• Title/Summary/Keyword: Double line

Search Result 774, Processing Time 0.024 seconds

Probiotic Conjugated Linoleic Acid Mediated Apoptosis in Breast Cancer Cells by Downregulation of NF-κB

  • Kadirareddy, Rashmi Holur;GhantaVemuri, Sujana;Palempalli, Uma Maheswari Devi
    • Asian Pacific Journal of Cancer Prevention
    • /
    • v.17 no.7
    • /
    • pp.3395-3403
    • /
    • 2016
  • Conjugated linoleic acid, a functional lipid, produced from Lactobacillus plantarum (LP-CLA), has been demonstrated to possess apoptotic activity. The anti-proliferative and apoptotic potential of LP-CLA was here evaluated in vitro using the MDA-MB-231 human breast cancer cell line as a model system. Proliferation of MDA-MB-231 cells was inhibited with increasing concentrations of LP-CLA with altered morphological features like cell detachment, rounding of cells and oligonucleosomal fragmentation of DNA. Flow cytometry confirmed the apoptotic potential of LP-CLA by ANNEXIN V/PI double staining. Furthermore, outcome results indicated that the apoptosis was mediated by downregulation of the NF-${\kappa}B$ pathway which in turn acted through proteasome degradation of $I{\kappa}B{\alpha}$, inhibition of p65 nuclear translocation, release of cytochrome-C from mitochondria and finally overexpression of Bax protein. Thus, conjugated linoleic acid, a natural product derived from probiotics, could therefore be a possible potential chemotherapeutic agent due to its apoptotic activity against estrogen receptor negative breast cancer cells.

The Cultural Phenomena of the Post modern-Feminism and Contemporary Fashion (Post modern-Feminism의 문화 현상과 패션)

  • Shon, Mi-Hee
    • Journal of the Korean Society of Costume
    • /
    • v.46
    • /
    • pp.49-66
    • /
    • 1999
  • The bisexuality deconstructivity and diversity that are great characteristics on the comtemporary fashion are showed in the fashion collections. The purpose of this paper is to investigate and analyze the influence of these characteristics made by the post modern-feminism fashion through the cultural pattern analysis. The post modern-feminism was analyzed by dividing the cultural pattern into 1) the deconstructivity of androcentrism -This characteristic was presented in the costume design that breaks the basic from of the line color and quality of the material showing in men's clothes. 2) By rejecting main current fashion -Subculture style appeared in main current fashion the boundary of main and anti-main current fashion was vagued and the phenomena that the identity of subgroup was weakened were showed. 3) In the coexistence of double-sided value -This characteristic was presented in the cross-dressing fashion that cut away women's slender part and men's rough part. 4) In the open-minded thought of gender -This tendency was reached an extreme from excessive exposure to design which gives the sexual stimulus. This paper is expected to be helpful to understand the contemporary fashion by treating the cultural category associated with post-modern feminism in relation to contemporary fashion and to establish the direction of 21 century fashion.

  • PDF

Highly Sensitive and Transparent Touch Sensor by a Double Structure of Single Layer Graphene

  • Kim, Youngjun;Jung, Hyojin;Jin, Hyungki;Chun, Sungwoo;Park, Wanjun
    • Proceedings of the Korean Vacuum Society Conference
    • /
    • 2014.02a
    • /
    • pp.228.2-228.2
    • /
    • 2014
  • Characteristics of high Fermi velocity, high mechanical strength, and transparency offer tremendous advantages for using graphene as a promising transparent conducting material [1] in electronic devices. Although graphene is a prospective candidate for touch sensor with strong mechanical properties [2] and flexibility, only few investigations have been carried out in the field of sensor as a device form. In this study, we suggest ultra-highly sensitive and transparent graphene touch sensor fabricated by single layer graphenes. One of the graphene layers is formed in the top panel as a disconnected graphene beam transferred on PDMS, and the other of the graphene layer is formed with line-patterning on the bottom panel of triple structure PET/PI/SiO2. The touch sensor shows characteristics of flexible. Its transmittance is approximately 75% where transmittance of the top panel and the bottom panel are 86.3% and 87%, respectively, at 550 nm wavelength. Sheet resistance of each graphene layer is estimated as low as $971{\Omega}/sq$. The results show that the conductance change rate (${\Delta}C/C0$) is $8{\times}105$ which depicts ultra-high sensitivity. Moreover, reliability characteristic confirms consistent behavior up to a 100-cycle test.

