• 한국임상약학회지
• /
• 제31권3호
• /
• pp.237-246
• /
• 2021

Background: Pembrolizumab, an anti-cancer drug, is known to increase the activity of the immune system, leading to side effects called immune-related adverse events (irAE), including type 1 diabetes. This study analyzed the correlation between blood glucose level and pembrolizumab administration and investigated the covariates that affect those changes in cancer treatment. Methods: The information of 133 adult cancer patients was obtained from the electronic medical record (EMR) to identify the changes in random blood glucose (RBG) levels during the pembrolizumab treatment. Subjects were classified into subgroups according to their baseline RBG level, history of diabetes, and the use of steroids, and linear regression analysis was conducted. In addition, a secondary analysis was performed within the group of subjects having a strong correlation to glycemic change, which was based on the Pearson correlation coefficient being less than -0.7 or greater than +0.7. Univariate and multivariate logistic regressions were conducted to identify the risk factors to glycemic increase. Results: The RBG level tended to descend without significant differences in total patients during the administration period of pembrolizumab. Despite the insignificance, the logistic regression analysis presents that the odds ratios of baseline RBG less than 130 mg/dL, prophylactic steroid use, and higher dose of pembrolizumab per cycle (mg/kg/cycle) were greater than 1. Conclusions: Prophylactic administration of steroids and a higher dose of pembrolizumab per cycle may increase the blood glucose level as irAE in cancer patients with a strong tendency to glycemic change.

• 대한방사선기술학회지:방사선기술과학
• /
• 제44권4호
• /
• pp.367-373
• /
• 2021

A quality assurance of computed tomography(CT) have done seven items that were water attenuation coefficient, noise, homogeneity, spatial resolution, contrast resolution, slice thickness, artifact using by standard phantom. But there is no quality assurance items and methods for CT simulator at domestic institutions yet. Therefore the study aimed to access the CT dose index(CTDI), table tilting, image distortion, laser accuracy, table movement accuracy and CT seven items for CT simulator quality assurance. The CTDI at the center of the head phantom was 0.81 for 80 kVp, 1.55 for 100 kVp, 2.50 for 120 mm, 0.22 for 80 kVp at the center of the body phantom, 0.469 for 100 kVp, and 0.81 for 120 kVp. The table tilting was within the tolerance range of ±1.0° or less. Image distortion had 1 mm distortion in the left and right images based on the center, and the laser accuracy was measured within ±2 mm tolerance. The purpose of this study is to improve the quality assurance items suitable for the current situation in Korea in order to protect the normal tissues during the radiation treatment process and manage the CT simulator that is implemented to find the location of the tumor more clearly. In order to improve the accuracy of the CT simulator when looking at the results, the error range of each item should be small. It is hoped that the quality assurance items of the CT simulator will be improved by suggesting the quality assurance direction of the CT simulator in this study, and the results of radiation therapy will also improve.

• 방사선산업학회지
• /
• 제17권2호
• /
• pp.173-181
• /
• 2023

3D printing is a technology that can transform and process computerized data obtained through modeling or 3D scanning via CAD. In the medical field, studies on customized 3D printing technology for clinical use or patients and diseases continue. The importance of research on filaments and molding methods is increasing, but research on manufacturing methods and available raw materials is not being actively conducted. In this study, we compare the characteristics of each material according to the manufacturing method of the phantom manufactured with 3D printing technology and evaluate its usefulness. We manufactured phantoms of the same size using poly methyl meta acrylate (PMMA), acrylonitrile butadiene styrene (ABS), and Poly Lactic Acid (PLA) based on the international standard phantom of aluminum step wedge. We used SITEC's radiation generator (DigiRAD-FPC R-1000-150) and compared the shielding rate and line attenuation coefficient through the average after shooting 10 times. As a result, in the case of the measured dose transmitted through each phantom, it was confirmed that the appearance of the dose measured for phantoms decreased linearly as the thickness increased under each condition. The sensitivity also decreased as the steps increased for each phantom and confirmed that it was different depending on the thickness and material. Through this study, we confirmed that 3D printing technology can be usefully used for phantom production in the medical field. If further development of printing technology and studies on various materials are conducted, it is believed that they will contribute to the development of the medical research environment.

