• 한국어류학회지
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• 제33권2호
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• pp.45-56
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• 2021

납자루 Tanakia lanceolata와 한강납줄개 Rhodeus pseudosericeus 간의 속간잡종으로 추정되는 수컷 1개체를 서해안 독립 하천인 보령 대천천에서 채집하였다. 해당 속간잡종 개체의 명확한 기원을 판별하기 위하여 형태학적 및 분자계통학적 분석을 수행하였다. 형태학적 분석 결과, 속간잡종 개체의 등지느러미 앞쪽 상단과 뒷지느러미 가장자리의 색상, 등과 배 쪽 색상 등은 납자루의 형태적 특징을 따랐으며, 미병부 중앙에 파란색 체측종대가 존재하는 점, 측선이 불완전한 점, 입수염이 없는 점 등은 한강납줄개의 형태적 특징을 따랐다. 또한, 미토콘드리아 DNA의 cytb 유전자 분석 결과, 속간잡종 개체는 납자루와 99.82~100%의 염기서열 유사도를 나타내어, 모계 종은 납자루로 판단되었다. 핵 DNA의 rag1 유전자 분석 결과, 속간잡종 개체는 납자루와 한강납줄개 간의 단일염기다형성 부위(38 bp)를 모두 반영하는 double peaks 양상을 나타내어, 부계 종은 한강납 줄개로 판단되었다. 따라서 본 연구에서 분석한 납자루아과 자연 잡종 추정 개체는 암컷 납자루와 수컷 한강납줄개 간의 속간잡종으로 판명되었다.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2009년도 춘계학술대회 논문집
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• pp.1254-1268
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• 2009

정부고속철도 건설계획이 1998년 IMF로 인하여 서울 시흥구간 및 대구$\sim$부산간은 기존 경부선을 이용하여 우선 개통하고, 2단계로 대구$\sim$부산구간을 신설 개통하는 것으로 변경됨에 따라 서울도심 입출구부인 서울$\sim$시흥구간은 고속열차, 일반열차 및 화물열차의 운용운행으로 일반열차 운행횟수 축소로 인한 서비스 저하, 고속철도 서비스 추가 어려움 등으로 동 구간의 신설확장에 대한 지속적인 필요성이 제기 되어 왔으며, 호남고속철도 또한 수서 출발을 위한 강남권 고속철도 건설계획이 경제성 등의 이유로 오송에서 분기하는 것으로 변경됨에 따라 강남권 및 경기남부지역 주민들의 고속철도 서비스혜택의 기회가 박탈되는 결과률 초래하였다. 경부고속철도 개통이후 국가교통체계가 고속철도 중심으로 변화하고 있고, 경부고속철도 2단계 개통, 경전선 및 전라선 복선전칠 완공, 2014년 호남고속철도 개통시 고속열차 추가수요가 발생하나, 서울$\sim$시흥구간의 선로용량 부족으로 고속열차 광명역 출발, 일반열차 운행횟수 축소 등의 파행적인 열차운영이 불가피하므로 이와 같은 문제점을 근본적으로 해소하기 위한 강북구간 (광명$\sim$화전) 의 선로확장과 더불어 강남구간 (수서$\sim$평택)의 고속철도 신설을 추진하여야 한다. 이에 따라 본 고찰에서는 수도권 고속철도 선로확충을 위한 효율적인 열차운영방안, 시설계획 등 고려 하여야 할 사항에 대하여 검토하고자 한다.

• 한국철도학회논문집
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• 제20권1호
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• pp.76-84
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• 2017

최근 한반도 생태축의 근간을 이루는 백두대간의 중심에 위치한 추풍령 생태축 연결 복원사업이 추진되고 있으며, 이 지역은 일제 강점기에 경부선 철도건설과 함께 산업화 과정에서 도로와 철도 건설 등에 의해 야생동물의 이동이 단절되어 로드킬의 주요 원인이 되어 온 것으로 지적되었다. 그러나 친환경적 교통수단인 철도에 대한 투자 비중이 증가하는 추세를 보이고 있으며, 현재 기존 선로의 고속화를 위한 단선철도의 복선전철화 및 선형개량 사업 등 전국 철도망이 지속적으로 확대되고 있다. 이에 따라 본 연구는 급증하는 철도노선 연장에 따른 국토공간의 생태적 취약성을 평가하는 주요 평가기준으로 토지이용을 검토할 것을 제안하였고, 환경부에서 제공하는 토지피복지도를 활용하여 철도노선과 중첩분석을 수행하였다. 그 결과 논, 밭, 활엽수림, 나지, 내륙수 등 5개 항목에 민감도가 높은 것으로 나타났다. 이러한 항목들에는 민감도에 따른 가중치 설정이 필요한 것으로 생각되며 이를 바탕으로 구체적인 평가 기준을 마련할 필요가 있다.

