• Journal of Gastric Cancer
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• 제14권3호
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• pp.156-163
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• 2014

Purpose: Information regarding antimicrobial prophylaxis (AMP) for gastric cancer surgery is limited. The present study investigated the efficacy of single-dose AMP for the prevention of surgical site infection (SSI) in patients undergoing gastrectomy for gastric carcinoma. Materials and Methods: Between 2011 and 2013, 1,330 gastric carcinoma surgery patients were divided into two AMP administration groups depending on the duration of treatment. Postoperative outcomes including morbidity and SSI were compared between the two groups overall and in matched patients. Risk factors for SSI were analyzed. Results: The extended group (n=1,129) received AMP until postoperative day 1 and the single-dose group (n=201) received single-dose AMP only during an operation. Postoperatively, there were no significant differences between the two groups with respect to overall morbidity, mortality, or length of hospital stay. The SSI rate of the single-dose group was not significantly different from that of the extended group overall (4.5% vs. 5.5%, respectively, P=0.556) or in matched patients (4.5% vs. 4.0%, respectively, P=0.801). There was no increase in the SSI rate of the single-dose group compared to the extended group in subgroups based on different clinicopathological and operative factors. Univariate and multivariate analyses revealed male gender, open surgery, and operating time (${\geq}180$ minutes) as independent risk factors for SSI. Conclusions: Single-dose AMP showed no increase in the postoperative SSI rate compared to postoperative extended use in patients undergoing gastrectomy for gastric carcinoma. The efficacy of single-dose AMP requires further investigation in randomized clinical trials specific to gastric cancer surgery.

• 한국임상약학회지
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• 제27권3호
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• pp.127-135
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• 2017

Background: Kawasaki disease (KD) is an acute febrile, systemic vasculitis as a leading cause of acquired heart disease in children. Intravenous immunoglobulin G (IVIG) and aspirin are the standard initial therapy in the treatment of acute KD. The purpose of this study was to investigate drug utilization in children with KD, and to compare "IVIG + high-dose aspirin" and "IVIG + moderate-dose aspirin" in preventing cardiac complications. Methods: We analyzed pediatric patient sample data compiled by the Health Insurance Review & Assessment Service from 2010 to 2015. We identified patients with KD using the KCD-6 code of M30.3. We excluded patients in chronic phase or ${\geq}1$0 years. We also excluded patients who were diagnosed KD in November or December. Drug utilization pattern were assessed in acute KD patients and 30-day and 60-day cardiac complications were investigated between "IVIG + high-dose aspirin" group and "IVIG + moderate-dose aspirin" group. Results: In acute phase, IVIG was administered to 95.8% patients, and 57.1% patients were prescribed moderate-dose aspirin and 25% patients were with high-dose aspirin. Steroid use was rapidly increased from 4.0% in 2010 to 11.3% in 2015. Both 30-day and 60-day cardiac complications occurred less in "IVIG + high-dose aspirin" group compared to "IVIG + moderate-dose aspirin" group, but not statistically significant (0.9% vs 1.8%, p=0.252 for 30-day complication rate; 1.5% vs 2.7%. p=0.073 for 60-day complication rate). Conclusion: We were not able to demonstrate which aspirin therapy is superior for preventing cardiac complications in acute KD patients and further research is warranted.

• Journal of Yeungnam Medical Science
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• 제17권2호
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• pp.123-128
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• 2000

본 연구에서 인체공학적으로 개선된 새로운 2-채널 고선량을 근접치료용 적용구(Shin's Applicator)를 개발하였으며, 기존의 단일 선원 근접치료 적용구와 비교하여 질벽에 더 균등한 방사선치료가 가능하고 방광과 직장선량이 적어 근접치료 후 발생할 수 있는 부작용이 감소될 가능성을 확인하였다. 임상적으로 Shin's Applicator는 자궁 경부암이나 자궁 체부암의 수술 후 국소재발이나, 절강에 발생한 다발설 악성종양을 효과적으로 치료하는 데 유용하게 사용될 수 있을 뿐 만 아니라, 방사선 치료 후 흔히 나타나는 질강의 협착을 예방할 수 있는 질 확장기(vaginal dilator)로도 사용 가능하였다. 이상의 결과에서 Shin's Applicator는 부인과 종양환자들의 방사선치료 뿐만 아니라 치료 후 삶의 질의 개선에도 크게 기여할 것으로 생각되었다.

