• Natural Product Sciences
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• 제22권3호
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• pp.180-186
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• 2016

This research is to estimate the toxicity of Atractylodis Rhizoma Alba (ARA) in F344 rats and to find a dose level for the 13 weeks toxicity study. A hot water extract of ARA (ARWE) was administered orally to F344 rats at dose levels of 0 (vehicle control), 500, 1000, 2000, 3500, and 5000 mg/kg/day for 2 weeks. Each group was composed to five male and five female F344 rats. According to the result, there were no ARWE-related adverse changes in mortality, body weights, food consumption, urinalysis, hematology, clinical chemistry, gross finding at necropsy, and organ weight examination. Salivation was observed in 3500 and 5000 mg/kg/day in male and female rats but it could not have found any relationship with ARWE administration. Based on our findings, ARWE may not cause toxicity in rats under the experimental conditions. Therefore, dose level of 5000 mg/kg/day as a highest treatment group in 13-week exposure study is recommended for further toxicity assessment.

• Nuclear Engineering and Technology
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• 제54권5호
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• pp.1781-1788
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• 2022

The containment building Kori Unit 1 may require sequential steps for full decommissioning. This study assumes that the containment building is to be used as an auxiliary building that handles nuclear power systems and materials during decommissioning before conversion into a greenfield. Through the derivation of guidelines and dose evaluation, it was confirmed whether the radiation workers were satisfied with the ALARA decision. The specific modeling of the external radiation exposure was performed based on the facility investigation procedures. The external radiation specific derived concentration guideline levels (DCGLs) for radiation workers in containment building were obtained using the RESRAD-BUILD code and were applied to the VISIPLAN 3D ALARA Planning Tool code to calculate the working dose and check worker safety. The derivation of site-specific and realistic DCGLs and dose evaluation via 3D modeling can contribute to the scenario development for the decommission and remediation of containment building.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.414.2-414.2
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• 2002

To secure the safety of drugs without compromising drug efficacy, it can not be more important to administer the exact intended amount of active ingredients to patients. Even if the correct amount of drugs are taken in the correct manner, drug can be overdosed or less-dosed without intention unless the content uniformity of the unit dose were secured. Especially, it can be a serious problem when it comes to drugs with narrow therapeutic windows or a strong pharmacological activity at a small dose. (omitted)

• 방사성폐기물학회지
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• 제2권3호
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• pp.155-164
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• 2004

사용후핵연료의 효율적인 관리를 위하여 원자력연구소에서 개발중인 사용후핵연료 차세대관리 종합공정(ACP)은 공정타당성연구 단계를 마치고 이의 실증을 위한 $\alpha$-${\gamma}$ type핫셀 건설 단계에 이르렀다. 핫셀의 설계에 앞서 사용후핵 연료를 취급하게 되는 과정에서 발생할 수 있는 방사능에 대한 환경영향평가를 정상운전 시와 사고발생 시로 나누어 수행하였다. 평가에 필요한 자료들은 공정의 개념설계 보고서와 최근 연구소부지 기상 테이터 및 부지특성 자료를 바탕으로 하였으며 기존의 유사한 시설에 대한 평가방법을 참조하였다. 각 핵종별 발생량과 방출량을 계산하여 피폭선량을 계산하였으며 평가결과 원자력법관련 규제기준과 핫셀이 위치하게 되는 IMEF 건물의 안전성분석 기준보다 매우 안전한 결과를 얻어 시설 운영에 대한 안전성을 확보하였다.

• 대한방사선기술학회지:방사선기술과학
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• 제39권3호
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• pp.435-441
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• 2016

현재 시중에 설치되어 있는 의료용 X선 장치는 선량표시를 할 때 일반적으로 DAP(Dose Area Product) meter를 부착한다. 그러나 DAP meter가 전부 수입에 의존하고 있기 때문에 고가의 설치 비용 등의 문제가 있다. 본 연구에서는 서울시의 지원을 받아 순수 국산기술의 DAP meter 프로토타입을 제작하였고, 이 프로토타입의 성능을 독일산 I사의 제품과 비교하여 평가하였다. 평가 항목은 전자포집효율, 선량의존성, 선질의존성, 재현성, 자체흡수율, 광투과율 6개 항목으로 IEC 60580를 평가 기준으로 삼았다. 평가 결과 전자포집효율이 고유오차 9.5%, 선량의존성이 선형성 99%, 재현성이 변동계수 2%, 자체흡수율이 9%로 각각 합격기준을 만족시켰으나, 선질의존성이 변동한계 29%, 광투과율이 55%로 합격기준에 미달하였다. 아직 프로토타입이기에 앞으로 개선될 여지가 많다. 회로부터 재료까지 국산기술로 개발하고 있기 때문에 합격 기준에 미달하는 항목은 추후 해결 가능할 것으로 사료된다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권8호
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• pp.3589-3593
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• 2012