• 복식
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• 제18권
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• pp.291-306
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• 1992

From the mid-1980s '91s, remarkable Ethnicism and Primitivism in the Europe fashion trend could be represented as an exotic taste longing for secenery and emotion of non-europe area in the West. These phenomenon could be found out in connection with Acculturation, which means when two different cultures or more were contacted they were identified or merged in process of diffusion and change of them. This point of view was the culture anthropologic one that make a comparison and analysis of sameness and difference between cultures. The purpose of this study was to illuminate exotic taste represented in costume in the cluture-anthroplogic aspect, to compare with beauty of costume that each culture of costume and the meaning of the times due to those differences. an aspect of the exotic taste and character in the western costume that was inspected by dividing into 'Primitivism', 'Oriental element' and 'the element of a national costume in the East European bloc ' were as follows; First, Primitivism had something in common with what was pursued in the trend of Modern Art, through the late 19th century to the early 20th century. In fashion fettered by technique, the creation expressed in a free was and showed simple beauty of costume. At the same time, pure emotion expression, creative power and witty strong expression give the cognition of transcendency breaking the routine and the cognition of complexity of an included conception. Those are garments showing not only the primitive thought and mysticism but a fancy, an abstraction, and a life. Colors and accessaries which described nature and matched simple costume composition to the expression of various material or patterns transmitted the image of the primitive strongly. Second, "Drental element" which had an effect on western custome historically in a long time had outstanding luxurios adornmental beauty of custome. Extending from the Arab stated India, China, Korea, Japan, each national costume with a gay national culture became one of motif. Various ornamental factors expressed on Trapez Line, Sime Line and Drape, or Raied style, which did not restrict the body. Those were not only functional Easy Look, but were also satisfying human's ornamental desire. Third, national factors in the East European bloc are theme that begins to be embossed in the late 80's. In view of a political change and cultural situation with a double character of Europe and Orient, it was estimated that national factors have great importance in fashion. Item concerned with new concern appeared at Autumn & Winter collection. It shows elegant and graceful beauty of costume by adding a fur or jewel to simple form. These national factors in the East European bloc are simple form, but shows the difference in more cubic formation than form expressed in Primitivism or Oriental factors Exotic taste appeared form 80's to 91's, is thought to create an forgotten romantic emotion and traditional fashion

• Asian Pacific Journal of Cancer Prevention
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• 제16권18호
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• pp.8259-8263
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• 2016

Background: Nano-therapy has the potential to revolutionize cancer therapy. Chrysin, a natural flavonoid, was recently recognized as having important biological roles in chemical defenses and nitrogen fixation, with anti-inflammatory and anti-oxidant effects but the poor water solubility of flavonoids limitstheir bioavailability and biomedical applications. Objective: Chrysin loaded PLGA-PEG-PLGA was assessed for improvement of solubility, drug tolerance and adverse effects and accumulation in a gastric cancer cell line (AGS). Materials and Methods: Chrysin loaded PLGA-PEG copolymers were prepared using the double emulsion method (W/O/W). The morphology and size distributions of the prepared PLGA-PEG nanospheres were investigated by 1H NMR, FT-IR and SEM. The in vitro cytotoxicity of pure and nano-chrysin was tested by MTT assay and miR-34a was measured by real-time PCR. Results: 1H NMR, FT-IR and SEM confirmed the PLGA-PEG structure and chrysin loaded on nanoparticles. The MTT results for different concentrations of chrysin at different times for the treatment of AGS cell line showed IC50 values of 68.2, 56.2 and $42.3{\mu}M$ and 58.2, 44.2, $36.8{\mu}M$ after 24, 48, and 72 hours of treatment, respectively for chrysin itslef and chrysin-loaded nanoparticles. The results of real time PCR showed that expression of miR-34a was upregulated to a greater extent via nano chrysin rather than free chrysin. Conclusions: Our study demonstrates chrysin loaded PLGA-PEG promises a natural and efficient system for anticancer drug delivery to fight gastric cancer.

