• Title/Summary/Keyword: Dosages

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Effect of Yongyanggaktang(YYG) on Regional Cerebral Blood Flow in Rats (영양각탕(羚羊角湯)이 뇌혈류량(腦血流量)에 미치는 영향(影響))

  • Kang Sung-Hyun;Yun Young-Gab
    • Herbal Formula Science
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    • v.10 no.1
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    • pp.105-112
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    • 2002
  • Yongyanggaktang has been used in oriental medicine as a therapeutic agent for cerebral disease and eclampsia for many years. The purpose of this study was to determine the effect of Yongyanggaktang and its exception of Cornu Saigae Tataricae(羚羊角) in YYG about regional cerebral blood flow(rCBF) in rats. 1. rCBF was increased by Yongyanggaktang in dose dependently. 2. rCBF was increased by exception of Cornu Saigae Tataricae(羚羊角) in YYG at high dosages. 3. rCBF was decreased by Yongyanggaktang pretreated propranolol. 4. L-NNA did not affect rCBF. 5.ODQ did not affect rCBF. Above the results. Yongyanggaktang relates to the symphathetic action.

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Ir-192 Brachytherapy Planning of Brain Tumor (Ir-192 방사성소선원에 의한 뇌종양의 치료계획)

  • Choi Tae Jin;Park Jeong Ho;Kim Ok Bae;Suh Soo Ji
    • Radiation Oncology Journal
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    • v.6 no.2
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    • pp.277-281
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    • 1988
  • Although widely used in external beam treatment planning, computed tomography scans are infrequent in incranial tumors by implanting of Radioactive isotope. This incranial brachytherapy has only become possible by using CT scans and stereotaxic operation methods. The coincidence of single source and tumor axes in brachytherapy is very important to determine the therapeutic dosages. Eventhough using the CT scan, according to spatial location of tumor tying, the section of tumor will be seen enlargement, cause the tumor will be cut off with slight angle to its axes. Correct analysis of tumor size from source is required for rotated axes in analytical geometry.

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Four-week Repeated Oral Dose Toxicity Study of A New Hepatotherapeutic Agent GODEX (HEPADIF-S) in Rats (새로운 간질환치료제(고덱스: 헤파디프에스)의 랫드에 대한 4주반복투여 경구독성시험)

  • 강종구;정은용;박선희;김선희;이수해;장호송;황재식;남상윤
    • Toxicological Research
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    • v.17 no.2
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    • pp.107-114
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    • 2001
  • This study was designed to evaluate a repeated oral dose toxicity of a new hepatotherapeutic agent GODEX in Sprague-Dawley rats. Male and female rats were orally administered with dosages of 500, 100, 20, and 0 /kg/day of GODEX daily for 4 weeks, respectively. There were no dose-related changes in clinical signs, body weight changes, food and water consumption, opthalmoscopy, organ weights, urine analysis, biochemical examination, and hematological findings of all animals treated with GODEX. Gross and histopathological findings revealed no evidence of specific toxicity related to GODEX. These indicate that GODEX may have no side effects and its oral maximum tolerated dose value may be over 500 mg/kg in rats.

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General Pharmacology of KI-60606 (KI-60606의 일반약리작용시험)

  • 김은주;김현진;김동연
    • Biomolecules & Therapeutics
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    • v.10 no.2
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    • pp.89-98
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    • 2002
  • In this study general pharmacological profiles of KI-60606 on the central nervous system, the cardiovascular system and the other organs were investigated. The dosages given were 0,5, 10 and 25 mg/kg and drugs were administered intravenously. The animals used for this study were mice, rats, cats and guinea pigs. KI-60606 showed no effects on general behavior, motor coordination, spontaneous locomotor activity, hexobarbital-induced hypnosis time, body temperature, analgesic activity, anticonvulsant activity and contraction of nictitating membrane in cats. Furthermore KI-60606 showed no effects on blood pressure, heart rate, LVP (left ventricular peak systolic pressure), LVEDP (left ventricular end diastolic pressure), LVDP (left ventricular developing pressure), DP(double product), CFR(coronary flow rate), smooth muscle contraction using guinea pig ileum and gastric secretion at all dosage tested except the increase of gastrointestinal transport and urinary $K^+$ excretion.

Effect of Treatments with Flame-retardant on Flame-resistance and Tensile Strength of Paper (난연 처리가 종이의 난연성 및 인장강도에 미치는 영향)

  • Song, Han-Kyu;Lee, Myoung-Ku
    • Journal of Korea Technical Association of The Pulp and Paper Industry
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    • v.38 no.4 s.117
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    • pp.61-67
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    • 2006
  • The effect of several inorganic flame-retardants such as ammonium phosphate, ammonium sulfate, aluminum hydroxide and antimony trioxide on the flame-retardant property and tensile strength of paper has been investigated. Flame-retardants were used preferably as a dry powdered mixture and added to the furnish. Both dipping and coating treatments were employed to apply flame-retardants to paper Flame-retardant paper was manufactured by treatment of $5{\sim}30%$ flame-retardants by weight of the paper on a dry weight. Paper's flame-retardant property and tensile strength were examined by comparison of char length and tensile index. As dosages of flame-retardant chemicals increased, flame-retardant property was improved but tensile index was decreased.