• 대한방사선기술학회지:방사선기술과학
• /
• 제40권2호
• /
• pp.245-251
• /
• 2017

복부-골반 CT검사 시 피폭선량을 측정해 보고, 영상 판독에 영향을 미치지 않는 범위에서 복부와 골반의 피폭선량 최적화를 위한 프로토콜을 제시하고자 하였다. 기존 임상의 스캔 방식인 120 kVp, AEC(auto exposure control) 기법을 이용한 복부-골반을 1 phase로 스캔을 하였고, 새로 제시한 2 phase 스캔 방식은 1 phase 복부검사와 2 phase 골반검사로 각각 나누어 복부검사는 관전압 120 kVp, AEC, 골반검사는 120 kVp, 100, 150, 200, 250, 300, 350, 400 mA로 고정 관전류 기법을 이용하여 실시하였다. 스캔 시 측정된 $CTDI_{VOL}$, DLP 값을 이용해 선량값을 비교하였고, 각 스캔 영상에서 CT 감약계수와 노이즈, SNR의 평균값을 구해 영상을 평가하였다. 연구결과는 2 phase 스캔 시 1 phase 스캔 시보다 $CTDI_{VOL}$ 값은 복부에서 26%, 골반 100~250 mA에서 1.8~59.5% 감소, 300~400 mA에서 12.7~30% 증가로 유의한 차이를 보였다. 또한, DLP값은 2 phase 스캔 시 1 phase 스캔 시보다 복부에서 약 53%, 골반에서 약 41~81% 감소를 보였으나 통계적으로 유의하지 않았다. SNR은 심장주변에서 2 phase 스캔 시, 골반주변에서는 1 phase 스캔 시, 상복부와 하복부에서 1 phase 스캔 시보다 2 phase 200~250 mA 스캔 시 높게 나타났다. 또한, CT Number와 노이즈는 전반적으로 비슷한 양상을 보였지만, 골반 주변에서 노이즈가 높게 나타났다. 그러나 2 phase의 골반주변 250 mA 스캔 시 1 phase와 비슷한 노이즈값을 나타냈고 통계적으로 유의한 차이를 보이지 않았기에 통상적인 1 phase 400 mA보다 골반을 분리시켜 250 mA 스캔 시 화질에 차이 없이 피폭선량 감소효과를 볼 수 있을 것으로 본다. 그러므로 잦은 복부-골반 CT를 시행하는 환자 혹은 가임기여성, 소아의 골반은 피폭을 줄이면서 화질차이 없이 검사를 위한 2 phase 검사를 제안한다.

• Journal of Radiation Protection and Research
• /
• 제40권4호
• /
• pp.252-260
• /
• 2015

본 논문은 ICRP103 환경방호를 대비하여 국내에서 개발된 야생동식물 선량평가 코드 K-BIOTA의 기술적 배경 및 적용 사례를 기술한다. K-BIOTA는 스크리닝(screening) 선량평가(Level 1&2)와 부지 특성적 상세평가(Level 3)의 3단계의 단계적 평가방법을 적용한다. 스크리닝 단계평가는 상세평가의 필요성 여부를 판단하기 위한 예비적 평가 단계로 개별적인 생물종보다는 동식물을 그룹별로 구분하여 평가한다. Level 1 평가는 스크리닝 목적의 참조준위로부터 유도된 최대환경매체농도 값과 실제 환경매체농도 값의 비교로부터 위험도 지표(risk quotient)를 계산한다. Level 1 평가 결과 위험도 지표가 1보다 작으면 생태계의 건전성이 유지된다는 결론과 함께 평가를 종료하고, 1 보다 크면 동식물 그룹별로 평균적인 전이계수나 평형분배계수 값을 적용하여 조금 더 실제적인 Level 2 평가를 수행한다. 따라서 Level 2 평가가 Level 1 평가보다 덜 보수적이다. Level 2평가에서 위험도지표가 1 보다 작으면 생태계의 건전성이 유지된다는 결론을 내리고 평가를 종료하고, 1보다 크면 Level 3 평가를 수행한다, Level 3 평가는 부지 특성적 데이터를 고려하는 상세평가단계로, 동식물 그룹별 평가 대신 부지 대표적 동식물에 대한 개별적 선량평가를 수행하며, 대표적 동식물의 종류 및 크기, 거주인자, 전이계수, 평형분배계수에 대한 부지 특성적인 값을 사용한다. 또한 Level 3 평가 단계에서는 전이계수, 평형분배계수, 환경매체농도 (토양농도 또는 물의 농도)에 대한 개별 동식물의 피폭 선량률에 대한 불확실도 분석을 선택적으로 수행할 수 있다. 적용 가능한 확률밀도함수는 정규분포, 로그정규분포, 균일분포, 지수분포의 4가지이다. 국제원자력기구의 EMRAS II (Environmental Modeling for Radiation Safety) 모델 시나리오 비교 공동연구에 참가하여 K-BIOTA의 적용성을 검증하였다. 그 결과로 K-BIOTA는 다양한 오염 환경에서 거주하는 야생동식물의 방사선 영향을 평가하는데 유용함이 입증되었다.