• Nuclear Engineering and Technology
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• 제52권8호
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• pp.1798-1806
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• 2020

In this study, we investigated whether there is a significant relationship between the natural radiation dose rate and the cancer incidences in Korea by using a big data analysis. The natural dose rate data for this analysis were the measurement data obtained from the 171 monitoring posts of the 113 administrative districts in Korea over the 10 years from 2007 to 2016. The relative cancer incidences for this analysis were the difference in the cancer patients per hundred thousand people year-on-year in the administrative districts with the five highest and the five lowest natural gamma dose rates each year over the same period. To analyze the correlation between the two variables, Spearman's rank correlation coefficient between the two rates was derived using R, a well-known big data analysis tool. The analysis showed that Spearman's rank correlation coefficient was more than 0.05 and that the correlation between the two variables was not statistically significant.

• Radiation Oncology Journal
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• 제2권1호
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• pp.101-106
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• 1984

Various methods are available for determination of exposure time in intracavitary radiotherapy of the carcinoma of the uterine cervix. To determine the accuracy of dose calculation with isodose curve for TAO applicator, comparison with results calculated by computer for radiotherapy treatment Planning was done in 24 procedures done in 12 consecutive patients with the carcinoma of the uterine cervix from May to December, 1983. The results are as follows: 1. The average dose rate Per hour of Point A was 87.70 rad, being 89.91 rad ana 85.49 rad in left and right, respectively. 2. The average percentage of dose rate of point A calculated by isodose curve method over that by computer was $101.28\%$ and the difference was less than $5\%$ in 17 Procedures and over $10\%$ in only 3 procedures. 3. The average percentage in case of point B was $108.67\%$. In conclusion, in most cases the difference was less than 200 rad for point A and less than 100 rad for point B during 2 courses of intracavitary radiotherapy. And so the dose rate calculation with isodose curve for TAO applicator is comparatively accurate.

• 한국의학물리학회:학술대회논문집
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• 한국의학물리학회 2005년도 제30회 춘계학술대회
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• pp.42-46
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• 2005

Buchler용 강내치료장치에 대한 선량계산 프로그램을 개발하였다. 프로그램 디스크를 5도씩 72분할하여 구한 좌표에서 선원의 왕복 크기와 선원분포를 결정하였다. 프로그램 디스크별 그리고 각 선원별로 선량률을 계산하여 표로 작성하였다. 이 선량률표를 이용하여 인체내 관심점에 대한 선량률 계산에 이용하였으며 등선량 분포곡선을 구하였다. 기존 Buchler용 등선량 분포곡선을 이용한 근사적 계산보다 정확한 선량계산을 손쉽게 할 수 있었다. 또한 탄뎀의 선원으로 이리듐을 사용하였기에 선원의 장기적 수급문제가 해결되었다.

• Journal of Radiation Protection and Research
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• 제34권2호
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• pp.77-81
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• 2009

An Area Radiation Monitoring System (ARMS) ionization chamber, which had an 11.8 L active volume, was fabricated and performance-tested at KAERI. Low leakage currents, linearities at low and high dose rates were achieved from performance tests. The correlation coefficients between the ionization currents and the dose rates are 1 at high dose rate and 0.99 at low dose rate. In this study, an integration-type ARMS ionization chamber was tested over a year for an evaluation of its long-term stability at a radioisotope (RI) repository of the Young-gwang nuclear power plant. The standard deviation of dose rate of 1 day data and over a 100-days mean value were 6.2 $\mu$R/h and 2.9 $\mu$R/h, respectively. The fabricated ARMS ionization chamber showed stable performance from the results of the long-term tests. Design and performance characteristics of the fabricated ionization chamber for the ARMS from performance-tests are also addressed.

• Nuclear Engineering and Technology
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• 제54권9호
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• pp.3398-3402
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• 2022

We fabricated a 15 m long position-sensitive plastic scintillation optical fiber (PSOF) detector consisting of a PSOF, two photomultiplier tubes, four fast amplifiers, and a digitizer. A single PSOF was used as a sensing part to estimate the gamma-ray source position, and ¹³⁷Cs, an uncollimated solid-disk-type radioactive isotope, was used as a gamma-ray emitter. To improve the sensitivity, accuracy, and measurement time of a PSOF detector compared to those of previous studies, the performance of the amplifier was optimized, and the digital signal processing (DSP) was newly designed in this study. Moreover, we could measure very low dose rates of gamma-rays with high sensitivity and accuracy in a very short time using our proposed PSOF detector. The results of this study indicate that it is possible to accurately and quickly locate the position of a very low dose rate gamma-ray source in a wide range of contaminated areas using the proposed position-sensitive PSOF detector.

