• Radiation Oncology Journal
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• v.12 no.1
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• pp.17-25
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• 1994

We evaluated the effect of nicotinamide on cellular $O_{2}$ consumption and metabolic status i.e., adenylate phosphates and $NAD^{+}$in-vitro, and changes in blood flow in-vivo, to determine whether changes in cellular metabolism or increased oxygen availability, was responsible for increased tumor oxygenation. Thirty min, pre-incubation of cells with$\∼$4mM (= 500mg/kg) nicotinamide resulted in no change in cellular $O_{2}$ consumption. Similarly neither the adenylate Phosphates nor the cellular $NAD^{+}$levels were altered in the presence of $\∼$4mM nicontinamide. In-vivo, nicotinamide (500mg/kg) increased $O_{2}$ availability as estimated by changes in relative tumor blood flow (RBC flux). The changes in RBC flux measured by the laser Doppler method, were tumor volume dependent and increased from$\∼$35$ \% $ in$\∼$ 150$mm_{3}$tumors to$\∼$~75$ \% $ in$\∼$500$mm^{3}$ tumors. In conclusion, these observations indicate a reduction in local tissue $O_{2}$ consumption is not a mechanism of improved tumor oxygenation by nicotinamide in FSa II murine tumor model. The primary mechanism of increased $pO_{2}$ appears to be an increased local tumor blood flow.

• Korean Journal of Clinical Laboratory Science
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• v.50 no.2
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• pp.126-135
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• 2018

This study examined whether the difference in the middle cerebral artery (MCA) velocities can predict the prognosis of stroke and whether the prognostic impact differs among stroke subtypes. Transient ischemic attack (TIA) or acute ischemic stroke patients, who underwent a routine evaluation and transcranial Doppler (TCD), were included in this study. The MCA asymmetry index was calculated using the relative percentage difference in the mean flow velocity (MFV) between the left and right MCA: (|RMCA MFV-LMCA MFV|/mean MCA MFV)${\times}100$. The stroke subtypes were determined using the TOAST classification. Poor functional outcomes were defined as a mRS score ${\geq}3$ at 3 months after the onset of stroke. A total of 988 patients were included, of whom 157 (15.9%) had a poor functional outcome. Multivariable analysis showed that only the MCA asymmetry index was independently associated with a poor functional outcome. ROC curve analysis showed that adding the MCA asymmetry index to the prediction model improved the discrimination of a poor functional outcome from acute ischemic stroke (from 88.6% [95% CI, 85.2~91.9] to 89.2% [95% CI, 85.9~92.5]). The MCA asymmetry index has an independent prognostic value for predicting a poor short-term functional outcome after an acute cerebral infarction. Therefore, TCD may be useful for predicting a poor functional outcome in patients with acute ischemic stroke.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.36 no.5B
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• pp.573-581
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• 2011

The underwater channel is known to offer poor communications channel. The channel medium is highly absorptive and the transmission bandwidth is limited. In addition, the channel is highly frequency selective; the degree of selectiveness depends on a detailed geometry of the channel. Furthermore, the response changes over time as the channel conditions affecting the response such as water temperature, sea surface wind and salinity are time-varying. The transceiver design to deal with the frequency and time selective channel, therefore, becomes very challenging. It has been known that deep fading at certain specific sub-carriers are detrimental to OFDM systems. To mitigate this negative effect, the proposed coded OFDM system employs an LDPC code based modulation. In this paper, we aim 1) to provide a detailed underwater channel model; 2) to design a robust LDPC coded OFDM system; 3) to test the proposed system under a variety of channel conditions enabled by the channel model.

• Journal of Ocean Engineering and Technology
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• v.19 no.6 s.67
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• pp.78-85
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• 2005

Initial alignment and localization are important topics in inertial navigation systems, since misalignment and initial position error wholly propagate into the navigation systems and deteriorate the performance of the systems. This paper presents the error convergence characteristics of the hybrid navigation system for underwater vehicles initial position, which is based on an inertial measurement unit (IMU) accompanying a range sensor. This paper demonstrates the improvement on the navigational performance oj the hybrid system with the range information, especially focused on the convergence of the estimation of underwater vehicles initial position error. Simulations are performed with experimental data obtained from a rotating ann test with a fish model. The convergence speed and condition of the initial error removal for random initial position errors are examined with Monte Carlo simulation. In addition, numerical simulation is conducted with an AUV model in lawn-mowing survey mode to illustrate the error convergence of the hybrid navigation System for initial position error.

• Journal of the Society of Naval Architects of Korea
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• v.56 no.5
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• pp.410-417
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• 2019

An axisymmetric submerged body(L=5.6m, Diam=0.53m) is installed in Large Cavitation Tunnel (LCT) of KRISO and the nominal and total velocities without and with the propeller in operation, respectively, are measured using Laser Doppler Velocimeter (LDV). The flow field is nearly axisymmetric except the wake of the supporting strut, and is considered ideal to study the hydrodynamic interaction between the propeller and the oncoming axisymmetric sheared flow. The measured velocity data are then provided to compute the propeller-induced velocity to get the effective velocity, which is defined by subtracting the propeller-induced velocity from the total velocity. We adopted, in computing the induced velocity, two different methods including the vortex lattice method and the vortex tube actuator model to evaluate the resultant effective velocity distribution. To secure a fundamental base of experimental data necessary for the research on the effective wake, we measured the drag of the submerged body, the nominal and total velocity distributions at various axial locations for three different tunnel water speeds.