Objective: Evaluation and assessment of response rate, duration and toxicity in patients subjected to 5-FU based chemotherapy. Background: The therapeutic ratio shifts with different 5FU/LV regimens and none yet serve as the internationally accepted Gold Standard. A bimonthly regimen of high dose leucovorin is reported to be less toxic and more effective than monthly low dose regimens. We here compare therapeutic responses and survival benefit of the two regimens in poor prognosis patients with advanced colorectal carcinoma. Patients and Methods: A total of 35 patients with histologically confirmed colorectal carcinoma were subjected to de Gramont and Mayo Clinic regimen. Nineteen patients were treated with high dose folinic acid ($200mg/m^2$), glucose 5%, 5-FU ($400mg/m^2$) and 22 hr. CIV ($600mg/m^2$) for two consecutive days every two weeks. These patients had failed responses to previous chemotherapy and were above sixty years of age with poor general status. Sixteen patients (six below 60 years) with progressive disease were subjected to low dose folinic acid ($20mg/m^2$)for five days, 5FU($425mg/m^2$) injection bolus for 5 days, every five weeks. An initial evaluation was made in sixty days and responders were reevaluated at sixty days interval or earlier in case of clinical impairment. Based on positive prognosis, the therapy was continued. Evaluation of treatment response was made on the basis of WHO criteria. Results: The response rate was 44% in thirty four evaluable patients, with 4 complete responses (11.8%) and 11 (32.4%) partial responses. The two schedules were well tolerated, whereas, mild toxicity without WHO Grade ${\geq}2$ events was assessed. The response duration was extended (12 months) in a few patients with age above sixty years treated by high dose bimonthly regimen of 5FU/LV. Conclusion: The regimens are safe and effective in advanced colorectal carcinoma patients with poor general status.

• Journal of Oral Medicine and Pain
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• 제41권2호
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• pp.61-71
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• 2016

Purpose: This study was designed to evaluate the comparison between the subjective and the objective evaluation of pain control effect in masticatory muscle pain depending on time and dose change. Methods: The patients were recruited to this study and diagnosed according to the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD). Experimental group were divided into three groups; saline injection group (n=10), morphine 1.5 mg injection group (n=10), and morphine 3.0 mg injection group (n=10). Evaluation list was the subjective pain evaluation (visual analogue scale, McGill pain questionnaire) and the objective pain evaluation (pressure pain threshold [PPT], pressure pain tolerance [PTO]). The subjective and the objective pain evaluation were performed at the times of just before injection, 10 minutes, 30 minutes, 1 hour, 24 hours, and 48 hours after injection. Then, data were statistically analyzed. Results: The results were as follows: 1) There is no statistically significant difference between the results of the subjective and the objective pain evaluation with regard to the short-term (within 1 hour) analgesic effect of morphine sulfate. 2) However, after 1 hour of injection, while the subjective pain evaluation score still decreased, the objective pain evaluation didn't show significant changes in PPT and PTO (1 hour, p<0.05; 24 hours, p<0.01; 48 hours, p<0.001). 3) In comparison to changes in the dose, the McGill pain questionnaire was the most statistically effective method among the subjective pain evaluations (1.5 mg, p<0.05; 3 mg, p<0.01). Conclusions: Therefore, it was revealed that the subjective pain evaluation was more effective to evaluate long-term pain control, and that the McGill pain questionnaire could be an effective way to evaluate pain control depending on dose changes. It requires further investigations with time and dose extension.