• 한국의학물리학회:학술대회논문집
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• 한국의학물리학회 2002년도 Proceedings
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• pp.407-410
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• 2002

Monochromatic x-ray CT has several advantages over conventional CT, which utilizes bremsstrahlung white x-rays from an x-ray tube. There are several methods to produce such monochromatic x-rays. The most popular one is crystal diffraction monochromatization, which has been commonly used because of the fact that the energy spread is very narrow and the energy can be changed continuously. The alternative method is the use of fluorescent x-ray, which has several advantages such as large beam size and fast energy change. We have developed a parallel-beam and a fan-beam monochromatic x-ray CT, and compared some characteristics such as accuracy of CT numbers between those systems. The fan beam monochromatic x-rays were generated by irradiating target materials by incident white x-rays from a bending magnet beam line NE5 in 6.5 GeV Accumulation Ring at Tukuba. The parallel beam monochromatic x-rays were generated by using a silicon double crystal monochromator at the bending magnet beam line BL-20BM in Spring-8. A Cadmium telluride (CdTe) 256 channel array detector with 512mm sensitive width capable of operating at room temperature was used in the photon counting mode. A cylindrical phantom containing eight concentrations of gadolinium was used for the fan beam monochromatic x-ray CT system, while a phantom containing acetone, ethanol, acrylic and water was used for the parallel monochromatic x-ray CT system. The linear attenuation coefficients obtained from CT numbers of those monochromatic x-ray CT images were compared with theoretical values. They showed a good agreement within 3%. It was found that the quantitative measurement can be possible by using the fan beam monochromatic x-ray CT system as well as a parallel beam monochromatic X-ray CT system.

• Asian Pacific Journal of Cancer Prevention
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• 제15권20호
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• pp.8693-8698
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• 2014

Background: Up-regulation of hsp90 gene expression occurs in numerous cancers such as lung cancer. D,L-lactic-co-glycolic acid-poly ethylene glycol-17-dimethylaminoethylamino-17-demethoxy geldanamycin (PLGA-PEG-17DMAG) complexes and free 17-DMAG may inhibit the expression. The purpose of this study was to examine whether nanocapsulating 17DMAG improves the anti cancer effect over free 17DMAG in the A549 lung cancer cell line. Materials and Methods: Cells were grown in RPMI 1640 supplemented with 10% FBS. Capsulation of 17DMAG is conducted through double emulsion, then the amount of loaded drug was calculated. Other properties of this copolymer were characterized by Fourier transform infrared spectroscopy and H nuclear magnetic resonance spectroscopy. Assessment of drug cytotoxicity on the grown of lung cancer cell line was carried out through MTT assay. After treatment, RNA was extracted and cDNA was synthesized. In order to assess the amount of hsp90 gene expression, real-time PCR was performed. Results: In regard to the amount of the drug load, IC50 was significant decreased in nanocapsulated(NC) 17DMAG in comparison with free 17DMAG. This was confirmed through decrease of HSP90 gene expression by real-time PCR. Conclusions: The results demonstrated that PLGA-PEG-17DMAG complexes can be more effective than free 17DMAG in down-regulating of hsp90 expression by enhancing uptake by cells. Therefore, PLGA-PEG could be a superior carrier for this kind of hydrophobic agent.

• Journal of Gastric Cancer
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• 제17권2호
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• pp.132-144
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• 2017

Purpose: To identify baseline prognostic factors for survival in patients with disease progression, during or after chemotherapy for the treatment of advanced gastric or gastroesophageal junction (GEJ) cancer. Materials and Methods: We pooled data from patients randomized between 2009 and 2012 in 2 phase III, global double-blind studies of ramucirumab for the treatment of advanced gastric or GEJ adenocarcinoma following disease progression on first-line platinum- and/or fluoropyrimidine-containing therapy (REGARD and RAINBOW). Forty-one key baseline clinical and laboratory factors common in both studies were examined. Model building started with covariate screening using univariate Cox models (significance level=0.05). A stepwise multivariable Cox model identified the final prognostic factors (entry+exit significance level=0.01). Cox models were stratified by treatment and geographic region. The process was repeated to identify baseline prognostic quality of life (QoL) parameters. Results: Of 1,020 randomized patients, 953 (93%) patients without any missing covariates were included in the analysis. We identified 12 independent prognostic factors of poor survival: 1) peritoneal metastases; 2) Eastern Cooperative Oncology Group (ECOG) performance score 1; 3) the presence of a primary tumor; 4) time to progression since prior therapy <6 months; 5) poor/unknown tumor differentiation; abnormally low blood levels of 6) albumin, 7) sodium, and/or 8) lymphocytes; and abnormally high blood levels of 9) neutrophils, 10) aspartate aminotransferase (AST), 11) alkaline phosphatase (ALP), and/or 12) lactate dehydrogenase (LDH). Factors were used to devise a 4-tier prognostic index (median overall survival [OS] by risk [months]: high=3.4, moderate=6.4, medium=9.9, and low=14.5; Harrell's C-index=0.66; 95% confidence interval [CI], 0.64-0.68). Addition of QoL to the model identified patient-reported appetite loss as an independent prognostic factor. Conclusions: The identified prognostic factors and the reported prognostic index may help clinical decision-making, patient stratification, and planning of future clinical studies.