• Journal of Preventive Medicine and Public Health
• /
• 제13권1호
• /
• pp.41-46
• /
• 1980

In order to study the effect of lead exposure on the hematocrit and hemoglobin values in accordance with the level of lead exposure, twenty-four Sprague-Dawley rats were equally divided into four groups of six rats each. Lead acetate disolved in glucose was injected intraperitoneally six times a week, for four weeks with dose of 0.05 mg/kg/day for group I, 0.5 mg/kg/day for group II, and 5 mg/kg/day for group III. Control group was injected glucose only. Blood samples for the checking of the hematocrit and hemoglobin values, were taking from tail vein of rats before lead injection and on the third, seventh, fourteenth, twenty-first, and twenty-eighth days after lead injection. And also, the concentration of lead and ALA in urine were checked for evaluating the lead absorption. The results were as follows: 1. The alteration of the hematocrit and hemoglobin values of the group I was not significant as that of the control group. 2. In group II, the hematocrit values were significantly decreased from the fourteenth day after lead injection, and the hemoglobin values were decreased from the twenty-first day after lead injection when the concentration of lead in urine was elevated more than $260{\mu}g/liter$. 3. In group III, the hematocrit values were decreased from the seventh day after lead injection, and the hemoglobin values were decreased even from the third day after lead injection. And the hemoglobin values were more rapidly decreased than the hematocrit values. 4. In all groups, the correlation coefficient between hematocrit and hemoglobin was highly significant. And the difference between the correlation coefficient of the group III and that of the others was highly significant.

• 대한기계학회논문집
• /
• 제16권10호
• /
• pp.1940-1954
• /
• 1992

본 연구에서는 가공기 자체의 파라메터와 성능에 관한 연구로서 출력 에너지 가 서로 다른 가공기를 사용하여 SUS 304 스테인리스 시험편을 관통, 절단하면서 출력 에너지와 최대 출력을 비교하여 보고, 시험편 관통시 주파수와 출력 에너지와의 관계, 시험편 관통시 응융 금속 제거량에 의한 절단 속도의 예측, 서로 다른 출력의 가공에 있어서 슬릿 절단 폭, 커프 폭, 드로스 길이, 절단면의 표면 거칠기 등을 비교하여 출 력차에 따른 가공 특성을 고찰하였다.

• 한국근적외분광분석학회:학술대회논문집
• /
• 한국근적외분광분석학회 2001년도 NIR-2001
• /
• pp.4111-4111
• /
• 2001

When a drug is prepared in a tablet, the active component represents only a small portion of the dosage form. The other components of the formulation include materials to assist in the dissolution, antioxidants, coloring agents and bulk fillers. The tablets are tested using approved testing methods usually involving separation and subsequent quantification of the active component. Tablets may also be tested by near-Infrared Reflectance spectrometry (NIRS). In the present study, based on NIRS and multivariate calibration methods, a novel and precise method is developed for direct determination of ascorbic acid in vitamin C tablet. Two different tablet formulations were powdered in three different sizes, 63-125 ${\mu}{\textrm}{m}$, and examined. Spectral region of 4750-4950 $cm^{-1}$ / was used and optimized for quantitative operations. Partial least squares (PLS) and multiple linear regression (MLR) methods were performed for this spectral region. The results of optimized PLS and MLR methods showed that reproducibility increase with decreasing grain size and standard error of calibration (SEP) of less than 1% w/w of ascorbic acid and a correlation coefficient of 0.998 can be achieved. The PLS method showed better results than MLR. Seven overdose and underdose samples (prepared in the laboratory to match marketed products) were tested by proposed and iodometric standard methods. A correlation between NIRS predicted ascorbic acid values and iodomet.ic values was calculated ($R^2$=0.9950). Finally, the direct analysis of individual intact tablets in their unit-dose packages (Blistering in aluminum and PVC foils) obtained from market were also carried out and a correlation coefficient of 0.9989 and SEP of 0.931% w/w of ascorbic acid were achieved.