• 대한방사선기술학회지:방사선기술과학
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• 제38권4호
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• pp.383-387
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• 2015

본 연구에서는 소아 CT검사에서 환자의 크기를 고려한 보정을 위해 검상돌기부위, 장골능부위, 대퇴골두가 처음으로 보이는 부위의 스캔영상과 전체 스캔영역의 중간 부위에서 산정된 크기보정선량을 비교하였다. 각 위치에서 측정한 size specific dose estimates(SSDE)와 $CTDI_{vol}$ 값의 평균오차는 스캔영역 중간에서 산정한 보정선량 값에서 107.63%로 가장 큰 차이를 보였으며 검상돌기 영역에서 산정한 평균오차는 92.91%로 가장 작은 차이를 보였다. 또한 스캔영역의 중간 부위에서 산정한 SSDE와 골반의 장골능 부위에서 산정한 SSDE의 오차는 최대 7.48%의 오차를 나타냈고, 검상돌기 부위에서 산정한 SSDE와는 17.81%, 대퇴골두 부위와는 14.04%의 차이를 나타냈다. 이와 같이 SSDE는 산정부위에 따라 상당한 오차를 나타내는 것을 확인할 수 있다. 따라서 임상에서 SSDE의 산정을 위해서는 환자의 신체적 형태를 파악하고 각 부위에서 SSDE를 산정하여 최대값을 사용하는 것이 방사선 방어의 입장에서 옳을 것으로 생각된다.

• 생물정신의학
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• 제5권2호
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• pp.263-277
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• 1998

Conventional high-dose antipsychotics tend to result in more side effects, negative symptoms and dysphoria, and at the same time lower the cognitive function which is already impaired in most schizophrenics. Florid psychotic symptoms, negative symptoms and cognitive impairment greatly impede psychosocial performance and eventual reintegration into society. The reduction of symptom and the improvement of cognitive funtions and social skills are therefore central to the psychiatric rehabilitation process. The purpose of this study was to evaluate the dose-reduction effects of antipsychotics on chronic schizophrenics prescribed conventional high-dose antipsychotics more than 1,500mg equivalent of chlorpromazine. Fifty-one chronic schizophrenics who maintained high-dose antipsychotics for more than three months were randomly assigned to two groups : 20 patients comprised the dose-maintaining group and 31 patients made the dose-reduction group. Over a sixteen weekperiod Positive and Negative Syndrome Scale(PANSS), Extrapyramidal Symptom(EPS), Nurses' Observation Scale for Inpatient Evaluation(NOSIE-30), Continuous Performance Test(CPT), Quality of Life(QOL), and haloperidol/reduced haloperidol blood levels were determined at the base line and after 2, 4, 6, 8, 12, 16 weeks to evaluate the dose reduction effects of high-dose antipsychotics. The results were as follows : 1) Dose-reduction is highly effective in reducing positive and negative symptoms, and general psychopathology. Effects were most prominent at 8, 12, 16 weeks. Among the dose reduction group, positive symptoms in positive symptom group and negative symptoms in negative symptom group were more reduced. 2 Extrapyramidal symptoms showed no significant difference between two groups. But the EPS was reduced time after time within two groups. 3) Hit rates of Continuous Performance Test, which indicate attentional capacity, increased significantly after dose reduction. 4) Haloperidol and reduced haloperidol blood levels decreased until the 4th week, after which they were constant. 5) Total scores of Nurses' Observation Scale for Inpatient Evaluation were unchanged between the two groups. But among the indices, social interest and personal neatness were improved in the dose-reduction group and retardation was aggrevated in the dose-maintaining group. 6) Total quality of life scores were unchanged between two groups. But in the dose maintaining group, satisfaction scores of attention, autonomy, and interpersonal relationship decreased progressively. These findings suggest that the dose reduction of antipsychotics for chronic schizophrenics on programs of high-dose antipsychotics were effective. Dose reduction should therefore be implemanted to spread the rehabilitation and improve quality of life for chronic schizophrenics.

• Journal of Radiation Protection and Research
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• 제18권1호
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• pp.1-7
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• 1993

국제방사선방어위원회(ICRP)는 최근의 권고 60(1990)에서 이전의 권고 26(1976)에는 없었던 새로운 용어들을 도입하였다. 이중에서도 동 위원회는 지금까지 사용되어 왔던 국제 방사선단위 및 측정위원회(ICRU) 개념의 '션량당량(dose equivalent)'을 대체하는 용어로 '등가선량(equivalent dose)'을 새로 정의하여 방사선방어 프로그램에의 적용을 권고하고 있다. 그러나 한편 동 위원회는 선량 당량이라는 용어도 여전히 채택하고 있기 때문에 경우에 따라 두 양의 사용시 불필요한 혼동을 불러일으킬 수가 있다. 따라서 본 해설문에서는 방사선 방어, 관리 및 측정분야 종사자들의 이해를 돕기 위하여 두 양의 정의와 사용상의 차이점에 대하여 정리하였다.