• 한국방사선학회논문지
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• 제13권4호
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• pp.653-659
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• 2019

본 연구는 고용량 $^{131}I$ 치료 후 방사선원이 된 퇴원 환자로부터 나오는 방사선 피폭에 관해 외부 선량률을 측정하고, 그에 따른 피폭선량을 예측하는 것이 목적이다. 200 mCi 이상 고용량 $^{131}I$ 치료를 받은 30명의 환자에서 구리링 3개를 이용하여 환자로부터 거리 및 방위각에 따른 선량평가를 시행하였다. 정확한 방사선 계측을 위하여 GM 계측기를 이용하여 2명의 측정자가 방위각 8 포인트와 거리 변화를 주며 계측하였다. 측정값을 기반으로 3가지 예측 시뮬레이션을 설정하여 불특정 다수 일반인에 대한 피폭선량을 계산하였다. 1m 높이에서 방위각에 따른 외부 선량률이 가장 높은 부위는 0도이다. 거리에 따른 선량률은 거리별 방위각의 선량률 평균값을 사용하였다. 거리에 따른 외부 선량률의 최고치는 50, 100, 150 cm에서 각각 $214{\pm}16.5$, $59{\pm}9.1{\mu}Sv/h$, $38{\pm}5.8{\mu}Sv/h$ 이다. 고용량 $^{131}I$ 치료 환자가 대중교통을 이용해서 5시간 이동할 때 반경 50 cm 지점의 옆좌석에 안은 불특정 일반인이 받을 수 있는 피폭선량은 1.14 mSv이다. 소변 통(urin bag)을 착용한 퇴원환자로부터 100 cm 거리에서 4일 동안 간병인이 받을 수 있는 최대 피폭선량은 6.5 mSv이다. 퇴원 환자 귀가로 인해 7일 동안 150 cm 거리에서 보호자가 받을 수 있는 최대 피폭선량은 1.08 mSv이다. 개발된 예측 모델링으로 불특정 $^{131}I$ 치료 환자의 주변 일반인에게 적용하였을 때 연간 선량 한도를 단시간에 초과하는 수준이었다. 따라서 본 연구를 통해 현행 고용량 $^{131}I$ 치료 환자의 퇴원 후 주변의 일반인의 방호체계의 합리적인 가이드라인을 제시하는 데 도움을 줄 수 있을 것으로 사료된다.

• 한국환경농학회지
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• 제28권3호
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• pp.281-288
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• 2009

Azoxystrobin과 kresoxim-methyl의 참외 중 반감기와 잔류양상을 조사하였다. Azoxystrobin의 참외 중 0일차 잔류량은 기준량 및 배량 처리구에서 각각 0.09 및 0.14 mg/kg으로 나타났으며 농약의 반감기 소실곡선식은 y=0.0766e$^{-0.138x}$ ($r^2$=0.9424) 및 y=0.1143e$^{-0.0890x}$ ($r^2$=0.9310) 이었으며 생물학적 반감기는 각각 5.0일 및 7.8일 이었다. Kresoxim-methyl의 참외 중 0일차 잔류량은 기준량 및 배량 처리구에서 각각 0.10 및 0.23 mg/kg으로 나타났으며 농약의 소실곡선식은 y=0.0896e$^{-0.1672x}$ ($r^2$=0.9428) 및 y=0.1504e$^{-0.1446x}$ ($r^2$=0.9040) 이었고 생물학적인 반감기는 각각 4.1일 및 4.8일 이었다. 재배기간 중 참외의 무게증가에 농약희석효과를 배제한 절대잔류농도는 약제 살포 후 14일 경과시 azoxystrobin은 기준량 및 배량에서 0.01 및 0.05 mg/kg으로서 각각 83.6 및 67%의 농약이 분해되었다. Kresoxim-methyl은 각각 0.01 및 0.03 mg/kg 으로서 86.2 및 87.8% 정도의 농약 분해율을 보였다.