• Archives of Pharmacal Research
• /
• 제14권2호
• /
• pp.181-187
• /
• 1991

The muscarinic antagonist 1-[benzilic 4, 4'-$[^3H]$ QUINUCLIDINYL BENZILATE $([^3H]$ QNB) bound to a single class of muscarinic receptors with high affinity in rabbit ileal membranes. The $K_D\;and\;B_{ max}$ values for $([^3H]$ QNB calculated from analysis of saturation isotherms were 52.5 pM AND 154 fmol/mg, respectively. Chlopheniramine (CHP), histamine $H_1$ blocker, increased $K_D$ vlue for $([^3H]$QNB without affecting the binding site concentrations and Hill coefficient. The $K_i$ value of CHP for inhibition of $([^3H]$QNB binding in ileal membranes was 1.44\mu{M}$ and the pseudo-Hill coefficient for CHP was close to unit. In the functional assay carbachol, muscarinic agonist, increased the contractile force of ileum with $ED_{50}$ value of $0.11\mu{M}$. CHP caused the rightward shift of the dose-response curve to carbachol. The $pA_2$ value of CHP determined from Schild analysis of carbacholinduced contraction was 5.77 and the slope was unity indicating competitive antagonism with carbachol. The dissociation constant $(K_i)$ of CHP obtained in competitive experiments with $([^3H]$ QNB was similar to the $K_A$ value (1.69 \mu{M)}$ of CHP as inhibitor of carbachol induced contraction in rabbit ileum. This result suggest that the binding of $H_i$ blocker. CHP, vs $([^3H]$QNB to muscarinic receptors in ileal membranes represents an interaction with a receptor of physiological relevance.

• Archives of Pharmacal Research
• /
• 제26권4호
• /
• pp.264-269
• /
• 2003

5-Aminosalicylic acid (5-ASA) is an active ingredient of therapeutic agents used for Crohn s disease and ulcerative colitis. Because it is absorbed rapidly and extensively in the upper intestine, delivery of the agent specifically to the colon is necessary. We selected taurine as a colon-specific promoiety and designed 5-aminosalicyltaurine (5-ASA-Tau) as a new colon-specific prodrug of 5-aminosalicylic acid (5-ASA). It was expected that introduction of taurine would restrict the absorption of the prodrug and show additive effect to the anti-inflammatory action of 5-ASA after hydrolysis. 5-ASA-Tau was prepared in good yield by a simple synthetic route. The apparent partition coefficient of 5-ASA-Tau in 1-octanol/pH 6.8 phosphate buffer or $CHCl_3$/pH 6.8 phosphate buffer was 0.10 or 0.18, respectively, at $37^{\circ}C$. To determine the chemical and biochemical stability in the upper intestinal environment, 5-ASA-Tau was incubated in pH 1.2 and 6.8 buffer solutions, and with the homogenates of tissue and contents of stomach or small intestine of rats at $37^{\circ}C$. 5-ASA was not detected from any of the incubation medium with no change in the concentration of 5-ASA-Tau. On incubation of 5-ASA-Tau with the cecal and colonic contents of rats, the fraction of the dose released as 5-ASA was 45% and 20%, respectively, in 8 h. Considering low partition coefficient and stability in the upper intestine, 5-ASA-Tau might be nonabsorbable and stable in the upper intestine. After oral administration, it would be delivered to the colon in intact form and release 5-ASA and taurine. These results suggested 5-ASA-Tau as a promising colon-specific prodrug of 5-ASA.