  • PDF

Percolation Threshold and Critical Exponent of Dielectric Breakdown Strength of Polyethylene Matrix Composites added Carbon Black (카본블랙 첨가 PMC(Polyethylene Matrix Composites)의 문턱스며들기(Percolation Threshold)와 절연파괴 강도 임계지수)

  • Shin, Soon-Gi
    • Korean Journal of Materials Research
    • /
    • v.21 no.9
    • /
    • pp.477-481
    • /
    • 2011
  • Composites of insulating polyethylene and carbon black are widely used in switching elements, conductive paint, and other applications due to the large gap of resistance value. This research addresses the critical exponent of dielectric breakdown strength of polymer matrix composites (PMC) made with carbon black and polyethylene below the percolation threshold (Pt) for the first time. Here, Pt means the volume fraction of carbon black of which the resistance of the PMC is transferred from its sharp decrease to gradual decrease in accordance with the increase of carbon-black-filled content. First, the Pt is determined based on the critical exponents of resistivity and relative permittivity. Although huge cohesive bodies of carbon black are formed in case of being less than the Pt, a percolation path connecting the conducting phases is not formed. The dielectric breakdown strength (Dbs) of the PMC below Pt is measured by using an impulse voltage in the range from 10 kV to 40 kV to avoid the effect of joule heating. Although the observed Dbs data seems to be well fitted to a straight line with a slope of 0.9 on a double logarithm of (Pt-$V_{CB}$) and Dbs, the least squares method gives a slope of 0.97 for the PMC. It has been found that finite carbon-black clusters play an important role in dielectric breakdown.

A Filtered-X LMS Algorithm by New Error Path Identification Method for Adaptive Active Noise Control (적응 능동소음제어를 위한 오차경로 인식 방법을 통한 filtered-X LMS 알고리듬)

  • 권기룡;송규익;김덕규;이건일
    • The Journal of Korean Institute of Communications and Information Sciences
    • /
    • v.19 no.8
    • /
    • pp.1528-1535
    • /
    • 1994
  • In this paper, a filtered-X LMS algorithm by new error path identification method is proposed for active noise control system. The proposed algorithm identifies accurately the error path transfer function using three microphones and the control of error signal through double loop scheme with on-line. In the computer simulation using the sinusoidal and the practical duct noise, the proposed algorithm reduces noise level about 29.1dB and 10.4dB, respectively. We can observe the improvement of about 0.5dB and 2.5dB in noise level compared with that obtained using the filtered-X LMS algorithm of Eriksson model.

  • PDF

A Plastic BGA Singulation using High Thermal Energy of $2^{nd}$ Harmonic Nd:YAG Laser

  • Lee, Kyoung-Cheol;Baek, Kwang-Yeol;Lee, Cheon
    • KIEE International Transactions on Electrophysics and Applications
    • /
    • v.2C no.6
    • /
    • pp.309-313
    • /
    • 2002
  • In this paper, we have studied minimization of the kerf-width and surface burning, which occurred after the conventional singulation process of the multi-layer BGA board with copper, polyethylene and epoxy glass fiber. The high thermal energy of a pulsed Nd:YAG laser is used to cut the multi-layer board. The most considerable matter in the laser cutting of the multi-layer BGA boards is their different absorption coefficient to the laser beam and their different heat conductivity. The cut mechanism of a multi-layer BGA board using a 2$^{nd}$ harmonic Nd:YAG laser is the thermal vaporization by high temperature rise based on the Gaussian profile and copper melting point. In this experiment, we found that the sacrifice layer and Na blowing are effective in minimizing the surface burning by the reaction between oxygen in the air and the laser beam. In addition, N2 blowing reduces laser energy loss by debris and suppresses surface oxidation. Also, the beam incidence on the epoxy layer compared to polyimide was much more suitable to reduce damage to polyimide with copper wire for the multi layer BGA singulation. When the polyester double-sided tape is used as a sacrifice layer, surface carbonization becomes less. The SEM, non-contact 3D inspector and high-resolution microscope are used to measure cut line-width and surface morphology.

Effects of Radix Saussurea on hepatoprotection (목향(木香)함유 DHL과 ML이 간세포 보호에 미치는 영향)

  • Park, Jong-Chan;Yun, Young-Gab
    • Herbal Formula Science
    • /
    • v.16 no.2
    • /
    • pp.193-204
    • /
    • 2008
  • Dehydrocostus lactone (DHL) and Mokko lactone (ML) were isolated from Saussureae Radix, and their effects on heme oxygenase-1 (HO-1) expression and hepatoprotection in the liver cell line HepG2 were investigated. DHL induced HO-1 expression and HO activity in a dose-dependent manner, whereas ML lacking one double bond property at 11 and 13 carbons on its own chemical structure had no apparent effects. DHL also induced Nrf2 nuclear translocation and enhanced antioxidant response element (ARE) activation which mediated HO-1 gene transcription. Pretreatment with DHL protected HepG2 cells against oxidative damages caused by H2O2. Interestingly, the hepatoprotective effects of DHL appeared to be associated with HO enzymatic activation, HO-1 expression and Nrf2 activation, because blockage of HO activity by a HO inhibitor and inhibition of HO-1 and Nrf2 cellular synthesis by small interfering RNA abolished heptoprotection afforded by DHL. Taken together, this investigation provides evidence supporting that Saussureae Radix is hepatoprotective against oxidative stress that causes abnormal liver damages.

