristics of the LC networks are also analyzed, including the transfer efficiency, parameter sensitivity and total harmonic distortion. Then, a design method for the system parameters is provided according to these characteristics. Simulations and experiments have been carried out to verify the system properties and the design method.