• Publications of The Korean Astronomical Society
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• v.30 no.2
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• pp.591-592
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• 2015

X1822-371 is a low mass X-ray binary with an accretion disk corona exhibiting partial eclipses and pulsations in the X-ray band. We update its orbital ephemeris by combining new RXTE observations and historical records, with a total time span of 34 years. There were 11 RXTE observations in 2011 but the eclipsing profile can be seen in only 4 of them. The eclipsing center times were obtained by fitting the profile with the same model as previous studies. Combined with the eclipsing center times reported by Iaria et al. (2011), the O-C analysis was processed. A quadratic model was applied to fit the O-C results and produced a mean orbital period derivative of $\dot{P}_{orb}=1.339(25){\times}10^{-10}s/s$, which is slightly smaller than previous records. In addition to the orbital modulation from the orbital profile, we also present our preliminary results for measuring the orbital parameters using the orbital Doppler effect from the pulsation of the neutron star in X1822-371. The updated orbital parameters from eclipsing profiles will be further compared with the ones from pulsar timing.

• Journal of Dental Anesthesia and Pain Medicine
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• v.18 no.2
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• pp.105-110
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• 2018

Background: A stellate ganglion block (SGB) causes increased blood flow in the maxillofacial region, exhibiting the potential for regenerative effects in damaged tissue. The focus of this study was to understand the efficacy of SGB for regenerative effects against nerve damage. A rat model of the superior cervical ganglion block (SCGB) was created instead of SGB, and facial blood flow, as well as sympathetic nervous system function, were measured. Methods: A vertical incision was made on the left side of the neck of a Wistar rat, and a 5-mm resection of the superior cervical ganglion was performed at the back of the bifurcation of the internal and external branches of the left common carotid artery. Blood flow in the skin at the mandibular angle and mean facial temperature were measured using a laser-Doppler blood flow meter and a thermographic camera, respectively, over a 5-week period after the block. In addition, the degree of ptosis and miosis were assessed over a period of 6 months. Results: The SCGB rat showed significantly higher blood flow at the mandibular angle on the block side (P < 0.05) for 3 weeks, and significantly higher skin temperature (P < 0.05) for 1 week after the block. In the SCGB rat, ptosis and miosis occurred immediately after the block, and persisted even 6 months later. Conclusions: SCGB in rats can cause an increase in the blood flow that persists over 3 weeks.

• The Journal of Korean Institute of Information Technology
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• v.17 no.9
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• pp.91-97
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• 2019

When a radar tracks the warhead of a ballistic missile, decoys of a ballistic missile put a heavy burden on the radar resource management tracking the targets. To reduce this burden, it is necessary to be able to separate the signal of the warhead from the received dynamic radar cross section (RCS) signal on the radar. In this paper, we propose the method of separating the dynamic RCS of each target from the received signal by the Hough transform which extracts straight lines from the image. The micro motion of the targets was implemented using a 3D CAD model of the warhead and decoys. Then, we calculated the dynamic RCS from the 3D CAD model having micromotion and verified the performance by applying the proposed algorithm. Simulation results show that the proposed method can separate the signals of the warhead and decoys at the signal-to-noise ratio (SNR) of 10dB.

• The Journal of the Acoustical Society of Korea
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• v.41 no.4
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• pp.468-479
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• 2022

To detect targets with active sonar system in the underwater environments, the targets are localized by receiving the echoes of the transmitted sounds reflected from the targets. In this case, reverberation from the scatterers is also generated, which prevents detection of the target echo. To detect the target effectively, reverberation suppression techniques such as pre-whitening based on autoregressive model and principal component inversion have been studied, and recently a Non-negative Matrix Factorization (NMF)-based technique has been also devised. The NMF-based reverberation suppression technique shows improved performance compared to the conventional methods, but the geometry of the transducer and receiver and attenuation by distance have not been considered. In this paper, the performance is improved through preprocessing such as the directionality of the receiver, Doppler related thereto, and attenuation for distance, in the case of using a continuous wave with a bistatic sonar. In order to evaluate the performance of the proposed system, simulation with a reverberation model was performed. The results show that the detection probability performance improved by 10 % to 40 % at a low false alarm probability of 1 % relative to the conventional non-negative matrix factorization.

• Journal of Veterinary Science
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• v.21 no.3
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• pp.21.1-21.14
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• 2020

Background: Physical exercise is known to cause significant joint changes. Thus, monitoring joint behavior of athletic horses is essential in early disorders recognition, allowing the proper management. Objectives: The aims of this study were to determine the morphological patterns, physical examination characteristics and ultrasound findings of show jumping horses in training and to establish a score-based examination model for physical and ultrasound follow-ups of metacarpophalangeal joint changes in these animals. Methods: A total of 52 metacarpophalangeal joints from 26 horses who were initially in the taming stage were evaluated, and the horses' athletic progression was monitored. The horses were evaluated by a physical examination and by B-mode and Doppler-mode ultrasound examinations, starting at time zero (T0), which occurred concomitantly with the beginning of training, and every 3 months thereafter for a follow-up period of 18 months. Results: The standardized examination model revealed an increase in the maximum joint flexion angles and higher scores on the physical and ultrasound examinations after scoring was performed by predefined assessment tools, especially between 3 and 6 months of evaluation, which was immediately after the horses started more intense training. The lameness score and the ultrasound examination score were slightly higher at the end of the study. Conclusions: The observed results were probably caused by the implementation of a training regimen and joint adaptation to physical conditioning. The joints most likely undergo a pre-osteoarthritic period due to work overload, which can manifest in a consistent or adaptive manner, as observed during this study. Thus, continuous monitoring of young athlete horses by physical and ultrasound examinations that can be scored is essential.