  • PDF

Printmaking Style Effect using Image Processing Techniques (영상처리 기법을 이용한 판화 스타일 효과)

  • Kim, Seung-Wan;Gwun, Ou-Bong
    • The Journal of the Korea Contents Association
    • /
    • v.10 no.4
    • /
    • pp.76-83
    • /
    • 2010
  • In this paper, we propose a method that converts a inputted real image to a image feeling like printmaking. That is, this method converts a inputted real image to man made rubber printmaking style image using image processing techniques such as spatial filters, image bit-block transfer, etc. The process is as follows. First, after detecting edges in source image, we get the first image by deleting noise lines and points, then by sharpening. Secondly, we get second image using the similar method to the first image. Finally, we blend the first and the second image by logical AND operation This processing enables us to represent rubber panel and knife effects. Also, the proposed method shows that double edge detecting is effective in enhancing line-width and removing the tiny lines.

Two Newly Recorded Estuarine Ciliates, Euplotes vannus and E. parawoodruffi (Ciliophora: Spirotrichea: Euplotida) from Korea

  • Kwon, Choon-Bong;Kang, Youn-Seung;Shin, Mann-Kyoon
    • Animal Systematics, Evolution and Diversity
    • /
    • v.23 no.2
    • /
    • pp.229-235
    • /
    • 2007
  • Two euplotid ciliates collected from the estuarine littorals in Korea were identified as Euplotes vannus ($M\ddot{u}ller$, 1786) and E. parawoodruffi Song and Bradbury, 1997. These species are reported taxonomically for the first time from Korea. These two species are redescribed with illustrations, photos and biometry based on live and silver impregnated specimens. Diagnostics of each species are as follows. E. vannus: size in vivo $94-111{\times}55-75{\mu}m$ (average $103{\times}60{\mu}m)$, adoral zone of membranelles (AZM) 70% of cell length with 57-74 adoral membranelles (AM) and terminating close to hook-shape, macronucleus (Ma) C-shaped with twisted foot-like, 10 frontoventral (FVC), 5 transverse (TC), 4-7 (average 5) caudal cirri (CC), 9-10 dorsal kineties (DK), mid dorsal kinety with 15-22 cilia; silver-line system single vannus type. E. parawoodruffi: size in vivo $125-163{\times}72-100{\mu}m$, (average $141{\times}87{\mu}m$), dorsally strongly arched, body shaped reserved triangular. AZM 67-83% of cell length with 60-85 AMs, 9 FVC, 5 TC, 4 CC, 9 DK; mid-dorsal kinety with 20-30 cilia, double-eurystomus type, T-shaped Ma with equal sized right and left arms or right arm shortened slightly.

The Experiment on The Efficiency of Heating System for Improving Farm Houses (농촌주택 개량을 위한 난방 효율 시험)

  • 이회만;최예환
    • Magazine of the Korean Society of Agricultural Engineers
    • /
    • v.16 no.2
    • /
    • pp.3395-3409
    • /
    • 1974
  • The purpose of this study is to test and compare the efficiency of heating-system for materials and construction of the wall, ceiling and window in soil brick house, cement house and boulder house respectively, in order to construct ideal farm houses in rural area. The results obtained were as follows: 1. In heat conservation due to construction of walls the thermal efficiency of cement brick house was equivalent to 66.3% of that of soil brick house, and boulder house 60.3% 2. In the case of ceiling, the thermal efficiency of paper ceiling was amounted to 84.2% of that of the composite ceiling (thickness 6mm veneer+thickness. l0m chaffs), and the common ceiling putting on soil above the ceiling, 76% of the composite while the efficiency of the ceiling putting on chaffs above them was 15.8% higher than that of the paper. 3. In the case of improving the window, the double type was 12% higher than. the efficiency of single type. 4. The warming velocity of conventional house was slower but the velocity of radiation was quicker than that of experimental one. It was thought to be due to unscietific constructions of the room bottom, fire inlet and chimney, 5. The temperature gradient line was not dependad upon the amount of throwing into fuel in the rural farm house. 6. It was concluded that the final thermal efficiency of the conventional farm house was 10.6% lower than that of experimental farm house.

  • PDF