• 한국정보통신학회논문지
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• 제8권6호
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• pp.1107-1114
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• 2004

시스템 패킷 인터페이스 4레벨 2단계(System Packet Interface Leve14 Phase 2)는 10Gbps 이더넷응용 뿐만 아니라, OC-192 대역폭의 ATM 및 POS를 통한 패킷 또는 셀 전송을 위한 물리계층과 링크계층 소자간의 인터페이스이다. SPI-4.2 코어는 전송 인터페이스 블록과 수신 인터페이스 블록으로 구성되어 있으며, 전이중 통신을 지원한다. 전송부는 사용자 인터페이스로부터 64비트의 데이터와 14비트의 헤더 정보를 비동기 FIFO에 쓰고, PL4 인터페이스를 통해 DDR 데이터를 전송한다. 그리고 수신부의 동작은 전송부와 역으로 동작한다. 전송부와 수신부는 캘런더 메모리를 컨피규레이션함으로서 최대 256개의 채널 지원이 가능하고, 대역폭 할당을 제어할 수 있도록 설계하였다 DIP-4 및 DIP-2 패리티 생성 및 체크를 자동적으로 수행하도록 구현하였다. 설계된 코어는 자일링스 ISE 5.li 툴을 이용하여 VHDL언어를 사용하여 기술하였으며, Model_SIM 5.6a를 이용하여 시뮬레이션 하였다. 설계된 코어는 라인당 720Mbps의 데이터 율로 동작하였다. 따라서 총 11.52Gbps의 대역폭을 지원할 수 있다. SPI-4.2 인터페이스 코어는 기가비트/테라비트 라우터, 광학 크로스바 스위치 및 SONET/SDH 기반의 전송 시스템에서 라인카드로 사용할 경우 적합할 것으로 사료된다.

• 고전문학과교육
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• 제15호
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• pp.355-387
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• 2008

The purpose of the study was to decide Korean translation and the copying period of "Korean Translation of " and to look all around their characteristics in different versions carefully until now. The "Korean Translation" is a collection of Korean-translated romance and love stories excavated by a professor Kim,Il Geun, and there is not a little meaning in the context of novel history in the point of view of 'Korean translation of a court possession'. Arranging conclusion of the study generally, it is as follows. (1) Considering phonological phenomena, grammar and vocabulary in the study of Korean language, it is presumed that they would be translated into Korean and copied between the regime period of the King Sukjong and the regime period of the King Yungjo in the Joseon Dynasty. For, they were composed of a middle declaration of copied 'Myeoknambon "Korean Translation of Taepyeonggwanggi(태평광기)"' and 'NakseonJaebon(낙선재본)' between the middle of the 17th century and the middle of the 18th century and the regime period of the King Jeongjo in the Joseon Dynasty appointed as the background period of the novels should be excepted. Consequently, through the Korean Translation, we can confirm that the novel scope between the 17th century and the 18th century in Korean novel history was widened until 'The Royal Court' and 'Women'. (2) In the side of vocabulary, the "Korean Translation" also has not a little meaning in the side of a collection translated in the Royal Court. It doesn't have new vocabularies, but partial vocabularies as '(Traces:痕)' '(Clean eyes:明眸)', ' (Sail:帆)', '(Get up:起)', '글이플(Weak grass:弱草)', '쇼록(Owl:? 梟 or 鴉?)', '이 사라심(This life:此生)', and '노혀오매(Look for:訪)' are good data in the study of Korean language. (3) The "Korean Translation" is a valuable data about translation and copying of a court novel and we can discover intentionally changed parts and partially omitted sentences rather in the than in the . There are differences between a translation book and a copying book and we can catch sight of intention of translation and unsettledness of copying in the second work. Therefore, we can know that the "Korean Translation" has a double context which one work is translated and a work in different version is derived, compared to a simple copy. (4) The "Korean Translation" has a close relation with "Hangoldong(閒汨董)", but it doesn't regard the same copy as a foundation. The basic copy of translation of the "Korean Translation" is a different version of the same line as "Hangoldong" and "Jeochobon(저초본:정명기 소장본)" and is more similar line to "Hangoldong", but it is also not the same basic copy. (5) Considering that the "Korean Translation" doesn't has a distinct relation with the "Hangoldong", there is no correlation between the "Korean Translation" and and the "Hangoldong" and . In addition, we could not discover a writer's identity between the two.