A Literary Study on Vermilionum (영사(靈砂)에 관(關)한 문헌적(文獻的) 고찰(考察))

  • Kwon, Ki-Rok;Kang, Tae-Sik;Kim, Sung-Wook
    • Journal of Pharmacopuncture
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    • v.6 no.2
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    • pp.113-118
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    • 2003
  • Results : 1. Vermilionum is made from the mixture of mercury and sulfur, resulting in reddish mercuric sulfide(Hg2S). 2. The characteristics for Vermilionum are pungent and sweet, has warm temperature, and enters heart, lung, and stomach meridians. 3. The efficacies of Vermilionum are to eliminate parasites, expels phlegm and dampness, and sedate heart and calm spirit. 4. Long-term intake make results in mercuric toxication. 5. Further researches on the administration methods and dosages are required to reduce side effects.

Effects of Crushed RAP on Free and Restrained Shrinkage of Mortars

  • Topcu, Ilker Bekir;Isikdag, Burak
    • International Journal of Concrete Structures and Materials
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    • v.3 no.2
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    • pp.91-95
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    • 2009
  • Reclaimed asphalt pavement (RAP) is abundant substitute for natural aggregate in many areas. It is obtained by crushing of old road pavements in milling machine during rehabilitation and reconstruction process. In this study, reclaimed asphalt pavement mortars (RAPM) have been produced with different cement dosages and replacement ratios. The destructive and nondestructive tests have been conducted on specimens to determine physical and mechanical properties of RAPM. The free and restrained shrinkage tests on RAPM have been conducted to predict fractural behavior of mortars. The aim of the shrinkage tests was to delay crack formation and improve strain capacity of mortars before cracking. The results showed that RAPM exhibits lower elasticity modulus; however the tensile capacity was improved for deformation before cracking.

Coagulation and Flotation Conditions of Humic Acid by Dissolved Air Flotation

  • Lee, Chang-Han
    • Journal of Environmental Science International
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    • v.21 no.9
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    • pp.1043-1051
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    • 2012
  • Coagulation, flocculation, and dissolved air flotation (DAF) experiments were performed with humic acid to evaluate the influence of operational conditions on removal efficiencies. We investigated coagulation, flocculation, and flotation conditions of humic acid removal using a laboratory-scale DAF system. This paper deals with coagulant type (aluminum sulfate and PSO-M) and the most relevant operational conditions (velocity gradients for coagulation and flocculation, retention time and recycle ratio and flotation time). Results showed that optimal conditions for removing humic acid, yielding CHA removal efficiencies of approximately 85 %, are a recycle ratio of 40 %, coagulant dosages of 0.15 - 0.20 gAl/gHA as aluminum sulfate and 0.03 - 0.12 gAl/gHA as PSO-M, coagulation($400s^{-1}$ and 60s), flocculation($60s^{-1}$ and 900s or more), and flotation(490 kPa or more and at least 10 min).

Interfacial and Thermal Characteristics of Natural Fiber Composites Reinforced with Henequen Surface-Treated with EBI

  • Pang Yansong;Han Seong Ok;Cho Donghwan;Drzal Lawrence T.
    • Proceedings of the Korean Society For Composite Materials Conference
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    • 2004.10a
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    • pp.88-91
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    • 2004
  • In this study, a number of natural fiber henequen reinforced polymer matrix composites were successfully fabricated by means of a compression molding technique using chopped henequen fibers surface-treated with different electron beam irradiation (EBI) dosages, thermoplastic poly(butylene succinate), thermosetting unsaturated polyester and phenolic resins. Their interfacial and thermal characteristics were studied in terms of interfacial shear strength, fracture surface, dynamic mechanical properties, dimensional stability, and thermal stability using single fiber microbonding test, SEM, DMA, TMA, and TGA. The results show that their interfacial and thermal properties significantly depend on the intensity of EBl treatment on the natural fiber surface.

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Acute Intramuscular Toxicity Study of Typhoid Vaccine in Rats and Beagle Dogs

  • Lee, Won-Woo;Che, Jeong-Hwan;Li, Guang-Xum;Kang, Byeong-Cheol;Ihm, Jong-Hee;Jun
    • Toxicological Research
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    • v.15 no.1
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    • pp.69-73
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    • 1999
  • Acute toxicity of typhoid vaccine was investigated using Sprague-Dawley (SD) rats and beagle dogs. SD rats and beagle dogs were administered intramuscularly with dosages of 0,. 0.2, 0.1, 0.05 and 0.025 mg/kg, respectively. In animals administered with typhoid vaccine, there were neither dead animals nor significant changes of body weights. In addition, no differences were found between control and treated groups in clinical signs and autopsy findings. Therefore, LD50 of typhoid vaccine was considered to be higher than 0.2 mg/kg in SD rats and beagle dogs.

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